Silvanus Innih

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Verified

Silvanus verified their affiliation via an institutional email.

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• B.Sc; M.Sc ; PhD
• Professor (Associate) at University of Benin

Voacanga Africana stapf (Apocynaceae) leaves is being used in herbal medicine to treat leprosy, diarrhoea, generalized oedema and convulsion in children as an infant tonic and the present study was aimed at its toxicological evaluation in wistar rats. The sub-acute toxicity was evaluated after administering daily oral doses of Voacanga Africana sta...

Background: Solanum torvum, commonly known as turkey berry, is used majorly as a medicinal plant, especially in Africa. Thus, this research investigated the effects of aqueous leaf extract of S. torvum on the status of liver (alkaline phosphatase [ALP], alanine transaminase, aspartate transaminase, plasma total protein, plasma albumin, plasma globu...

Background Momordica. charantia is popularly used as a medicinal herb in ethnomedicine for the management of cardiovascular diseases. In this study, we evaluated the beneficial effects of the ethanolic extract of M. charantia (Linn.) in experimentally induced cardiovascular disorders using cholesterol-fed Wistar rat. Methods Seventy-two experiment...

Background Momordica charantia is popularly used in folk medicine in the management of hyperlipidemia and atherosclerosis. Purpose To evaluate the anti-atherosclerotic potential of M. charantia as well as its haematinic and antioxidant potential. Methods Seventy-two experimental rats were randomly assigned into 9 groups (I-IX) of 8 rats each. Gro...

Considerable attention from basic to clinical scientists has been given to the toxicity of drugs and other related agents, because of the passionate sourcing for the readily available and cheap agents against organotoxicity. We evaluated the protective effects of ethanol leaf extract of Irvingia gabonensis on arsenic trioxide-induced spleen damage...

BACKGROUND AND AIM: The toxic effects of drugs and other related substances have attracted concerns from scientists. The passion about the availability of effective and cheap substances against organotoxicity in humans is increasing daily. This work assessed the histopathological changes in the heart of arsenic trioxide-induced Wistar rats and the...

Alcoholic beverages are renowned as the most common types of alternative medicine, but the frequent over indulgence in the use of alcoholic beverages however, have been linked with a number of social and importantly health problems and death. Herbs, such as Stigma maydis, which have been used for centuries in treating various illnesses, play a majo...

BACKGROUND AND AIM: Dimethyl nitrosamine (DMN) burden compromises liver function due to its complicated pathophysiology. Zingerone (ZG), is a phenolic compound in ginger rhizome with pharmacological potential against chemo toxin mediated hepatic damage. This study investigated the therapeutic efficacy of Zingerone against DMN in the liver METHODOLO...

Mercury chloride (HgCl2) is a compound of mercury, which is highly toxic and corrosive. Mercury chloride was formerly utilized as a treatment for syphilis; however, it is no longer employed for medical purposes due to its toxicity. A chemical evaluation of Tetracarpidium conophorum nuts revealed it can be useful to manage cardiovascular and live...

The shrub tree Lonchocarpus cyanescens is one of the herbal remedies traditionally used in Nigeria to promote human health. In the western part of the nation Nigeria, it is used to treat diabetes mellitus. Investigating the histomorphological activities of an aqueous extract of Lonchocarpus cyanescens leaf on the cardiovascular status of normal Wis...

The present study investigated the possible effects of Newbouldia laevis on mercury induced toxicity on the haematological parameters and cardiac architecture of adult Wistar rats. Twenty-five Wistar rats were randomly divided into five groups (A-E). All rats had free access to feed and water. Group A served as the normal control. Group B was admin...

Corn silk is the long shiny fibers at the top of an ordinary ear of corn (Zea mays). Corn silk contains phytochemicals of medical benefit such as flavonoids compounds which act as antioxidant agents and has been widely reported possess hepatoprotective effect. The objective of this paper is to evaluate the hepatoprotective effect of corn silk extra...

Caffeine has been used for thousands of years. When taken in excess, caffeine can have negative effects on the body's overall health, including the cardiovascular system. Hence, the objective of this study was to evaluate the impact of caffeine on the cardiovascular toxicity in adult Wistar rat's using histological techniques. Twenty rats were rand...

