Simon Bouffler

Simon Bouffler
UK Health Security Agency · Radiation Effects Department

BSc, PhD

About

195
Publications
31,906
Reads
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5,373
Citations
Citations since 2016
69 Research Items
2572 Citations
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20162017201820192020202120220100200300400

Publications

Publications (195)
Article
Purpose: The Adverse Outcome Pathway (AOP) framework, a systematic tool that can link available mechanistic data with phenotypic outcomes of relevance to regulatory decision-making, is being explored in areas related to radiation risk assessment. To examine the challenges including the use of AOPs to support the radiation protection community, an i...
Article
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The aim of this review is to investigate the literature pertaining to the potential risks of low-dose ionizing radiation to Lynch syndrome patients by use of computed tomography (CT), either diagnostic CT colonography (CTC), standard staging CT or CT surveillance. Furthermore, this review explores the potential risks of using radiotherapy for treat...
Article
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Background: There is accumulating evidence of excess risk of cancer in various populations exposed at acute doses below several tens of mSv or doses received over a protracted period. There is also evidence that relative risks are generally higher after radiation exposures in utero or in childhood. Methods and Findings: We reviewed and summarised...
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La Commission internationale de protection radiologique (CIPR) a initié un examen et une révision du système de radioprotection afin de mettre à jour les recommandations générales de 2007 dans la Publication 103 de la CIPR. Il s’agit du début d’un processus de plusieurs années qui nécessite une collaboration ouverte et transparente avec les organis...
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Background: The detrimental health effects associated with the receipt of moderate (0.1–1 Gy) and high (>1 Gy) acute doses of sparsely ionising radiation are well established from human epidemiological studies. There is accumulating direct evidence of excess risk of cancer in a number of populations exposed at lower acute doses or doses received ov...
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Generally, intentional exposure of pregnant women is avoided as far as possible in both medical and occupational situations. This paper aims to summarise available information on sources of radiation exposure of the embryo/fetus primarily in medical settings. Accidental and unintended exposure is also considered. Knowledge on the effects of radiati...
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The International Commission on Radiological Protection (ICRP) has embarked on a review and revision of the System of Radiological Protection that will update the 2007 General Recommendations in ICRP Publication 103. This is the beginning of a process that will take several years, involving open and transparent engagement with organisations and ind...
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This study aimed to investigate the impact of chronic low-level exposure to chemical carcinogens with different modes of action on the cellular response to ionising radiation. Human lymphoblastoid GM1899A cells were cultured in the presence of 4-nitroquinoline N-oxide (4NQO), N-nitroso-N-methylurea (MNU) and hydrogen peroxide (H2O2) for up to 6 mon...
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Purpose The overall aim of this contribution to the “Second Bill Morgan Memorial Special Issue” is to provide a high-level review of a recent report developed by a Committee for the National Council on Radiation Protection and Measurements (NCRP) titled “Approaches for Integrating Information from Radiation Biology and Epidemiology to Enhance Low-D...
Article
It is increasingly recognized that stakeholder views can be essential to ascertain the credibility of those entrusted with protection of the public and workers against radiation risks, the robustness of the approaches to protection and the relevance of research underpinning radiation protection. The CONCERT European Joint Programme of radiation pro...
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Since early April 2020, there has been intense debate over proposed clinical use of ionizing radiation to treat life-threatening pneumonia in Coronavirus Disease 2019 (COVID-19) patients. At least twelve relevant papers appeared by 20 May 2020. The radiation dose proposed for clinical trials are a single dose (0.1–1 Gy) or two doses (a few mGy foll...
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Several papers have recently suggested clinical trials of low dose radiation therapy (LDRT) for COVID-19 pneumonia. However, there is very little, if any, supportive evidence that LDRT will be a curative or palliative treatment for COVID-19 pneumonia or be superior to any of potential therapeutic agents currently under clinical trials. It would app...
Technical Report
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Global concerns on the potential for malevolent use of high activity sealed sources of ionising radiation have prompted moves to identify options for their replacement with alternative technologies. Sealed sources of caesium-137 are in common use in biological sciences research and in the production of blood products in blood transfusion services....
Book
The overall aim of this Report is to provide input for the development of biologically based dose-response (BBDR) models for radiation- induced cancers and circulatory disease that use an adverse outcome pathways and key-events approach for providing parameters for these models. These mechanistic data can be integrated with the most recent epidemio...
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Tissue reactions and stochastic effects after exposure to ionising radiation are variable between individuals but the factors and mechanisms governing individual responses are not well understood. Individual responses can be measured at different levels of biological organization and using different endpoints following varying doses of radiation, i...
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Purpose: For more than a century, ionizing radiation has been indispensable mainly in medicine and industry. Radiation research is a multidisciplinary field that investigates radiation effects. Radiation research was very active in the mid- to late 20th century, but has then faced challenges, during which time funding has fluctuated widely. Here we...
Article
Studies of the responses of haematopoietic stem and progenitor cells (HSPCs) to low doses of ionising radiation formed an important aspect of the RISK-IR project (www.risk-ir.eu) . A brief overview of these studies is presented here. The findings confirm the sensitivity of HSPCs to radiation even at low doses, and illustrate the substantial impact...
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Purpose Work package 5 of the CONCERT European Joint Programme deals with stakeholder engagement and communication strategies in radiation protection. In particular, Task 5.3 of the WP5 concerns the development of survey activities for a more efficient interaction with civil society and the use of social media for public communication. This task fa...
