siti fathiah Masre

siti fathiah Masre
Universiti Kebangsaan Malaysia | ukm · centre for toxicology and health risk studies

Doctor of Philosophy

About

40
Publications
3,646
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
141
Citations
Introduction
Siti Fathiah Masre currently works at the Faculty of Health Sciences , National University of Malaysia. Siti Fathiah does research in Molecular Carcinogenesis. Their most recent publication is 'ROCK2/rasHa co-operation induces malignant conversion via p53 loss, elevated NF-κB and tenascin C-associated rigidity, but p21 inhibits ROCK2/NF-κB-mediated progression'.

Publications

Publications (40)
Article
ROCK2 roles in epidermal differentiation and carcinogenesis have been investigated in mice expressing an RU486-inducible, 4HT-activated ROCK2 transgene (K14.creP/lslROCKer). RU486/4HT-mediated ROCKer activation induced epidermal hyperplasia similar to cutaneous oncogenic rasHa (HK1.ras); however ROCKer did not elicit papillomas. Instead, anomalous...
Article
Tissues become more rigid during tumorigenesis and have been identified as a driving factor for tumor growth. Here, we highlight the concept of tissue rigidity, contributing factors that increase tissue rigidity, and mechanisms that promote tumor growth initiated by increased tissue rigidity. Various factors lead to increased tissue rigidity, promo...
Article
Lung cancer is one of the most lethal forms of cancer known to man, affecting millions of individuals worldwide. Despite advancements being made in lung cancer treatments, the prognosis of patients with the disease remains poor, particularly among patients with late‑stage lung cancer. The elucidation of the signaling pathways involved in lung cance...
Article
Full-text available
Cell proliferation and cell death abnormalities are strongly linked to the development of cancer, including lung cancer. The purpose of this study was to investigate the effect of pterostilbene on cell proliferation and cell death via cell cycle arrest during the transition from G1 to S phase and the p53 pathway. A total of 24 female Balb/C mice we...
Article
Full-text available
Mice have served as an excellent model to understand the etiology of lung cancer for years. However, data regarding dual-stage carcinogenesis of lung squamous cell carcinoma (SCC) remain elusive. Therefore, we aim to develop pre-malignant (PM) and malignant (M) lung SCC in vivo using N-nitroso-tris-chloroethylurea (NTCU). BALB/C mice were allotted...
Article
Full-text available
The study evaluated the antioxidant capacity of hexane extract of Canarium odontophyllum Miq. leaf; its fatty acids and terpenoids content; and cytotoxic effects on UVB-induced human keratinocytes (HaCaT). FRAP assay was used to determine antioxidant capacity. GC-MS analysis to identify the fatty acids and terpenoids’ in the hexane extract of Canar...
Article
Full-text available
Increased tissue rigidity is able to activate the Hippo signaling pathway, leading to YAP inactivation by phosphorylation and translocation into the cytoplasm. Accumulating evidence suggests that cytoplasmic pYAP serves as a tumor suppressor and could be a prognostic biomarker for several solid cancers. However, the relationship between tissue rigi...
Article
Full-text available
Increased tissue rigidity is an emerging hallmark of cancer as it plays a critical role in promoting cancer growth. However, the field lacks a defined characterization of tissue rigidity in dual-stage carcinogenesis of lung squamous cell carcinoma (SCC) in vivo. Pre-malignant and malignant lung SCC was developed in BALB/c mice using N-nitroso-tris-...
Article
Full-text available
Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype that is often associated with a poorer prognosis and does not respond to hormonal therapy. Increasing evidence highlights the exploitability of Annexin A1 (AnxA1), a calcium dependent protein, as a precision medicine for TNBC. To systematically summarize the role of AnxA1 a...
Article
Full-text available
Humans have 24 different types of chromosomes and each chromosome can be identified by its unique characteristics. In a cytogenetics laboratory, analyzing chromosomal characteristics is crucial because it is performed on real patient samples, allowing diseases to be diagnosed directly. However, identification of these chromosomes is difficult to pe...
Article
Full-text available
Canarium odontophyllum Miq., renowned locally as “dabai,” is an endemic plant in Sarawak, Malaysia. Most people, especially in rural areas, consume this plant to maintain their health. A few medicinal studies have investigated C. odontophyllum Miq.’s biological properties to substantiate its use as nutraceuticals and health supplements. Crude extra...
Article
Full-text available
Asian Conference on Biomedical Research and Laboratory Medicine was organized by three associations: Malaysian Association of Clinical Biochemists (MACB), Association of Scientific Officers Ministry of Health (ASOMH), and Malaysian Biomedical Science Association (MyBIOMED). The conference was held on 24th-25th August 2021 and a workshop on 26th Aug...
Article
Full-text available
Understanding the molecules that are essential for severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) entry can provide insights into viral infection and dissemination. Recently, it has been identified from several studies that angiotensin‐converting enzyme 2 receptor and transmembrane serine protease 2 are the main entry molecules for th...
Chapter
Lung cancer produces the highest mortality rate among cancers, mainly due to its late diagnosis accompanied by single or multiple organ metastasis to the lymph node, pleura, liver, brain and/or bones. In this chapter, we will review the major cellular signalling pathways that promote the proliferation and metastasis of lung cancer cells to each of...
