Silvia Coelho

Silvia Coelho
University of Porto | UP · Departamento de Engenharia Química

PhD in Chemical and Biological Engineering

About

21
Publications
1,776
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268
Citations

Publications

Publications (21)
Article
Full-text available
Colloidal gold nanoparticles are targeting probes to improve varlitinib delivery into cancer cells. The nanoconjugates were designed by the bioconjugation of pegylated gold nanoparticles with varlitinib via carbodiimide-mediated cross-linking and characterized by infrared and X-ray photoelectron spectroscopy. The drug release response shows an init...
Article
Water-soluble vitamins are essential micronutrients in diets and crucial to biochemical functions in human body physiology. These vitamins are essential for healthy diets and have a preventive role against diseases. However, their limitations associated with high sensitivity against external conditions (temperature, light, pH, moisture, oxygen) can...
Article
Full-text available
Gold nanoparticles (AuNPs) are inorganic and biocompatible nanovehicles capable of conjugating biomolecules to enhance their efficacy in cancer treatment. The high and reactive surface area provides good advantages for conjugating active compounds. Two approaches were developed in this work to improve the Epigallocatechin-3-gallate (EGCG) antioxida...
Article
Electrohydrodynamic techniques have been focus for the development of structures for encapsulation purposes. Their physico-chemical characteristics confer them significant benefits for food and nutraceutical applications. The study reports the optimization of zein microstructures (electrosprayed beads/electrospun fibers/films). The effect of zein p...
Article
In this study, vitamin B12, the most chemically complex and the largest molecule among all the vitamins, was successfully incorporated into zein microstructures via electrospinning and spray drying techniques. Scanning electron microscopy analysis revealed that different microstructures were obtained by electrospinning technique: films, micropartic...
Article
Full-text available
Plant-derived products have been present in human pharmacopeia for thousands of years, several botanical-based products are unstable and low aqueous solubility compromising their efficiency. The strategy of applying nanotechnology to botanical extracts may potentiate their biological action, promote the sustained release, reduction of required dose...
Article
Nowadays the world population has been more conscious about healthy food products based on bioactive ingredients in order to protect against diseases and to develop healthy diets. Emerging electrohydrodynamic techniques have been object of interest in the scientific community as well as in the industry. In fact, electrospinning and electrospraying...
Article
Full-text available
The aim of this study was to develop drug delivery nanosystems based on pegylated gold nanoparticles (PEGAuNPs) for a combination against pancreatic cancer cells. Doxorubicin and varlitinib, an anthracycline and a tyrosine kinase inhibitor respectively, were conjugated with gold nanoparticles. The systems were characterized, after synthesis, regard...
Article
Objectives: Gold nanoparticles have become promising vectors for cancer diagnosis and treatment. The present study investigates the effect of bortezomib (BTZ), a proteasome inhibitor, conjugated with pegylated gold nanoparticles (PEGAuNPs) in pancreatic and lung cancer cells. Methods: Synthesized gold nanoparticles (PEGAuNPs) were conjugated wit...
Article
Objectives: A drug delivery system based on colloidal pegylated gold nanoparticles (PEGAuNPs) conjugated with the tyrosine kinase inhibitor afatinib was designed and tested for enhancing the drug activity against pancreatic and NSCLC cells. Methods: PEGAuNPs were synthesized and characterized physicochemically. Confocal imaging was performed to...
Article
Nanocarriers based on polymers, metals and lipids have been extensively developed for cancer therapy and diagnosis due to their ability to enhance drug accumulation in cancer cells and decrease undesired drug toxicity in healthy tissues. Overcoming multidrug resistance by designing proper drug nanocarriers will improve outcome of existing oncologic...
Article
Full-text available
In the present paper, we report results from a study of the structure and physicochemical properties of gold nanoparticles modified with poly(ethylene glycol) (PEG) designed for drug delivery of the proteasome inhibitor Bortezomib (BTZ) in cancer therapy. A number of advanced analytical techniques were used to define important physicochemical chara...
Article
Colloidal gold nanoparticles intensify the anticancer response of the drug bortezomib, a proteasome inhibitor. Polyethylene glycol-coated gold nanoparticles and the drug show a synergistic effect in reducing the cell viability of prostate cancer cell line Du145. It was observed a significant cell viability reduction with bortezomib concentrations a...
Article
Organic–inorganic hybrid nanoparticles are potential effective systems for drug delivery in cancer therapy and diagnosis. Chitosan–gum arabic with entrapped gold nanoparticles were developed as a carrier for an anticancer drug bortezomib. The nanosystem was designed to enhance the proteasome inhibitor activity in pancreatic cell lines, S2-013 and h...
Article
Full-text available
Background: Proteasome inhibition is a current therapeutic strategy used in the treatment of multiple myeloma. Drugs controlling proteasome activity are ideally suited for unidirectional manipulation of cellular pathways such as apoptosis. The first proteasome inhibitor approved in clinics was bortezomib. This drug is currently used in combination...
Conference Paper
Gold nanoparticles are versatile vectors for biological applications including in cancer therapy and diagnosis. Combining gold nanoparticles/anticancer drugs with X-rays radiation may contribute to tumor eradication and treatment efficacy. The conjugation of a proteasome inhibitor (BTZ) with functionalized gold nanoparticles were tested. The drug a...
Conference Paper
Design and testing drug delivery systems using biodegradable and biocompatible colloidal carriers made of functionalized gold nanoparticles are the vectors of this project. The systems will be tested in therapy strategies for cancer. The main objective is to develop nanoparticles that increase radiation absorption in diseased areas and minimize dam...
Article
The interaction of gum arabic (GA) with chitosan (Ch) of different degree of deacetylation was studied by turbidity measurements, dynamic light scattering and atomic force microscopy. The structure of the complexes was found to be directly related to the charge density of chitosan molecules. Gum arabic and chitosan with a degree of deacetylation of...

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