Simin Hemati

Isfahan University of Medical Sciences · Imaging and Radiology Department

Objective: Gastric cancer (GC) is an exceedingly prevalent cancer worldwide and one of the main reasons for death from cancer. The individuals’ susceptibility to GC depends upon several genetic and epigenetic alterations that occur over their lifetime. The C-FOS is an oncoprotein that engages in tumorigenesis through its oncogenic roles. It modulat...

Background: Cognitive impairment is one of the common problems in patients undergoing radiotherapy, but there is no way to prevent it until this time. The aim of this study was to determine the effect of memantine on the prevention of cognitive impairment in patients with brain tumour undergoing radiotherapy. Method: In this clinical trial study, 7...

Colorectal cancer is highly prevalent worldwide and has significant morbidity and mortality in humans. High-atomic-number nanoparticles such as iodine can act as X-rays absorbers to in-crease the local dose. The synthesis and fabrication of oxaliplatin-loaded iodine nanoparticles, their characterization, cell toxicity, radiosensitivity, cell apopto...

Background: Long noncoding RNAs (lncRNAs) have been recognized as the main modulatory molecules in various cancers and perform as competing endogenous RNAs (ceRNAs). The nuclear hormone receptor superfamily of ligand-activated transcription factors (NR3C1) regulates numerous proliferative and metabolic processes such as tumorigenesis and metabolic...

Background: Cognitive impairment is one of the common problems in patients undergoing radiotherapy, but there is no way to prevent it until this time. The aim of this study was to determine the effect of memantine on the prevention of cognitive impairment in patients with brain tumour undergoing radiotherapy. Method: In this clinical trial study, 7...

It has been found that the bystander effect plays a key role in the survival of cells exposed to highly non-uniform radiation beams. However, the linearquadratic (LQ) model cannot predict these effects well. The present study aimed to explore the potential impact of the radiation-induced signaling effects on treatment plans for spatially fractionat...

Objective: Gastric cancer (GC) is the fourth most common cancer worldwide, occurring in approximately two-thirds of developing countries, and is one of the leading causes of cancer deaths. The mitogen-activated protein kinase 14 (MAPK14) plays an important role in the conversion of extracellular stimuli to a wide range of cellular responses. The 5-...

Background. Long noncoding RNAs (lncRNAs) perform as competing endogenous RNAs (ceRNAs) to sponge microRNAs (miRNAs) lead to the advancement of cancer. In this work, we attempted to identify possible long noncoding RNA biomarkers as well as a new regulatory axis in colorectal cancer. This investigation was carried out in consideration of the critic...

The use of nanoparticles as a sonosensitizer in cancer sonodynamic therapy has been gaining attention because of their great advantages in drug delivery applications. By conjugating chemotherapy agents with nanoparticles, we can develop a drug delivery platform, control drug release and improve the outcome of treatments. The in-vitro study describe...

Background: Prostate cancer is the second most common malignancy among Iranian men after stomach cancer. To understand the nature of the disease and plan and develop a population-based cancer registry, it is essential to recognize the clinical and pathological characteristics of the tumors, as well as treatment results. Objectives: The present stud...

Background: Quality of life among cancer patients after diagnosis and treatment steps is an important factor in preventing further cancer complications. Thus, appropriate tools to evaluate the quality of life among this group are required. Quality of life in Adult Cancer Survivors (QLACS) questionnaire is a suitable tool which evaluates different a...

Background: Oral squamous cell carcinoma (SCC) is the most common oral malignancy. Some evidence indicated that there is a correlation between microRNA single nucleotide polymorphisms and the risk of oral cancer. The aim of the current study was to investigate the association between mir-499 polymorphism with the risk of oral cavity and oropharynge...

Introduction: Oral mucositis is a complication of radiation therapy in cancer patients. We designed a trial to evaluate efficacy of plantago major on symptoms of radiation induced mucositis in cancer patients. Methods: In this randomized double blind, placebo-controlled trial 23 patients received plantago major syrup as intervention group and 23...

Introduction: Healthcare professionals should seek the necessary resources to improve the quality of care. Given the cultural, social, and economic differences, in every health care system, there are increasing needs for the adapted versions of clinical practice guidelines (CPGs). This study aimed to introduce an innovative CPG adaptation approach...

83 Background: Breast carcinoma is the second cause of mortality between female cancers and metastasis is the main contributing factor to the mortality in patients with breast cancer. Optimal management for visceral metastatic breast cancer (MBC) remains unknown. In this study we aimed to assess if adding pioglitazone to chemotherapy regimen can im...

