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Sockalingam Anbazhagan

Sockalingam Anbazhagan
Independent Researcher

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70
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1,378
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Publications

Publications (70)
Article
Full-text available
Quetiapine Fumarate is potent, and the daily therapeutic dose can be delivered easily across the skin with the help of permeation enhancers. Quetiapine Fumarate-loaded transdermal patches were prepared by solvent evaporation technique. Various formulation parameters, excipients, and their combinations were optimized to get thin, translucent, smooth...
Article
Full-text available
Parkinson’s disease is the major neurodegenerative disorder, which is due to the loss of dopaminergic neurons in the brain and results in bradykinesia, rigidity, tremor and instable posture. Oxidative stress, Inflammation, Apoptosis has been implicated in the molecular etiopathogenesis of Parkinson disease. In the present study, Nebivolol, a Cardio...
Article
The objective of the present learns to improve solubility and dissolution of Olmesartan Medoxomil (OM) by improving water solubility by reliable dispersion methods using fusion method (FM) and solvent evaporation (SE) method via hydrophilic polymers PEG 6000 and PVP K30 in different ratios. Preformulation studies of OM: polymers were carried using...
Article
Full-text available
Objective: The present study was aimed to enhance the solubility of poorly water-soluble drug (BCS Class II) Febuxostat using water-soluble polymers.Methods: Pre-formulation studies like drug excipient compatibility studies by Fourier-transform infrared spectroscopyDifferential scanning calorimetry and determination of saturation solubility of drug...
Article
Full-text available
The solubility/dissolution behavior of a drug is key factor influencing its oral bioavailability, being the rate-limiting step for absorption of drugs from the gastrointestinal tract. For effective pharmacological action, aqueous solubility is the most important criteria for prompt dissolution and good absorption. The present study was aimed to enh...
Article
Simple and sensitive infrared spectrophotometric method has been developed for the estimation of modafinil in tablet dosage form and the Beer’s Law concentration range was found to be 1.0mg to 2.5mg. The correlation coefficient for the method was found to be 0.999 and the developed method was analyzed for specificity, limit of detection (LOD), limi...
Article
Background: The absorption of drug through skin avoids many side effects of oral route like gastric irritation, nausea, systemic toxicity etc and thus improves patient compliance. Naproxen sodium (NPRS) is one of the potent NSAID agents. Objective: The present study was aimed to develop and evaluate the gel formulation containing NPRS for transd...
Article
Monoamine oxidase-A and B have been studied over a long period as one of the promising drug targets for the treatment of depression and neurodegenerative disorders. Commonly, MAO-A is associated with depression because of its relation with the control of serotonin levels. On the other hand, MAO-B has been associated with Alzheimer’s and Parkinson’s...
Article
Previously we have reported 5-substituted phenyl-3-(thiophen-2-yl)-4, 5-dihydro-1hpyrazole-1-carboxamides as a novel class of antidepressants. The aim of the current study is to proposing the reason for such biological activities of the molecules by using molecular docking studies using AutoDock4.2. Using molecular docking studies, we propose that...
Article
Full-text available
The solubility enhancement process of hydrophobic drugs plays a key role in the formulation development to achieve the bioavailability and therapeutic action of the drug at the target site. About 40% of the new chemical entities identified by pharmaceutical industry screening programs face numerous problems in the formulation and development stage...
Article
Full-text available
This work summarizes of the analytical methods reported in the literature for the separation and quantification using several liquid chromatographic methods for the determination of antihypertensives in biological matrices and pharmaceutical formulations have been discussed in the course of this review, namely RPHPLC, HPTLC and LC-MS methods; their...
Article
The main objective of present investigation was to study the influence of Piper betle on the permeation of Naproxen sodium gel when applied on skin. This route avoids the side effects of NSAIDS on oral administration like irritation of the gastrointestinal tract, and systemic toxicity and improves the patient compliance and therapeutic efficacy. Th...
Article
The objective of the present study was to develop and characterize extended release tablets of Pramipexole dihydrochloride monohydrate to be taken once daily. The combination of different polymers like hydroxypropyl methyl cellulose (HPMC K 100M) and Eudragit L 100 in varying concentrations were studied to get the desired extended release profile o...
