Siti Mariyah Ulfa

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Verified

Siti verified their affiliation via an institutional email.

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• Dr.Sc
• Professor (Associate) at University of Brawijaya

Leptastrea purpureais a species of hard coral with potential bioactive properties. This study aimed to evaluate the antioxidant properties of the n-hexane extract of L. purpureain vitroand in silico. The in vitroantioxidants activity was assessed by the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging, and ferric reducing antioxidant power (...

Breast cancer remains a major public health challenge, highlighting the importance of finding new therapeutic approaches, including the use of traditional plants with unstudied medicinal properties. This study aims to explore the bioactive potential of Tinospora cordifolia stem extract by investigating the content of flavonoids, phenols, terpenoids...

Excessive inflammation, driven by macrophage activation and nitric oxide (NO) production, underlies various diseases. This study investigates the anti-inflammatory potential of bungur (Lagerstroemia speciosa L.) leaf extract. We characterized its phytochemical profile and evaluated the effects using in silico approaches. Bungur leaves (L. speciosa...

Ruellia tuberosa L. leaf and root extracts have been investigated for their biological activity and potential health advantages, including their antidiabetic, antioxidant, and antidiuretic qualities. This research evaluates the freeze-drying microencapsulation of R. tuberosa L. extracts using gum Arabic, maltodextrin, and their combination as coati...

-Pinene is the primary compound ofturpentine oil. Itis widely utilized in fragrances, fine chemicals, flavors, and antibacterial applications. This compound exhibits relatively high chemical reactivity due to its unsaturated double bonds. Hydrogenation is a common method for saturating compounds, and nickel has demonstrated effective catalytic acti...

Advanced drug delivery systems are required due to the increasing advancement in science and technology, with a common example being microencapsulation. This system is affected by the manufacturing conditions and slow release of bioactive compounds inside microcapsule. In general, phytochemicals in the edible plant, Cosmos caudatus Kunth, specifica...

Breast cancer is a type of cancer that has a high rate of diagnosis and mortality in the world. Lagerestroemia speciosa is a herb that has anticancer activity. This study aims to analyze the compounds in L. speciosa that most act as anticancer of the breast. The compounds in L. speciosa were selected based on drug-likeness, physicochemical properti...

The flavonoid compounds in C. caudatus K., known for their various benefits, are prone to quick degradation, leading to reduced biological activity. This research aimed to evaluate the types of coatings: gum Arabic (GA), maltodextrin (MD), and a combination of both (MDGA) in C. caudatus K. extract microcapsules. The extract of C. caudatus K. was en...

Breast cancer remains a significant challenge in oncology, necessitating the exploration of novel therapeutic options. This study investigates the anticancer effects of ethanol and n-hexane fractions derived from the methanol extract of the Leptastrea purpurea sponge on T47D breast cancer cells. Employing cytotoxicity assays (MTT and WST-1), mitoch...

Hydrogels are a 3D polymer network capable of absorbing large amounts of water or biological fluids without dissolving, due to chemical or physical crosslinking. They are made from cellulose derivatives and are a promising research area for developing smart drug carriers in modern drug delivery systems. The present research aimed to synthesize h...

The materials sector has grown significantly over the last few decades. One from the community worldwide has embraced using natural fibers and biopolymers in many products due to significant problems with petroleum supplies and concerns about using synthetic plastics as biomaterials. The availability of lignocellulosic fiber polymer composites worl...

The main structure of novel bromoalkyl-1,4-benzoquinones is quinoid ring that can be modified to increase the bioavailability as a drug candidate. In this research, the modifications were carried out as 2-(4-bromobutyl)-3.5-dimethyl-1,4-benzoquinone (C4), 2-(7-bromoheptyl)-3,5-dimethyl-1,4-benzoquinone (C7), and 2-(10-bromodecyl)-3.5-dimethyl-1,4-b...

Caesalpinia sappan, commonly known as secang in Indonesia, has been used in traditional medicine to treat inflammation, microbial infection, diabetes, and cancer. In this study, the chromatographic separation of the ethyl acetate fraction of C. sappan was carried out. It resulted in the isolation of 2′,5,6-trimethoxyflavone (TM) and cirsimaritin (C...

