Silvio Sarubbo

Silvio Sarubbo
Azienda Provinciale per i Servizi Sanitari | ASL Trento · Department of Neurosurgery

MD, PhD

About

100
Publications
25,550
Reads
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2,009
Citations
Additional affiliations
November 2019 - present
Azienda Provinciale per i Servizi Sanitari
Position
  • Head of Department
February 2013 - November 2019
Azienda Provinciale per i Servizi Sanitari, Trento APSS, Italy
Position
  • Neurosurgeon, MD, PhD
January 2012 - February 2013
Università degli Studi di Trento
Position
  • Research Associate
Education
January 2013 - April 2020
University of Ferrara
Field of study
  • Biomedical Sciences, Neurosciences
October 2005 - October 2010
University of Ferrara
Field of study
  • Residency in Neurosurgery
September 1999 - April 2005
University of Ferrara
Field of study
  • Medical School

Publications

Publications (100)
Article
Phonemic and semantic fluency are neuropsychological tests widely used to assess patients’ language and executive abilities and are highly sensitive tests in detecting language deficits in glioma patients. However, the networks that are involved in these tasks could be distinct and suggesting either a frontal (phonemic) or temporal (semantic) invol...
Article
We constantly face situations involving interactions with others that require us to automatically adjust our physical distances to avoid discomfort or anxiety. To the best of our knowledge, only one case study has demonstrated that the integrity of both amygdalae is essential to regulate interpersonal distances. While unilateral lesion to the amygd...
Article
Full-text available
Background People with gliomas need specialized neurosurgical, neuro-oncological, psycho-oncological, and neuropsychological care. The role of language and cognitive recovery and rehabilitation in patients’ well-being and resumption of work is crucial, but there are no clear guidelines for the ideal timing and character of assessments and intervent...
Article
Full-text available
The temporo-parietal junction (TPJ) is a cortical area contributing to a multiplicity of visual, language-related, and cognitive functions. In line with this functional richness, also the organization of the underlying white matter is highly complex and includes several bundles. The few studies tackling the outcome and neurological burdens of surgi...
Article
Full-text available
The study of patients after glioma resection offers a unique opportunity to investigate brain reorganization. It is currently unknown how the whole-brain connectomic profile evolves longitudinally after surgical resection of a glioma and how this may be associated with tumor characteristics and cognitive outcome. In this longitudinal study, we inve...
Preprint
The angular gyrus (AG) has been described in numerous studies to be consistently activated in various functional tasks. The angular gyrus is a critical connector epicenter linking multiple functional networks regarding its location in the posterior part of the inferior parietal cortex, namely at the junction between the parietal, temporal, and occi...
Preprint
Full-text available
The temporo-parietal junction (TPJ) is a cortical area contributing to a multiplicity of visual, language-related and cognitive functions. In line with this functional richness, also the organization of the underlying white matter is highly complex and includes several bundles. The few studies tackling to date the outcome and neurological burdens o...
Article
Full-text available
The description of human white matter pathways experienced a tremendous improvement, thanks to the advancement of neuroimaging and dissection techniques. The downside of this progress is the production of redundant and conflicting literature, bound by specific studies’ methods and aims. The Superior Longitudinal System (SLS), encompassing the arcua...
Article
Full-text available
Introduction: Since its first description in the early 19th century, the inferior frontooccipital fascicle (IFOF) and its anatomo-functional features were neglected in the neuroscientific literature for the last century. In the last decade, the rapid development of in vivo imaging for the reconstruction of white matter (WM) connectivity (i.e., tra...
Article
Full-text available
BACKGROUND: Functional preoperative planning for resection of intrinsic brain tumors in eloquent areas is still a challenge. Predicting subcortical functional framework is especially difficult. Direct electrical stimulation (DES) is the recommended technique for resection of these lesions. A reliable probabilistic atlas of the critical cortical epi...
Article
BACKGROUND Functional preoperative planning for resection of intrinsic brain tumors in eloquent areas is still a challenge. Predicting subcortical functional framework is especially difficult. Direct electrical stimulation (DES) is the recommended technique for resection of these lesions. A reliable probabilistic atlas of the critical cortical epic...
Article
Introduction Left atrial appendage is the source of more than 90% of thrombi in patients with atrial fibrillation (AF). ESC guidelines state as class IIB indication left appendage exclusion in patients with contraindication to oral anticoagulation. Here we give our contribute to the issue of safety and efficacy of standalone totally thoracoscopic l...
Article
Full-text available
Virtual delineation of white matter bundles in the human brain is of paramount importance for multiple applications, such as pre-surgical planning and connectomics. A substantial body of literature is related to methods that automatically segment bundles from diffusion Magnetic Resonance Imaging (dMRI) data indirectly, by exploiting either the idea...
Article
Full-text available
Background Awake surgery has become a key treatment of diffuse low-grade gliomas (DLGG) and is divided in three main phases: opening, tumor resection – during which the patient needs to be fully awake – and closure. The anesthetic management of awake neurosurgery is a challenge, and there are currently no guidelines.Objective The objective of the s...
Article
Full-text available
