Sobhi M. Gomha

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• Professor
• Professor (Full) at Islamic University of Madinah

A series of new polyazaheterocyclic ring systems was synthesized via the reaction of enaminone 5 with active methylene compounds, hydrazine hydrate, hydroxylamine, and heterocyclic amines. The structures of the newly synthesized compounds were substantiated on the basis of spectral data and elemental analyses. The antitumor activity of the enaminon...

Heavy metal contamination in wastewater remains a critical environmental concern. This study investigates the adsorption performance of pyridine-functionalized chitosan (CS-PY) for the removal of arsenic (As) and antimony (Sb) from aqueous solutions. Batch experiments were conducted using unmodified chitosan (CS) and CS-PY under varying conditions,...

Seawater represents a viable alternative to freshwater for cooling and desalination applications; however, its use is often limited by issues related to scaling and corrosion. This work presents a comprehensive evaluation of a novel inhibitor, isophorone–thiosemicarbazone (ITB), designed to prevent CaCO3 scale formation in seawater environments. IT...

Background/aim: Despite the known harmful effect associated with malathion toxicity in various organs, it continues to be widely used for plant protection and insect control. This study is the first to compare the protective effects of estradiol and ascorbic acid against malathion-induced nephrotoxicity through histopathological assessment and mole...

Energy storage has become an essential need for today’s applications. Thus, the development of capacitors and their materials has gotten great attention. In this study, a high mass loading (2 mg cm⁻²) NiMn2O4/carbon felt (CF-NMO) was fabricated using a hydrothermal process and used as a new material for a pseudo-capacitive electrode having a potent...

Background Given the inadequacies of current chemotherapy, there is a need for more effective anticancer agents. Imidazole and thiazole compounds have demonstrated significant biological activity, making them promising candidates Aims and Objective This study investigates the anticancer potential of imidazole and thiazole derivatives, focusing on...

The discharge of untreated dye waste from various industrial sectors into wastewater poses significant environmental and health risks. This study presents an innovative approach by developing a cost-effective and eco-friendly hybrid mesoporous nanocomposite, silver nanoparticles@mesoporous mango peel-derived carbon (AgNPs@MMC), synthesized from agr...

New thiocarbohydrazone ligand (N′‐((E)‐3,3‐diphenyl‐2,3‐dihydro‐1H‐inden‐1‐ylidene)‐2‐((Z)‐2‐oxoindolin‐3‐ylidene)hydrazine‐1‐carbothiohydrazide; H2L) and its Co (II), Ni (II), Fe (III), Cu (II), Cd (II), Zn (II), and Mn (II) complexes were prepared in good yields ranging from 60% to 90% and characterized by spectroscopic and analytical tools. Uv–v...

Background Significant research efforts have been directed towards developing systems for enhancing the intracellular delivery of phosphate-substituted compounds, such as biologically active peptides and nucleotides. Phosphoramidates (P-N) are organophosphorus structures containing a single covalent bond between the P(V) and N(III) atoms. Three typ...

Cyclodextrin and related compounds acquired considerable interest in the last decades in chemical and biomedical fields due to the broad spectrum of applications in various fields. The current review shed light on recent aspects related to cyclodextrin structural features, recent applications in polymer chemistry, medical aspects as well as the adv...

In the current study, pyromellitimide benzoyl thiourea cross-linked chitosan (PIBTU-CS) hydrogel, was evaluated as a green biocatalyst for the efficient synthesis of novel thiazole derivatives. The PIBTU-CS hydrogel showcased key advantages, such as an expanded surface area and superior thermal stability, establishing it as a potent eco-friendly ca...

Background: Previous studies have reported various biological activities of indeno-pyridazine and thiazole derivatives, including antiviral activity and CoV-19 inhibition. In this paper, the authors aimed to design, synthesize, and characterize a novel series of indenopyridazinethiazoles, starting with 2-(4-cyano-3-oxo-2,3-dihydro-9H-indeno[2,1-c]p...