The roots of Polygonum multiflorum Thunberg (Polygonaceae) are used as a crude drug Kashu that is considered to improve blood deficiency based on a Kampo concept. Kashu has been included in Kampo formulas, such as Tokiinshi, which is used to treat eczema and dermatitis with itchiness by inhibiting inflammation and facilitating blood circulation in...

Garam merupakan komoditas strategis yang tidak dapat digantikan oleh komoditas lain. Kebutuhan garam terus meningkat dimana Propinsi Jawa Timur merupakan lumbung garam nasional. Kabupaten Malang memiliki potensi wilayah di pantai selatan. Hanya saja, sampai dengan kegiatan ini dimulai, Kabupaten Malang belum menjadi penghasil garam. Kegiatan ini di...

Synthesis and characterization of cellulose acetate and nanocellulose acetate have been carried out. Cellulose was isolated from sengon wood powder waste using 6% NaOH solution and bleached with NaOCl. The cellulose was hydrolyzed with 60% formic acid to obtain nanocellulose. Cellulose and nanocellulose were then modified with acetic anhydride. The...

Biofilm is the predominant habitat of microbes in aquatic ecosystems. Microhabitat inside the biofilm matrix is a nutrient-rich environment promoted by the adsorption of nutrient ions from the surrounding water. Biofilms can not only adsorb ions that are nutrients but also other ions, such as heavy metals. The ability of biofilm to attract and reta...

Breast cancer is the most common type of cancer women suffer from worldwide in 2020 and the 4th leading cause of cancer death. Boesenbergia rotunda is an herb with high potential as an anticancer agent. This study explores the potential bioactive compounds in B. rotunda as anti-breast cancer agents using in silico and in vitro approaches. The in si...

Sponge Halichondriidae sp. obtained from the Kangean Islands belongs to the Demospongiae class, which has much potential in drug development, especially to treat cancer. The study aims to extract the Halichondriidae sponge with various solvents n-hexane, EtOAc, n-BuOH, and MeOH. Each extract was tested for its anti-cancer activity, including toxici...

The content of active compounds in plants can be analyzed by phytochemical tests. One of the herbal plants that is widely consumed is secang (Caesalpinia sappan). Secang is usually stored in the form of herbal tea and brewed with hot water then drunk to reduce throat inflammation or any other symtompts. To introduce simple research activities in sc...

One of the main focuses in microbial ecology is the analysis of microbial communities in water, especially concerning bacteria. The results of the analysis related to the abundance of bacteria will be essential knowledge for the development of aquaculture, especially those relating to the dynamics of pond water quality. This study aims to analyze t...

Biosorption is an alternative technology developed to overcome pollution, including heavy metal contamination in aquatic ecosystems. The accuracy of choosing a biosorbent strongly influences the success of biosorption. The organisms that are widely developed as biosorbents are microbes. Microbes live in ecosystems by forming biofilms. Therefore, kn...

Background: The roots of Polygonum multiflorum Thunberg (Polygonaceae) are a crude drug known as Kashu and are thought to improve blood deficiency as a Kampo concept. Kashu is added to Kampo formulas, including Tokiinshi, which is used to treat eczema and dermatitis with itchiness by facilitating blood circulation in the skin. Although anti- inflam...

The wide therapeutic effect of quinone-based drugs has received considerable interest for a long time. In this research, Friedel-Crafts performed a facile synthesis of quinone derivatives using the mixture of Brønsted acid. Reflux of 2,3-dimethylhydroquinone (1), isopropanol, glacial acetic acid, and H2SO4 for 15 minutes gave yellow oil product of...

Hydrodeoxygenation (HDO) is applied in fuel processing technology to convert bio-oils to green diesel with metal-based catalysts. The major challenges to this process are feedstock, catalyst preparation, and the production of oxygen free diesel fuel. In this study, we aimed to synthesize Ni catalysts supported on silica-zirconia and alumina-zirconi...

