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April 2007 - June 2011
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Publications (142)
In the present study, we tested the hypothesis that walking intolerance in intermittent claudication (IC) is related to both slowed whole body oxygen uptake (VO2) kinetics and altered activity of the active fraction of the pyruvate dehydrogenase complex (PDCa) in skeletal muscle. Ten patients with IC and peripheral arterial disease [ankle/brachial...
To shed light on the potential efficacy of cycling as a testing modality in the treatment of intermittent claudication (IC), this study compared physiological and symptomatic responses to graded walking and cycling tests in claudicants. Sixteen subjects with peripheral arterial disease (resting ankle: brachial index (ABI) < 0.9) and IC completed a...
This study tested the hypotheses that skeletal muscle mitochondrial ATP production rate (MAPR) is impaired in patients with peripheral arterial disease (PAD) and that it relates positively to their walking performances. Seven untrained patients, eight exercise-trained patients and 11 healthy controls completed a maximal walking test and had muscle...
It has been frequently argued that haemodynamic limitations are poor predictors of exercise performance in people with peripheral arterial disease (PAD) and intermittent claudication. This review has tried to address this argument through a review of published data that appears to support or counterbalance it, brief consideration of some of the met...
Supplementation with propionyl-L-carnitine (PLC) may be of use in improving the exercise capacity of people with peripheral arterial disease.
After a 2-wk exercise familiarization phase, seven subjects displaying intermittent claudication were studied over a 12-wk period consisting of three 4-wk phases, baseline (B), supplementation (S), and placeb...
1. Circulation around tendons may act as a shunt for muscle during exercise. The perfusion and oxygenation of Achilles' peritendinous tissue was measured in parallel with that of calf muscle during exercise to determine (1) whether blood flow is restricted in peritendinous tissue during exercise, and (2) whether blood flow is coupled to oxidative m...
The purpose of this study was to examine whether microdialysis and the internal reference thallium-201 ((201)Tl) could accurately measure muscle interstitial K+ (Ki+) before, during, and after exercise. The relative loss of (201)Tl and simultaneous relative recovery of K+ were measured in vitro for 12 microdialysis probes that were bathed in Ringer...
An elite ultra-endurance athlete, who had previously undergone physiological and performance testing, developed chronic fatigue syndrome (CFS). An incremental cycling exercise test conducted while he was suffering from CFS indicated decreases in maximum workload achieved (Wmax; -11.3%), the maximum oxygen uptake (VO2max; -12.5%), and the anaerobic...
In contrast to endurance training, little research has been carried out to investigate the effects of short (< 10 s) sprint training on performance, muscle metabolism and fibre types. Nine fit male subjects performed a mean of 16 outdoor sprint running training sessions over 6 weeks. Distances sprinted were 30-80 m at 90-100% maximum speed and betw...
The standard critical power test protocol on the cycle ergometer prescribes a series of trials to exhaustion, each at a different but constant power setting. Recently the protocol has been modified and applied to a series of trials to exhaustion each at a different ramp incremental rate. This study was undertaken to compare critical power and anaer...
This investigation compared the variance in times to exhaustion among four different methods of supra-VO2peak power output calculation. Ten male subjects cycled to exhaustion at power outputs equivalent to 1) 120% VO2peak, 2) 6 W.kg-1, 3) 100% VO2peak + 10% of the peak anaerobic scope (PAS), and 4) 100% VO2peak + 20% of the mean anaerobic scope (MA...
This investigation compared the variance in times to exhaustion among four different methods of supra-˙VO2peak power output calculation. Ten male subjects cycled to exhaustion at power outputs equivalent to 1) 120%˙VO2peak, 2) 6 W·kg-1, 3) 100% ˙VO2peak + 10% of the peak anaerobic scope (PAS), and 4) 100% ˙VO2peak + 20% of the mean anaerobic scope...