Gastric cancer is one of the most common upper gastrointestinal malignancies. Some Iranian provinces, such as in the northern and northwestern areas, are at a high risk, whereas the central and western provinces are at a medium and the southern regions at low risk. This study was carried out to estimate the impact of the expression patterns of ASIC...

Background: Febrile neutropenia is a common and serious chemotherapy side effect, is associated with increased mortality, morbidity, and treatment expenditures. Several CPGs (Clinical practice guidelines) have been released for managing chemotherapy-induced febrile neutropenia. The aim of this study is Appraisal of the clinical practice Guidelines...

Background: Improvement of the quality of cancer-related fatigue clinical practice guidelines (CPGs) is an important issue in oncology. Aim: This study aimed to determine the methodological quality of CPGs about cancer-related fatigue management using the AGREE II instrument. Method: This study involved a systematic search, followed by a descriptiv...

Abstract Background: Breast cancer is one of the most common cancers among Iranian women whose relationship with mutation status in BRCA1 is previously approved. Therefore, screening of the most mutated exons in BRCA1 in hereditary breast cancer patients provides beneficial information about the main disease-causing reason. Methods: A total of 14 I...

Background: Src is a non-receptor protein tyrosine kinase that has a crucial role in signaling pathways involved in cell division, motility, adhesion, and survival in cells. To date, there has been no report on the association between polymorphism of CA dinucleotide repeat in the c-src gene and risk of prostate cancer. In this study, the associatio...

Background: Prostate cancer is increasing among Iranian men and gene polymorphisms may play a role in the development of prostate cancer. Insulin-like growth factor 1 (IGF1) gene polymorphisms have been deeply explored in different malignancies. In this study, we aimed to explore the association of IGF1 CA repeat length polymorphism with the risk o...

ABSTRACT: In Iran, as in many Asian and Middle Eastern countries, a significant proportion of cancer patients are never informed of their illness. One of the proposed solutions to tackle this challenge is to develop a localized protocol based on the culture and values of community members about cancer and the truth-telling phenomenon, and training...

Background: CD8-positive T lymphocytes are important part of cell-mediated immunity and play a central role in induction of immune response against tumor progression. So, these cells might have potential to be used in clinic along with other prognostic biomarkers; however no definite comparison on validation of this maker has been conducted. The pu...

Context: Oral mucositis is a common complication in patients with cancer therapy. Oral and dental care should be considered as a vital component of caring before, during and after chemotherapy. This study aimed to assess the methodological quality of existing CPGs about cancer therapy-induced mucositis. Evidence Acquisition: We conducted a review o...

Background: Cancer patients undergoing chemotherapy have unmet needs. Oncologists play a central role in their supportive treatment. This study aims to describe Iranian oncologists' perceptions in terms of priorities in supportive care needs for nonmetastatic cancer patients undergoing chemotherapy. Methods: We conducted this study using a descript...

Background: Breast cancer is the most common malignancy in women and is the first cause of death among the women in the world. Disruption of gene expression of src family members has been observed in many cancers. Repeated sequences in introns influence gene expression, splicing or change the structure of product. In the present study, the associat...

Background: Sleep disturbances are common, but widely underdiagnosed in cancer patients. Thus, the aim of the present study was to evaluate sleep quality and its associated factors among women with breast cancer. Methods: This cross-sectional study was conducted on women with breast cancer referring to 2 outpatient clinics in Isfahan, Iran. Sleep...

Introduction: The treatment process and loss of aerobic fitness can weaken the body's antioxidant status and increase the risk of disease recurrence in patients with breast cancer. Therefore, this study was performed with aim to investigate the effect of six weeks of moderate-intensity continuous running on oxidative stress, lipid peroxidation and...

Purpose: The findings of numerous studies have illustrated that there is still a high proportion of cancer patients in Eastern and Middle-East countries including Iran, who are not properly informed of their disease due to the concealment atmosphere which still prevails. This descriptive qualitative study is aimed at exploring perceptions of patie...

Background Participation of Iranian women with a family history of breast cancer in breast cancer screening programs is low. This study evaluates the compliance of women having a family history of breast cancer with clinical breast exam (CBE) according to the stage of transtheoretical model (TTM) and health belief model (HBM). Materials and Method...

Introduction: Many breast cancer survivors experience post-treatment metabolic complications based on their regimen. Various results have been reported regarding tamoxifen therapy effects on lipid profile and FBS level. But, no study investigate adriamycine, cytoxan with taxol treatment on them one year after finishing the treatment. Patients and m...