Water quality and waste management are significant problems for aquaculture in Indonesia, including catfish (Clarias gariepinus) aquaculture. A combination of Aquaponics Systems and Recirculating Aquaculture Systems (A-RAS) has been developed to address this problem. This study analyzed A-RAS application for catfish (Clarias gariepinus) aquaculture...

The modification structure of 1,4-benzoquinone is fascinating in the frame of drug design. The solubility properties of a new drug are important, especially for oral drug administration. The 2-isopropyl-5-methyl-1,4-benzoquinone (known as thymoquinone) which is the major constituent in Nigella sativa seed extract is known as an active compound with...

The solubility of the compound is a crucial task for new drug design. Quinone is a promising candidate to develop as a new drug. In this research, the synthesis of 1,4-benzoquinone derivatives, that is, 2-(5-bromoamyl)-3,5-dimethyl-1,4-benzoquinone (2a) and 2-(5-bromoamyl)-5-methyl-1,4-benzoquinone (2b) were carried out by decarboxylation and inser...

For measuring vitamins A and E in fortified palm oil, trichloroacetic acid (TCA) through visible spectrophotometry and total antioxidant capacity (TAC) through phenanthroline method were developed. Using TCA determination method, vitamin A was directly measured at λ = 620 nm, with 92.84 % ± 0.74 accuracy, 0.79 % RSD, 2.15 IU/g limit of detection (L...

Dunaliella sp. adalah mikroalga halotoleran yang banyak dijumpai pada lingkungan hipersalin. Mikrolaga ini mengandung berbagai substansi yang berharga seperti karetonoid, gliserol, lipid, protein dan vitamin sehingga banyak dibudidayakan. Salah satu faktor utama yang memengaruhi pertumbuhan Dunaliella sp. yang dibudidayakan adalah ketersediaan seny...

The synthesis of 2-methyl-5-methoxy-1,4-benzoquinone ( 2 ) was carried out by reflux of 2-methyl-1,4-benzoquinone ( 1 ) with MeOH and ZnCl 2 for 12 hours at ambient. The reaction resulted a yellow needle crystal in 6.92 % yield (m.p 173-175°C). The FT-IR analysis showed the presence of -OCH 3 group at 1210 cm ⁻¹ . The analysis using ¹ H-NMR showed...

The synthesis of 3-(7-triphenylphosphonioheptyl)-2,6-dimethyl-1,4-benzoquinone) (TFH) is carried out by bromoalkylation and insertion of triphenylphosphonium moiety by refluxed of 2,3-dimethyl-1,4-benzoquinone using bromooctanoic acid triphenylphosphine. The alkylation gave 17.14% yield of 2-(7-bromoheptyl)-3,5-dimethyl-1,4-benzoquinone (C7) and 3-...

Graphene is a two-dimensional carbon which has many applications. Due to high utilities of graphene, the synthetic procedures should be developed to increase its production. The synthesis of reduced graphene oxide (rGO) using lycopene were carried out in the presence of polar and non-polar solvent. The lycopene was extracted from watermelon by soli...

Hydrodeoxygenation (HDO) reaction is a fundamental step for producing bio-oil from lignocellulosic biomass. One of the major components from biomass is lignin which can be hydrolysed into phenolic derivatives. Here, we reported the preparation of Ni-based metal catalysts with the variation of a metal oxide for HDO of phenol. The Ni loading for each...

Hydrodeoxygenation is a one-step reaction that involve the hydrogenation of unsaturated carbon followed with the deoxygenation of the carbon-oxygen bond. This reaction is effective for converting biomass-derived chemicals from bio-oils, fats, woods, and lignocellulosic materials into biofuels using metal-based oxide catalysts. A Ni based-metal oxid...

Hydrodeoxygenation (HDO) reaction of furfural-acetone condensation adduct (FAA) using Ni-supported catalyst were investigated. The used of alumina-zirconia and silica-zirconia served as the support of Ni catalyst. The physicochemical properties of the catalysts were evaluated by X-Ray Diffraction (XRD) and N2-physisorption. The catalyst testing usi...