Article
Modified release matrix tablets of Tapentadol hydrochloride were prepared with HPMC K100 M as retarding polymer by wet granulation method. The granules were evaluated for angle of repose, bulk density, tapped density, bulkiness, compressibility index and Hausners ratio. The tablets were subjected to weight variation, hardness, friability and drug c...
Article
In the context of the discovery of new potential antidepressant candidates and in the light of promising antidepressant action of pyrazoline nucleus, a new series of thiophene bearing pyrazoline carboxamides were synthesized and examined for their antidepressant effect by two behavioural models viz. Forced Swim Test (FST) and Tail Suspension Test (...
Article
Full-text available
The liquid chromatography–tandem mass spectrometric assay method for the simultaneous determination of rosuvastatin and amlodipine in human plasma using deuterated analogues as internal standards has been developed and validated. The analytes were extracted from 100 μL aliquots of human plasma via liquid–liquid extraction using a mixture of ethyl a...
Article
The validity of pyrazoline heterocyclic core for the design of inhibitors of monoamine oxidase has been previously established. Recently our group synthesized some novel thiophene based pyrazoline-carbothioamides and found good antidepressant activity. The objective of the current study is to identify the reason for such biological activities of th...
Article
In this paper, the authors proposed a simple, rapid and highly sensitive liquid chromatography-tandem mass spectrometric (LC-MS/MS) assay method for the determination of riluzole in human plasma. Carbamazepine was used as an internal standard (IS). The method employed only 100 μL of human plasma for sample processing by a simple protein precipitati...
Article
Various structural modifications of the heteroaryl chalcones templates have been made to explore its promising biological potential in recent years. This review article is an effort to sum up the design, chemistry and biological activities of heteroaryl chalcones. In this connection, we highlighted the brief summary about the therapeutic potential...
Article
A series of phenyl-3-(thiophen-2-yl)-4, 5-dihydro-1H-pyrazole-1-carbothioamides (TTa-TTg) were synthesized by the ring closure reaction of phenyl-1-(thiophen-2-yl) prop-2-en-1-ones with thiosemicarbazide in alcoholic basic medium. All the final derivatives were evaluated for their antidepressant and neurotoxicity screening. The structures of the co...
Article
Full-text available
In the five membered nitrogen containing heterocyclic family, pyrazoline could be recognized as the promising scaffold for the inhibition of Monoamine oxidase. Substitution at 1, 3 and 5-position of the pyrazoline nucleus displayed a significant activity towards MAO in the past 15 years. Our study identified the detailed structure activity relation...
Article
Ficus virens aiton (Moraceae) which is commonly known as white fig is abundantly distribute throughout India. The present study was aimed to investigate the wound healing activity by excision wound model to evaluate the wound healing activity of Ficus virens methanolic extract, prepared as ointment form 10% and applied on Wistar albino rats of eith...
Article
A series of 5-{[(1E, 2E)-1-(1H-benzimidazol-2-yl)-3-phenylprop-2-en-1-ylidene] amino}-1,3,4-thiadiazole-2-thiol have been synthesized by the reaction between (2E)-1-(1H-benzimidazol-2-yl)-3-substituted phenylprop-2-en-1-ones and 5-amino-1,3,4-thiadiazole-2-thiol in presence of conc. HCl. The structures of the final derivatives were established on t...
Article
The present paper demonstrates the utility of PASS computer-aided program and makes a clear comparison of predicted and observed pharmacological properties of some novel 5-[(2E)-1-(1H-benzimidazol-2-yl)-3-substituted phenylprop-2-en-1-ylidene] pyrimidine-2, 4, 6 (1H, 3H, 5H)-triones (5a-f). The synthesis of the titled derivatives were achieved by t...
Article
Full-text available
A series of some novel imines (6a–f) of 2-amino, 5-thio 1,3,4-thiadiazole connected to benzimidazole chalcones were prepared. The structures of the final imines were ascertained by IR, 1HNMR, mass and elemental analyses. Predicted activity spectra of all the final derivatives were determined in the category of mucomembranous protector nature with a...
