Simon Henin

Simon Henin
NYU Langone Medical Center | NYUMC · Department of Neurology

PhD

About

55
Publications
7,716
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904
Citations

Publications

Publications (55)
Article
Full-text available
Noninvasive brain stimulation techniques are used in experimental and clinical fields for their potential effects on brain network dynamics and behavior. Transcranial electrical stimulation (TES), including transcranial direct current stimulation (tDCS) and transcranial alternating current stimulation (tACS), has gained popularity because of its co...
Article
Full-text available
Direct recordings from the human brain have historically involved epilepsy patients undergoing invasive electroencephalography (iEEG) for surgery. However, these measurements are temporally limited and affected by clinical variables. The RNS System (NeuroPace, Inc.) is a chronic, closed-loop electrographic seizure detection and stimulation system....
Preprint
Full-text available
Sensory input arrives in continuous sequences that humans experience as units, e.g., words and events. The brain’s ability to discover extrinsic regularities is called statistical learning. Structure can be represented at multiple levels, including transitional probabilities, ordinal position, and identity of units. To investigate sequence encoding...
Article
Full-text available
Slow oscillations and spindle activity during non-rapid eye movement sleep have been implicated in memory consolidation. Closed-loop acoustic stimulation has previously been shown to enhance slow oscillations and spindle activity during sleep and improve verbal associative memory. We assessed the effect of closed-loop acoustic stimulation during a...
Article
Full-text available
Transcranial electrical stimulation has widespread clinical and research applications, yet its effect on ongoing neural activity in humans is not well established. Previous reports argue that transcranial alternating current stimulation (tACS) can entrain and enhance neural rhythms related to memory, but the evidence from non-invasive recordings ha...
Article
Research has shown that sleep is beneficial for the long-term retention of memories. According to theories of memory consolidation, memories are gradually reorganized, becoming supported by widespread, distributed cortical networks, particularly during postencoding periods of sleep. However, the effects of sleep on the organization of memories in t...
Article
Full-text available
We describe the spatiotemporal course of cortical high-gamma activity, hippocampal ripple activity and interictal epileptiform discharges during an associative memory task in 15 epilepsy patients undergoing invasive EEG. Successful encoding trials manifested significantly greater high-gamma activity in hippocampus and frontal regions. Successful cu...
Article
Full-text available
Sensory input arrives in continuous sequences that humans experience as segmented units, e.g., words and events. The brain’s ability to discover regularities is called statistical learning. Structure can be represented at multiple levels, including transitional probabilities, ordinal position, and identity of units. To investigate sequence encoding...
Preprint
We describe the spatiotemporal course of cortical high-gamma activity (HGA), hippocampal ripple activity and interictal epileptiform discharges (IEDs) during an associative memory task in 15 epilepsy patients undergoing invasive electroencephalography. Successful encoding trials manifested significantly greater HGA in hippocampus and frontal region...
Article
Memory consolidation is hypothesized to involve the distribution and restructuring of memory representations across hippocampal and cortical regions. Theories suggest that, through extended hippocampal-cortical interactions, cortical ensembles come to represent more integrated, or overlapping, memory traces that prioritize commonalities across rela...
Conference Paper
Full-text available
Noninvasive transcranial brain stimulation has been widely used in experimental and clinical applications to perturb the brain activity, aiming at promoting synaptic plasticity or enhancing functional connectivity within targeted brain regions. However, there are different types of neurostimulations and various choices of stimulation parameters; ho...
Article
Objective: Sleep spindles have been implicated in memory consolidation and synaptic plasticity during NREM sleep. Detection accuracy and latency in automatic spindle detection are critical for real-time applications. Approach: Here we propose a novel deep learning strategy (SpindleNet) to detect sleep spindles based on a single EEG channel. Whil...
Preprint
Full-text available
Online educational materials are largely disseminated through videos, and yet there is little understanding of how these videos engage students and fuel academic success. We hypothesized that components of the electroencephalogram (EEG), previously shown to reflect video engagement, would be predictive of academic performance in the context of educ...
Article
Human brain mapping relies heavily on fMRI, ECoG and EEG, which capture different physiological signals. Relationships between these signals have been established in the context of specific tasks or during resting state, often using spatially confined concurrent recordings in animals. But it is not certain whether these correlations generalize to o...
