Silke Salavati (nee Schmitz)

Silke Salavati (nee Schmitz)
The University of Edinburgh | UoE · Royal (Dick) School of Veterinary Studies

Dr.med.vet. Dipl ECVIM-CA, PhD

About

53
Publications
9,945
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458
Citations
Introduction
Graduated in vet medicine from JLU Giessen, Germany. Internship and Residency in Small Animal Internal Medicine in Giessen. PhD at the Royal Veterinary College, London (studying the effects of the probiotic Enterococcus faecium on canine chronic enteropathy). From 2013 to 2016 junior lecturer in Small Animal Internal Medicine in Giessen. Since 2016 senior lecturer at the Hospital for Small Animals, Royal (Dick) School of Veterinary Studies, University of Edinburgh.
Additional affiliations
October 2013 - April 2016
Justus-Liebig-Universität Gießen
Position
  • Lecturer
October 2009 - September 2013
Royal Veterinary College
Position
  • PhD Student
October 2009 - October 2013
University of London
Position
  • PhD Student

Publications

Publications (53)
Article
Full-text available
Objectives: Current blood tests to diagnose feline liver diseases are suboptimal. Serum concentrations of microRNA (miR)-122 have been shown in humans, dogs and rodents to be a sensitive and specific biomarker for liver injury. To explore the potential diagnostic utility of measuring serum concentrations of miR-122 in cats, miR-122 was measured in...
Article
To assess small animal practitioner's awareness of the relatively novel procedure of faecal microbiota transplantation (FMT) in dogs and their practices, indications, experience and assessment of outcome of this in canine patients. An anonymous online questionnaire was distributed to practitioners in the UK and around the world, assessing demograph...
Article
Probiotics/or synbiotics products for small animals do not fulfill the criteria required to qualify as a probiotic. Studies explaining modes of action are lacking. Outcome measures are inconsistent, with some trials assessing only nonspecific routine diagnostic parameters or fecal scores. Preliminary evidence shows that specific preparations are be...
Article
Full-text available
Background Minimally invasive diagnostic imaging techniques to detect intestinal inflammation in dogs are lacking. Contrast‐enhanced ultrasound (CEUS) and endoscopic narrow band imaging‐like endoscopy (Storz Professional Image Enhancement System [SPIES]) might allow quantification of intestinal mucosal perfusion and microvessel density in chronic i...
Article
A six-year-old male entire dachshund presented for investigation of decreased testicular size noted over the last six months and progressive lethargy for two months. Apart from small symmetrical testicles and a small prostate gland, physical examination revealed no abnormalities. Neurological examination was repeatably normal. Extensive diagnostic...
Article
Full-text available
Background Dogs with hypoadrenocorticism (HA) frequently show signs of gastrointestinal disease (SGD). The prevalence of dogs presented for chronic SGD with HA is unknown. Objectives The aims of this study were to determine the prevalence of HA in dogs with chronic SGD and to identify clinical and laboratory variables for HA in this population. A...
Article
A 7-year-old male neutered crossbreed dog was presented for investigation of a 2-year history of worsening aggression and changes in behavior. Complete hematology, serum biochemistry, ammonia, basal cortisol, total thyroxine, ionized calcium, testosterone levels, urine analysis, magnetic resonance imaging and cerebrospinal fluid were unremarkable....
Chapter
Gastrointestinal (GI) motility disorders are a diagnostic and therapeutic challenge. They can consist of delayed or accelerated transit times as well as impaired or inappropriate relaxation anywhere in the GI tract. The classic clinical sign of esophageal disease is regurgitation. Survey radiographs do not assess esophageal motility, but can be inf...
Article
Full-text available
Chronic diarrhoea is a frequent complaint in canine practice and the diagnostic path is often characterised by numerous diagnostic tests and stepwise empirical treatments, often applied before gastrointestinal (GI) endoscopy/mucosal biopsies. These include dietary interventions (novel protein, hydrolysed protein diet), parasiticides and still, in m...
Article
Full-text available
Background: Idiopathic renal hematuria (IRH) generally occurs in healthy large-breed dogs that are <2-years-old. It is characterized by recurrent bleeding from the kidneys of unidentified cause. The final diagnosis is reached through the exclusion of primary urinary system and systemic causes of hematuria along with the direct visualization by cys...
Article
Background Chronic enteropathies (CEs) are a common cause of morbidity in dogs. CEs are diagnosed in dogs with chronic gastrointestinal clinical signs (>3 weeks), inflammatory changes on intestinal biopsies and where no other underlying cause is determined based on a thorough, standardised diagnostic work-up. Based on response to therapy, CEs are s...
Article
Full-text available