Background: Prostate cancer has a high degree of heterogeneity in pathology and clinical appearance. In response to stress, P53 plays an important role in preventing cancer development. To our knowledge, this is the first report about polymorphic TAAAA repeat of the P53 gene and its relation to prostate cancer risk. The purpose of this study was to...

Background: Li-Fraumeni syndrome (LFS) is one of the most serious hereditary cancer syndromes with a high risk of malignancy in childhood. This syndrome is an autosomal dominant cancer predisposing syndrome due to a germline mutation in the TP53 tumor suppressor gene. Methods: In this study, a representative family case of Li-Fraumeni syndrome i...

Background: Hepatitis B virus infection (HBV) and its complications is one of the most serious problems of the health system in many parts of the world. In the present study, we will assess chronic and occult HBV and isolated anti-Hepatitis B core antigen whose screening and evaluation is not routine in different populations. Materials and method...

Background: Aprepitant is one of the effective antiemetic drugs that usually used for a period of 3 days for prevention of anthracycline/cyclophosphamide (AC) induced nausea and vomiting. However, many patients still experience nausea and vomiting on days 3-5. The aim of this study was to evaluate the effect of an increase in duration of aprepitan...

Background: The presence of estrogen receptor alpha has been reported in the cell and tissue levels in gastric cancer; however, its impact on patients' survival remains unclear. The aim of this study was to investigate the expression of estrogen receptor in gastric carcinoma as well as its relationship with the clinicopathologic findings of the pa...

Malignant neoplasms are the second most common cause of death in women during childbearing age; however, the occurrence of cancer during pregnancy is rare and only 0.02-0.1 percent of all pregnancies is associated with cancer. By increasing the rate of pregnancies in older ages, the incidence of cancer during pregnancy is also being increased. Brea...

Background and aims: NFκB1 encodes for a DNA binding subunit of NF-κB complex. Overexpression of NFκB1 has been reported in a number of human cancers including breast cancer. To date there has been no study on the relation between microsatellites in the NFκB1 gene and risk of breast cancer in Isfahan population. This study was aimed to investigate...

Background: Genetic alternation in p53 gene is associated with tumorgenesis, especially in breast, colon and lung tumors. Somatic mutation of the p53 gene is the most common genetic alteration seen in human cancers. To our knowledge, before this research, there was no study on the relationship of TAAAA repeat in the first intron of p53 gene and can...

Numerous epidemiological studies have evaluated the association between transforming growth factor beta receptor type 1 (TGFBR1) polymorphisms and the risk of cancer; however, the results remain inconclusive and controversial. To determine the association between breast cancer risk and the *6A polymorphism of the TGFBR1 gene, a case-control study o...

Various symptoms frequently affect cancer patients' quality of life. Appropriate assessment of these symptoms provides valuable data for cancer management. This study aimed to validate the Persian version of the M. D. Anderson Symptom Inventory (MDASI-P). This cross-sectional study was conducted at four cancer treatment centers in two cities in Ira...

Activated PI3K generate PIP3 to trigger different signaling pathways which regulate a number of cellular functions including cell survival, apoptosis, proliferation and motility. Mutations in many cancers were discovered in the gene encoding the PI3k catalytic subunit, PIK3CA. To date, there has been no report on the association between polymorphis...

Depending on the site of irradiation, about 40-80% of patients undergoing radiotherapy (RT) will experience nausea and/or vomiting. The current study aimed to investigate the efficacy of ondansetronas as a single agent and with a combination to aprepitant on preventing RT-induced nausea and vomiting (RINV). In a clinical randomized controlled trial...

Purpose: Radiation-induced injury to the normal tissues is a common complication of radiotherapy in cancer patients. Considering the role of vitamin D in mucosal barrier hemostasis and inflammatory responses, we investigated whether vitamin D deficiency is associated with the severity of radiation-induced acute proctitis in cancer patients. Methods...

Background: The PIK3CA oncogene, which encodes p110α, is one of the most mutated genes in human cancers such as colorectal. A polymorphic GT dinucleotide repeat exists in intron 1 of the PIK3CA gene. Till this research, there were no study on polymorphism of PIK3CA gene microsatellites and their relationship with cancer risk. In the present study,...

Background: Colorectal cancer is the third leading cause of cancer deaths in men and the fourth in women in Iran. Eukaryotic release factor 3 (eRF3) is a GTPase associated with eRF1 in a complex that mediates translation termination in eukaryotes .Apart from its role in translation termination, the eukaryotic translation release factor 3 (eRF3) is...