α Glucosidase inhibitors are critical for diabetes management, with pyrazoles and thiazoles emerging as effective options. This research highlights curcumin‐based pyrazole‐thiazole hybrids as potential inhibitors, synthesizing derivatives and evaluating their inhibitory capabilities. The study involved the synthesis of novel compounds using hydrazo...

The Co2O3-Chitosan composite (Co@Chitosan) nanoparticles were synthesized through a green approach. The composite under investigation was characterized by various analytical methods, including scanning electron microscopy (SEM), transmitted electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), and atomic force microscope (AFM) confirmi...

Aim: This research aims to expand the established pharmacological space of tumor-associated carbonic anhydrases (TACAs) by exploring the synthetically accessible chemical space of 3-substituted coumarins, with the help of in silico pharmacology prediction.Materials & methods: 52 novel 3-substituted coumarins were sketched, prioritizing synthetic fe...

4-Amino-5-ethyl-4H-1,2,4-triazole-3-thiol was used as a key intermediate for the synthesis of triazolo[3,4-b][1,3,4]thiadiazines, triazolo[4,3-b][1,2,4,5]tetrazines and Schiff’s base via reactions with various hydrazonoyl halides and salicyaldehyde, respectively. Moreover triazolyl-N-N′-triazole derivatives were prepared from reaction of Schiff’s b...

Green synthesis using L-proline as an organocatalyst is crucial due to its reusability, mild conditions, clean reactions, easy workup, high purity, short reaction times, and high yields. However, existing methods often involve harsh conditions and longer reaction times. In this study, 2-cyano-N’-(2-cyanoacetyl)acetohydrazide (3) was prepared and co...

The study focuses on green methodologies in synthetic organic chemistry, emphasizing the use of thiamine hydrochloride (Vitamin B1) as an eco-friendly catalyst for synthesizing hydrazono-thiazolones. These compounds serve as versatile core units with various therapeutic activities, including anti-HIV, anti-tubercular, antifungal, antiviral, and ant...

Recycling and efficient management of urban solid waste, including medical X-ray sheets (MXS) and food waste, pose a significant challenge for conserving environmental and water resources. Exploiting waste materials, this study developed a cost-effective, eco-friendly, and efficient adsorbent/photocatalyst to eliminate crystal violet (CV) dye and d...

This study aims to combat breast cancer, which is a significant health concern for women worldwide. By targeting aromatase, an enzyme crucial in estrogen synthesis, the research focuses on breast cancer cases, emphasizing the importance of hormonal therapy. The innovative approach of this study involves the synthesis of novel bis‐triazolopyridopyri...

In this paper, we utilized a simple and readily available bifunctionalized compound, terephthalaldehyde, for the preparation of bis-pyrimidinthione derivative 4. The thiocarbonyl group, along with its adjacent NH functions, underwent Michael-like addition with activated unsaturated compounds such as arylidenemalonitrile and DMAD, yielding bis-thiaz...

In the present study, vegetable castor oil was utilized to prepare cost-effective polyurethane for encapsulating solar cells. In addition to its affordability and straightforward preparation, polyurethane encapsulant demonstrated an inherent capability to absorb ultraviolet (UV) radiation (UV-blocking). This polymer’s unique quality is valuable for...

Background Innovations in cancer chemotherapy continue to occupy the priority list of demands to ensure our health security. The vast chemical space provides a plethora of anticancer discovery opportunities, however, limited by the boundaries of synthetic feasibility. Objective Expand the established pharmacological space of tumor-associated carbon...

Aim In this study, a neoteric and expedient oxidation method is applied for a variety of Hantzsch 1,4-dihydropyridine derivatives such as 1,4-dihydro- 2,6-dimethyl-3,5-diacetylpyridine, 3,5-bis-hydrazono--2,6-dimethyl-1,4-dihydropyridine, and 3,5-bis-thiazoly-2,6-dimethyl-1,4-dihydro pyridines. Method This simple oxidation is based upon the in sit...