Article
A series of 1-(1H-benzimidazol-2-yl)-3-substituted phenylprop-2-en-1-ylidene] amino}-1,3,4-thiadiazole-2- thiols (6a-6f) were synthesized by the acid catalyzed nucleophilic addition reaction between 1-(1H-benzimidazol-2-yl)-3- phenylprop-2-en-1-ones (4a-4f) and 5-amino-1,3,4-thiadiazole-2-thiol. All the synthesized compounds were characterised by I...
Article
It is challenging for many drugs to be transported across various biological membranes. Furthermore, development of many drugs gets thwarted owing to their hydrophilic nature. The bioavailability of such drugs, which is the function of their ability to cross the membrane, tends to be low and exhibit high intra and inter subject variability. At pres...
Article
Full-text available
The asymmetric unit of the title compound, C13H8Br2OS, contains two mol­ecules, in which the dihedral angles between the thio­phene and benzene rings are 10.5 (3) and 33.2 (4)°. There are no significant directional inter­actions in the crystal.
Article
A series of (2E)-1-(H-benzimidazol-2-yl)-3-substituted phenyl 2-propen-1-one linked with barbitone (5a-g) are synthesized by both conventional method and microwave assisted method. The benzimidazole chalcones (4a-g) were prepared from the condensation of 2-acetyl benzimidazole (3a) with different aromatic aldehydes. These chalcones on reaction with...
Article
Full-text available
A rapid and precise RP-HPLC method for determination of Olmesartan medoxomil and Hydrochlorothiazide in bulk and pharmaceutical dosage forms. Olmesartan medoxomil & Hydrochlorothiazide are found to be degraded together under different set of conditions as followed according to ICH guidelines and the degradants so formed along with olmesartan & hydr...
Article
A simple, specific and economic spectroscopic method has been developed for the estimation of Rosavastatin calcium in bulk and tablet dosage form. In the developed method water was used as the solvent. The absorption maximum of the drug was found to be 241nm. The drug follows a linear Lambert-Beer law relationship with respect to the drug concentra...
Article
Full-text available
The synthesis of some novel (1-H) benzimidazole bearing pyrimidine-trione based MAO-A inhibitors were achieved by the reaction between 2E)-1-(1H-benzimidazol-2-yl)-3-phenylprop-2-en-1-ones(4a–f) and barbituric acid in the presence of a catalytic amount of acetic acid medium. All the final structures were assigned on the basis of IR, 1HNMR and mass...
Article
Solid state structure information for (2E)-1-(5-bromothiophen-2-yl)-3-[4- (dimethylamino)phenyl]prop-2-en-1-one is revealed by using single crystal X-ray diffraction study. The conformation of the molecule in solid state is used to carry out the drug design studies like structure optimization by Density Functional Theory (DFT) and Induced Fit Docki...
Article
Full-text available
In order to elucidate the structural requirements for human factor Xa receptor antagonism, 72 antagonists belonging to isoxazolidine chemical class were selected from the literature and conducted molecular modeling studies. Best binding conformations were isolated by docking selected molecules into the receptor binding site. To further explore the...
Article
Full-text available
Objective: To develop transfersomal formulation integrated with piperine intended for vitiligo. Methods: Film hydration technique was employed in the preparation of transfersomes. Modified dreifsfpuesciotinv ecleyl lw, choilnes itsatpene csyt rtiepspteinr gw mereet hfaobdr iwcaatse din ftoerg eraxt veidv ow ditihff utsisiosune s teuxdtrieasc taionn...
Article
Full-text available
It has become increasingly apparent that vesicular drug delivery elicits modest possessions in drug targeting. Transfersomes are a form of elastic or deformable vesicle, which were first introduced in the early 1990s. Elasticity can be achieved by using an edge activator in the lipid bilayer structure. Molecules greater than 500 Da normally do not...
Article
Full-text available
Two new, rapid, precise, accurate and specific chromatographic methods for the simultaneous determination of Telmisartan,Amlodipine besylate and Hydrochlorothiazide in combined pharmaceutical dosage forms. The first method based on reverse phase liquid chromatography by using Qualisil BDS C18 column (250 mm X 4.6 i.d., 5 μm). Mobile phase consists...
