Silvia Maggini

Silvia Maggini
Bayer · Bayer HealthCare Consumer Care

About

37
Publications
98,242
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5,313
Citations
Citations since 2016
6 Research Items
4053 Citations
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201620172018201920202021202202004006008001,000
201620172018201920202021202202004006008001,000

Publications

Publications (37)
Article
Introduction: The human body, particularly the brain, requires energy, stored in the form of adenosine triphosphate. Energy metabolism during cellular respiration is dependent on the presence of multiple micronutrients, which act as essential components, coenzymes, or precursors at every stage. An adequate supply of multiple micronutrients is vita...
Article
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Breastfed infants require an adequate supply of critical nutrients for growth, tissue functions, and health. Recommended intakes for several nutrients are considerably higher in lactating than non-lactating women but are not always met with habitual diets. We report a randomized, double-blind clinical trial in 70 healthy lactating women in Germany...
Article
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Maternal dietary intake during pregnancy needs to meet increased nutritional demands to maintain metabolism and to support fetal development. Docosahexaenoic acid (DHA) is essential for fetal neuro-/visual development and in immunomodulation, accumulating rapidly within the developing brain and central nervous system. Levels available to the fetus...
Article
Full-text available
Immune support by micronutrients is historically based on vitamin C deficiency and supplementation in scurvy in early times. It has since been established that the complex, integrated immune system needs multiple specific micronutrients, including vitamins A, D, C, E, B6, and B12, folate, zinc, iron, copper, and selenium, which play vital, often sy...
Article
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As humans age, the risk and severity of infections vary in line with immune competence according to how the immune system develops, matures, and declines. Several factors influence the immune system and its competence, including nutrition. A bidirectional relationship among nutrition, infection and immunity exists: changes in one component affect t...
Article
Full-text available
Vitamin C is an essential micronutrient for humans, with pleiotropic functions related to its ability to donate electrons. It is a potent antioxidant and a cofactor for a family of biosynthetic and gene regulatory enzymes. Vitamin C contributes to immune defense by supporting various cellular functions of both the innate and adaptive immune system....
Chapter
This chapter focuses on the current understanding of vitamin D and immunity, with special attention to the elderly. Vitamin D insufficiency and deficiency are common among the elderly population. Vitamin D plays an immunoregulatory role in innate and adaptive immunity, and low vitamin D status has been implicated in the etiology of immune disorders...
Chapter
Aging is accompanied by physiological, psychological, economic, and social changes. Physiological changes in particular affect the requirements for several micronutrients, and the elderly are at high risk for micronutrient deficiencies. Inadequate intake and status of micronutrients leads to suppressed immunity, predisposing people to infections an...
Article
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Exercise undertaken in a fasted state can lead to higher post-exercise mental fatigue. The administration of a vitamin and mineral complex with guaraná (MVM + G) has been shown to attenuate mental fatigue and improve performance during cognitively demanding tasks. This placebo-controlled, double-blind, randomized, balanced cross-over study examined...
Article
Our bodies are normally well protected against continual attack from pathogens and noxious insult by a complex and integrated immune system. However, daily bombardment from indoor and outdoor air pollutants can compromise immune function and ultimately lead to infection (e.g. acute respiratory tract infections, diarrhoea) and conditions such as sic...
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Objectives: Relatively few studies have explored the possibility of acute cognitive effects of multivitamin ingestion. This report explores the acute brain electrophysiological changes associated with multivitamin and mineral supplementation, with and without guaraná, using the steady-state visually evoked potential (SSVEP). Methods: Based on th...
Chapter
Diet and nutrition are important in the promotion and maintenance of good health throughout the entire life span and are required for optimal immune function. Despite improved nutritional status, hygienic conditions and worldwide vaccination programs, infectious diseases continue to represent a major threat to human health even in the 21st century....
Article
Micronutrients are essential to support the energy generation in the heart, and they have antioxidant and anti-inflammatory properties important for both heart and blood vessel health. Plant-derived phytosterols reduce the absorption of cholesterol and are also able to lower serum low-density lipoprotein (LDL) cholesterol. Oxidized LDL cholesterol...
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Previous work has identified the positive effects of the acute administration of a multivitamin-guaraná preparation during an effortful executive/working memory task. Here, we aimed to differentiate the effects of multivitamins with and without guaraná and to examine the neural substrates of such effects using functional magnetic resonance imaging...
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Vitamin C and zinc play important roles in nutrition, immune defence and maintenance of health. Intake of both is often inadequate, even in affluent populations. The common cold continues to place a great burden on society in terms of suffering and economic loss. After an overview of the literature on the effects of the separate administration of e...
Article
