Simon Moosburner

Simon Moosburner
Charité Universitätsmedizin Berlin | Charité · Department of General, Visceral and Transplantation Surgery

Doctor of Medicine

About

43
Publications
4,189
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248
Citations
Introduction
Simon Moosburner currently works at the Department of General, Visceral and Transplantation Surgery, Charité Universitätsmedizin Berlin and is an active BIH Charité Junior Clinician Scientist. Simon focuses on research in transplantation as well as emerging technologies such as Augmented/Mixed and Virtual Reality and their application in surgery.
Education
October 2013 - June 2020

Publications

Publications (43)
Article
Objective: The paper evaluates the application of a mixed reality (MR) headmounted display (HMD) for the visualization of anatomical structures in complex visceral-surgical interventions. A workflow was developed and technical feasibility was evaluated. Summary of background data: Medical images are still not seamlessly integrated into surgical...
Article
Normothermic ex vivo liver machine perfusion might be a superior preservation strategy for liver grafts from extended criteria donors. However, standardized small animal models are not available for basic research on machine perfusion of liver grafts. A laboratory‐scaled perfusion system was developed consisting of a custom‐made perfusion chamber,...
Article
Full-text available
Due to the shortage of liver allografts and the rising prevalence of fatty liver disease in the general population, steatotic liver grafts are considered for transplantation. This condition is an important risk factor for the outcome after transplantation. We here analyze the characteristics of the donor pool offered to the Charité – Universitätsme...
Article
We read, with great interest, the work from Croome et al. on “The impact of post‐reperfusion syndrome using livers with significant macrosteatosis” in which the authors demonstrate in a propensity score matched cohort, that steatosis hepatis is associated with post‐reperfusion syndrome (PRS), early allograft dysfunction (EAD) and renal dysfunction,...
Article
Full-text available
Concepts to ameliorate the continued mismatch between demand for liver allografts and supply include the acceptance of allografts that meet extended donor criteria (ECD). ECD grafts are generally associated with an increased rate of complications such as early allograft dysfunction (EAD). The costs of liver transplantation for the health care syste...
Article
Full-text available
Background While laparoscopic liver surgery has become a standard procedure, experience with robotic liver surgery is still limited. The aim of this prospective study was to evaluate safety and feasibility of robotic liver surgery and compare outcomes with conventional laparoscopy. Methods We here report the results of a single-center, prospective...
Article
The most common preservation technique for liver grafts is static cold storage. Due to the organ shortage for liver transplantation, extended criteria donation (ECD) allografts are increasingly used - despite the higher risk of inferior outcome after transplantation. Ex vivo liver machine perfusion has been developed to improve the outcome of liver...
Article
Full-text available
Background Due to the COVID-19 pandemic, an extensive reorganisation of healthcare resources was necessary—with a particular impact on surgical care across all disciplines. However, the direct and indirect consequences of this redistribution of resources on surgical therapy and care are largely unknown. Methods We analysed our prospectively collec...
Conference Paper
*Purpose: We aimed to characterize the performance of old vs. young liver grafts in a standardized rat model of normothermic ex vivo liver machine perfusion (NEVLP), as liver grafts are frequently declined due to high donor age or age mismatch with the recipient. *Methods: Livers from Sprague Dawley rats aged 3 months or 12 months were harvested a...
Article
Full-text available
Background Not all patients suffer from a severe course of SARS-CoV-2 infection, demanding a definition of groups at risk. Short bowel syndrome (SBS) has been assumed to be a risk factor, due to the complexity of disease, the need for interdisciplinary care and frequent contact with caretakers. We aimed to establish data on the course of infection...
Article
Full-text available
Background: Pediatric liver transplantation (LT) is the treatment of choice for children with end-stage liver disease and in certain cases of hepatic malignancies. Due to low case numbers, a technically demanding procedure, the need for highly specialized perioperative intensive care, and immunological, as well as infectious, challenges, the highe...
Article
Full-text available
Background Since autologous veins are unavailable when needed in more than 20% of cases in vascular surgery, the production of personalized biological vascular grafts for implantation has become crucial. Surface modification of decellularized xenogeneic grafts with vascular cells to achieve physiological luminal coverage and eventually thromboresis...
Conference Paper
Pancreatic surgery is associated with a high risk for postoperative complications and death of patients. Complications occur in a variable interval after the procedure. Often, a patient has already left the ICU and is not properly monitored anymore when the complication occurs. Risk stratification models can assist in identifying patients at risk i...
Article
Full-text available
Background and Objectives: In children, hepatoblastoma preferentially is managed by liver resection (LR). However, in irresectable cases, liver transplantation (LT) is required. The aim of our study was to compare short- and long-term results after LR and LT for the curative treatment of hepatoblastoma. Materials and Methods: Retrospective analysis...
Article
Background and objective: Due to the coronavirus disease 2019 (COVID-19) pandemic extensive reorganization and limitation of resources within the healthcare system became inevitable. This review highlights the direct and indirect impact of the COVID-19 pandemic on the fields of hepato-pancreato-biliary (HPB) surgery and organ transplantation incor...
Preprint
Full-text available
IntroductionIn children, hepatoblastoma preferentially is managed by liver resection (LR). However, in irresectable cases, liver transplantation (LT) is required. Aim of our study was to compare short- and long-term results after LR and LT for the curative treatment of hepatoblastoma. Materials and methodsRetrospective analysis of all patients trea...
Article
