Simon S Kessner

Simon S Kessner
University of Hamburg | UHH · Department of Neurology

Dr. med. Dr. rer. biol. hum.

About

26
Publications
5,650
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557
Citations

Publications

Publications (26)
Article
Full-text available
The success of medical treatment, especially for subjectively evaluated conditions such as pain, is usually influenced by a patienttextquoterights expectations. In particular, patients who have been exposed to unsuccessful treatment attempts in the past often do not respond as strongly to subsequent treatments. To assess whether a change in drug ro...
Article
In the past years, there have been increasing research activities focusing on somatosensory symptoms following stroke. However, as compared to the large number of clinical and neuroimaging studies on motor symptoms, the number of studies tracing somatosensory symptoms after stroke and their recovery is rather small. It is an ongoing discussion, to...
Article
Full-text available
Placebo responses have been shown to contribute to clinical treatment outcomes. The pharmacological enhancement of placebo responses therefore has the potential to increase treatment benefits. The neuropeptide oxytocin may mediate processes such as empathy, trust, and social learning. These are key elements of the patient-physician relationship, wh...
Article
Full-text available
Background We report the case of a patient with recurrent episodes of disturbed memory suggestive of transient epileptic amnesia, and a focal hippocampal lesion typically associated with transient global amnesia. We argue how careful consideration of clinical, electrophysiological and imaging findings can resolve this apparent contradiction and lea...
Article
Full-text available
Somatosensory deficits after ischaemic stroke are common and can occur in patients with lesions in the anterior parietal cortex and subcortical nuclei. It is less clear to what extent damage to white matter tracts within the somatosensory system may contribute to somatosensory deficits after stroke. We compared the roles of cortical damage and disr...
Article
Full-text available
The brain systems underlying placebo analgesia are insufficiently understood. Here we performed a systematic, participant-level meta-analysis of experimental functional neuroimaging studies of evoked pain under stimulus-intensity-matched placebo and control conditions, encompassing 603 healthy participants from 20 (out of 28 eligible) studies. We f...
Article
Full-text available
Cerebral small vessel disease is a common disease in the older population and is recognized as a major risk factor for cognitive decline and stroke. Small vessel disease is considered a global brain disease impacting the integrity of neuronal networks resulting in disturbances of structural and functional connectivity. A core feature of cerebral sm...
Article
Full-text available
Corticospinal tract integrity after stroke has been widely investigated through the evaluation of fibres descending from the primary motor cortex. However, about half of the corticospinal tract is composed by sub-pathways descending from premotor and parietal areas, to which damage may play a more specific role in motor impairment and recovery, par...
Article
Internal carotid artery stenosis is a risk factor for ischemic stroke. Even in the absence of visible structural brain changes, patients with asymptomatic stenosis are prone to cognitive impairment. On a neuronal level, it was suggested that stenosis may lead to disturbed functional brain connectivity. If so, carotid revascularization should have a...
Article
Full-text available
Background: We investigated changes of cortical thickness and its association with cognitive performance in patients with high-grade carotid artery stenosis without ischemic brain lesions. Methods: We studied 25 patients with unilateral carotid artery stenosis ≥50% and 25 age-matched controls. All subjects underwent T1-weighted MRI, and cortical...
Article
Background and Purpose— About 50% to 80% of stroke survivors present with somatosensory deficits. Somatosensory deficits because of an ischemic stroke are determined by the infarct location. However, a detailed understanding of the long-term effect of lesions on somatosensory performance is lacking. Methods— This prospective observational study en...
Article
Full-text available
Introduction There is evidence suggesting a detrimental effect of asymptomatic carotid artery stenosis on cognitive function even in the absence of ischemic cerebral lesions. Hypoperfusion has been suggested as pathophysiological mechanism causing cognitive impairment. We aimed to assess cognitive performance and cerebral perfusion changes in patie...
Article
Full-text available
Background Aberrant functional connectivity in brain networks associated with motor impairment after stroke is well described, but little is known about the association with somatosensory impairments. Aim The objective of this cross-sectional observational study was to investigate the relationship between brain functional connectivity and severity...
Data
Prevalence of ROI's that showed overlap with the lesions of each patient. ROI: region of interest. (DOCX)
Data
Overview of lesion location for each patient. ACM: arteria cerebri media; ACA: arteria cerebri anterior; ACP: arteria cerebri posterior; BA: arteria basilaris; C: cortical lesion; SC: subcortical lesion. (DOCX)
Article
Background: Proportional motor recovery in the upper limb has been investigated, indicating about 70% of the potential for recovery of motor impairment within the first months poststroke. Objective: To investigate whether the proportional recovery rule is applicable for upper-limb somatosensory impairment and to study underlying neural correlate...
Article
Full-text available
The aim of this study was to investigate the relationship between stroke lesion location and the resulting somatosensory deficit. We studied exteroceptive and proprioceptive somatosensory symptoms and stroke lesions in 38 patients with first-ever acute stroke. The Erasmus modified Nottingham Sensory Assessment was used to clinically evaluate somato...
Data
3D neuroimage of voxels with significant lesion-symptom association
Data
Glass brain of probabilistic fiber tracts
Article
Full-text available
It is increasingly recognized that the efficacy of medical treatments is determined in critical part by the therapeutic context in which it is delivered. An important characteristic of that context is treatment history. We recently reported first evidence for a carry-over of treatment experience to subsequent treatment response across different tre...
Article
According to experimental and clinical evidence, the experiences of previous treatments are carried over to different therapeutic approaches and impair the outcome of subsequent treatments. In this behavioral pilot study we used a change in administration route to investigate whether the effect of prior treatment experience on a subsequent treatmen...
Article
Full-text available
Therapeutic context can critically determine treatment outcome.1 Prior experience with a treatment is an important contextual factor that has been shown to modulate treatment efficacy.2,3 To date, this influence of prior treatment experience has been studied only within the same treatment approach. However, in clinical practice, treatments are ofte...

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I am looking for fiber-tracking data on radiation from thalamus to cortex to compare it with my results.

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