Article
Online educational materials are largely disseminated through videos, and yet there is little understanding of how these videos engage students and fuel academic success. We hypothesized that components of the electroencephalogram (EEG), previously shown to reflect video engagement, would be predictive of academic performance in the context of educ...
Conference Paper
Stimulus frequency otoacoustic emissions (SFOAEs) were evoked and estimated using swept-frequency tones with and without the use of swept suppressor tones. SFOAEs were estimated using a least-squares fitting procedure. The estimated SFOAEs for the two paradigms (with- and without-suppression) were similar in amplitude and phase. The fitting procedu...
Preprint
Full-text available
Some patients with medically refractory focal epilepsy are chronically implanted with a brain-responsive neurostimulation device (the RNS ® System), permitting neurophysiological measurements at millisecond resolution. This clinical device can be adapted to measure hippocampal dynamics time-locked to cognitive tasks. We illustrate the technique wit...
Poster
Full-text available
Introduction A technique for measuring high-resolution OAEs using frequency-swept tones (e.g. Long et al., 2008) produces reliable estimates of DPOAEs consistent with measurements using discrete tones. The swept-tone DPOAE paradigm enables component separation and provides information about fine-structures that may be sensitive to pathological chan...
Article
Full-text available
It has come to our attention that we did not specify whether the stimulation magnitudes we report in this Article are peak amplitudes or peak-to-peak. All references to intensity given in mA in the manuscript refer to peak-to-peak amplitudes, except in Fig. 2, where the model is calibrated to 1 mA peak amplitude, as stated. In the original version...
Article
Full-text available
Neural development is generally marked by an increase in the efficiency and diversity of neural processes. In a large sample (n = 114) of human children and adults with ages ranging from 5 to 44 yr, we investigated the neural responses to naturalistic video stimuli. Videos from both real-life classroom settings and Hollywood feature films were used...
Article
Full-text available
It is said that we lose track of time - that “time flies” - when we are engrossed in a story. How does engagement with the story cause this distorted perception of time, and what are its neural correlates? People commit both time and attentional resources to an engaging stimulus. For narrative videos, attentional engagement can be represented as th...
Article
Full-text available
Here we report the methods and output of a workshop examining possible futures of speech and hearing science out to 2030. Using a design thinking approach, a range of human-centered problems in communication were identified that could provide the motivation for a wide range of research. Nine main research programs were distilled and are summarized:...
Article
Full-text available
Human brain activity can be studied at different spatial and temporal scales using fMRI, ECoG and EEG. To assess how reliably these imaging methods reflect brain responses related to a complex audio-visual stimulus and how similar stimulus-related responses are across methods, we presented a movie clip twice to three different cohorts of subjects (...
Poster
Full-text available
Stimulus frequency otoacoustic emissions (SFOAEs) can be evoked using either swept-frequency tones or fixed-frequency tones. SFOAEs for each stimulus paradigm were estimated using a least-squares (LS) fitting procedure. To estimate SFOAEs, the fitting procedure minimizes the square error between a parametric model of total ear-canal pressure (with...
Article
Full-text available
We present a dataset combining electrophysiology and eye tracking intended as a resource for the investigation of information processing in the developing brain. The dataset includes high-density task-based and task-free EEG, eye tracking, and cognitive and behavioral data collected from 126 individuals (ages: 6-44). The task battery spans both the...
Preprint
Full-text available
It is said that we lose track of time - that “time flies” - when we are engrossed in a story. How does engagement with the story cause this distorted perception of time, and what are its neural correlates? People commit both time and attentional resources to an engaging stimulus. For narrative videos, attentional engagement can be represented as th...
Preprint
Full-text available
We present a dataset combining electrophysiology and eye tracking intended as a resource for the investigation of information processing in the developing brain. The dataset includes high-density task-based and task-free EEG, eye tracking, and cognitive and behavioral data collected from 126 individuals (ages: 6–44). The task battery spans both the...
Article
Full-text available
Neural development is generally marked by an increase in the efficiency and diversity of neural processes. In a large sample (N = 114) of children and adults with ages ranging from 5 −44 years, we investigated the neural responses to naturalistic video stimuli. Videos from both real-life classroom settings and Hollywood feature films were used to p...