Primary brain tumors are notoriously hard to resect surgically. Due to their infiltrative nature, finding the optimal resection boundary without damaging healthy tissue can be challenging. One potential tool to help make this decision is diffusion-weighted magnetic resonance imaging (dMRI) tractography. dMRI exploits the diffusion of water molecule...
Article
Full-text available
PurposeAwake surgery is an established technique for resection of low-grade gliomas, while its possible benefit for resection of high-grade gliomas (HGGs) needs further confirmations. This retrospective study aims to compare overall survival, extent of resection (EOR) and cognitive outcome in two groups of HGGs patients submitted to asleep or awake...
Article
In 2018 the SINch (Italian Society of Neurosurgery) Neuro-Oncology section, AINO (Italian Association of Neuro-Oncology) and SIN (Italian Association of Neurology) Neuro-Oncology section formed a collaborative Task Force to look at the diagnosis and treatment of low-grade gliomas (LGGs). The Task Force included neurologists, neurosurgeons, neuro-on...
Article
Full-text available
Disagreement exists regarding representational and connectionist interpretations of semantic knowledge subserved by the right versus left anterior temporal lobes (ATLs). These interpretations predict a different pattern of impairment in patients with a right unilateral ATL lesion. We conducted a neuropsychological study of a selective semantic pict...
Preprint
Full-text available
Virtual delineation of white matter bundles in the human brain is of paramount importance for multiple applications, such as pre-surgical planning and connectomics. A substantial body of literature is related to methods that automatically segment bundles from diffusion Magnetic Resonance Imaging (dMRI) data indirectly, by exploiting either the idea...
Article
Full-text available
Investigative studies of white matter (WM) brain structures using diffusion MRI (dMRI) tractography frequently require manual WM bundle segmentation, often called “virtual dissection.” Human errors and personal decisions make these manual segmentations hard to reproduce, which have not yet been quantified by the dMRI community. It is our opinion th...
Article
Full-text available
In this data article, we provide the dataset which served as the basis for our related research article "Mapping critical cortical hubs and white matter pathways by direct electrical stimulation: an original functional atlas of the human brain" [1], which represents the first probabilistic cortical and subcortical atlas of critical structures media...
Article
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Abstract No abstract available Keywords: association pathways; dissection; human brain; nomenclature; taxonomic classification; tractography; white matter anatomy.
Article
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Objective: The structural and functional organization of brain networks sub-serving basic daily activities (i.e. language, visuo-spatial cognition, movement, semantics, etc.) are not completely understood to date. Here, we report the first probabilistic cortical and subcortical atlas of critical structures mediating human brain functions based on...
Article
Full-text available
Editorial on the Research Topic Organization of the White Matter Anatomy in the Human Brain Between nineteenth and twentieth centuries, neurosciences experienced the first sharing of experiences and competences between the world of brain anatomy and clinics. The improvements in the knowledge of human white matter (WM) anatomy provided the natural b...
Article
Full-text available
Purpose: The practical management of cavernous angioma located within eloquent brain area before, during and after surgical resection is poorly documented. We assessed the practical pre-operative, intra-operative, and post-operative management of cavernous angioma located within eloquent brain area. Method: An online survey composed of 61 items...
Article
Full-text available
Whether brain networks underlying the multimodal processing of language in humans are present in non-human primates is an unresolved question in primate evolution. Conceptual awareness in humans, which is the backbone of verbal and non-verbal semantic elaboration, involves intracerebral connectivity via the inferior fronto-occipital fascicle (IFOF)...
Preprint
Full-text available
Investigative studies of white matter (WM) brain structures using diffusion MRI (dMRI) tractography frequently require manual WM bundle segmentation, often called "virtual dissection". Human errors and personal decisions make these manual segmentations hard to reproduce, which have not yet been quantified by the dMRI community. The contribution of...
Article
Full-text available
BACKGROUND The postoperative outcomes and the predictors of seizure control are poorly studied for supratentorial cavernous angiomas (CA) within or close to the eloquent brain area. OBJECTIVE To assess the predictors of preoperative seizure control, postoperative seizure control, and postoperative ability to work, and the safety of the surgery. M...
Article
Full-text available
Diffusion MRI tractography allows in-vivo characterization of white matter architecture, including the localization and description of brain fibre bundles. However, some primary bundles are still only partially reconstructed, or not reconstructed at all. The acoustic radiation (AR) represents a primary sensory pathway that has been largely omitted...
Article
Full-text available
The auditory system of mammals is dedicated to encoding, elaborating and transporting acoustic information from the auditory nerve to the auditory cortex. The acoustic radiation (AR) constitutes the thalamo-cortical projection of this system, conveying the auditory signals from the medial geniculate nucleus (MGN) of the thalamus to the transverse t...
Article
Full-text available
Fiber tractography (FT) using diffusion magnetic resonance imaging (dMRI) is widely used for investigating microstructural properties of white matter (WM) fiber-bundles and for mapping structural connections of the human brain. While studying the architectural configuration of the brain’s circuitry with FT is not without controversy, recent progres...
