Siva Prasad Panda

Siva Prasad Panda
Jadavpur University | JU · Department of Pharmaceutical Technology

PhD

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57
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499
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Publications

Publications (57)
Article
Schizophrenia is a severe psychological disorder in which reality is interpreted abnormally by the patient. The symptoms of the disease include delusions and hallucinations, associated with extremely disordered behavior and thinking, which may affect the daily lives of the patients. Advancements in technology have led to understanding the dynamics...
Article
Objective: A simultaneous estimation of Esomeprazole and Ondansetron by HPLC-DAD method with degradation studies was developed. Method: It was carried out using Kromasil (150mm×4.6mm, 5µm particle size) column with mobile phase consists 0.01M KH2PO4 Phosphate buffer (1mL of Triethylamine added and pH was adjusted to 3.5 with Orthophosphoric acid):...
Article
Tuberculosis infection has always been a global concern for public health, and the mortality rate has increased tremendously every year. The ability of the resuscitation Mycobacterium tuberculosis (Mtb) from the dormant state is one of the major reasons for the epidemic spread of tuberculosis infection, especially latent tuberculosis infection (LTB...
Article
Neuronal necroptosis (programmed necrosis) in the CNS naturally occurs through a caspase-independent way and, especially in neurodegenerative diseases (NDDs) such as Alzheimer's disease (AD), Parknson's disease (PD), Amyotrophic Lateral Sclerosis (ALS) and viral infections. Understanding necroptosis pathways (death receptor-dependent and independen...
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Male sexual dysfunctions such as infertility and impotence are recognized as the consequences of diabetes. Salazinic acid (Sa) is a depsidone found in lichen genera of Lobaria, Parmelia, and Usnea, which has prominent free radical and α-glucosidase inhibitory actions. The present study establishes the beneficial role of salazinic acid (Sa) to comba...
Preprint
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Estrogen receptor α (ER-α) plays a crucial role in the start and progression of breast cancer. ER-α stimulates the expression of oncogenic proteins including Cyclin D1 and c-Myc while inhibiting the expression of cell cycle inhibitors like P21. ER-α has critical functions in the development, survival, and architecture of cancer cells and the regula...
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Introduction: The mixed flavonoid supplement (MFS) [Trimethoxy Flavones (TMF) + epigallocatechin-3-gallate (EGCG)] can be used to suppress inflammatory ulcers as an ethical medicine in Ayurveda. The inflammation of the rectum and anal regions is mostly attributed to nuclear factor kappa beta (NF-κB) signaling. NF-κB stimulates the expression of mat...
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The goal of this review is to increase public knowledge of the etiopathogenesis of diabetic eye diseases (DEDs), such as diabetic retinopathy (DR) and ocular angiosarcoma (ASO), and the likelihood of blindness among elderly widows. A widow’s life in North India, in general, is fraught with peril because of the economic and social isolation it bring...
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The Japanese encephalitis virus (JEV) is the most common cause of neurodegenerative disease in Southeast Asia and the Western Pacific region; approximately 1.15 billion people are at risk, and thousands suffer from permanent neurological disorders across Asian countries, with 10–15 thousand people dying each year. JEV crosses the blood-brain barrie...
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Shorea hemsleyana (King) King ex Foxw is used to treat various ailments in humans. Numerous biological activities have been reported previously. The current study sought to identify S. hemsleyana phyto-derived anti-viral compounds against the SARS-CoV-2 main protease to gain insight into the molecular interactions. In the present research, nine com...
Article
Parkinsonism is a complex neurodegenerative disease that is difficult to differentiate because of its idiopathic and unknown origins. The hereditary parkinsonism known as autosomal recessive-juvenile parkinsonism (AR-JP) is marked by tremors, dyskinesias, dystonic characteristics, and manifestations that improve sleep but do not include dementia. T...
Preprint
Full-text available
The goal of this review is to increase public knowledge of the etiopathogenesis of diabetic eye diseases (DEDs), such as diabetic retinopathy (DR) and ocular angiosarcoma (ASO), and the likelihood of blindness among elderly widows. A widow's life in North India, in general, is fraught with peril because of the economic and social isolation it bring...
Chapter
Present surgical and repair treatments for articular cartilage abnormalities do not produce long-term results that are adequate due to its avascular and alymphatic system. Polycaprolactone (PCL) is a synthetic polyester biomaterial with characteristics of bioresorbable, controlled biodegradation, nontoxic and excellent biocompatibility used for art...
Article
The objective of the review led to the pursuit of adopting dipeptidyl peptidase-4 inhibitors (DPP4i) as a novel pharmacotherapy in diabetes mellitus (DM) and cardiorenal syndrome (CRS). The CRS is defined as the co-existence of myocardial ischemia with renal failure. At present, the commercially available drugs either enhance insulin secretion or a...
Article