Background and AimThere is evidence that gastric cancer patients suffer from thyroid disorders. However, the relationship between thyroid receptor (TR) expression and gastric cancer remains unknown. The aim of this study was to evaluate the status of promoter methylation and expression of the thyroid hormone receptor beta (THRβ) gene in gastric can...

Background and aim: Cytotoxic T lymphocyte-associated antigen-4 (CTLA4) is a crucial immune-checkpoint receptor regulating T-cell activation. The current study was carried out to evaluate the function of CTLA4 gene in patients with gastric cancer. Methods: The methylation of CTLA4 gene promoter was evaluated by methylation-specific polymerase ch...

Background & Aim: Cytotoxic T lymphocyte-associated antigen-4 (CTLA4) is a crucial immune-checkpoint receptor regulating T-cell activation. The current study was carried out to evaluate the function of CTLA4 gene in patients with gastric cancer.Methods: The methylation of CTLA4 gene promoter was evaluated by methylation-specific polymerase chain re...

Background: HOXA1 is a transcription factor. In the human mammary gland, the expression of the HOXA1 gene is very low or absent during normal growth and differentiation, but it is expensed at high levels in breast cancer lesions. To date, there has been no study on the relationship between CAC repeat (polyhistidine) in the first exon of HOXA1 gene...

In the issue No. 247 (October 2013) of Journal of Isfahan Medical School, an interesting article entitled “Survival time and recurrent rate in patients with rectum cancer” was reported by Sanei et al. That study was one of the largest reports of rectal cancer from Iran. It provided valuable information regarding the characteristics and oncologic ou...

The phosphatidylinositol 3-kinase (PI3 K)/Akt signaling pathway is one of the most commonly mutated pathways in breast cancer. To date, there has been no study on polymorphism of phosphatidylinositol-3,4-bisphosphonate 3-kinase, catalytic subunit alpha (PIK3CA) gene microsatellites and their link with breast cancer risk. In the present study, we in...

Spiritual well-being in patients with an advanced cancer has been found to positively correlate with subjective well-being, lower pain levels, hope and positive mood states, high self-esteem, social competence, purpose in life, and overall quality of life. In this regard, Quran recitation is stated to be an efficient way to increase patient spiritu...

Background: High-grade astrocytoma (Grade 4) or glioblastoma multiforme (GBM) are deadly brain tumors. New therapies attempt to increase lifetime and quality of life in patients with malignant astrocytoma. O6-methylguanine-DNA methyltransferase (MGMT) enzyme expression may be effective in prognosis and response to treatment of these patients. The a...

Background: The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire for Colorectal Cancer (EORTC QLQ-CR29) is developed to specifically evaluate the quality of life in patients with colorectal cancer. In this study, we aimed to validate the QLQ-CR29 in Iranian patients with Persian language linguistically and to...

Context: Colorectal cancer is one of the most common cancers and the leading cause of cancer death in Iran. This study aimed to identify the clinical and pathological characteristics, as well as survival rate of colorectal cancer in Iran. Evidence Acquisition: The articles published in PubMed without language and time restrictions were included in...

There is still contradictory evidence on disclosure preferences regarding cancer diagnosis. The aim of this study was to evaluate the preference of cancer patients for knowing the truth about their disease, as well as the factors that might have an impact on these preferences. This study was conducted in 11 cancer centers in Iran. A questionnaire w...

Background: Hydroxyurea is a chemotherapeutic agent for treatment of cancer. This drug induces globin-γ synthesis, so it could be used for treatment of thalassemia. Several studies have been shown that treatment with hydroxyurea increases Hb and HbF levels in patients with intermediate betathalassemia. However, the efficiency of hydroxyurea treatme...

Estrogen-related receptors (ERRs) alpha, beta, and gamma are orphan nuclear receptors that modulate the estrogen signaling pathway and play roles in the regulation of breast cancer cell growth. To determine the association between breast cancer risk and alleles of the tetranucleotide repeat (AAAG)n in the intron of ERRγ gene, a case-control study o...

Background: Transforming growth factor beta receptor type 1 (TGFBR1) is a serine–threonine protein kinase which mediates the growth-inhibitory signals of TGFB1 through a complex with TGFBR2. Numerous epidemiological studies have evaluated the association of TGFBR1 polymorphisms and the risk of cancer. The purpose of this study was to investigate th...

Introduction: Hepatitis B virus (HBV) infection and its complications are major public health problems. As it is hard to treat and control the chronic state, control of disease depends on the prevention especially by vaccination. There is an impaired immune response to vaccinations including HBV in patients with some malignancies. The aim of this...