Article
Full-text available
Purpose The aim of this Pictorial Essay is to illustrate the metabolic aspect of PET (positron emission tomography) imaging in relation to conventional and advanced MR (magnetic resonance) of brain neoplasms. Materials 10 patients, who performed PET–CT with amino acid tracers and/or FDG were selected from a series of more than 250 cases from a sin...
Article
Full-text available
The heterogeneity and complexity of white matter (WM) pathways of the human brain were discretely described by pioneers such as Willis, Stenon, Malpighi, Vieussens and Vicq d’Azyr up to the beginning of the 19th century. Subsequently, novel approaches to the gross dissection of brain internal structures have led to a new understanding of WM organiz...
Article
Full-text available
OBJECTIVE Resting-state functional MRI (rs-fMRI) represents a promising and cost-effective alternative to task-based fMRI for presurgical mapping. However, the lack of clinically streamlined and reliable rs-fMRI analysis tools has prevented wide adoption of this technique. In this work, the authors introduce an rs-fMRI processing pipeline (ReStNeuM...
Article
Full-text available
Production of fluent speech in humans is based on a precise and coordinated articulation of sounds. A speech articulation network (SAN) has been observed in multiple brain studies typically using either neuroimaging or direct electrical stimulation (DES), thus giving limited knowledge about the whole brain structural and functional organization of...
Article
Full-text available
Objective: Imaging studies in diffuse low-grade gliomas (DLGG) vary across centers. In order to establish a minimal core of imaging necessary for further investigations and clinical trials in the field of DLGG, we aimed to establish the status quo within specialized European centers. Methods: An online survey composed of 46 items was sent out to...
Article
Full-text available
INTRODUCTION The postoperative outcomes and the predictors of seizure control are poorly documented for supratentorial cavernous angiomas within or close to eloquent brain area. We assessed the predictors of preoperative and postoperative seizure control and ability to work, and the safety of the surgery. METHODS Multicenter international retrospe...
Conference Paper
Full-text available
Synopsis: This study presents the first tractography-based atlas of the acoustic radiation from a population of 34 young healthy subjects. The atlas was constructed using high quality MRI data from the Human Connectome Project. The acoustic radiation reconstruction was optimized with a systematic evaluation of MRI acquisition and analysis parameter...
Preprint
Full-text available
Substantial progress in acquisition, processing, and analysis boosted the reliability of diffusion-weighted MRI and increased the accuracy of mapping white matter pathways with fiber tractography. Since the introduction of 'region of interest' (ROI) based virtual dissection by Conturo et al. in 1999, researchers have used tractography to identify w...
Conference Paper
Brain functional connectivity at rest in the default mode network (DMN) is a biomarker of functional integrity in patients affected by various diseases. The ventral (vDMN) and dorsal (dDMN) parts of the DMN may be differentially sensitive to different pathological states. In fact, previous studies suggest that these sub-components are engaged durin...
Article
Background: Anatomical awareness of brain's structural connectivity is mandatory for neurosurgeons, to select the most effective approaches for brain resections. Although standard micro-dissection is a validated technique to investigate the different white matter (WM) pathways and to verify results coming from tractography, the possibility of an i...
Article
Perimesencephalic nonaneurysmal subarachnoid hemorrhage (SAH) is a form of SAH. Symptomatic vasospasm represents a lower rate of this benign condition, and is characterized by diffuse SAH pattern. Computed tomography perfusion (CTP) scanning provides an accurate assessment of cerebral hemodynamic disturbances in patients with SAH-related vasospasm...
Article
Full-text available
The acoustic radiation is a compact bundle of fibers conveying auditory information from the medial geniculate nucleus of the thalamus to the auditory cortex. Topographical knowledge of this bundle in primates is scarce and in vivo diffusion-based tractography reconstructions in humans remains challenging, especially with the most widely used MRI a...
Article
Full-text available
This paper presents an on-going interdisciplinary collaboration to advance brain connectivity studies. Despite the evolution of noninvasive methods to investigate the brain connectivity structure using the diffusion magnetic resonance, in the neuroscientific community there is an open debate how to collect quantitative information of the main neuro...
Article
Full-text available
Despite its significant functional and clinical interest, the anatomy of the uncinate fasciculus (UF) has received little attention. It is known as a ‘hook-shaped’ fascicle connecting the frontal and anterior temporal lobes and is believed to consist of multiple subcomponents. However, the knowledge of its precise connectional anatomy in humans is...
Article
Full-text available
Background High-grade gliomas are the most frequently occurring brain tumors and carry unfavorable prognosis. Literature is controversial regarding the effects of surgery on cognitive functions. Methods We analyzed a homogenous population of 30 patients with high-grade glioma who underwent complete resection. Patients underwent extensive neuropsyc...
Article
Full-text available
Diffuse low-grade glioma form a rare entity affecting young people. Despite advances in surgery, chemotherapy, and radiation therapy, diffuse low-grade glioma are still incurable. According to current guidelines, maximum safe resection, when feasible, is the first line of treatment. Apart from surgery, all other treatment modalities (temozolomide,...