The catalytic activity of chitosan (Cs) and grafted Cs led to the preparation of terephthalohydrazide Cs Schiff’s base hydrogel (TCsSB), which was then investigated as an eco-friendly biocatalyst for synthesizing novel thiazole derivatives. TCsSB exhibited greater surface area and higher thermal stability compared to Cs, making it a promising eco-f...

Aim: This study focuses on advancing green chemistry in anticancer drug discovery, particularly through the synthesis of azine derivatives with a naphthalene core using CS–SO 3 H as a catalyst. Methods: Novel benzaldazine and ketazine derivatives were synthesized using ( E)-(naphthalen-1-ylmethylene)hydrazine and various carbonyl compounds. The met...

Background Previous studies have reported various biological activities of indeno-pyridazine and thiazole derivatives, including antiviral activity and CoV-19 inhibition. In this paper, the authors aimed to design, synthesize, and characterize a novel series of indenopyridazinethiazoles, starting with 2-(4-cyano-3-oxo-2,3-dihydro-9H-indeno[2,1-c]py...

To highlight the importance of thiazole and thiadiazole derivatives in the progression of cancer and microbial treatments and to aid in drug design, we have synthesized a new series of 1,3,4-thiadiazole and 1,3-thiazole derivatives. These were created by a two-step reaction process: initially, 2-(4-(2-bromoacetyl)phenyl)isoindoline-1,3-dione was re...

Aim: This study was designed to synthesize a novel series of terpyridines with potential antibacterial properties, targeting multidrug resistance. Materials & methods: Terpyridines (4a–h and 6a–c) were synthesized via a one-pot multicomponent reaction using 2,6-diacetylpyridines, benzaldehyde derivatives and malononitrile or ethyl 2-cyanoacetate. T...

Aims: Development of some potent bis-thiazole and bis-thiazine derivatives that could be used as antiviral prototypes. Materials & methods: Xylenyl-spaced bis-carbazone scaffold 3 was used as a versatile building block for bis-thiazole derivatives 6a–e and 9a–d and bis-thiazine derivatives 12a–f. These bis-heterocycles were screened as herpes simpl...

A new class of liquid crystalline materials, 4-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)phenyl 4-(alkoxy)benzoates (Mn), derived from maleic anhydride, was synthesized and studied for mesomorphic and optical properties. These materials consist of three derivatives with varying terminal flexible chain lengths (6–12 carbons) linked to the phenyl ring ne...

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Crystals _ Special Issue _ The Crystal Structure of New Derivatives_ Synthesis, Characterization, Structure Activity and Molecular Docking Studies.pdf

Eur J Med Chem

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Terephthalohydrazide chitosan hydrogel (TCs) was prepared and investigated as an ecofriendly biopolymeric catalyst for synthesis of some novel thiazole and thiadiazole derivatives. Thus, TCs was used as a promising ecofriendly basic biocatalyst for preparation of three new series of thiazoles and two thiadiazoles derivatives via reacting 2-(2-oxo-1...

The diverse applications of metal oxide-biopolymer matrix as a nanocomposite heterogenous catalyst have caused many researches to scrutinize the potential of this framework. In this study, a novel hybrid barium oxide-chitosan nanocomposite was synthesized through a facile and cost-effective co-precipitation method by doping barium oxide nanoparticl...

ACKNOWLEDGEMENT We would like to thank the Deanship of scientific research at the Islamic University of Madinah, Saudi Arabia for the financial support of this work through the program Tammayz 2 of the academic year 2020/2021, research project No.: 654 ‫العلـــــــوم‬ ‫كليـة‬ ‫قسم‬ ‫الكيمياء‬ RESULTS AND DISCUSSION CONCLUDING REMARKS Conical symmet...