The toxicity of drugs and other related agents attracts considerable attention from basic scientists to clinicians. Humankind has been passionate about the availability of cheap and readily available agent against organotoxicity. Therefore this paper investigated the effects of ethanolic leaves extract of Irvingia gabonensis on arsenic trioxide-ind...

Due to its key ingredient, curcumin, Curcuma longa functions as a powerful chemopreventive agent and natural antioxidant. The purpose of this study is to evaluate the protective and ameliorative effects of an aqueous extract of Curcuma longa on adult Wistar rats' liver damage caused by ethanol. Thirty Wistar rats weighing between 160 and 220 g were...

BACKGROUND AND AIM: Iron is essential for body metabolic activities but excessive iron exposure poses a significant threat to cardiovascular health due to its role in oxidative stress and tissue damage. Natural iron-chelating agents from plants offer a promising alternative to synthetic chelators with potentially fewer side effects. The efficacy of...

Background Tetrapleura tetraptera Taubert (Fabaceae) fruits are employed by herbal practitioners in the management of uterine leiomyoma, but its usage in this regard and level of safety in chronic administration has not been sufficiently established. This study evaluated the toxicity effects of T. tetraptera ethanol fruit extract and explored its a...

This work is aimed at the ameliorative effect of aqueous extract of mistletoe on the spleen of lead acetate-induced toxicity in rat. Twenty-five adults male Wistar rats used for this experiment were divided into five groups. Group A (control) was administered 1ml of distilled water. Low dose, 200mg/kg of mistletoe extract and 10mg/kg of lead acetat...

The aim of this study is to offer a thorough examination of contemporary research concerning cardiovascular complications induced by diabetes, with a specific focus on coronary artery disease (CAD), diabetic heart attacks, diabetic peripheral artery disease (PAD), and diabetic hypertension. The period of analysis spans from 1988 to 2022, and the da...

Drug-induced injury is a key cause of kidney disease. Mercuric chloride, an antineoplastic agent used for treating various malignancies can cause kidney injury and induce nephrotoxicity. This study was to determine the effects of Newbouldia laevis on mercury chloride-induced kidney damage in adult male Wistar rats. Twenty-five adult male Wistar rat...

Ketoconazole is an imidazole-derived drug used in the treatment of a broad-spectrum offungal diseases. It is also believed to be hepatotoxic. This present study investigatesthe effect of aqueous leaf extract of Psidium guajava on liver function parameters inadult male wistar rats treated with ketoconazole. Twenty rats were divided into fourgroups,...

The effect of the aqueous extract of Emilia coccinea leaves on ethanol- induced gastric damage was investigated on adult wistar rats for four weeks. 30 experimental animals weighing between 180g and 250g were used and they were divided into five groups of six animals each; groups A,B,C,D and E. Group A animals served as negative control, group B an...

Background The use of Viscum album to treat different diseases is popular in the practise of alternative medicine. We investigated the ability of the aqueous extract of V. album to protect against the toxic effects of cadmium. Methods Thirty rats used for the experiment were treated as follows; Group 1 – no cadmium or extract. Group 2 - 10mg/kg bo...

Background: Acalypha wilkesiana Hoffmanni commonly has been reported to possess many beneficial phytoconstituents. The effect of hexane and ethanol extracts of Acalypha wilkesiana Hoffmannii on lipid profile and oxidative stress markers were investigated. Methods: A total of 60 rats were divided into 12 groups with 5 rats in each group; Group A re...

Introduction / Background Inadvertent poisoning from indiscriminate use of lead acetate-containing agents has transformed into an issue of public health concern, most especially in developing countries, coupled with the paucity of potent antidotes. Aims We investigated the protective effect of Vernonia amygdalina in lead acetate-induced nephrotox...

Hyperlipidaemia also called high cholesterol level is an important cause of adverse health outcomes including cardiovascular complications, obesity, metabolic disorders, infertility. Date fruit is rich in phytochemicals such as carotenoids, polyphenols (e.g., phenolic acids, isoflavons, lignans, and flavonoids), tannins, and sterols. Thus with prot...

Elevated cholesterol level is a major cause of disease burden in developing Nations. This study seeks to evaluate the ameliorative and hepatoprotective potentials of aqueous extract of date palm (Phoenix dactylifera) on high fat diet-induced liver damage. Thirty (30) adult wistar rats weighing 110-180g were randomly divided into six group of five a...