Article
Full-text available
The effect of chloroform, ethyl acetate and ethanolic extract of ficus nervosa bark was investigated in rats to evaluate the anti-ulcer activity by using aspirin, alcohol and pyloric ligation models experimentally induced gastric ulcer. The parameters taken to assess anti-ulcer activity were volume of gastric secretion, pH, free acidity, total acid...
Article
Solid state structure of a compound reveals the information on intermolecular forces experienced by the molecule. This information is helpful in understanding the molecular recognition process. One of the most important features in intermolecular forces is halogen bond which has been identified as similar to hydrogen bond. Halogen bond in solid sta...
Article
A study has been carried out to investigate the physicochemical, binding and disintegrating properties of starch isolated from grains of Carica papaya (Family: Caricaceae). The studies indicated that this starch is qualitatively and quantitatively comparable to Corn starch as also the rheological and swelling characteristics. Paracetamol (500mg) ta...
Article
Full-text available
In the title compound, C16H15BrO4S, the dihedral angle between the thio­phene and benzene rings is 13.08 (16)°. The C atoms of the meta meth­oxy groups of the substituted benzene ring lie close to the plane of the ring [displacements = 0.049 (5) and −0.022 (4) Å], whereas the para-C atom is significantly displaced [−1.052 (4) Å]. In the crystal, mo...
Article
A simple, selective, accurate and precise RP-HPLC method has been developed for estimation of low content of Fenpiverinium bromide in their combined dosage form of Metamizole sodium and Pitofenone Hydrochloride of high content. The developed method uses Sodiumdihydrogenphosphate and Methanol (66:34%V/V) as the mobile phase with flow rate of 1ml/min...
Article
Vitiligo also known as leukoderma is a pigmentation disorder in which melanocytes (the cells that make pigment) in the skin are destroyed. As a result, white patches appear on the skin on different parts of the body which affects even the psychology and social status of the patient. In recent years, it has been proved that Piperine, an alkaloid fro...
Article
The synthesis of a series of novel dispiropyrrolidines has been accomplished by 1,3-dipolar cycloaddition reaction with 5-arylidene-1,3-thiazolidine-2,4-dione and 5-arylidene-4-thioxo-1,3-thiazolidine-2-one derivatives as dipolarophiles. The structure and stereochemistry of the cycloadduct have been established by single crystal X-ray structure and...
Article
The aerial portions of the plant Trianthema decandra was extracted with 90% ethanol by soxhlet extraction. The extracts were vacuum dried and subjected to analgesic and anti inflammatory activities by using acetic acid induced writhing response, hot plate method and carrageenan induced rat paw oedema methods respectively. It was observed that the e...
Article
Full-text available
Vitiligo also known as Leukoderma is caused by the loss of pigment, resulting in irregular pale patches of skin. Vitiligo develops patches of de-pigmented skin appearing on extremities. A team of scientists at King's College London have discovered that Piperine and its synthetic derivatives can stimulate pigmentation in the skin. The present study...
Article
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Article
The synthesis of a series of novel dispiropyrrolidines has been accomplished by 1,3-dipolar cycloaddition reaction with 5-arylidene-1,3-thiazolidine-2,4-dione and 5-arylidene-4-thioxo-1,3-thiazolidine-2-one derivatives as dipolarophiles. The structure and stereochemistry of the cycloadduct have been established by single crystal X-ray structure and...
Article
The aerial portions of the plant Notonia grandiflora DC was successively extracted with hexane, chloroform and ethanol by soxhlet extraction. The extracts were vaccum dried and subjected to antibacterial (Staphylococcus aureus, Bacillus subtilis, Escherichia coli and Klebsiella pneumoniae) and antifungal (Aspergillus niger and Aspergillus fumigatus...
Article
The plant Trianthema decandra, Linn was successively extracted with petroleum ether, chloroform and ethanol by soxhlet extraction. The extracts were vaccum dried and subjected to antibacterial (B.cereus, S.aureus, K.pneumoniae and E.coli.) and antifungal (C. albicans and A.Fumigatus) screening by agar disc diffusion method. It was observed that the...