Investigation of hydrogenation catalytic application has become an interesting subject area by many experts, especially in nanoscience and nanotechnology. In general, metal-based SiO2 and ZrO2 composites become one of the promising materials to be applied as a hydrogenation support catalyst. In this work, we report the synthesis of Ni/SiO2/ZrO2 nan...

Pada kajian ini, penulis bermaksud untuk mengetahui pengaruh proses pretreatment resistive heating pada proses pembuatan furfural dari bahan alang-alang dan juga untuk mengetahui karakter furfural yang dihasilkan. Rancangan percobaan terdiri dari 2 faktor, faktor 1 yaitu konsentrasi NaOH (0,01; 0,05; 0,09 M) dan faktor 2 yaitu suhu pretreatment (65...

The utilization of modified sawdust cellulose and the adsorption capacity for Cu(II) removal in aqueous solution is reported. The modification of cellulose was conducted by delignification using NaOH followed by esterification using citric acid. Delignification sawdust (DLSD) using NaOH 0.5 M gave the increasing cellulose content to 22.38%. Then, t...

Contamination of heavy metals such as Cu²⁺ and Pb²⁺ have become serious problems in the aquatic ecosystems. Various efforts to prevent the negative impacts of pollution are being conducted. One of the crucial efforts is to monitor the concentration of heavy metals in aquatic ecosystems. However, the monitoring the heavy metal concentration faces va...

Furfural is one of the promising precursors obtained from dehydration and hydrolysis of hemicellulose. Condensation reaction of furfural and acetone gives furfurylidene and difurfurylideneacetone in 96% yield by reflux. The conjugated system between C=C and C=O bond in furfurylidene skeleton provide a new challenge for hydrodeoxygenation (HDO) reac...

Biomass as a renewable material became a prospective precursor for the development of alternative energy. It contains cellulose, hemicellulose, and lignin. The decomposition of lignin gives phenolic derivatives, which represent a major fraction of bio-oil after catalytic hydrodeoxygenation (HDO) treating. Here, an attempt to get hydrocarbon based-f...

Pengenalan pembuatan pupuk organik cair dari limbah padat biogas yang diperkaya oleh unsur Nitrogen (N) telah dilakukan pada peternak sapi perah di Desa Tutur Kabupaten Pasuruan. Desa Tutur. Pupuk organik cair diproduksi dengan menggunakan fermentor portabel kapasitas 60 L dan difermentasi selama 21-30 hari. Bahan dasar yang digunakan adalah limbah...

Sequential condensation and hydrodeoxygenation reaction were perform using autoclave batch reactor in the presence of water as a solvent. The condensation of furfural and acetone was performed using MgO catalyst followed by hydrodeoxygenation using mix catalyst Ni/SiO2 and Cu/SiO2. The catalyst was prepared by wet-impregnation method and analyzed b...

The paper studies recent application of cone flower waste from Pinus merkusii Jungh & De Vriese for an environmentally unclear method for synthesis silver nanoparticle. Phytochemical characterization using iron trichloride solution showed the extract of Pinus merkusii cone flower contains of phenolic group of secondary metabolite. This group acts a...

Sustainable agricultural applications in green chemistry was associated with the development of insecticide production based on secondary metabolites, such as essential oils. This research used In Silico modeling for insecticide formulation based on essential oils. The insecticidal formula was made on the basis of the Ki value of multiple docking r...

Modification of furfural by condensation and hydrogenation reaction is a promising approach to produce higher alkane derivatives (C8-C13) as diesel fraction. This research investigated the catalytic activity of Ni/MgO as bifunctional catalyst compared with MgO-Ni/Al2O3 mixed catalyst for condensation-hydrogenation reaction. The Ni/MgO and Ni/Al2O3...

The DSSC prototype using activated carbon (AC) and natural dye from Robusta coffee bean peels have been investigated. The natural dye obtained from the extraction of Robusta coffee bean peels is identified as anthocyanin by UV-Vis spectrophotometer at maximum wavelength 219.5 nm and 720.0 nm in methanol. From the FT-IR analysis, the vibration of O–...