Dementia, in particular, is a defining feature of Alzheimer's and Parkinson's diseases. Because of the combination of motor and cognitive impairments, Parkinson's disease dementia (PDD) has a greater impact on affected people than Alzheimer's disease dementia (ADD) and others. If one family member develops dementia, the other members will suffer gr...
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Background The isolated trimethoxy flavonoid 4a,5,8,8a-tetrahydro-5-hydroxy-3,7,8-trimethoxy-2-(3,4-dimethoxyphenyl) chromen-4-one (TMF) from methanolic stem extract of T chrysantha (METC) and - (-)-epigallocatechin-3-gallate (EGCG) can be used to suppress acute inflammation and arthritis as an ethical medicine in Ayurveda. The nuclear factor kappa...
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Cocculus hirsutus, a tropical South Asian creeper,traditionally used as a diuretic, laxative, cardiotonic, anti-microbial, antidiabetic, anti-inflammatory and spermatogenic. However, the neuroprotective role was less explored; therefore, this researchwas conducted to investigate neuroprotective potentials of Cocculus hirsutus leaf hydroalcoholic ex...
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Objectives: Abiraterone acetate is a well-known anticancer drug and a steroidal derivative of progesterone for treatment of patients with hormone-refractory prostate cancer. Chemometrics-assisted reverse phase high performance liquid chromatography (RP-HPLC) development of the drug abiraterone acetate has been employed in this study using an analy...
Article
Objective A selective and sensitive liquid chromatography–tandem mass spectrometer (LC–MS/MS) method has been developed for the quantification of 1,1-dimethyl-3-hydroxy-pyrrolidinium bromide impurity in glycopyrrolate oral solution. Materials and method The LC–MS/MS analysis was done on X Bridge HILIC (100 × 4.6 mm, 5 μm) analytical column, and th...
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Melissa officinalis (Lamiaceae) was used to treat multiple human afflictions. Literary works demonstrated that it has many biological activities. Today's research aims to recognise Melissa officinalis phyto-derived anti-viral compounds against main protease and spike protein of COVID-19, to gain insight into the molecular interactions. In the curre...
Article
Controlling residual solvents in the drug substances or active pharmaceutical ingredients (API) is mandatory to the specified limits as per the International Conference on Harmonisation (ICH) Q3C guidelines. Residual solvents in pharmaceuticals are mostly determined by Gas Chromatography with Headspace. A simple and sensitive headspace gas chromato...
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Background: Zingiber officinale (Zingiberaceae) has been utilized to remedy many afflictions of humans. Literary works illustrate that it possesses numerous biological activities. Methods: Today, research study intended to recognize the Phyto-derived anti-viral substances from Zingiber officinale against COVID-19 main protease enzyme and to underst...
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Objectives: Mansoa alliacea has been utilized to remedy many afflictions of humans. Literary works illustrate that it possesses numerous biological activities. Our analysis work aims to distinguish phyto-derived anthelmintic substances from M. alliacea against the enzyme β-tubulin and to consider the cause of its function in the molecular basis on...
Article
Background COVID-19, a pandemic respiratory contagious viral (SARS-CoV-2) disease associated with high morbidity and mortality worldwide. Currently, there areno effective preventive or treatment strategies for COVID-19 and has been declared as a global health emergency by WHO. In silico molecular docking studies can be useful to predict the binding...
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Cinnamon has been utilized to remedy a lot of afflictions of humans. Literary works illustrate that it possesses numerous biological activities. Our research study is intended to recognize the phyto-derived antiviral substances from Cinnamon against COVID-19 main protease enzyme and to understand the in silico molecular basis of its activity. In th...
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Background: The current study assesses the anthelmintic impact of root extracts of Pavetta tomentosa on Pheretima posthuma compiled by molecular docking analysis of phytocompounds steemed from the plant with the β-Tubulin (PDB ID: 1SA0). Methods: In this study, P. tomentosa root was subjected to extraction using methanol and water. In vitro, anthel...
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Objectives This research aimed to evaluate the antiangiogenic activity of isolated flavonoid 4a,5,8,8a‐tetrahydro‐5‐hydroxy‐3,7,8‐trimethoxy‐2‐(3,4‐dimethoxyphenyl) chromen‐4‐one (TMF) from Tabebuia chrysantha. STAT3‐MMP9 signalling is a signal transduction mechanism that promotes angiogenesis in various cancers. Methods The tumour xenografting ch...
Article
Background Quality by design based software’s in analytical research and development normally encompasses multiple objectives. For decades, this task has been attempted through trial and error, supplemented with the previous experience, knowledge, and wisdom of the analytical researchers. Objective The study analyzes the current QbD-assisted softw...
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Its based on QbD based method development, Optimization and validation of the drug using RP-HPLC.
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The present investigation is concerned with formulation and evaluation of Transdermal gels of Tacrolimus, anti-psoriasis drug, to circumvent the first pass effect and to improve its bioavailability with reduction in dosing frequency and dose related side effects. Twelve formulations were developed with varying concentrations of polymers like Carbop...