Anaerobic ATP production in skeletal muscle and the accumulated oxygen deficit (O2D) incurred during an exhaustive cycle bout (duration = 173 +/- 24 s; intensity = 112 +/- 3% VO2peak), were determined in 10 male cyclists (mean +/- SD: VO2peak = 69.8 +/- 4.2 ml.kg-1.min-1). Anaerobic ATP production (mmol.kg-1 d.w.) was determined from changes in lac...
The VO2-power regression and O2 demand predicted for a supra-VO2peak intensity (i.e., 432 W) were determined in seven well-trained male cyclists (mean +/- SD: VO2peak = 5.29 +/- 0.51 l.min-1), using five incremental exercise protocols. These protocols were either continuous (CON) or discontinuous (DISCON), and comprised five to eight work bouts ran...
Anaerobic ATP production in skeletal muscle and the accumulated oxygen deficit (O2D) incurred during an exhaustive cycle bout (duration = 173± 24 s; intensity = 112 ± 3%˙VO2peak), were determined in 10 male cyclists (mean ± SD: ˙VO2peak = 69.8± 4.2 ml·kg⁻¹·min⁻¹). Anaerobic ATP production (mmol·kg⁻¹ d.w.) was determined from changes in lactate, pho...
The ˙VO2-power regression and O2 demand predicted for a supra-˙VO2peak intensity (i.e., 432 W) were determined in seven well-trained male cyclists (mean ± SD: ˙VO2peak = 5.29± 0.51 l·min⁻¹), using five incremental exercise protocols. These protocols were either continuous (CON) or discontinuous(DISCON), and comprised five to eight work bouts rangin...
The purpose of the present study was to provide initial data upon which field tests of anaerobic capacity for cyclists might be developed, by examining the relationships between the y-intercept of the maximal work-duration regression (Y-int) and cycle performance variables in fifteen well-trained male cyclists (mass = 73.3±8.6kg; VO2peak = 4.93±0.7...
This study examined the effect of end-point cadence on the parameters of the work-time relationship determined for cycle ergometry. Eight male subjects completed four maximal tests on an electrically-braked cycle ergometer that regulated a constant power output independent of cadence. The power outputs imposed ranged between an average of 259 W and...
The regression of oxygen uptake (VO2) on power output and the O2 demand predicted for suprapeak oxygen uptake (VO2peak) exercise (power output = 432 W) were compared in ten male cyclists [C, mean VO2peak = 67.9 (SD 4.2) ml.kg-1.min-1] and nine active, yet untrained men [UT, mean VO2peak = 54.1 (SD 6.5) ml.kg-1.min-1]. The VO2-power regression was d...
The development of simple, noninvasive tests of work capacities, underpinned primarily by anaerobic metabolism, proliferated in the early 1970s. A 30-second maximal cycle test developed at the Wingate Institute initiated efforts to develop work tests of anaerobic capacities. Such tests can be developed using any ergometer which simulates competitiv...
The purpose of this paper is both to define terms used in exercise physiology, i.e. anaerobic capacity, anaerobic work capacity and anaerobic potential, and develop a systems perspective of anaerobic capacity. Philosophical argument is used to support the proposed definitions and systems view, which is an approach to assist in the universal accepta...
The degree to which the y-intercept (Y-int) of the linear regression of maximal work output on exercise duration represented anaerobic capacity was determined in ten well-trained male cyclists [peak oxygen uptake (VO2peak) = 69.8 (SD 4.2) ml.kg-1.min-1]. Each cyclist performed three exhausting cycle sessions on separate occasions; the mean exercise...
Anaerobic capacity is defined as the maximal amount of adenosine triphosphate resynthesized via anaerobic metabolism (by the whole organism) during a specific mode of short-duration maximal exercise. This review focuses on laboratory measures which attempt to quantify anaerobic capacity; it examines the evidence supporting or challenging the validi...
In partial fulfillment of the requirements for the degree of Master of Arts, School of Physical Education. Thesis (M.A.)--University of Victoria, 1990. Includes bibliographical references. Microfiche.