Hepatic encephalopathy is a frequent and debilitating complication of liver disorders. Lactulose is an established and reasonably effective treatment, yet with incompletely understood mechanisms of action. The aims of this study were to examine how the faecal microbiota composition changed before, during and after lactulose treatment in a large ani...
Article
Full-text available
Background: Canine chronic enteropathies (CE) are a group of intestinal diseases that can be categorized based on treatment response into diet- or food- responsive enteropathy (FRD), antibiotic-responsive enteropathy, steroid-responsive enteropathy, and non-responsive enteropathy. CE can often be associated with intestinal dysbiosis and thus admini...
Article
Full-text available
Background: Protein-losing enteropathy (PLE) because of chronic inflammatory enteropathy (CIE) in dogs is often treated with a combination of glucocorticoids and second-line immunosuppressant (SLI). This combined approach might not be necessary in all dogs. Hypothesis/objectives: To describe diagnostic features and outcomes of dogs with PLE trea...
Article
Full-text available
Background: Idiopathic esophageal dysmotility (ED) is increasingly recognized in young dogs of brachycephalic breeds. Few studies have objectively associated specific videofluoroscopic swallowing study (VFSS) features with brachycephaly, leading to under-recognition of ED in brachycephalic breeds. Hypothesis/objectives: To describe and compare V...
Article
Full-text available
Acinetobacter species can be important opportunistic pathogens in humans, especially in healthcare settings. We report here the first isolation ofAcinetobacter ursingiifrom an animal species; it was isolated from a canine urinary tract infection, and phenotypic identification proved unreliable.
Article
Objective: To assess if prebiotics at different concentrations can accelerate the growth of selected probiotic bacterial strains. Materials and methods: Enterococcus (E.) faecium NCIMB 10415 E1707 was chosen as it is the most common probiotic strain used for small animals. In addition, E. faecium NCIMB 30183, Bifidobacterium (B.) longum NCIMB 30182...
Article
Abstract Objective: To assess if prebiotics at different concentrations can accelerate the growth of selected probiotic bacterial strains. Materials and methods: Enterococcus (E.) faecium NCIMB 10415 E1707 was chosen as it is the most common probiotic strain used for small animals. In addition, E. faecium NCIMB 30183, Bifidobacterium (B.) longum NC...
Article
Background: Idiopathic purulent mesenteric lymphadenitis or lymph node abscessation, even though rare in dogs, are important diseases in which rapid diagnosis and treatment is critical. This study aimed to characterise the typical features of these conditions in dogs. Material and methods: Archived records from 2005 to 2015 were retrospectively...
Article
Objective: Delayed gastric emptying is a well-recognised phenomenon in a number of canine disease conditions. Only a limited number of drugs have been reported to have some gastrokinetic effect in the dog. The aim of this study was to investigate prokinetic effects of maropitant. Material and methods: In a cross-over study 24 healthy adult Beagl...
Article
A two-year-old female French bulldog was presented for chronic large bowel diarrhoea. The dog had been suspected to have granulomatous colitis, but no improvement was noted with enrofloxacin treatment. Diagnosis was confirmed by histology and fluorescent in situ hybridisation. Isolated Escherichia coli strains showed multiple resistances to antimic...
Article
In a female dog with unspecific clinical symptoms, sonography detected a hyperechoic mass in the middle abdomen and blood analysis a middle grade systemic inflammatory reaction. Laparotomy revealed a peritoneal larval cestodosis (PLC). The diagnosis of an infection with tetrathyridia of Mesocestoides spp. was confirmed by parasitological examinatio...
Article
Full-text available
Interest in the composition of the intestinal microbiota and possibilities of its therapeutic modifications has soared over the last decade and more detailed knowledge specific to the canine microbiota at different mucosal sites including the gut is available. Probiotics, prebiotics or their combination (synbiotics) are a way of modifying the intes...
Article
Inflammasomes coordinate the maturation of IL-1β and IL-18 in response to danger signals. They are vital for maintenance of intestinal homeostasis and have been linked to chronic intestinal inflammation in humans. Probiotics have been advocated as treatment in intestinal inflammation. So far, no study has investigated the role of the inflammasome i...
Article
Canine chronic enteropathies (CE) are believed to be caused by an aberrant immune response towards the intestinal microbiome. Administration of probiotics can alleviate colitis in people. In vitro effects of the probiotic Enterococcus faecium NCIMB 10415 E1707 (EF) previously have been evaluated using canine cells (e.g., whole blood, intestinal bio...
Article
