Snober S Mir

Snober S Mir
Integral University · Department of Bioengineering

Ph.D

About

59
Publications
14,642
Reads
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905
Citations
Citations since 2016
29 Research Items
690 Citations
2016201720182019202020212022020406080100120140
2016201720182019202020212022020406080100120140
2016201720182019202020212022020406080100120140
2016201720182019202020212022020406080100120140
Introduction
We are currently working on elucidating the role of protein aggregates and deregulation of protein quality control pathways (PQC) in tumorigenesis.
Additional affiliations
July 2010 - present
Integral University
Position
  • Professor (Associate)
January 2009 - July 2010
Central Drug Research Institute
Position
  • Senior Research Associate (EU sponsored MEPHITIS Program)
January 2005 - April 2008
Augusta University
Position
  • PostDoc Position

Publications

Publications (59)
Article
Cells are exposed to several environmental or chemical stressors that may cause DNA damage. DNA damage alters the normal functioning of the cell and contributes to several diseases, including cancer. Cells either induce DNA damage repair pathways or programmed cell death pathways to prevent disease formation depending on the severity of the stress...
Article
Full-text available
Cancer formation is a highly regulated and complex process, largely dependent on its microenvironment. This complexity highlights the need for developing novel target-based therapies depending on cancer phenotype and genotype. Autophagy, a catabolic process, removes damaged and defective cellular materials through lysosomes. It is activated in resp...
Preprint
Full-text available
Multi-drug resistance microorganisms and the rising numbers of cancer cases possess a critical threat to humankind, thereby motivating research on new weapons to combat the problem. To address these issues, researchers are now focusing on secondary metabolites produced by bacteria. Because of having outstanding antibiotic capabilities, actinobacter...
Article
Full-text available
The World Health Organization (WHO) recognized a novel coronavirus as the causative agent of a new form of pneumonia. It was subsequently named COVID-19 and reported as the source of a respiratory disease occurrence starting in December 2019 in Wuhan, Hubei Province, China. It has been affirmed a public health emergency of international significanc...
Article
The SARS-CoV-2 contagion has had a huge impact on world population. It has been observed that despite massive spread of the contagion in India particularly during the second wave, the overall case fatality rates remain low. This prompted us to look into dietary factors that can possibly modulate the viral impact and/or host response. In silico stud...
Research
Full-text available
Background: Apolipoprotein A-I (apoA-I) protects against atherosclerosis and participates in the removal of excess cellular cholesterol from peripheral organs. Several naturally occurring apoA-I mutations are associated with familial systemic amyloidosis, with deposition of amyloid aggregates in peripheral organs, resulting in multiple organ failu...
Article
Aims Hsp90 is regarded as an important therapeutic target in cancer treatment. Client proteins of Hsp90 like Beclin-1, PI3K, and AKT, are associated with tumor development, poor prognosis, and resistance to cancer therapies. This study aims to analyze the role of Gedunin, an Hsp-90 inhibitor, in mediation of crosstalk between apoptosis and autophag...
Article
Protein glycation and protein aggregation are two distinct phenomena being observed in cancer cells as factors promoting cancer cell viability. Protein aggregation is an abnormal interaction between proteins caused as a result of structural changes in them after any mutation or environmental assault. Protein aggregation is usually associated with n...
Research
Full-text available
Apolipoprotein A1 (ApoA1) is a prominent component of the "good cholesterol" and facilitates its functioning. Its misfolding is a critical risk factor for several diseases, such as cardiovascular diseases, Alzheimer's, diabetes and hereditary amyloidoses. Several naturally occuring mutants of ApoA1 are also associated with amyloidoses. The structur...
Article
Abstract Background: Type 2 diabetes mellitus (T2DM) consists of an array of dysfunctions characterized by hyperglycemia. Oxidative stress through the production of reactive oxygen species, leading to the development of insulin resistance, β-cell dysfunction, impaired glucose tolerance, T2DM and their vascular complications. Glutathione S-transfera...
Article
Background Diabetes mellitus is a metabolic disorder which can affects the body's ability to produce or use of the hormone insulin leads to high blood sugar levels and it may serves as a host of complications. Emerging evidence suggests that common and rare genetic polymorphisms can influence the risk of developing diabetic complications. We attemp...
Article
