Siriporn Sangsuthum

• PhD (Biomedical Science)
• Lecturer at Chulalongkorn University

This study explores the association between genetic variations in the vitamin D pathway and autism spectrum disorder (ASD) susceptibility and severity in Thai children. A total of 276 participants, including 169 children with ASD and 107 healthy controls, were recruited. Genotyping of vitamin D pathway genes (CYP2R1, CYP27B1, GC, and VDR) was condu...

Lead and cadmium are commonly found in electronic waste or e-waste. High blood lead levels (BLLs) and blood cadmium levels (BCLs) are associated with children’s abnormal physical and mental development. This study aimed to determine BLLs and BCLs and examine the physiological effects of lead and cadmium exposure in children in Sue Yai Utit, Bangkok...

E-waste dismantling activities can release heavy metals into the environment. Heavy metals cause environmental problems and adverse health effects, especially exposure to lead (Pb) and cadmium (Cd) of e-waste dismantling workers. The health risk of lead and cadmium from e-waste dismantling was evaluated. Blood lead and cadmium levels, which serve a...

Background The mechanisms underlying autism spectrum disorder (ASD) remain unclear, and clinical biomarkers are not yet available for ASD. Differences in dysregulated proteins in ASD have shown little reproducibility, which is partly due to ASD heterogeneity. Recent studies have demonstrated that subgrouping ASD cases based on clinical phenotypes i...

Significantly differentially expressed genes in each subgroup that were associated with the IPA categories “developmental disorder” and “neurological disease”. (XLS)

Demographic information of individuals with ASD and unaffected individuals included in this study. (XLS)

Differentially expressed spots from the 2D-PAGE and LC-MS/MS analyses. (XLS)

Representative images of the 2D-PAGE analysis. (PDF)

List of significantly differentially expressed transcripts in the ASD group and in each subgroup compared to the unaffected control group. (XLS)

Top diseases/disorders associated with 18 differentially expressed proteins in ASD with severe language impairment. (XLS)

Overlapping proteins between the 18 differentially expressed proteins from the LC-MS/MS analysis and those proteins encoded by transcripts found to be differentially expressed in previous ASD transcriptome studies. (XLS)

Western blot analysis of the DBI and IDH2 proteins in the ASD subgroups. (PDF)

Potentially useful in the treatment of neurodegenerative disorders, Kaempferia parviflora and Myristica fragrans have been shown to possess a wide spectrum of neuropharmacological activities and neuroprotective effects in vivo and in vitro. In this study, we determined whether and how K. parviflora ethanolic extract and M. fragrans volatile oil cou...

Recognized as an incurable disease, psoriasis is a chronic inflammatory disease, which is characterized by hyperproliferation and abnormal differentiation of keratinocytes. Although psoriasis has become a public health concern, its precise causes remain to be elucidated. The current study aimed at evaluating the suppressive effect of each of these...

Export Date: 8 September 2014

Insulin resistance plays a role in diabetic dyslipidaemia, especially postprandial hypertriglyceridaemia, through the overproduction of very low-density lipoprotein (VLDL). However, the role of insulin resistance on the apoprotein profile of VLDL has not been explored. To study the influence of insulin resistance on the VLDL proteome in the fasting...

Little is known about the postprandial remodelling of erythrocytes phospholipids (PLs) in type 2 diabetics (T2DM). Therefore, this study aims to compare the alterations of erythrocyte PLs in T2DM to those of healthy subjects after ingestion of a high-fat meal. Eleven T2DM and ten healthy subjects underwent a high-fat meal loading. Erythrocytes were...

Thesis (M.Sc.)--Chulalongkorn University, 2003 Oxidatively modified LDL is likely to be the main source of cholesterol that accumulates in arteriosclerotic plaques. Trace amount of copper can induce LDL oxidation that generate the lipid peroxidation products such as malondialdehyde (MDA) and 4-hydroxy-2-nonenal (HNE). These aldehydes especially HNE...