Silke Anders

Universität zu Lübeck · Klinik für Neurologie

Current theories in cognitive neuroscience assume that internal simulation, i.e., the reproduction of brain activity underlying another person’s inner state and behaviour in the perceiver’s brain, plays an important role in understanding others. Here we test the prediction that common neural activity during facial communication of affect leads to i...

Observational and experimental studies have shown that sleep deprivation disinhibits emotional responses to disturbing and rewarding external events. On the other hand, most studies on sleep deprivation and interpersonal emotion recognition report that sensitivity to others’ emotions is dampened during sleep deprivation. This is at odds with curren...

Background: Affective dysfunctions are common in patients with Parkinson's disease, but the underlying neurobiological deviations have rarely been examined. Parkinson's disease is characterized by a loss of dopamine neurons in the substantia nigra resulting in impairment of motor and non-motor basal ganglia-cortical loops. Concerning emotional def...

Significance Humans interacting with other humans must be able to understand their interaction partner’s affect and motivations, often without words. We examined whether people are attracted to others whose affective behavior they can easily understand. For this, we asked participants to watch different persons experiencing different emotions. We f...

Social context plays an important role in human communication. Depending on the nature of the source, the same communication signal might be processed in fundamentally different ways. However, the selective modulation (or “gating”) of the flow of neural information during communication is not fully understood. Here, we use multivoxel pattern analys...

Research on the mechanisms underlying human facial emotion recognition has long focussed on genetically determined neural algorithms and often neglected the question of how these algorithms might be tuned by social learning. Here we show that facial emotion decoding skills can be significantly and sustainably improved by practice without an externa...

The goal of this study was to test whether central mechanisms of scratching-induced itch attenuation can be activated by scratching the limb contralateral to the itching limb when the participant is made to visually perceive the non-itching limb as the itching limb by means of mirror images. Healthy participants were asked to assess the intensity o...

Imitation of facial expressions engages the putative human mirror neuron system as well as the insula and the amygdala as part of the limbic system. The specific function of the latter two regions during emotional actions is still under debate. The current study investigated brain responses during imitation of positive in comparison to non-emotiona...

By minimizing the zero-norm of the separating hyperplane, the support feature machine (SFM) finds the smallest subspace (the least number of features) of a data set such that within this subspace, two classes are linearly separable without error. This way, the dimensionality of the data is more efficiently reduced than with support vector-based fea...

We used functional magnetic resonance imaging (fMRI) to investigate brain processes underlying control of emotional responses towards a person in distress by cognitive social distance modulation. fMRI and peripheral physiological responses (startle response and electrodermal activity) were recorded from 24 women while they watched victim-offender s...

Modern functional brain imaging methods (e.g. functional magnetic resonance imaging, fMRI) produce large amounts of data. To adequately describe the underlying neural processes, data analysis methods are required that are capable to map changes of high-dimensional spatio-temporal patterns over time. In this paper, we introduce Multivariate Principa...

Patients with Parkinson's disease suffer from significant motor impairments and accompanying cognitive and affective dysfunction due to progressive disturbances of basal ganglia-cortical gating loops. Parkinson's disease has a long presymptomatic stage, which indicates a substantial capacity of the human brain to compensate for dopaminergic nerve d...

Ziele / Fragestellung: Um neurodegenerative Prozesse in verschiedenen neurologischen und psychiatrischen Erkrankungen mittels Resting-state-fMRI zu untersuchen, beschäftigen sich bestehende Arbeiten überwiegend mit faktorenanalytischen Verfahren (PCA/ICA). In dieser Studie untersuchen wir ob sich die Krankheitsstadien des M. Parkinson anhand global...

Zusammenfassung Seit dem Aufkommen der funktionellen Magnetresonanztomografie (fMRT) vor 20 Jahren steht eine neue Methode zur nicht invasiven Messung von Gehirnfunktionen zur Verfügung, welche in den kognitiven Neurowissenschaften inzwischen weit verbreitet ist. Traditionell wurden fMRT-Daten vor allem verwendet, um globale Änderungen der Aktivitä...

Previous studies have shown overlapping neural activations for observation and execution or imitation of emotional facial expressions. These shared representations have been assumed to provide indirect evidence for a human mirror neuron system, which is suggested to be a prerequisite of action comprehension. We aimed at clarifying whether shared re...

Theories of emotion propose that responses to emotional pictures can occur independently of whether or not people are aware of the picture content. Because evidence from dissociation paradigms is inconclusive, we manipulated picture awareness gradually and studied whether emotional responses varied with degree of awareness. Spider fearful and non-f...

The advent of functional magnetic resonance imaging (fMRI) of brain function 20 years ago has provided a new methodology for non-invasive measurement of brain function that is now widely used in cognitive neuroscience. Traditionally, fMRI data has been analyzed looking for overall activity changes in brain regions in response to a stimulus or a cog...

Mentalizing, i.e. the process of inferring another person's mental state, is thought to be primarily subserved by three brain regions, the VMPFC (ventromedial prefrontal cortex), precuneus and TPJ (temporo-parietal junction). However, it is still unclear what the exact roles of these regions in mentalizing are. Here, we compare activity within, and...

Supplementary materials.

When people interact, affective information is transmitted between their brains. Modern imaging techniques permit to investigate the dynamics of this brain-to-brain transfer of information. Here, we used information-based functional magnetic resonance imaging (fMRI) to investigate the flow of affective information between the brains of senders and...

Classification-based data analysis is receiving increasing attention in neuroimaging. Here we decode the real-life relation between senders and perceivers of facial signals of affect by measuring the similarity of their brain activity during affective communication. Our results show that the brain activity of romantic partners is more similar durin...

