Simona Catozzi

Simona Catozzi
Institut Curie · Cancer and Genome: Bioinformatics, Biostatistics and Epidemiology of Complex Systems (U900)

PhD
Postdoctoral Researcher

About

8
Publications
565
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32
Citations
Introduction
I am currently working on the optimization of personalized chronomodulated combination therapy for pancreatic cancer patients. The in silico investigation of efficacy/toxicity of the standard-of-care treatment (FOLFIRINOX regimen) in association with targeted molecules will then support the translation of novel therapeutics from preclinical to clinical research.
Additional affiliations
February 2019 - present
University College of Dublin
Position
  • PostDoc Position
November 2013 - December 2016
Institut Non Linéaire de Physique
Position
  • PhD Student

Publications

Publications (8)
Article
Full-text available
Background - Ras is a key cellular signaling hub that controls numerous cell fates via multiple downstream effector pathways. While pathways downstream of effectors such as Raf, PI3K and RalGDS are extensively described in the literature, how other effectors signal downstream of Ras is often still enigmatic. Methods - A comprehensive and unbiase...
Article
Full-text available
Ras is a plasma membrane (PM)-associated signaling hub protein that interacts with its partners (effectors) in a mutually exclusive fashion. We have shown earlier that competition for binding and hence the occurrence of specific binding events at a hub protein can modulate the activation of downstream pathways. Here, using a mechanistic modeling ap...
Article
Full-text available
Cancer is the second leading cause of death globally, and colorectal cancer (CRC) is among the five most common cancers. The small GTPase KRAS is an oncogene that is mutated in~30% of all CRCs. Pharmacological treatments of CRC are currently unsatisfactory, but much hope rests on network-centric approaches to drug development and cancer treatment....
Article
In living organisms, cascades of covalent modification cycles are one of the major intracellular signaling mechanisms, allowing to transduce physical or chemical stimuli of the external world into variations of activated biochemical species within the cell. In this paper, we develop a novel method to study the stimulus-response of signaling cascade...
Thesis
Full-text available
Living cells communicate with their external environment, by means of a signal transduction network, which allows them to interpret physico-chemical signals and produce appropriate responses. This complex machinery is orchestrated by signaling cascades, which play the role of intracellular transmitters, by transferring biochemical stimuli between c...
Article
Full-text available
Background Signal transduction is the process through which cells communicate with the external environment, interpret stimuli and respond to them. This mechanism is controlled by signaling cascades, which play the role of intracellular transmitter, being able to transmit biochemical information between cell membrane and nucleus. In theory as well...

Projects

Projects (2)
Archived project
Working on the mathematical modeling (ODEs) of the signaling network related to oncoproteins Ras, especially in the context of colorectal cancer. The aim is to study the properties of network rewiring, under different stimuli and Ras mutations, in tight collaboration with biologists that are testing multiple conditions on Caco-2 cells and measuring the proteomic profile and the phenotypic output thereof.