Background: Despite a number of measures having been taken for cancer management, it is still the second leading cause of death worldwide. p53 is the protein principally being targeted for cancer treatment. Targeting p53 localization may be an effective strategy in chemotherapy as it controls major cell death pathways based on its cellular localiz...
Article
The differentiation of epithelial cells to mesenchymal cells is known as epithelial-mesenchymal transition (EMT) which plays a significant role in embryo and organ development, wound healing and tissue regeneration. Off late, EMT has emerged as a major factor contributing towards cancer metastasis. Cancer metastasis is a key challenge faced during...
Article
Full-text available
Background: Type 2 diabetes mellitus describes a metabolic disorder characterised by prolonged elevated blood glucose that brings a risk of developing microvascular and macrovascular disease. Several factors, such as dysregulation of the Toll-like receptor 4 (TLR-4), are reputed to contribute to the multiple pathophysiological disturbances respons...
Article
Diabetes is a deteriorating metabolic ailment which negatively affects different organs; however, its prime target is insulin secreting pancreatic β-cells. Although, different medications have been affirmed for diabetes management and numerous drugs are undergoing clinical trials, no significant breakthrough has yet been achieved. Available drugs e...
Conference Paper
Full-text available
Hyperactivation of PI3K/Akt pathway is associated with tumor development, progression, poor prognosis, and resistance to cancer therapies. PI3K and AKT proteins are also known to be stabilized by heat shock protein 90 (HSP-90). Several studies have shown the antitumor role of HSP-90 inhibitors as it can target a variety of pathways, and may provide...
Article
The accumulation of aggregate-prone proteins is a major representative of many neurological disorders, including Parkinson's disease (PD) wherein the cellular clearance mechanisms, such as the ubiquitin-proteasome and autophagy pathways are impaired. PD, known to be associated with multiple genetic and environmental factors, is characterized by the...
Article
Loss of p53 function via mutation is a very common cause of human cancers. Recent studies have provided evidence on presence of self aggregated p53 in cancer cells leading to its altered functions towards cause of cancer. The general notion has been that mutated p53 exposes adhesive sites that promote self aggregation, however a complete mechanisti...
Article
Full-text available
Accumulation of misfolded proteins or their aggregates in various organs is the hallmark of protein misfolding disorders (PMD), including Alzheimer’s and Parkinson’s Diseases. Recent studies have shown accumulation of protein aggregates in some non-neurodegenerative diseases like cancer and type-II diabetes. Deposition of toxic aggregates of islet...
Article
GRP78 (glucose regulated protein 78) is a major Endoplasmic Reticulum (ER) chaperone that plays a pivotal role in normal ER functioning. Its increased expression also works as an indicator of ER stress. Its anti-apoptotic and pro-autophagic activity makes it an intriguing target to study the relationship between GRP78 and p53, which is also a major...
Article
Full-text available
Parkinson's disease (PD) is the second most common progressive neurodegenerative disorder, defined clinically by degeneration of dopaminergic neurons and the development of neuronal Lewy bodies. Current treatments of PD are inadequate due to a limited understanding of molecular events of the disease, thus calling for intense research efforts toward...
Article
A number of pathogenic fungi like Candida, cannot survive upon damage to mitochondrial DNA (mtDNA) while the budding yeast can tolerate the damage therefore we chose Saccharomyces cerevisiae as a model system for this study. Since a number of potent antifungals have originated from various natural sources, we decided to use a triterpenoid and tetra...
Article
Full-text available
Enterovirus D68 (EV-D68) is being reported as a cause of respiratory illness across USA along with some parts of Canada. Non polio EV-D68 has been associated with respiratory illness followed by acute flaccid paralysis in children which clearly suggests that there should be appropriate screening and treatment of EV-D68 virus. Thus, this review aims...
Article
Rheumatic heart disease (RHD) is an inflammatory, autoimmune disease; occurring as a consequence of group A streptococcal infection complicated by rheumatic fever (RF).An inappropriate immune response is the central signature tune to the complex pathogenesis of RHD. However, some of those infected develop RHD, and genetic host susceptibility factor...
Article
Full-text available
For years, conventional medicines have been broadly used for treatment of malaria. As malaria is a widespread disease, resistance of Plasmodium species towards conventional treatments has driven our attention towards the cons of this therapy. Another factor that has encouraged us to review use of these conventional medicines is their toxicity and a...