This study was carried out to investigate the effects of T etracarpidium conophorum on iron overload-induced cardiac toxicity in wistar rats. A total of 30 rats weighing between 170-245g were divided into six groups (A, B, C, D, E and F) of five per group. Group A (control) was administered 1ml of distilled water, group B, C, D, E, and F were induc...

Background In recent times, medicinal plants has been explored for their ameliorating effect on Cadmium induced organ toxicity in Wistar rats. Aims and Objectives This study investigates the protective effects of aqueous extract of Cyperus esculentus (tiger nut) on cadmium-induced biochemical and histological alterations in heart of rats. Materia...

Background: This study was aimed at evaluating the hematinic effect of Spondias mombin and its protective role against the spleenotoxic effect of Phenylhydrazine (PHZ). Methods: Thirty Wistar rats were randomized into 6 groups. Group A (Control) animals were neither given the extract nor PHZ. Rats in groups B and C were administered 150 mg/kg body...

ISO was used to induce MI by intraperitoneal injection at the dose of 100mg/kg to Wistar rats Serum lipid profile and cardiac marker enzymes were obtained and then measured calorimetrically. The results show that isoproterenol‐induced myocardiac infarction were associated with significant (p<0.05) increase in the activities of cardiac marker enzyme...

Mucuna pruriens (velvet beans) is an unconventional legume commonly found in the tropical regions of Africa with several ethnomedicinal uses. The present study was designed to investigate the effect of aqueous extract of Mucuna pruriens leaves in rats intoxicated with lead acetate. Thirty rats were divided into six groups (five rats per group). Gro...

Brachystegia eurycoma is a mainstay in the treatment of malaria, diabetes, hypertension, microbial infections and inflammatory conditions in folkloric medicine in Eastern Nigeria. Thus, the present study investigated the in vivo sub-acute toxicity of its aqueous stem bark extract. Toxicological evaluation was done using organ weight index, haematol...

Background: There is an increasing reliance on neutrophil/lymphocyte ratio (NLR) as a prognostic marker in certain diseases. Observations have suggested the effects of administering highly active antiretroviral therapy (HAART) to human immunodeficiency virus (HIV) patients to be beneficial as well as having its side effects. Hence, this study is de...

The present study was conducted to investigate the antioxidant effect of ethanolic and aqueous extract of schwenkia americana Linn on aspirin-induced gastric ulcers in wistar rats and its safety. Gastric ulceration was induced in wistar rats with 200mg/kg body weight of aspirin for 3 days and was treated with 200mg/kg body weight of ethanolic and a...

Alcohol has been reported as one of the major predisposing agents of gastric ulcer, liver diseases and renal failures. This study was thus carried out to investigate the influence of the aqueous leaf extract of Agerantum conyzoides on ethanol-treated in adult wistar rats by carrying out biochemical and histological on gastric mucosa, hepatocytes an...

Elaeis guineensis- Jacq (Arecaceae) is reported for the treatment of a variety of ailments notable amongst these are diabetes and hyperlipidemia. The present study is aimed at evaluating its anti-hyperlipedemic effect, via olive oil induced hyperlipidemia.The aqueous extract was obtained from a decoction of the roots, and later administered to oliv...

This study was designed to ascertain the effect of ethanol extract of Anthocleista vogelii Planch root bark on liver function and antioxidant status of obese rats. Forty male wistar rats were divided into five groups of 8 rats per group. Group 1 was fed the normal pellet diet (NPD), Group 2-3 were fed high fat diet (HFD) and Group 4-5 were fed the...

The role of the disturbances of hepcidin metabolism, the master regulator of iron homeostasis synthesized in the liver, has been raised In cases of impaired liver function. The aims of this study were to evaluate the serum levels of prohopcidin, serum iron, interleukin-6, liver enzymes: aspartate transaminase (AST), alanine transaminase (ALT) and a...

Medicinal plants are part of human society to combat diseases. Azadirachta indica evidently has great medicinal potentials. This work was undertaken to investigate the morphological and some enzymatic effect of A. indica extract on the tissues of the liver. Twenty four (24) adult Wistar rats of both sexes, average weight, 195g were randomly divided...