Silvia Romero-Sanz- PhD Student at University of Valladolid
Silvia Romero-Sanz
- PhD Student at University of Valladolid
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7
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Publications (7)
We have previously shown that the compound CGP37157, a mitochondrial Na⁺/Ca²⁺ exchanger inhibitor, increases lifespan and improves muscle and mitochondrial structure during aging in wild-type C. elegans nematodes. We used here a rotenone model of Parkinson’s disease in C. elegans to test the ability of CGP37157 to rescue the alterations induced by...
Caenorhabditis elegans (C. elegans) es un nematodo no parásito ampliamente utilizado como modelo animal de investigación científica. Se trata de un animal pluricelular con tejidos y anatomía simple, que alcanza un número fijo de células en su etapa adulta, 959, de las cuales 302 son neuronas [1]. Es precisamente su sencillez lo que le confiere un g...
Mitochondria exhibit a close interplay between their structure and function. Understanding this intricate relationship requires advanced imaging techniques that can capture the dynamic nature of mitochondria and their impact on cellular processes. However, much of the work on mitochondrial dynamics has been performed in single celled organisms or i...
Mitochondria exhibit a close interplay between their structure and function. Understanding this intricate relationship requires advanced imaging techniques that can capture the dynamic nature of mitochondria and their impact on cellular processes. However, much of the work on mitochondrial dynamics has been done in single celled organisms or in vit...
Introduction: The high prevalence of neurodegenerative diseases in our population and the lack of effective treatments encourage the search for new therapeutic targets for these pathologies. We have recently described that submaximal inhibition of the Sarco-Endoplasmic Reticulum Ca²⁺ ATPase (SERCA), the main responsible for ER calcium storage, is a...
Glucose sensing in pancreatic beta-cells depends on oxidative phosphorylation and mitochondria-derived signals that promote insulin secretion. Using mass spectrometry-based phosphoproteomics to search for down-stream effectors of glucose dependent signal transduction in INS-1E insulinoma cells, we identified the outer mitochondrial membrane protein...