Article
Full-text available
Recently, the venues of exposure to nanoparticles have increased significantly owing to their increased deliberate production. In this study the interaction of fullerenes with DNA was analyzed along with various factors affecting this interaction like mol. wt. of fullerenes (C20 to C180), the form of DNA i.e., A, B and Z, and sequences of DNA, and...
Article
Background: Cissus quadrangularis Linn. (CQ) commonly known as Hadjod (Family: Vitaceae) is usually distributed in India and Sri Lanka and contains several bioactive compounds responsible for various metabolic and physiologic effects. Objective: In this study, the biological effects of CQ ethanolic extract were evaluated by in vitro and supporte...
Article
Full-text available
The field of cancer research and treatment has made significant progress, yet we are far from having completely safe, efficient and specific therapies that target cancer cells and spare the healthy tissues. Natural compounds may reduce the problems related to cancer treatment. Currently, many plant products are being used to treat cancer. In this s...
Article
Full-text available
Colon cancer is the third most common cause of death in the United States. Therefore, new preventive strategies are warranted for preventing colon cancer. Nexrutine (NX), an herbal extract from Phellodendron amurense, has been shown to have anti-inflammatory, anti-microbial and anti-cancer activity for various tissue specific cancers, but its chemo...
Conference Paper
Full-text available
Nanotechnology, actually means the exploitation of the substances at their nano-meter size, is expected to enhance the quality of life and economic development on the global basis. Recently some of the nanoparticles have been employed in scavenging the high molecular weight polycyclic aromatic hydrocarbons (PAHs) from the contaminated soils. Amphip...
Article
Full-text available
Polycyclic aromatic hydrocarbons (PAH), like Benzo[alpha]Pyrene (BaP) are known to cause a number of toxic manifestations including lung cancer. As Titanium dioxide Nanoparticles (TiO2 NPs) have recently been shown to adsorb a number of PAHs from soil and water, we investigated whether TiO2 NPs could provide protection against the BaP induced toxic...
Article
This study was aimed to assess the association of Protein tyrosine phosphatase non-receptor22 (PTPN22) gene single nucleotide polymorphisms (SNPs) with rheumatic heart disease (RHD) susceptibility in 400 RHD patients and 300 controls. The PTPN22 polymorphisms (rs2476601, rs1217406 and rs3789609) were genotyped using Taqman probes (Applied Biosystem...
Article
Rheumatic heart disease (RHD) is the most serious complication of heart that comprises inflammatory reactions in heart valves. Cytokines play a critical role in triggering inflammatory reactions and they activate the Janus Kinase/Signal Transducers and Activators of Transcription (JAK/STAT) signaling pathway. Altered signals of STATs play important...
Article
The antidyslipidemic effect of the ethanolic extract of Dysoxylum binectariferum stem bark and its major active constituent rohitukine was evaluated in a high fat diet (HFD)-fed dyslipidemic rat model. Chronic feeding of ethanolic extract (200 mg/kg) in HFD-fed rats showed significant lipid lowering activity. The bioassay guided fractionation of et...
Article
Context: In our previous study we have suggested that Rohitukine attenuates gastric mucosal injury; however its exact mechanism has not yet been established. Objective: The aim of present study was to evaluate the gastro protective mechanism of Rohitukine. Materials and methods: Sprague dawley rats and guinea pigs weighing 180–200 g were used. Dude...
Article
The aim of the present study was to evaluate the antidyslipidemic effect of ethanolic extract of Rheum emodi rhizomes and its constituents in Triton-WR-1339 and high-fat diet (HFD)-induced dyslipidemic rats. In preliminary screening, the ethanolic extract showed significant activity in Triton-treated rats. Bioassay-guided fractionation of the ethan...
Article
Inhibition of growth of the malaria parasite Plasmodium falciparum by known translation-inhibitory antibiotics has generated interest in understanding their action on the translation apparatus of the two genome containing organelles of the malaria parasite- the mitochondrion and the relic plastid (apicoplast). We report GTPase activity of recombina...
Article
Full-text available
A series of Lupeol-based chalcones have been synthesized aiming to enhance the therapeutic efficacy of parent compound, the novel compounds were evaluated for their antidyslipidemic activity in triton-WR 1339 induced hyperlipidemic rats. Among the ten synthesized chalcones, the most active K4, K8, and K9 reversed the plasma levels of TC by (24, 25,...
Article
Full-text available