Full-text available
Background Many patients suffering from peripheral arterial disease (PAD) are dependent on bypass surgery. However, in some patients no suitable replacements (i.e. autologous or prosthetic bypass grafts) are available. Advances have been made to develop autologous tissue engineered vascular grafts (TEVG) using endothelial colony forming cells (ECFC...
Article
Full-text available
Background Liver transplantation is the only curative treatment option for end-stage liver disease; however, its use remains limited due to a shortage of suitable organs. In recent years, ex vivo liver machine perfusion has been introduced to liver transplantation, as a means to expand the donor organ pool. Purpose To present a systematic review o...
Article
Islet-based recellularization of decellularized, repurposed rat livers may form a transplantable Neo-Pancreas. The aim of this study is the establishment of the necessary protocols, the evaluation of the organ structure and the analysis of the islet functionality ex vivo. After perfusion-based decellularization of rat livers, matrices were repopula...
Article
Zusammenfassung Hintergrund Der Mangel an Spenderorganen für die Lebertransplantation limitiert die Verfügbarkeit dieser lebensrettenden Therapieoption in Deutschland. Die Qualität der potenziell verfügbaren Spenderorgane wurde bislang nicht bundesweit untersucht. Methoden Analyse aller durch die Deutsche Stiftung Organtransplantation an Eurotransp...
Article
Full-text available
PurposeAugmented reality (AR) and head-mounted displays (HMD) in medical practice are current research topics. A commonly proposed use case of AR-HMDs is to display data in image-guided interventions. Although technical feasibility has been thoroughly shown, effects of AR-HMDs on interventions are not yet well researched, hampering clinical applica...
Article
Full-text available
Background Normothermic ex vivo liver perfusion (NEVLP) is a promising strategy to increase the donor pool in liver transplantation. Small animal models are essential to further investigate questions regarding organ preservation and reconditioning by NEVLP. A dual vessel small animal NEVLP (dNEVLP) model was developed using metamizole as a vasodila...
Article
The production of biomaterials that endow significant morphogenic and microenvironmental cues for the constitution of cell integration and regeneration remains a key challenge in the successful implementation of functional organ replacements. Despite the vast development in the production of biological and architecturally native matrices, the compl...
Article
Current developments in the field of extended reality (XR) could prove useful in the optimization of surgical workflows, time effectiveness and postoperative outcome. Although still primarily a subject of research, the state of XR technologies is rapidly improving and approaching feasibility for a broad clinical application. Surgical fields of appl...
Article
Full-text available
Hepatocyte transplantation (HcTx) is a promising approach for the treatment of metabolic diseases in newborns and children. The most common application route is the portal vein, which is difficult to access in the newborn. Transfemoral access to the splenic artery for HcTx has been evaluated in adults, with trials suggesting hepatocyte translocatio...
Article
Impact statement: Ex vivo liver machine perfusion (MP) is an emerging preservation alternative to static cold storage. Even though clinical studies have shown benefits for extended criteria donor grafts, standardized systems for perfusion of rat liver grafts are not available, which are inevitable for large-scaled studies on liver reconditioning b...
Article
Three‐dimensional tissue cultures are important models for the study of cell‐cell and cell‐matrix interactions, as well as, to investigate tissue repair and reconstruction pathways. Therefore, we designed a reproducible and easy to handle printable bioreactor system (Teburu), that is applicable for different approaches of pathway investigation and...
Article
Full-text available
Research and therapeutic applications create a high demand for primary human hepatocytes. The limiting factor for their utilization is the availability of metabolically active hepatocytes in large quantities. Centrifugation through Percoll, which is commonly performed during hepatocyte isolation, has so far not been systematically evaluated in the...
Article
Background Liver transplantation is the only curative treatment option for patients with end-stage liver disease; however, the 40% decline of available organ donors in recent years in Germany necessitates the optimization of available resources and possibly extending the criteria to older donors. Material and methods All 2652 livers made available...
Article
Background Recent developments in the field of augmented reality (AR) have enabled new use cases in surgery. Initial set‐up of an appropriate infrastructure for maintaining an AR surgical workflow requires investment in appropriate hardware. Methods We compared the usability of the Microsoft HoloLens and Meta 2 head mounted displays (HMDs). Fiftee...
Article
Hintergrund: Mit zunehmendem Alter stellen Stürze ein enormes Problem dar. Die Folgen von Fehleinschätzungen des eigenen Sturzrisikos sind bislang wenig untersucht. Ziel: Die Studie verfolgte die Frage, ob Physiotherapeuten eine inadäquate Selbsteinschätzung des Sturzrisikos bei älteren Menschen mithilfe von ausschließlich funktionellen Untersuchun...

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Projects

Projects (2)
Project
So far, Head Mounted Displays (HMD) were bulky, heavy devices and their displays had an inadequate resolution. Furthermore, hiding the real world Virtual Reality HMD are not allowing the surgeon to directly see the surgical site: This limited their use significantly. The recent availability of high-resolution displays, tremendously faster processors, and – most importantly – the development of Mixed Reality technology will dramatically change the way surgeons might use this technology in the future. Together with the Interdisciplinary Laboratory Image Knowledge Gestaltung at the Humboldt-Universität zu Berlin we are currently working on 1. Preoperative surgical planning in visceral surgery (VR, MR) 2. MR assisted surgery, tele-consulting & mentoring and 3. Training of surgical technicians via 360° videos and immersive 3D spaces.
Project
Our novel concept of metabolic reprogramming envisions reconstitution of endogenous repair in severely steatotic liver grafts during extracorporeal machine perfusion in the period between explantation and implantation.