Book
Amalan perubatan tradisional terutamanya dari tumbuh-tumbuhan kini diterokai secara saintifik bagi menyelami dan membongkar rahsia alam. Layari : http://ukmpress.ukm.my/index.php?route=product/product&path=93&product_id=1263
Article
Full-text available
Background: The Malaysian Dietary Guidelines recommended that at least two servings of fruits and three servings of vegetables be consumed daily. However, is there a relationship between daily fruit and vegetable intake and body mass index (BMI)? The aim of this study was to identify the relationship between fruit and vegetable intake and BMI among...
Chapter
Strategies to control the occurrence of skin cancer are actively pursued by preventing the formation in the precancerous stage and reversing or slowing down the pathological process using synthetic or natural products. Olives and their derivatives have been applied as a medicine since ancient times. They are largely consumed in the diet of the popu...
Article
Background: Lung cancer is the leading cause of cancer-related deaths, and squamous cell carcinoma (SCC) is one of the most common types of lung cancer. Chemoprevention of lung cancer has gained increasing popularity as an alternative to treatment in reducing the burden of lung cancer. Pterostilbene (PS) may be developed as a chemopreventive agent...
Article
Full-text available
Background: Time management is one of the factors that may influence students’ academic performance in university. A cross-sectional study was carried out to evaluate the role of motivation camp programme towards time management among first-year undergraduate students of the Biomedical Science Programme, Universiti Kebangsaan Malaysia (UKM) by usin...
Article
Full-text available
Monosodium glutamate (MSG) is widely used as an additive in food. Excess consumption of MSG was reported to cause oxidative stress on brain, liver and renal resulted in increased production of reactive oxygen species (ROS). This study aims to determine the biochemical and histological effects of low dose MSG on the liver of adult male Sprague-Dawle...
Article
Full-text available
Among all types of human cancers, lung cancer is one of the most common and has the highest mortality rate. Two major groups of lung cancer based on histological features are non-small cell lung cancers (NSCLCs) and small cell lung cancers (SCLCs). NSCLCs are further subdivided into few subtypes such as adenocarcinoma(AD), squamous cell carcinoma (...
Article
Full-text available
Oleuropein is a phenolic compound that can be abundantly found in the olive plant and it possesses pharmacological properties including anticancer, antioxidant, and anti-inflammatory. This present study was designed to determine the effects of oleuropein on tumour promotion stage, particularly on the histopathological changes, apoptotic rates and o...
Article
Full-text available
Background Oleuropein is a phenylethanoid, a form of a phenolic compound which found in olive leaf. It is known to have numerous pharmacological roles such as antioxidant, antibacterial, anti-inflammatory and anti-tumour. This study was carried out to investigate the effect of oleuropein on the two-stage skin carcinogenesis mouse model including th...
Article
Full-text available
Sea cucumbers, blind cylindrical marine invertebrates that live in the ocean intertidal beds have more than thousand species available of varying morphology and colours throughout the world. Sea cucumbers have long been exploited in traditional treatment as a source of natural medicinal compounds. Various nutritional and therapeutic values have bee...
Article
In vivo stability of biomaterial-based bone scaffolds often present a significant drawback in the development of materials for tissue engineering purpose. Previously developed nanobiocomposite bone scaffold using alginate and nano cockle shell powder has shown ideal characteristics. However, it showed high degradation rate and reduced stability in...
Article
To study ROCK2 activation in carcinogenesis, mice expressing 4-hydroxytamoxifen (4HT)-activated ROCK2 (K14.ROCK(er)) were crossed with mice expressing epidermal-activated ras(Ha) (HK1.ras(1205)). At 8 weeks, 4HT-treated K14.ROCK(er)/HK1.ras(1205) cohorts exhibited papillomas similar to HK1.ras(1205) controls; however, K14.ROCK(er)/HK1.ras(1205) his...
Article
The serine/threonine kinases ROCK1 and ROCK2 are central mediators of actomyosin contractile force generation that act downstream of the RhoA small GTP-binding protein. As a result, they have key roles in regulating cell morphology and proliferation, and have been implicated in numerous pathological conditions and diseases including hypertension an...
Article
Full-text available
Massive nutritional and medicinal values of sea cucumbers have long been reported in the past that may be due to sulfated Glycosaminoglycan (GAG). Thus, the effects of total sulfated GAG from local Stichopus vastus coelomic fluid were analyzed for its potential in full-fhickness excisional wound healing. The 20 uL of 1 jag mL-1 total sulfated GAG w...
Article
To study tumour progression mechanism in vivo, ROCK 2 signalling deregulation and co-operation with activated rasHa or PTEN loss was investigated in transgenic mouse skin carcinogenesis. Transgenic mice that expressed a 4-hydroxytamoxifen (4HT)-activated human ROCK 2-estrogen receptor fusion transgene from a keratin 14 promoter [K14.ROCKer] were cr...
Article
Full-text available
Stichopus hermanni and Stichopus vastus are sea cucumber species from the Stichopodidae family within the coastal waters of Malaysia. The integument of these invertebrates is hypothesised to contain abundant glycosaminoglycans (GAGs). GAGs are divided into non-sulphated and sulphated GAGs. Sulphated GAGs have various chemico-biological functions th...

Network

Cited By

Projects