The paper report antibacterial activity of flower extract from Pinus merkusii Jungh Et De Vriese and its mixture with copper nanoparticle on Staphylococcus aureus. This finding revealed the potency of pine forestry waste to overcome a bacterial-resistance problem on some commercially antibiotics. The extract was prepared by hot water extraction of...

Cassava starch is a polysaccharide consists of amylose and amylopectin. This research was purposed to modify the starch isolated from local cassava (Manihot esculenta). Modification was undertaken to study the esterification reaction of cassava starch with acetic acid and with isopropyl myristate. Moreover, morphology observation was also conducted...

Polyaniline (PANI) is a conductive polymer and potential for application in the electronic device manufacturing. This paper discloses a recent strategy in synthesis polyaniline nanoparticle (NP-PANI) using inverse micelle (IM) microemulsion method, and also characterization of the provided products. The synthesis step was conducted by mixing of ani...

Thymoquinone derivatives which synthesized in this research is bromoalkylquinones with alkyl chain consist of seven carbons (C7) and ten carbons (C10). The synthesis was carried out by oxidation of 2,3-dimethylhydroquinone followed by alkylation using reflux for 1.5 hours. The alkylation products were successfully characterized as 5-(7-bromoheptyl)...

Influence of water and acidic protic solvent on hydrodeoxygenation (HDO) of the furfural-acetone adduct (FAA) over Ni/Al2O3-ZrO2 (NiAZ) catalysts were investigated. The HDO of FAA was carried out in a batch reactor at 150°C for 8 hours. The NiAZ catalysts were home-made catalysts which were prepared by wet impregnation method with 10 and 20% nickel...

In this work, a molecular dynamics simulation was performed to investigate a reversible hydrophobic-hydrophilic properties of a surface model as a function of external electric potential. The surface is composed of a self-assembled monolayer (SAM) of a functionalized carbon chains that are immobilized on a supporting metal surface. The simulation s...

The catalytic hydrogenation/deoxygenation (H/D) reaction was carried out using Ni/Al2O3-ZrO2 catalyst. The 10% (wt/wt) of Ni were impregnated on Al2O3-ZrO2 (10NiAZ) by wet impregnation method followed by calcination and reduction. X-Ray diffraction analysis showed that Nideposited on the surface, with specific surface areas (SBET) was 48.616 m2/g....

This research aims to determine changes of the chemical composition in the hydration and oxidation reaction of Kaffir lime ( Cytrus hystrix DC.) oil. The hydration reaction was carried out using a Amberlyst catalyst with variation time for 1.5, 3, and 4.5 hours. Furthermore, the oxidation process was carried out using PCC catalyst with variation ti...

Hydrogenation of furfurylidene acetone has been carried out using Ni/γ−Al2O3 and Cu/γ−Al2O3 catalyst in the presence of isopropanol in autoclave batch reactor. The hydrogenation using Cu/γ−Al2O3 at 120oC for 6h gives main formation of 1,5-bis-(furan-2-yl)-pentan-3-one. Reaction at higher temperature at 140oC for 8h using Ni/γ−Al2O3 leads to 1,5-bis...

The profile of chemical potential of benzene fluid has been investigated using Anisotropic United Atom (AUA) model. A Monte Carlo simulation in canonical ensemble was done to obtain the isotherm of benzene fluid, from which the excess part of chemical potential was calculated. A surge of potential energy is observed during the simulation at high te...

The reaction of o-methylphenylnitrene in the presence of alcohol and amine was expected to give isomeric pairs of 3- and 7-methyl-3H-azepine derivatives. The formation ratio between these isomers was found to be obviously influenced by reaction temperature, that is, reaction at 150 degrees C gave 7-methyl-3H-azepine derivative, however, it became m...

The steric influence of the ortho-alkyl group of the nitrobenzene substrate and the nucleophile on the reaction pathway is investigated.