Sócrates Herrera

Sócrates Herrera
Institute of Immunology | INMUNO

About

244
Publications
25,061
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4,536
Citations
Citations since 2016
105 Research Items
2513 Citations
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20162017201820192020202120220100200300400

Publications

Publications (244)
Article
Full-text available
The currently devastating pandemic of severe acute respiratory syndrome known as coronavirus disease 2019 or COVID-19 is caused by the coronavirus SARS-CoV-2. Both the virus and the disease have been extensively studied worldwide. A trimeric spike (S) protein expressed on the virus outer bilayer leaflet has been identified as a ligand that allows t...
Article
Full-text available
Despite the global interest and the unprecedented number of scientific studies triggered by the COVID-19 pandemic, few data are available from developing and low-income countries. In these regions, communities live under the threat of various transmissible diseases aside from COVID-19, including malaria. This study aims to determine the severe acut...
Article
Full-text available
A randomized, double-blind, controlled vaccine clinical trial was conducted to assess, as the primary outcome, the safety and protective efficacy of the Plasmodium vivax circumsporozoite (CS) protein in healthy malaria-naïve (phase IIa) and semi-immune (phase IIb) volunteers. Participants (n = 35) were randomly selected from a larger group (n = 121...
Article
Background Pvs48/45 is a Plasmodium vivax gametocyte surface protein involved in the parasite fertilization process. Previous studies showed that Pvs48/45 proteins expressed in Escherichia coli (E. coli) and Chinese hamster ovary (CHO) cells were highly immunoreactive with sera from malaria-endemic areas and highly immunogenic in animal models. Her...
Article
Full-text available
P48/45 is a conserved gametocyte antigen involved in Plasmodium parasite fertilization. A recombinant Plasmodium vivax P48/45 (Pvs48/45) protein expressed in Escherichia coli (E. coli) was highly antigenic and immunogenic in experimental animals and elicited specific transmission-blocking (TB) antibodies in a previous pilot study. Here, a similar P...
Preprint
Full-text available
A randomized, double-blind, controlled clinical trial was conducted to assess the safety and protective efficacy of the Plasmodium vivax circumsporozoite (CS) protein. A total of 35 healthy adults, either malaria-naïve (n=17) or P.vivax semi-immune (n=18), were enrolled and immunized intramuscularly (i.m.) at months 0, 2, and 6, with the Pv CS (150...
Preprint
Full-text available
A randomized, double-blind, controlled clinical trial was conducted to assess the safety and protective efficacy of the Plasmodium vivax circumsporozoite (CS) protein. A total of 35 healthy adults, either malaria-naïve (n=17) or P.vivax semi-immune (n=18), were enrolled and immunized intramuscularly (i.m.) at months 0, 2, and 6, with the PvCS (150...
Preprint
Full-text available
A randomized, double-blind, controlled clinical trial was conducted to assess the safety and protective efficacy of the Plasmodium vivax circumsporozoite (CS) protein. A total of 35 healthy adults, either malaria-naïve (n = 17) or P.vivax semi-immune (n = 18), were enrolled and immunized intramuscularly (i.m.) at months 0, 2, and 6, with the Pv CS...
Article
Full-text available
Over the last four decades, significant efforts have been invested to develop vaccines against malaria. Although most efforts are focused on the development of P. falciparum vaccines, the current availability of the parasite genomes, bioinformatics tools, and high throughput systems for both recombinant and synthetic antigen production have helped...
Preprint
Introduction COVID-19 pandemic is currently the most significant global public health challenge, with more than 31 million cases reported to date. Colombia first reported COVID-19 cases in the country by early March 2020, and six months later it has reached ∼750,471 clinical cases, with significant regional differences in morbidity, mortality, and...
Article
Full-text available
Plasmodium vivax , the most widely distributed human malaria parasite, causes severe clinical syndromes despite low peripheral blood parasitemia. This conundrum is further complicated as cytoadherence in the microvasculature is still a matter of investigations. Previous reports in Plasmodium knowlesi , another parasite species shown to infect human...
