Silvia Maggi

Silvia Maggi
University of Nottingham | Notts · School of Psychology

PhD

About

31
Publications
3,129
Reads
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427
Citations
Citations since 2016
18 Research Items
362 Citations
201620172018201920202021202201020304050
201620172018201920202021202201020304050
201620172018201920202021202201020304050
201620172018201920202021202201020304050
Introduction
Silvia Maggi currently works at the School of Psychology, University of Nottingham. Silvia does research in Systems Neuroscience and Cognitive Science.
Additional affiliations
April 2018 - present
The University of Manchester
Position
  • Visiting Research
April 2018 - present
University of Nottingham
Position
  • PostDoc Position
March 2015 - March 2018
The University of Manchester
Position
  • PostDoc Position

Publications

Publications (31)
Preprint
Full-text available
Investigating the strategies engaged by subjects in decision making and learning requires tracking their choice strategies on a trial-by-trial basis. Here we present a simple but effective probabilistic approach to tracking choice strategies at trial resolution, using Bayesian evidence accumulation. We show this approach identifies both successful...
Article
Full-text available
Trace amine-associated receptors (TAARs) are a family of G protein-coupled receptors present in mammals in the brain and several peripheral organs. Apart from its olfactory role, TAAR5 is expressed in the major limbic brain areas and regulates brain serotonin functions and emotional behaviours. However, most of its functions remain undiscovered. Gi...
Article
Full-text available
Medial prefrontal cortex (mPfC) activity represents information about the state of the world, including present behavior, such as decisions, and the immediate past, such as short-term memory. Unknown is whether information about different states of the world are represented in the same mPfC neural population and, if so, how they are kept distinct....
Preprint
Trace amine-associated receptors (TAARs) are a family of G protein-coupled receptors present in mammals in the brain and in several peripheral organs. Apart from its olfactory role, TAAR5 is expressed in the major limbic brain areas and regulates brain serotonin functions and emotional behaviors. However, most of its functions remain undiscovered....
Article
Full-text available
Discovering low-dimensional structure in real-world networks requires a suitable null model that defines the absence of meaningful structure. Here we introduce a spectral approach for detecting a network’s low-dimensional structure, and the nodes that participate in it, using any null model. We use generative models to estimate the expected eigenva...
Preprint
Full-text available
Medial prefrontal cortex (mPfC) activity represents information about the state of the world, including present behaviour, such as decisions, and the immediate past, such as short-term memory. Unknown is whether information about different states of the world are represented in the same mPfC neural population and, if so, how they are kept distinct....
Preprint
Full-text available
Discovering structure in real-world networks requires a suitable null model that defines the absence of meaningful structure. Here we introduce a spectral approach for testing structural hypotheses at both network and node levels, by using generative models to estimate the eigenvalue distribution under a specified null model. On synthetic networks,...
Article
Full-text available
The prefrontal cortex is implicated in learning the rules of an environment through trial and error. But it is unclear how such learning is related to the prefrontal cortex's role in short-term memory. Here we ask if the encoding of short-term memory in prefrontal cortex is used by rats learning decision rules in a Y-maze task. We find that a simil...
Preprint
Full-text available
The prefrontal cortex is implicated in learning the rules of an environment through trial and error. But it is unclear how such learning is related to the prefrontal cor-tex’s role in short-term memory. Here we asked if the encoding of short-term memory in prefrontal cortex was used by rats learning decision rules in a Y-maze task. We found that a...
Article
Full-text available
Circadian clock is known to adapt to environmental changes and can significantly influence cognitive and physiological functions. In this work, we report specific behavioral, cognitive, and sleep homeostatic defects in the after hours (Afh) circadian mouse mutant, which is characterized by lengthened circadian period. We found that the circadian ti...
Article
Full-text available
Abnormal feeding behavior is one of the main symptoms of Prader-Willi syndrome (PWS). By studying a PWS mouse mutant line, which carries a paternally inherited deletion of the small nucleolar RNA 116 (Snord116), we observed significant changes in working-for-food behavioral responses at various timescales. In particular, we report that PWS mutant m...
Article
Full-text available
An AT motif-dependent axis, modulated by the transcription factor Zfhx3, influences the circadian clock in mice. In particular, gain of function of Zfhx3 significantly shortens circadian rhythms and alters the transcriptional activity of an important class of neuropeptides that controls intercellular signaling in the suprachiasmatic nucleus (SCN) o...
Article
Full-text available
Study objectives: Sleep-wake disturbances are often reported in Prader-Willi syndrome (PWS), a rare neurodevelopmental syndrome that is associated with paternally-expressed genomic imprinting defects within the human chromosome region 15q11-13. One of the candidate genes, prevalently expressed in the brain, is the small nucleolar ribonucleic acid-...
Article
Full-text available
Trace Amine-Associated Receptor 1 (TAAR1) is a G protein-coupled receptor expressed in the mammalian brain and known to influence subcortical monoaminergic transmission. Monoamines, such as dopamine, play also an important role within the prefrontal cortex (PFC) circuitry, which is critically involved in high order cognitive processes. TAAR1 select...
Article
Full-text available
The recent identification of multiple dominant mutations in the gene encoding β-catenin in both humans and mice has enabled exploration of the molecular and cellular basis of β-catenin function in cognitive impairment. In humans, β-catenin mutations that cause a spectrum of neurodevelopmental disorders have been identified. We identified de novo β-...
Article
Full-text available
Fast-spiking interneurons (FSIs) play a central role in organizing the output of striatal neural circuits, yet functional interactions between these cells are still largely unknown. Here we investigated the interplay of action potential (AP) firing between electrically connected pairs of identified FSIs in mouse striatal slices. In addition to a lo...
Article
Full-text available
Phenotyping behavioral and cognitive processes is a critical practice in mouse research and reliable phenotypic assessment is an essential component of building well-defined links between genes and behavioral/cognitive functions. The success of behavioral screens in neurobehavioral mouse genetics depends on the identification of reliable, reproduci...
Data
Full-text available
Parvalbumin-positive fast-spiking interneurons of the striatum (FSIs) mediate feed-forward inhibition of principal cells and are thought to play a central role in network electrical oscillations. Striatal FSIs are interconnected via gap-junction mediated electrical synapses and often by GABAergic synapses. Here, we investigated the interplay of fir...
Data
Full-text available
Multiple-rebound values are plotted for NREM (a) and REM (b) after sleep deprivation (SD), FC and during the “Switch” and “Probes” condition of the Switch-task. The interrupted circular lines indicate the 100% baseline values. (c) Mean power densities of frequencies in NREM (red lines) and REM (blue lines) epochs are reported for all experimental c...
Data
Full-text available
Four-hour bins percentage and shadowed ± s.e.m of REM (lower panel) sleep during 6-hour sleep deprivation (SD) and the following 6-hour recovery period. Grand-averages and shadowed ± s.e.m. of body temperature (upper panel) are plotted for the same period. (PDF)
Article
Full-text available
It has been suggested that imprinted genes are important in the regulation of sleep. However, the fundamental question of whether genomic imprinting has a role in sleep has remained elusive up to now. In this work we show that REM and NREM sleep states are differentially modulated by the maternally expressed imprinted gene Gnas. In particular, in m...

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