A novel set of thiazolylhydrazonothiazoles bearing an indole moiety were synthesized by subjection reactions of carbothioamide derivative and hydrazonoyl chlorides (or α-haloketones). The cytotoxicity of the synthesized compounds was evaluated against the colon carcinoma cell line (HCT-116), liver carcinoma cell line (HepG2), and breast carcinoma c...

The thiazole ring is naturally occurring and is primarily found in marine and microbial sources. It has been identified in various compounds such as peptides, vitamins (thiamine), alkaloids, epothilone, and chlorophyll. Thiazole-containing compounds are widely recognized for their antibacterial, antifungal, anti-inflammatory, antimalarial, antitube...

Innovations in cancer chemotherapy continue to occupy the priority list of demands to ensure our health security. The vast chemical space provides a plethora of anticancer discovery opportunities, however, limited by the boundaries of synthetic feasibility. This study aims at expanding the established pharmacological space of tumor-associated carbo...

Background The emergence of drug-resistant bacteria and multidrug-resistant diseases, both of which are associated with high mortality, has posed a serious global health issue. Thiazoles and coumarins were reported as antimicrobial agents. Objective This research paper aims to describe the synthesis of some novel thiazole derivatives bearing a cou...

A series of new indenoquinoxaline-thiazole hybrids were synthesized by combining indenoquinoxaline thiosemicarbazone with appropriate hydrazonoyl chlorides or α-halo ketones using DABCO as a catalyst. The short reaction times and excellent yields make this method simple, green, and economic to synthesize new compounds with potential biological acti...

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Many literature reports revealed the anticancer activity of pyridine and thiazole derivatives, especially in lung cancer. Therefore, a new series of thiazolyl pyridines linked with thiophene moiety via hydrazone group was prepared by one-pot multi-component reaction of (E)-1-(4-methyl-2-(2-(1-(thiophen-2-yl)ethylidene)hydrazinyl)thiazol-5-yl)ethano...

The development of new approaches for the synthesis of new bioactive heterocyclic derivatives is of the utmost importance for pharmaceutical industry. In this regard, the present study reports the green synthesis of new benzaldazine and ketazine derivatives via the condensation of various carbonyl compounds (aldehydes and ketones with the 3-(1-hydr...

The development of new approaches for the synthesis of new bioactive heterocyclic derivatives is of the utmost importance for pharmaceutical industry. In this regard, the present study reports the green synthesis of new benzaldazine and ketazine derivatives via the condensation of various carbonyl compounds (aldehydes and ketones with the 3-(1-hydr...

A novel catalytic approach for the synthesis of symmetric and asymmetric azines has been developed. The environmentally benign protocol was achieved via condensation of 1-[(2-thienyl)ethylidene]hydrazine (1) with different aromatic aldehydes 2a–h and acetyl heterocyclic compounds (4, 6, 8, 10, and 12) in the presence of cellulose sulfuric acid (CSA...

A number of new three-armed heterocycles as thiazoles and thiazines linked to triazine moiety was prepared starting from cyanuaric chloride and thiothemicarbazide which gave the target compound 1. The reaction of the tris-thiosemicarbazide with a variety of hydrazonoyl halides afforded thiazole derivatives. In addition, a thiazole derivative could...

Many biological activities of pyridine and thiazole derivatives have been reported, including antiviral activity and, more recently, as COVID-19 inhibitors. Thus, in this paper, we designed, synthesized, and characterized a novel series of N-aminothiazole-hydrazineethyl-pyridines, beginning with a N′-(1-(pyridine-3-yl)ethylidene)hydrazinecarbothioh...

One crucial strategy for the treatment of breast cancer involves focusing on the Vascular Endothelial Growth Factor Receptor (VEGFR-2) signaling system. Consequently, the development of new (VEGFR-2) inhibitors is of the utmost importance. In this study, novel 3-thiazolhydrazinylcoumarins were designed and synthesized via the reaction of phenylazoa...