Article
A simple, fast, precise and accurate reverse phase high performance liquid chromatographic technique developed for the simultaneous determination and validation of gabapentin and methylcobolamin in its tablet form. A hypersil C18, 5 micron, 250 X 4.6mm, 5 mm i.d column in isocratic mode, mobile phase, buffer: acetonitrile: methanol (75:15:10v/v). T...
Article
In this study, the Tsunami-caused deterioration of soil and groundwater quality in the agricultural fields of coastal Nagapattinam district of Tamilnadu state in India is presented by analyzing their salinity and sodicity parameters. To accomplish this, three sets of soil samples up to a depth of 30 cm from the land surface were collected for the f...
Article
A precise, validated and accurate method for the determination of aripiprazole has been developed by using UV spectrophotometry and Reverse phase high performance liquid chromatographic method in tablet dosage form. Spectroscopic determination was carried out at an absorption maximum of 254nm for aripiprazole using acetonitrile as solvent and 0.1M...
Article
In the present study, simultaneous quantification of stavudine (SV), lamivudine (LV) and nevirapine (NV) in tablets by UV spectroscopy, reverse phase HPLC (RP-HPLC) and HPTLC methods were developed. In the UV multi-component spectral method, SV, LV and NV was quantified at 266, 271 and 315 nm, respectively. In the RP-HPLC method, the drugs were res...
Article
A simple, fast and precise reverse phase high performance liquid chromatographic method developed for the simultaneous estimation of Domperidone and Pantoprazole in it's tablet form. A Hypersil C 18 Octa Decyl Silane (ODS) column 250 mm X 4.6 mm i.d, 5 μm particle size in isocratic mode, with mobile phase 50 mM Potassium Dihydrogen Phosphate and Ac...
Article
A simple, fast, specific and precise high performance thin layer chromatographic method (HPTLC) has been developed for estimation of pioglitazone hydrochloride in its tablet dosage form. Separation was carried out on precoated silica gel 60 F254 HPTLC plate and developed using a mixture of toluene: methanol: acetone: ammonia (10%v/v) in the ratio o...
Article
A simple, fast and precise reverse phase high performance liquid chromatographic method developed for the simultaneous estimation of atorvastatin and aspirin in its capsule form. A Hypersil C 18 Octa Decyl Silane (ODS) column 250 mm X 4.6 mm i.d, 5 μm particle size in isocratic mode, with mobile phase 50 mM potassium dihydrogen phosphate, acetonitr...
Article
Two simple, accurate, rapid and sensitive methods were developed for the estimation of ritodrine hydrochloride (RH) in tablets. The first method is based on the formation of a complex (green coloured chromagen - λ max 765nm) of RH with ferric chloride in the presence of potassium ferricyanide. The second method is based on the formation of a conden...
Article
Full-text available
Antioxidant activity of the aqueous (AET) and methanolic extracts (MET) of the Thespesia populnea bark was investigated in rats by inducing liver injury with carbon tetrachloride:olive oil (1:1). The extracts exhibited significant antioxidant activity showing increased levels of glutathione peroxidase (GPX), glutathione S-transferase (GST), glutath...
Article
Full-text available
In the present study, Thespesia populnea (Malvaceae) bark was extracted with methanol and water. The extracts were vacuum dried to yield the respective methanol (MET) and aqueous extract (AET). The extracts were evaluated for hepatoprotective activity against carbon tetrachloride (CC14) induced liver damage at 2 dose levels (250 and 500 mg/kg). The...
Article
Levels of blood glucose, lipid peroxidation, glutathione (GSH), glutathione peroxidase (GPx), glutathione S-transferase (GST) activities and blood selenium levels were determined in streptozotocin (STZ)-induced diabetic mice. The effect of oral administration of sodium selenite was studied on the above parameters. Diabetes caused hyperglycemia (2.8...
Article
Full-text available
One of the most feasible approaches for achieving a prolonged and predictable drug delivery profiles in the GIT is to control the gastric residence time (GRT) using gastroretentive dosage forms. The aim of the present study is to prepare the floating microspheres of lansoprazole and sustain the drug release for longer time to over come the short ha...

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