GATA3 is an enriched transcription factor in mammary epithelium. To date, there has been no study on the relationship between microsatellites in the GATA3 gene and breast cancer risk. In this study, we investigated the existence of polymorphisms in the cytosine-thymine (CT) dinucleotide repeat in intron 3 of the GATA3 gene and its association with...

Background: Oral mucositis is a debilitating side effects of cancer treatment for which there is not much successful treatments at yet. We evaluated the effectiveness of topical morphine compared with a routine mouthwash in managing cancer treatment-induced mucositis. Materials and Methods: Thirty head and neck cancer patients with severe mucositi...

The Neuro-Oncology Scientific Club (in short, NOSC) is a local initiative by Iranian neuro-oncology experts who have particularly been interested in optimal management of brain tumor patients. Since October 2011, NOSC’s serial meetings in Iran major provinces have focused on executive strategies to improve brain tumor care through an interdisciplin...

Background: One of the most important environmental risk factors for kidney cancer is occupational exposure to chemical carcinogens. Since the Isfahan province is one of the major industrial centers in Iran and various chemical industries operating in the province, this study was conducted to determine the association of kidney cancer and occupatio...

Breast cancer is a hormone-dependent tumor which is regulated by steroid hormones including estrogen and progesterone. Therefore, estrogen-related receptors (ERRs) which belong to orphan nuclear receptor groups can interfere with the estrogen signaling pathway and cause the growth of solid tumors. In the present study, blood samples of 150 women wi...

Background: Eukaryotic release factor 3 (eRF3) is known as a polypeptide chain releasing factor in the translation process. It is necessary for G1 to S phase transition (GSPT1). Recent studies have demonstrated that this protein may have a potential role in development of cancer. The purpose of this study was to investigate the tri-nucleotide polym...

Taste abnormalities are common among cancer patients after starting radiotherapy or chemotherapy. Considering the role of zinc and reports on its beneficial effects in taste perception, we evaluated the preventive effects of zinc sulfate on radiation-induced taste alterations. In a randomized, placebo-controlled trial, adult patients with head and...

Background: Breast cancer is the most common cancer among women. Genetic is a proven risk factor in this disease. As breast cancer genes (BRCA1 and BRCA2) affect the incidence of this type of cancer, identification of mutation carriers is important in reduction of the overall risk. The purpose of this study was to determine the prevalence of BRCA1...

Background: Upper limb lymphedema is a rather common and debilitating sequel of breast cancer treatment. The incidence of this sequel has been reported at different rates by different sources ranging from 6% to 31%. The aim of this study was to evaluate the incidence and risk factors including age, body mass index (BMI), region and size of the tumo...

مقدمه: لنفادم اندام فوقاني از عوارض به نسبت شايع و ناتوانكننده در بيماران مبتال به سرطان پستان ميباشد كه در 6 تا 31 درصد موارد درمانشدهي سرطان پستان ديده شده است. اين مطالعه به بررسي ميزان فراواني لنفادم در بيماران با سرطان پستان درمان شده و عوامل مرتبط با ٓان پرداخته است. روشها: اين مطالعه به صورت گذشتهنگر بود. اطالعات حاصل از پروندههاي 170 بيمار...

چكيده مقدمه: شواهد فزايندهاي پيشنهاد ميكند كه ٓانزيم ژالتيناز B عالوه بر نقش در متاستاز از طريق تغيير و پردازش فاكتورهاي رشد، گيرندههاي فاكتورهاي رشد، فاكتورهاي ٓانژيوژنيك و ديگر پروتئينازها در شكلگيري سرطان نيز درگير ميباشد و بنابراين نقش اساسي در شروع و پيشروي سرطان دارد. وجود پليمورفيسم ژنتيكي در پروموتور ژن ژالتيناز B و ارتباط ٓان با چندين سرطا...

Background: Gelatinase B is not only involved in metastasis, but also alters and processes growth factors, growth factor receptors, angiogenic factors, and other proteinases and thus affects early carcinogenesis. In other words, it has a fundamental role in initiation and development of cancer. Genetic polymorphism in the promoter of gelatinase B h...

Background: Type IV collagenase gene is capable of degrading type IV collagen which is the major structural component of basement membrane. It also increased the bioavailability of pro-angiogenic factors including vascular endothelial growth factor and transforming growth factor-β. A cytosine (C) thymine (T) single nucleotide polymorphism (SNP) at...

Matrix metalloproteinases comprise a family of enzyme degrade components of extra cellular matrix. There are single nucleotide polymorphisms in the promoter regions of several genes with ability to influence cancer susceptibility. The aim of this study was to analyze association between MMP3 promoter polymorphisms and colorectal cancer occurrence a...