Article
Full-text available
Background Malaria remains endemic in several countries of South America with low to moderate transmission intensity. Regional human migration through underserved endemic areas may be responsible for significant parasite dispersion making the disease resilient to interventions. Thus, the genetic characterization of malarial parasites is an importan...
Data
MOI and its 95% profile-likelihood confidence intervals. Top: alleles with absolute frequency ≤ 5 among all populations were removed. Bottom: alleles with absolute frequency ≤ 10 among all populations were removed. (PDF)
Data
Mean multiplicity of infection (MOI) estimated without alleles removed for Buenaventura. (PDF)
Data
Measurements of conditional asymmetric linkage disequilibrium (ALD) per pair of microsatellite loci for each P. vivax population. (PDF)
Data
Mean multiplicity of infection (MOI) estimated without alleles removed for the four Colombian population. (PDF)
Data
Heterozygosity and its 95% bias-corrected and accelerated non-parametric bootstrap confidence intervals. Top: alleles with absolute frequency ≤ 5 among all populations were removed. Bottom: alleles with absolute frequency ≤ 10 among all populations were removed. (PDF)
Data
Poisson parameter for MOI estimated for each population and Buenaventura alone. (PDF)
Data
Alelle frequencies per microsatellite loci in all Colombian P. vivax populations. (PDF)
Data
Description of isolates genotyped. (PDF)
Preprint
Full-text available
The development of vaccines that provide sterile protection against human malaria is a major global public health priority requiring a better understanding of the mechanisms involved in natural and vaccine-induced sterile immunity. RNAseq was used to profile gene expression of peripheral blood samples from 12 Duffy positive (Fy+) (Plasmodium vivax...
Article
Full-text available
To evaluate whether recovery from complicated malaria follows a common trajectory in terms of immunological mechanism or, rather, is highly individualized for each patient, we performed longitudinal gene expression profiling of whole blood. RNA sequencing (RNAseq) was performed on blood samples obtained from eight patients on four consecutive days...
Article
Full-text available
Objectives: To dissect the transcriptional networks underpinning immune cells responses during primary Plasmodium vivax infection of healthy human adults. Methods: We conducted network co-expression analysis of next-generation RNA sequencing data from whole blood from P. vivax and P. falciparum controlled human malaria infection (CHMI) of health...
Article
Clinical immunity to malaria is associated with acquisition of IgG specific for members of the Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family of clonally variant antigens on the surface of infected erythrocytes (IEs). The VAR2CSA subtype of PfEMP1 mediates IE binding in the placenta. VAR2CSA-specific IgG is normally acquired o...
Article
Full-text available
Almost invariably, humans become ill during primary infections with malaria parasites which is a pathology associated with oxidative stress and perturbations in metabolism. Importantly, repetitive exposure to Plasmodium results in asymptomatic infections, which is a condition defined as clinical tolerance. Integration of transcriptomics and metabol...
Article
Full-text available
BACKGROUND Rapid urbanisation in difficult socio-economic conditions such as inadequate housing infrastructure, lack of public services, improper sanitation, and poor water drainage systems in vegetation-rich areas lead to ecological conditions that are conducive to the breeding of mosquitoes and transmission of malaria, in semi-urban and urban set...
Article
Full-text available
Introduction Inborn errors of metabolism (IEM) represent an important public health problem due to current diagnosis and treatment limitations, poor life quality of affected patients, and consequent untimely child death. In contrast to classical methods, tandem mass spectrometry (MS/MS) has allowed simultaneous evaluation of multiple metabolites as...
Article
Full-text available
Background Complicated malaria remains an important public health problem, particularly in endemic settings where access to health services is limited and consequently malaria fatal outcomes occur. Few publications describing the clinical course and outcomes of complicated malaria in Latin America are found in the literature. This prospective study...