Objective: To directly compare solid-phase gastric emptying times assessed by means of a [(13)C]sodium acetate breath test ([(13)C]-SABT) and technetium Tc 99m albumin colloid radioscintigraphy ((99m)Tc-ACR) in healthy cats. Animals: 12 healthy cats. Procedure: After ingestion of a test meal containing 50 mg of [(13)C]sodium acetate and 250 MB...
Article
The composition of the microbiome plays a significant role in the pathogenesis of Inflammatory Bowel Disease (IBD) in humans and chronic enteropathies (CE) in dogs. The administration of probiotic microorganisms is one way of modulating the microbiome, but experiments elucidating mechanisms of action of probiotics in the intestine of healthy and CE...
Article
Full-text available
Objective: The aim of the study was to assess solid phase gastric emptying via non-invasive 13C-sodium acetate breath test in large breed dogs with or without gastric dilatation-volvulus (GDV). Material and methods: Dogs were recruited into one of the following groups: group 1 = healthy large breed dogs with no history of GDV, group 2 = dogs tha...
Article
Trefoil factors (TFF) are small peptides produced by goblet cells, which are crucial for epithelial restitution. In humans with inflammatory bowel disease (IBD), TFF expression is up-regulated as part of an unspecific repair mechanism. The goal of this study was to assess TFF gene expression in the gastrointestinal tract from dogs with IBD compared...
Article
Inflammatory bowel disease (IBD) is a common cause of chronic diarrhoea in dogs. Diagnosis of canine IBD is often challenging and relies on an exclusion diagnosis with histopathological assessment of intestinal mucosal biopsies. Therefore, non-invasive serological markers may help to simplify diagnosis and possibly predict prognosis in canine IBD....
Article
CD11c serves as a marker for human and murine dendritic cells (DCs) and cells expressing this marker have been shown to have similar morphological and functional characteristics in the canine immune system. The aim of this study was to quantify CD11c(+) cells in the duodenum, ileum and colon of healthy dogs and dogs with inflammatory bowel disease...
Article
Full-text available
Gastric emptying disorders are known in the dog and cat as a primary process as well as a secondary phenomenon to different underlying diseases. Diagnosing gastric emptying disorders remains difficult in veterinary medicine; however, gastric scintigraphy is considered the gold standard method. Unfortunately, determination of reference values is pro...
Article
Full-text available
Objective: The aim of the study was to assess solid gastric emptying via non-invasive 13C-sodium acetate breath test and compare this technique to 99mTechnetium scintigraphy in 12 healthy adult dogs. Material and methods: The dogs were fed a test meal containing either 100mg 13C-sodium acetate or 150-250 MBq 99mTechnetium albumin colloid. Breath...
Article
Full-text available
The clinical and laboratory findings in a 1-year-old male Jack Russel Terrier dog with lung worm induced coagulopathy are described. The diagnosis was based upon history, clinical findings, radiography, endoscopy, cytology and laboratory results. The presenting complaint was chronic cough. Radiographically, a diffuse interstitial to bronchial lung...
Article
Full-text available
Different antibody-based tests for rapid detection of Canine parvovirus antigens in feces are commercially available, allowing quick diagnosis in a clinical setting. However, the diagnostic accuracy of these tests compared with standard methods has not been evaluated so far. In the current study, 3 commercial tests were compared with immune-electro...
Article
Im Folgenden werden die klinischen und labordiagnostischen Befunde eines 1-jahrigen mannlichen Jack Russel Terriers mit einer Koagulopathie aufgrund einer Lungenwurminfektion beschrieben. Die Diagnose basierte auf den anamnestischen, klinischen, radiologischen, endoskopischen, zytologischen und labordiagnostischen Befunden. Klinisch stand chronisch...
Article
This is a case report of an 8-year-old female spayed European Shorthair cat with idiopathic hyperaldosteronism and includes a discussion of the clinical and laboratory findings. The diagnosis was based upon the history, clinical examination, ultrasonography and laboratory results. The most obvious clinical signs were an acute onset of blindness wit...
Article
Full-text available
Gastric emptying disorders are known in the dog as a primary process as well as a secondary phenomenon to different underlying diseases. Understanding the physiological processes in gastric motility, knowledge about the chief influences and regulatory mechanisms of gastric emptying and about the main differential diagnoses for delayed gastric empty...
Article
Full-text available
The gold standard method to assess gastric emptying in both humans and animals has been suggested to be 99mT scintigraphy. Lately, non-invasive 13C-breath tests have been used successfully as an alternative in human medicine, but have not been compared to scintigraphy in the dog. The aim of this study was to evaluate the 13C-sodium acetate breath t...

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