Obesity is a global public health concern brought on by a combination of excessive dietary intake, inactivity and genetic predisposition. Pyridopyrimidines have received considerable interest in the development of obesity and diabetes. Mannich reaction was applied on 2-thioxo-pyridopyrimidinone derivative with a variety of aromatic and heterocyclic...

A literature survey revealed that a great deal of interest had been focused on the synthesis of functionalized heterocyclic compounds due to their wide range of biological activities such as antimicrobial, antitumor, anti-inflammatory, antiviral, antibiotic, antidepressant, antimalarial, antifungal and antihypertensive. Moreover, it is used as phar...

Owing to its broad spectrum biological activity, pyrimidines have been extensively employed as building blocks for synthesizing various drug mimic molecules. In the present work, a novel 2-hydrazineyl-5-(2-phenylhydrazineylidene)pyrimidine-4,6(1H,5H)-dione 3 was prepared and was subsequently reacted with a variety of substituted benzaldehyde deriva...

One of the worst diseases, cancer claims millions of lives each year throughout the world, necessitating the creation of novel treatments. In this study, we designed a novel series of 1,3,4-thiadiazoles through the reaction of 2-(4-methyl-2-(2-(1-phenylethylidene)hydrazineyl)thiazole-5-carbonyl)-N-phenylhydrazine-1-carbothioamide (3) with the prope...

A novel series of bis-[1,3,4]thiadiazolimines, and bis-thiazolimines, with alkyl linker, were synthesized through general routes from cyclization of 1,1′-(hexane-1,6-diyl)bis(3-phenylthiourea) and hydrazonoyl halides or α-haloketones, respectively. Docking studies were applied to test the binding affinity of the synthesized products against the Mpr...

Pyridine, 1,3,4-thiadiazole, and 1,3-thiazole derivatives have various biological activities, such as antimicrobial, analgesic, anticonvulsant, and antitubercular, as well as other anticipated biological properties, including anticancer activity. The starting 1-(3-cyano-4,6-dimethyl-2-oxopyridin-1(2H)-yl)-3-phenylthiourea (2) was prepared and react...

Calcium oxide (CaO) nanoparticles have recently gained much interest in recent research due to their remarkable catalytic activity in various chemical transformations. In this article, a chitosan calcium oxide nanocomposite was created by the solution casting method under microwave irradiation. The microwave power and heating time were adjusted to...

The viral RNA-dependent RNA polymerase (RdRp) complex is used by SARS-CoV-2 for genome replication and transcription, making RdRp an interesting target for developing the antiviral treatment. Hence the current work is concerned with the green synthesis, characterization and docking study with the RdRp enzyme of the series of novel and diverse hydra...

Three novel aza-acyclic nucleosides and two hydrogen complexes were isolated by flash chromatography after being produced in a reaction between indole and dibenzosulfonyl diethylamine (which had previously been prepared) in the presence of sodium and absolute ethanol as a basic catalyst. Structures of new compounds and complexes were determined by...

Investigating novel compounds that may be useful in designing new, less toxic, selective, and potent breast anticancer agents is still the main challenge for medicinal chemists. Thus, in the present work, acetylthiophene was used as a building block to synthesize a novel series of thiazole-bearing thiophene derivatives. The structures of the synthe...

Acetylthiophene was used as a building block to synthesize a novel series of thiazole-bearing thiophene derivatives.  The cytotoxic activities of the synthesized compounds were evaluated against MCF-7 tumor cells and compared to a cisplatin reference drug, and against the LLC-Mk2 normal cell line using the MTT assay, and the results revealed promi...

The liquid crystalline materials named (E)-4-(2-(4-oxo-5,5-diphenyl-4,5-dihydro-1H-imidazol-2-yl)hydrazineylidene)methyl)phenyl and 4-(alkoxy)benzoate, In, were synthesized and their mesomorphic behaviors were examined. The chemical structures of the produced compounds were confirmed by Fourier-transform infrared spectroscopy (FT-IR), NMR, and elem...