Affective neuroscience has been strongly influenced by the view that a 'feeling' is the perception of somatic changes and has consequently often neglected the neural mechanisms that underlie the integration of somatic and other information in affective experience. Here, we investigate affective processing by means of functional magnetic resonance i...

This event-related functional magnetic resonance imaging (fMRI) study investigated brain activity elicited by emotional adjectives during silent reading without specific processing instructions. Fifteen healthy volunteers were asked to read a set of randomly presented high-arousing emotional (pleasant and unpleasant) and low-arousing neutral adject...

With the advent of studies showing that amygdala responses are not limited to fear-related or highly unpleasant stimuli, studies began to focus on stimulus valence and stimulus-related arousal as predictors of amygdala activity. Recent studies in the chemosensory domain found amygdala activity to increase with the intensity of negative and positive...

Gender specific differences in cognitive functions have been widely discussed. Considering social cognition such as emotion perception conveyed by non-verbal cues, generally a female advantage is assumed. In the present study, however, we revealed a cross-gender interaction with increasing responses to the voice of opposite sex in male and female s...

The capacity to voluntarily regulate emotions is critical for mental health, especially when coping with aversive events. Several neuroimaging studies of emotion regulation found the amygdala to be a target for downregulation and prefrontal regions to be associated with downregulation. To characterize the role of prefrontal regions in bidirectional...

Amyotrophic lateral sclerosis (ALS), a progressive motor neuron disease, affects movement and communication abilities and emotional processing. Subjective ratings of emotional stimuli depicting social interactions and facial expressions differed significantly between ALS patients and healthy controls in a previous study with a reduction of negative...

Interactive paradigms inducing reactive aggression are absent in the brain mapping literature. We used a competitive reaction time task to investigate brain regions involved in social interaction and reactive aggression in sixteen healthy male subjects with fMRI. Subjects were provoked by increasingly aversive stimuli and were given the opportunity...

Emotional information can be conveyed by various means of communication, such as propositional content, speech intonation, facial expression, and gestures. Prior studies have demonstrated that inputs from one modality can alter perception in another modality. To evaluate the impact of emotional intonation on ratings of emotional faces, a behavioral...

This study was conducted to investigate the connectivity architecture of neural structures involved in processing of emotional speech melody (prosody). 24 subjects underwent event-related functional magnetic resonance imaging (fMRI) while rating the emotional valence of either prosody or semantics of binaurally presented adjectives. Conventional an...

Functional magnetic resonance imaging was used to investigate hemodynamic responses to adjectives pronounced in happy and angry intonations of varying emotional intensity. In separate sessions, participants judged the emotional valence of either intonation or semantics. To disentangle effects of emotional prosodic intensity from confounding acousti...

Empathy is the ability to perceive and understand other people's emotions and to react appropriately. This ability is a necessary prerequisite for successful interpersonal interaction. Empathy is a multifaceted construct including low-level mechanisms like emotional contagion as well as high-level processes like perspective-taking. The ability to e...

Amyotrophic lateral sclerosis (ALS) is a fatal disease, leaving the patient in a partially or completely deafferented state. In an explorative study, we investigated responses to visual socio-emotional stimuli in ALS patients. Pictures from the International Affective Picture System (IAPS) were verbally judged by 12 moderately affected ALS patients...

A left visual hemifield advantage for the processing of negative facial expressions has been demonstrated in a variety of studies. We tested whether the same effect is found for a neutral facial expression that had acquired a negative meaning through pairing with an aversive event. Startle reflex amplitudes, skin-conductance responses (SCR), and tw...

To investigate lateralization of duration and pitch discrimination processing with emphasis on the influences of task difficulty, we used event-related functional magnetic resonance imaging. Seventeen healthy volunteers performed paired auditory discrimination tasks at varying levels of difficulty. Analysis of lateralization effects revealed leftwa...

In addition to the propositional content of verbal utterances, significant linguistic and emotional information is conveyed by the tone of speech. To differentiate brain regions subserving processing of linguistic and affective aspects of intonation, discrimination of sentences differing in linguistic accentuation and emotional expressiveness was e...

Emotional behavior is organized along two psychophysiologic dimensions: (1) valence, varying from negative to positive, and (2) arousal, varying from low to high. Behavioral responses along these dimensions are assumed to be mediated by different brain circuits. We recorded startle reflex modulation and skin conductance responses in healthy volunte...

Amplitude modulation of the eyeblink component of the startle response is a commonly used index for the emotional state of an organism. The use of electromyography (EMG) to determine startle eyeblink amplitudes during functional magnetic resonance imaging (fMRI) is limited as interactions between strong switching magnetic fields, radio pulses and e...

To investigate the neural substrates underlying emotional feelings in the absence of a conscious stimulus percept, we presented a visual stimulus in the blind field of partially cortically blind patients and measured cortical activity (by functional magnetic resonance imaging, fMRI) before and after the stimulus had been paired with an aversive eve...

Einleitung: In Verhaltensstudien zur Verarbeitung emotionaler Reize konnte eine wechselseitige Beeinflussung von emotionaler Mimik (eM) und affektiver Prosodie (aP) nachgewiesen werden (1). Auserdem konnte gezeigt werden, dass es zu Aktivierung der Amygdala kommt, wenn Kongruenz im emotionalen Gehalt von akustisch und visuell prasentierten Reizen b...

Motor training consisting of voluntary movements leads to performance improvements and results in characteristic reorganizational changes in the motor cortex. It has been proposed that repetition of passively elicited movements could also lead to improvements in motor performance. In this study, we compared behavioural gains, changes in functional...