Article
Full-text available
Background The recent scale-up in malaria control measures in Latin America has resulted in a significant decrease in the number of reported cases in several countries including Ecuador, where it presented a low malaria incidence in recent years (558 reported cases in 2015) with occasional outbreaks of both Plasmodium falciparum and Plasmodium viva...
Article
Full-text available
Background: Reported urban malaria cases are increasing in Latin America, however, evidence of such trend remains insufficient. Here, we propose an integrated approach that allows characterizing malaria transmission at the rural-to-urban interface by combining epidemiological, entomological, and parasite genotyping methods. Methods/principal find...
Data
Prevalence of responders to P. vivax coiled coil fragments in young children from Ilahita and Sunuhu villages. (DOCX)
Data
Prevalence of antibody responders to P. vivax coiled coil fragments in donors from Burkina Faso. (DOCX)
Data
Reactivity pattern of sera samples against the P. vivax coiled coil fragments. (PDF)
Data
Prevalence of responders reactive to P. vivax coiled coil fragments in volunteers from the different tested villages in PNG. (XLSX)
Data
Association between IgG levels to P. vivax antigens and protection against P. falciparum clinical disease (with parasite density >2500/μl of blood). (DOCX)
Data
Antibody reactivity at enrollment by age group. (DOCX)
Data
Reactivity of antibodies at enrollment and molecular Force of Infection. (XLSX)
Data
Association between IgG levels to P. vivax antigens and protection against clinical malaria (XLSX)
Article
Full-text available
The global prevalence of malaria has decreased over the past fifteen years, but similar gains have not been realized against Plasmodium vivax because this species is less responsive to conventional malaria control interventions aimed principally at P. falciparum. Approximately half of all malaria cases outside of Africa are caused by P. vivax. This...
Data
TPP PvB2: Population screening for Plasmodium vivax infection surveillance. (PDF)
Data
TPP PvB1: Point-of-care diagnosis of subpatent Plasmodium vivax infection. (PDF)
Data
Summary of existing malaria diagnostic TPPs. (PDF)
Data
TPP PvA: Diagnosis of Plasmodium vivax malaria acute infection. (PDF)
Article
Full-text available
Background Immunizing human volunteers by mosquito bite with radiation-attenuated Plasmodium falciparum sporozoites (RAS) results in high-level protection against infection. Only two volunteers have been similarly immunized with P. vivax (Pv) RAS, and both were protected. A phase 2 controlled clinical trial was conducted to assess the safety and pr...
Data
Kaplan-Meier analysis of pre-patent and incubation period after P. vivax sporozoite CHMI. Days after CHMI to detect parasites by microscopy (A) or RT-qPCR (B) and onset of symptoms (C). (TIF)
Data
Antibody response against PvCS-N peptide and PvMSP-1. ELISA antibody response in RAS group (n = 12; A and C) and in Fy- group (n = 5; B and D) as well as in Ctl group (n = 2; red line in A to D) against PvCS-N (A-B) and PvMSP-1 (C-D) are shown. Values are expressed as reactivity index (RI) defined as sample OD at 1:200 serum dilutions divided by th...
Data
Plasmodium vivax CS protein recognized by immunized volunteers. Western blot analysis of P. vivax sporozoites lysate separated on 12% SDS-PAGE under non-reducing conditions. Sera from RAS group (n = 12), Fy- group (n = 5), and Ctl group (n = 2) are shown. Negative (naïve volunteers) and positive (volunteers immunized with PvCSP) controls are also s...
Data
Adverse events during immunizations and after CHMI. (XLS)
Data
Indirect immunofluorescence using Plasmodium vivax sporozoites. (DOC)
Data
Clinical and laboratory exclusion criteria, assessment techniques and excluded volunteers. (DOC)
Data
Screening of common infectious agents for recruited volunteers. (DOC)
Data
Total number of mosquito bites received during immunizations. (XLSX)
Article
Full-text available
Background Even though malaria incidence has decreased substantially in Guatemala since 2000, Guatemala remains one of the countries with the highest malaria transmission in Mesoamerica. Guatemala is committed to eliminating malaria as part of the initiative ‘Elimination of Malaria in Mesoamerica and the Island of Hispaniola’ (EMMIE); however, it i...