Siyuan Wu

• Doctor of Philosophy
• Early Career Postdoctoral Researcher & Lecturer at James Cook University

Single-cell sequencing technologies have revolutionised the life sciences and biomedical research. Single-cell sequencing provides high-resolution data on cell heterogeneity, allowing high-fidelity cell type identification, and lineage tracking. Computational algorithms and mathematical models have been developed to make sense of the data, compensa...

Although multistability is an important dynamic property of a wide range of complex systems, it is still a challenge to develop mathematical models for realising high order multistability using realistic regulatory mechanisms. To address this issue, we propose a robust method to develop multistable mathematical models by embedding bistable models t...

Mathematical modelling and inference methods are powerful tools to study genetic regulatory networks. This thesis focuses on the development of mathematical methods to explore and analyze the dynamical mechanisms of genetic regulation related to cell fate determination in hematopoiesis.

Hematopoiesis is a highly complex developmental process that produces various types of blood cells. This process is regulated by different genetic networks that control the proliferation, differentiation, and maturation of hematopoietic stem cells (HSCs). Although substantial progress has been made for understanding hematopoiesis, the detailed regu...