Simone Hageneder

Simone Hageneder
AIT Austrian Institute of Technology | ait · Biosensor Technologies

About

16
Publications
1,188
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184
Citations

Publications

Publications (16)
Article
Plasmonic nanomaterials have become an integral part of numerous technologies, where they provide important functionalities spanning from extraction and harvesting of light in thin film optical devices to probing of molecular species and their interactions on biochip surfaces. More recently, we witness increasing research efforts devoted to a new c...
Article
Full-text available
A novel metallic nanostructure for efficient plasmon-enhanced fluorescence readout of biomolecular binding events on the surface of a solid sensor chip is reported. It is based on gold multiperiod plasmonic grating (MPG) that supports spectrally narrow plasmonic resonances centered at multiple distinct wavelengths. They originate from diffraction c...
Chapter
Plasmonic nanostructures serve in a range of analytical techniques that were developed for the analysis of chemical and biological species. Among others, they have been pursued for the investigation of odorant binding proteins (OBP) and their interaction with odorant molecules. These compounds are low molecular weight agents, which makes their dire...
Conference Paper
Actively tunable plasmonic materials were developed for advanced optical biosensors. They are composed of metallic nanostructures and responsive hydrogels and were tailored for plasmon-enhanced fluorescence analysis of trace amounts of analytes.
Chapter
This chapter focuses at bioassays that take advantage of amplification of fluorescence signal by the coupling of fluorophore labels with confined electromagnetic field of surface plasmons. It provides a brief introduction to surface plasmon-coupled fluorescence emission (SPCE) and it describes the enhancement of fluorescence signal by combined effe...
Article
Full-text available
A biosensor for the detection of hepatitis B antibodies in clinical saliva was developed. Compared to conventional analysis of blood serum, it offers the advantage of non-invasive collection of samples. Detection of biomarkers in saliva imposes two major challenges associated to the low analyte concentration and increased surface fouling. The detec...
Article
Herein, we present a fast and sensitive biosensor for detection of Ochratoxin A (OTA) in a red wine that utilizes gold nanoparticle-enhanced surface plasmon resonance (SPR). By combining an indirect competitive inhibition immunoassay and signal enhancement by secondary antibodies conjugated with gold nanoparticles (AuNPs), highly sensitive detectio...
Article
A plasmonic biosensor for rapid detection of protein biomarkers in complex media is reported. Clinical serum samples were analyzed by using a novel biointerface architecture based on poly[(N-(2-hydroxypropyl) methacrylamide)-co-(carboxybetaine methacrylamide)] brushes functionalized with bioreceptors. This biointerface provided an excellent resista...
Conference Paper
Plasmonic amplification of fluorescence signal in bioassays with microarray detection format is reported. A crossed relief diffraction grating was designed to couple an excitation laser beam to surface plasmons at the wavelength overlapping with the absorption and emission bands of fluorophore Dy647 that was used as a label. The surface of periodic...
Article
Corrugated metallic surfaces offer means for efficient amplification of fluorescence bioassay signal based on the near field coupling between surface plasmons and fluorophore emitters that are used as labels. This paper discusses the design of such plasmonic structure to enhance the sensitivity of immunoassays with epi-fluorescence readout geometry...

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Projects

Project (1)
Project
Our goal is to develop novel sensors for pathogen detection using novel photonic concepts in combination with isothermal amplification technologies.