Article
This article describes and reviews the steps involved in risk assessment of the twenty-four (24) potential elemental impurities in pharmaceutical drug products, as per the permitted daily exposure limits. Screening and estimation of prescribed elemental impurities in pharmaceutical drug substances, inactive excipients and drug products by inductive...
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Objective: Our previous research isolated Cucurbitacin B (CuB) and ebonone leucopentaacetate (ELP) from methanolic fruit extract of Cucumis callosus (MFCC). The fruits of C. callosus (Rottl.) Cogn. (Family: Cucurbitaceae) plant have been traditionally used for antioxidant, anti-inflammatory, and antidiabetic actions. The objective of this research...
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Fruits of Cucumis callosus (Rottl.) Cogn. (Family: Cucurbitaceae) plant, are commonly known as “bitter cucumber” (English) and “Kachri” (Hindi) in India and have been traditionally used for antioxidant, rich source of vitamin C, antidiabetic and anticancer actions. Tribal peoples of Odissa and West-Bengal are using these fruits during worship and a...
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Objective: The pericarp of fruits of Cucumis callous (Rottl.) Cogn. (Cucurbitaceae) is traditionally used for curing diabetes, epilepsy, and diarrhea. It has an active compound include Cucurbitacin-B (CuB), which acts as a potent inducer of CYP450 of rat enterocytes. This study was conducted with the aim of elaborating and reconciling our previous...
Article
A unique and speedy colorimetric method has been developed and validated for the estimation of Raltegravir in pharmaceutical formulation and human biological fluids using 3-methyl-2-benzothiazolinone hydrazone (MBTH) reagent. The projected technique is based on oxidative coupling reaction of MBTH reagent with Raltegravir by using ferric chloride so...
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!--[if gte mso 9]> ABSTRACT Objective: This research investigated in vitro hypoglycemic and antimicrobial activity of methanolic fruit extract of Cucumis callosus (MECC) (Rottl.) cogn. Methods: The in vitro antidiabetic ability of MECC was evaluated by inhibition studies of the digestive enzymes including α-amylase and α-glycosidase. The antimicro...
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ABSTRACT: Cucumis callosus (Rottl.) Cogn. (Cucurbitaceae) is a highly branched very common prostate, perennial herb, distributed throughout India in the arid zones. Objective: To evaluate the antihyperglycemic potential of C. callosus fruit in experimental animal model. Materials and methods: Hyperglycemia was induced in rats by single intraperiton...
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In present study, the defatted methanol extract of Swietenia mahagoni bark (MESM) was evaluated for its protective effect on paracetamolinduced liver damage in Wistar rats. Liver histopathology, serum biochemical parameters viz. serum glutamine oxaloacetate transaminase (SGOT), serum glutamine pyruvate transaminase (SGPT), serum \alkaline phosphata...
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In present study the methanol extract of Cyperus tegetum rhizome (MECT) was evaluated for its effect on paracetamol-induced liver damage in Wistar rats. Serum biochemical parameters viz. serum glutamine oxaloacetate transaminase (SGOT), serum glutamine pyruvate transaminase (SGPT), serum alkaline phosphatase (ALP), total serum protein, total biliru...
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In this study we evaluated the analgesic and anti-inflammatory activities of the methanol extract of stem bark of Diospyros cordifolia (MEDC) Roxb. The analgesic effects of the stem bark of the plant was assessed in mice using the tail-flick method while carrageenan, histamine and dextran induced paw oedema was used to study the antiinflammatory ef...
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Citrus fruits are rich in flavonoids and limonoids which are known to possess antitumor and anti-inflammatory activities. Citrus limetta Risso and Citrus maxima (J. Burm.) Merr. are two widely distributed indigenous plants found in Indian subcontinent. Methanol extracts of peel of Citrus limetta fruits (MECL) and leaves of Citrus maxima (MECM) were...
Article
The present study was designed to investigate the anticonvulsant and sleep potentiation effect of methanolic extract of Clerodendron infortunatum Linn. (MECI) leaves in Swiss albino mice. The anticonvulsant effect of the MECI (250, 500 mg/kg body weight b.w, intraperitoneal i.p.) was examined against pentylenetetrazole- (PTZ, 80 mg/kg b.w; i.p.) an...
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Swietenia mahagoni L. Jacq. (Meliaceae) is a medium to large evergreen tree native to Southern Florida, Cuba, The Bahamas, Hispaniola, and Jamaica. To evaluate the antidiabetic and antioxidant potential of S. mahagoni bark. In the present study, the antidiabetic activity of the methanol extract of S. mahagoni (MESM) bark in streptozotocin (STZ; 65...
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The present study was undertaken to evaluate the sleep potentiation (depressant) and anticonvulsant effect of methanol extract from bark of Swietenia mahagoni L. Jacq. (MESM) (Meliaceae) in Swiss male albino mice. The sleep potentiation effect of MESM (25 and 50 mg/kg, i. p.) significantly increased pentobarbitone (45 mg/kg, i. p.) induced sleeping...

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