Article
Full-text available
Background: Tinnitus correlates with elevated hearing thresholds and reduced cochlear compression. We hypothesized that reduced peripheral input leads to elevated neuronal gain resulting in the perception of a phantom sound. Objective: The purpose of this pilot study was to test whether compensating for this peripheral deficit could reduce the t...
Data
Summary Results Table. For each subject, table shows treatment order, change in behavioral measures (change from baseline, post-pre), and episode number used in each treatment. (DOCX)
Article
Distortion product otoacoustic emissions (DPOAE) in newborns and adults were evoked by sweeping primaries up and down in frequency at 1 s/octave. Sweeping up and down in frequency resulted in changes in the amplitude vs. frequency functions of the composite DPOAE and its two major components. In addition, DPOAE component phases differed slightly be...
Article
Full-text available
Distortion product otoacoustic emissions (DPOAEs), a by-product of normal outer hair cell function, are used in research and clinical settings to noninvasively test cochlear health. The composite DPOAE recorded in the ear canal is the result of interactions of at least two components: a nonlinear distortion component (the generator component) and a...
Article
Full-text available
The measurement of efferent-induced suppression of otoacoustic emissions (OAEs) using contralateral acoustic stimulation (CAS) is complicated by potential contamination by the middle ear muscle reflex (MEMR), particularly at moderate to high CAS levels. When logarithmically sweeping primaries are used to measure distortion product otoacoustic emiss...
Article
Distortion product otoacoustic emissions (DPOAEs) are a vector sum of two components, generator and reflection, which produce overall DPOAE levels with a pattern of minima and maxima across frequency referred to as fine structure. The pattern of maxima and minima shifts higher or lower in frequency dependent on sweep direction (Henin et al., 2011),...
Article
Full-text available
The auditory system continuously adapts to changes in the acoustic environment. Behavioral experiments in humans have demonstrated that changes in the acoustic environment produce dynamic changes in perception, for example, increases in thresholds in the presence of background noise. This dynamic change in the auditory system is hypothesized to be...
Article
Full-text available
Distortion product otoacoustic emissions (DPOAEs) are generated when two primary tones (f1, f2 with f2 > f1) are presented simultaneously to the ear. Inter-modulation between primary tones produces distortion products at predictable frequencies not present in the original signal (e.g., 2f1 - f2). In persons with negative middle ear pressure (NMEP),...
Article
Full-text available
Medial olivocochlear (MOC) efferent fibers synapse directly on the outer hair cells (OHCs). Efferent activation evoked by contralateral acoustic stimulation (CAS) will affect OHC amplification and subsequent measures of distortion-product otoacoustic emissions (DPOAEs). The aim of this study was to investigate measures of total and separated DPOAEs...
Article
Full-text available
The presence of tinnitus often coincides with hearing loss. It has been argued that reduced peripheral input leads to frequency-specific increase in neuronal gains resulting in tinnitus-related hyper-activity. Following this gain-adaptation hypothesis, impaired cochlear function should be predictive of the presence and spectral characteristics of t...
Conference Paper
Full-text available
High resolution DPOAE fine structure was evaluated when the output impedance of the cochlea was modified by: (1) Changes in outer ear volume, due to accumulation of cerumen, which does not modify input impedance. (2) Manipulation of middle ear pressure and scarring of the tympanic membrane (which modify both input and output impedance). At high pri...
Conference Paper
Full-text available
Continuously sweeping primaries provide an efficient tool for measuring DPOAE amplitude and phase over a wide range of frequencies (Long et al, JASA 124, 1613-1626, 2008). Different analyses of data collected in this way permits one to either extract the total DPOAE providing information about the DPOAE fine structure generated by the interaction o...
Article
Full-text available
Neuronal gain adaptation has been proposed as the underlying mechanism leading to the perception of phantom sounds such as Zwicker tones and tinnitus. In this gain-adaptation theory, cochlear compression plays a significant role with weaker compression leading to stronger phantom percepts. The specific aim of this study was to find a link between t...

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Project (1)
Project
This is a user friendly software platform for measuring and analyzing frequency swept tone otoacoustic Emissions Source code available at https://gitlab.com/simonhenin/oaetoolbox/commits/master Log into the website and download the source code. Wiki pages on the same website offer details on how to calibrate and use the software.