A significant minority of the population consume multi-vitamins/minerals for their putative health benefits, including potentially beneficial effects on cognitive performance, fatigue and mood. The current study investigated the effect of supplementation with a multi-vitamin/mineral on fatigue and cognitive function in healthy females. In this plac...
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A significant proportion of the general population report supplementing their diet with one or more vitamins or minerals, with common reasons for doing so being to combat stress and fatigue and to improve mental functioning. Few studies have assessed the relationship between supplementation with vitamins/minerals and psychological functioning in he...
Chapter
Diet and nutrition are important in the promotion and maintenance of good health throughout the entire life. A common denominator playing a role in the prevention of both chronic diseases and infections and hence important for maintaining health is a good functioning immune system. The competence of the immune system is an excellent marker of prope...
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With the progressive elimination of dietary protein-energy deficits, deficiencies of micronutrients are emerging as the limiting factors in ensuring children's optimal health. Data from several countries in Asia and Latin America indicate that deficiencies of vitamin C and zinc continue to be at alarming levels. This article reviews the roles of vi...
Article
The immune system protects the body against pathogens and cancer cells, thereby defending it against infections and diseases via three main components: epithelial barriers, immune cells and proteins including antibodies. Immune defences are constantly active and consist of a complex network of coordinated biological responses. Therefore, the immune...
Article
Full-text available
Vitamin C concentrations in the plasma and leukocytes rapidly decline during infections and stress. Supplementation of vitamin C was found to improve components of the human immune system such as antimicrobial and natural killer cell activities, lymphocyte proliferation, chemotaxis, and delayed-type hypersensitivity. Vitamin C contributes to mainta...
Article
This double-blind, randomised, placebo-controlled, parallel group study examined the effects of a multivitamin–mineral supplement with guaraná (Berocca Boost Performance®) on aspects of cognitive performance and self-reported mental fatigue during sustained, effortful mental processing. The acute effects of a single dose of either the vitamin/miner...
Article
Guaraná (Paullinia cupana) extracts are most commonly used in Western markets as putatively psychoactive food and drink additives. This double-blind, randomised, placebo-controlled, parallel groups study assessed the acute effects of either a vitamin/mineral/guaraná supplement or placebo drink in 129 healthy young adults (18-24 years). Participants...
Article
Full-text available
Adequate intakes of micronutrients are required for the immune system to function efficiently. Micronutrient deficiency suppresses immunity by affecting innate, T cell mediated and adaptive antibody responses, leading to dysregulation of the balanced host response. This situation increases susceptibility to infections, with increased morbidity and...
Article
Full-text available
Physicians are frequently confronted with patients complaining of fatigue, tiredness and low energy levels. In the absence of underlying disease, these symptoms could be caused by a lack of vitamins and minerals. Certain risk groups like the elderly and pregnant women are well-recognized. Our aim was, therefore, to find out if other, less well-esta...
Article
Adequate intakes of vitamins and trace elements are required for the immune system to function efficiently. Micronutrient deficiency suppresses immune functions by affecting the innate T-cell-mediated immune response and adaptive antibody response, and leads to dysregulation of the balanced host response. This increases the susceptibility to infect...
Article
Full-text available
There has been much media speculation (often sensationalist and conflicting) regarding the potential influence of micronutrients on cognitive function and performance. Our aim was to identify the micronutrients specifically implicated in cognitive function and to review the literature to identify original sources underlying the media coverage. Lite...
Article
Full-text available
Vitamin C concentrations in the plasma and leukocytes rapidly decline during infections and stress. Supplementation of vitamin C was found to improve components of the human immune system such as antimicrobial and natural killer cell activities, lymphocyte proliferation, chemotaxis, and delayed-type hypersensitivity. Vitamin C contributes to mainta...
Article
Full-text available
COBAS INTEGRA 400 is a random-access analytical system consolidating assays for clinical chemistry analytes, electrolytes, serum proteins, drugs of abuse and therapeutic drugs. Analytical performance and practicability of the instrument were evaluated in seven laboratories over a 2-year period in parallel with system development. Good within-run an...
Article
Phosphoenolpyruvate carboxykinase (GTP) (PEPCK) is one of the key enzymes of gluconeogenesis. Mechanisms responsible for rapid regulation of enzyme activity include activation by bivalent cations such as Mn2+ and Fe2+ and/or alterations of the oxidation state of the enzyme's SH groups. A cytosolic cell free system prepared from rat liver was used t...
Article
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A cytosolic cell-free system prepared from rat liver was used to study the effect of bivalent cations on the activity of the gluconeogenic enzyme phosphoenolpyruvate carboxykinase (PEPCK). Steady-state concentrations of oxaloacetate in the range 5-50 microM were generated from increasing concentrations of malate+fumarate (10:1); 2 mM ITP and 3 mM M...
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A cytosolic cell-free system from rat liver containing the last three enzymes of the urea cycle, a number of cofactors and the substrates aspartate and citrulline was shown to synthesize urea at near-physiological rates ranging between 0.40 and 1.25 mumol/min per g of liver. This system was used to determine the kinetic parameters for arginase. Wit...

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