The reduced genomes of the apicoplast and mitochondrion of the malaria parasite Plasmodium falciparum are actively translated and antibiotic-mediated translation inhibition is detrimental to parasite survival. In order to understand recycling of organellar ribosomes, a critical step in protein translation, we identified ribosome recycling factors (...
Article
tInhibition of growth of the malaria parasite Plasmodium falciparum by known translation-inhibitoryantibiotics has generated interest in understanding their action on the translation apparatus of thetwo genome containing organelles of the malaria parasite: the mitochondrion and the relic plastid (api-coplast). We report GTPase activity of recombina...
Article
Full-text available
Neurodegenerative diseases are multifactorial debilitating disorders of the nervous system that affect approximately 30 millionindividuals worldwide. Neurodegenerative diseases such as Alzheimer’s, Parkinson’s, Huntington’s, and amyotrophic lateral sclerosis diseases are the consequence of misfolding and dysfunctional trafficking of proteins. Besid...
Article
Full-text available
Neurodegenerative diseases are known to be associated with genetic and environmental factors. The multifactorial Parkinson's disease (PD) is triggered and/or further worsened by exposure to certain pesticides. Existing literature suggests a link between pesticide exposure and increased incidence of PD. We carried out the present study to look into...
Article
Full-text available
The malaria parasite carries a plastid called the apicoplast that has been the subject of intense study in the last 15 years. Having originated from red-algal plastids, the apicoplast has lost its ability to photosynthesize, but carries out other essential functions such as type-II fatty acid synthesis, biosynthesis of haem and isoprenoid synthesis...
Article
Neurodegenerative Parkinson's disease (PD) is associated with aggregation of protein alpha synuclein and selective death of dopaminergic neurons, thereby leading to cognitive and motor impairment in patients. The disease has no complete cure yet; the current therapeutic strategies involve prescription of dopamine agonist drugs which turn ineffectiv...
Article
Protein translation in the plastid (apicoplast) of Plasmodium spp. is of immense interest as a target for potential anti-malarial drugs. However, the molecular data on apicoplast translation needed for optimisation and development of novel inhibitors is lacking. We report characterisation of two key translation elongation factors in Plasmodium falc...
Chapter
The single apicoplast of Plasmodium and related Apicomplexans is essential for survival of the parasite, and is the focus of interest for identifying novel drug targets in order to develop future antimalarial agents. In this chapter, investigations into the apicoplast pathways conducted during the past decade are described, with particular emphasis...
Article
Full-text available
In the budding yeast Saccharomyces cerevisiae, the Hsp104-mediated disaggregation of protein aggregates is essential for thermotolerance and to facilitate the maintenance of prions. In humans, protein aggregation is associated with neuronal death and dysfunction in many neurodegenerative diseases. Mechanisms of aggregation surveillance that regulat...
Article
Full-text available
The fragile histidine triad (FHIT) gene located at the 3p14.2 locus plays an important role in the pathogenesis of lung cancer. The objective of this study was to analyze loss of heterozygosity and FHIT gene methylation status and correlate them to fhit expression. Bronchoscopically obtained lung biopsies from 30 cases of histologically proven carc...
Article
The present study was designed to analyze the expression of the major antiapoptotic molecules Bcl-2, Bcl-XL and the proapoptotic Bax in pancreatic ductal carcinoma and their correlation to the extent of apoptosis. Tissue samples were obtained from patients (age, 27-78 years) having surgery for pancreatic cancer. Normal pancreatic tissue away from t...
Article
Full-text available
In recent times, the possibility of detecting lung cancer using microsatellite alterations (microsatellite instability and loss of heterozygosity) in DNA of bronchial washings has been explored. However, no data regarding the presence of microsatellite alterations in lung cancer are available from India, a country which contributes significantly to...
Article
Bcl-2 family of proteins plays a critical role in the regulation of apoptosis. This pathway may be dysregulated leading to an altered ratio of pro- and anti-apoptotic molecules, hence rendering cells resistant to chemotherapy. The objective of this study was to understand the role of Bcl-2 family members in mediation of apoptosis in squamous cell c...

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Project (1)
Project
The prion like behaviour of some regulatory proteins has been implicated in various disease conditions our endeavour is to understand the ambience in the cells that lead to such an abnormal behaviour.