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The separate use of the terms "radiosensitivity" and "radiosusceptibility" has been suggested to describe variability in the risk of, respectively, adverse tissue reactions (deterministic effect) following radiotherapy and radiation-induced cancer (stochastic effect). The aim of this note is to present arguments against such distinction. We feel th...
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Epidemiological studies have demonstrated an increased leukemia incidence following ionizing radiation exposure, but to date, the target cells and underlying mechanisms of radiation leukemogenesis remain largely unidentified. We engineered a mouse model carrying a different fluorescent marker on each chromosome 2, located inside the minimum deleted...
Article
In the past few decades, it has become increasingly evident that sensitivity to ionising radiation is variable. This is true for tissue reactions (deterministic effects) after high doses of radiation, for stochastic effects following moderate and possibly low doses, and conceivably also for non-cancer effects such as cardiovascular disease, the cau...
Article
People are more often exposed to low as opposed to high doses of ionising radiation (IR). Knowledge on the health risks associated with exposures to ionising radiation above 100 mGy is quite well established, while lower dose risks are inferred from higher level exposure information (ICRP). The health risk assessments are mainly based on epidemiolo...
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MELODI (Multidisciplinary European Low Dose Initiative) is a European radiation protection research platform with focus on research on health risks after exposure to low-dose ionising radiation. It was founded in 2010 and currently includes 44 members from 18 countries. A major activity of MELODI is the continuous development of a long-term Europea...
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Purpose: To determine whether low dose/low dose rate radiation-induced genetic instability may result from radiation-induced inactivation of mechanisms induced by the ATM-dependent DNA damage response checkpoint. To this end, we analysed the faithfulness of T cell receptor (TR) gene rearrangement by V(D)J recombination in DNA from mice exposed to...
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In order to quantify radiation risks at exposure scenarios relevant for radiation protection, often extrapolation of data obtained at high doses and high dose rates down to low doses and low dose rates is needed. Task Group TG91 on ‘Radiation Risk Inference at Low-dose and Low-dose Rate Exposure for Radiological Protection Purposes’ of the Internat...
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Studies suggest iodinated contrast media (ICM) may increase organ dose and blood cell DNA damage for a given X-ray exposure. The impact of ICM on dose/damage to extravascular cells and cancer risks is unclear. Methods We used Monte Carlo modelling to investigate the microscopic distribution of absorbed dose outside the lumen of arteries, capillari...
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While the biological effects of high-dose-ionizing radiation on human health are well characterized, the consequences of low-dose radiation exposure remain poorly defined, even though they are of major importance for radiological protection. Lymphocytes are very radiosensitive, and radiation-induced health effects may result from immune cell loss a...
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Биологические эффекты ионизирующего излучения в малых дозах и с низкой мощностью дозы всегда вызывали большой интерес. В настоящее время Международная комиссия по радиологической защите (МКРЗ) предлагает экстраполировать результаты эпидемиологических исследований по оценке влияния больших доз и высоких мощностей доз излучений на малые дозы и низкие...
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A review was undertaken of studies reporting increased DNA damage in circulating blood cells and increased organ doses, for x-ray exposures enhanced by iodinated contrast media (ICM), compared to unenhanced imaging. This effect may be due to ICM molecules acting as a source of secondary radiation (Auger/photoelectrons, fluorescence x-rays) followin...
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Risk estimates for radiation-induced cancer in humans are based on epidemiological data largely drawn from the Japanese atomic bomb survivor studies, which received an acute high dose rate (HDR) ionising radiation. Limited knowledge exists about the effects of chronic low dose rate (LDR) exposure, particularly with respect to the application of the...
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Exposure to ionizing radiation increases the incidence of acute myeloid leukemia (AML), which has been diagnosed in Japanese atomic bombing survivors, as well as patients treated with radiotherapy. The genetic basis for susceptibility to radiation-induced AML is not well characterized. We previously identified a candidate murine gene for susceptibi...
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Scid hematopoietic stem cells (HSCs) have an intrinsic defect in their maintenance within the bone marrow (BM) niche which facilitates HSC transplantation without the absolute requirement of prior conditioning. Nevertheless, NOD scid mice have a significantly altered life span due to early development of thymic lymphomas, which compromises the abil...
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A combined transcriptome and proteome analysis of mouse radiation-induced AMLs using two primary AMLs, cell lines from these primaries, another cell line and its in vivo passage is reported. Compared to haematopoietic progenitor and stem cells (HPSC), over 5000 transcriptome alterations were identified, 2600 present in all materials. 55 and 3 alter...
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Quantification of biological effects (cancer, other diseases, and cell damage) associated with exposure to ionising radiation has been a major issue for the International Commission on Radiological Protection (ICRP) since its foundation in 1928. While there is a wealth of information on the effects on human health for whole-body doses above approxi...
Article
Radiological protection standards generally assume that all members of the population are equally sensitive to the adverse health effects associated with radiation exposure, recognising the age- and sex-related differences in sensitivity to radiation-induced cancer. It has become very clear over recent years that genetic and lifestyle factors can p...
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The aim of this paper is to explore the evidence for the revised EU basic safety standard (BSS) radiation dose limits to the lens of the eye, in the context of medical occupational radiation exposures. Publications in the open literature have been reviewed in order to draw conclusions on the exposure profiles and doses received by medical radiation...
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The biological effects on humans of low-dose and low-dose-rate exposures to ionizing radiation have always been of major interest. The most recent concept as suggested by the International Commission on Radiological Protection (ICRP) is to extrapolate existing epidemiological data at high doses and dose rates down to low doses and low dose rates re...