Sindri Traustason

Sindri Traustason
Ascendis Pharma · Non-Clinical Development and Bioanalysis

PhD

About

10
Publications
384
Reads
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175
Citations
Introduction
Skills and Expertise
Additional affiliations
November 2008 - April 2014
Glostrup Hospital
Position
  • Researcher
May 2005 - October 2008
University of Iceland
Position
  • Research Assistant

Publications

Publications (10)
Article
Purpose: To assess whether the direct and consensual postillumination (ipRGC-driven) pupil light responses to chromatic light stimuli are equal in healthy subjects. Methods: Pupil responses in healthy volunteers were recorded using a prototype binocular chromatic pupillometer (IdeaMedical, Copenhagen), which is capable of both direct and consens...
Article
To investigate the effect of intravitreal injections of the vascular endothelial growth factor inhibitor ranibizumab on retinal oxygenation in patients with central retinal vein occlusion (CRVO). Retinal oxygen saturation in patients with CRVO was analysed using the Oxymap Retinal Oximeter P3, before and during 6 months of treatment with intravitre...
Article
Purpose: To assess the validity of spectrophotometric retinal oximetry by comparison to blood gas analysis and intravitreal measurements of partial pressure of oxygen (pO(2)). Methods: Female domestic pigs were used for all experiments (n = 8). Oxygen fraction in inspired air was changed using a mixture of room air, pure oxygen, and pure nitroge...
Article
Purpose To investigate the effect of intravitreal anti-VEGF on retinal oxygenation in patients with central retinal vein occlusion. Intravitreal anti-VEGF injections have recently become an approved method of treatment for retinal vein occlusions, as several studies have shown a beneficial effect on visual acuity and retinal thickness. However, the...
Article
To assess spectrophotometric oximetry across a broad range of arterial saturation levels and to study the effect of chronic systemic hypoxemia on retinal oxygen extraction. The study included 16 patients with Eisenmenger syndrome, a cyanotic cardiac defect, and 17 healthy volunteers. Oxygen saturation in selected major retinal arteries and veins wa...
Article
To examine whether the addition of dorzolamide to timolol monotherapy influences oxygen saturation in the human retina. Non-invasive spectrophotometric retinal oximetry was used to measure oxygen saturation in retinal vessels. Twenty patients with open-angle glaucoma (11) and ocular hypertension (9) were recruited. The patients were randomised into...
Article
The purpose of this study was to test the hypothesis that ischemia/reperfusion injury in the rat retina may be ameliorated by reducing retinal metabolism with either hypothermia or inhibitory GABA agonists. The intraocular pressure of each right eye in rats was raised to 130 mm Hg for 60 min with the left eye serving as normal control. The rats wer...
Article
Purpose Disturbances in blood flow and oxygenation are believed to be involved in diseases such as diabetic retinopathy, retinal vascular occlusion and possibly glaucoma. The purpose of the studies presented here is to measure haemoglobin oxygen saturation (SatO2) in retinal vessels in patients with these diseases.

Projects