Silje Bakken Jørgensen

Silje Bakken Jørgensen
Akershus universitetssykehus | Ahus · Department of Clinical Microbiology and Infection Control

Doctor of Medicine

About

51
Publications
3,615
Reads
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422
Citations
Introduction
Silje Bakken Jørgensen currently works at the Department of Clinical Microbiology and Infection Control, Akershus universitetssykehus and at the Norwegian Institute of Public Health. Silje does research in Infectious Diseases, Medical Microbiology, and Molecular Biology.
Additional affiliations
April 2014 - present
Vestre Viken Hospital Trust
Position
  • PhD Student

Publications

Publications (51)
Article
Full-text available
Objectives Describe patient transfer patterns within a large Norwegian hospital. Identify risk factors associated with a high number of transfers. Develop methods to monitor intrahospital patient flows to support capacity management and infection control. Design Retrospective observational study of linked clinical data from electronic health recor...
Article
Background Minority groups and immigrants have been hit disproportionally hard by COVID-19 in many developed countries, including Norway. Methods Using individual-level registry data of all Norwegian residents, we compared infections across all multiperson households. A household with at least one member born abroad was defined as an immigrant hou...
Article
Full-text available
Long-COVID-19 is a proposed syndrome negatively affecting the health of COVID-19 patients. We present data on self-rated health three to eight months after laboratory confirmed COVID-19 disease compared to a control group of SARS-CoV-2 negative patients. We followed a cohort of 8786 non-hospitalized patients who were invited after SARS-CoV-2 testin...
Preprint
Full-text available
Background Minority ethnic groups and immigrants have been hit disproportionally hard by COVID-19 in many developed countries, including Norway. Most transmissions of SARS-CoV-2 occur in households. Methods Using individual-level registry data of all Norwegian residents we compared infections across all multi-person households. A household with at...
Article
Full-text available
To characterize the family index case for detected SARS-CoV-2 and describe testing and secondary attack rates in the family, we used individual-level administrative data of all families and all PCR tests for SARS-CoV-2 in Norway in 2020. All families with at least one parent and one child below the age of 20 who lived at the same address (N = 662,5...
Article
Full-text available
Outbreak investigations are essential to control and prevent the dissemination of pathogens. This study developed and validated a complete analysis protocol for faster and more accurate surveillance and outbreak investigations of antibiotic-resistant microbes based on Oxford Nanopore Technologies (ONT) DNA whole-genome sequencing. The protocol was...
Preprint
Full-text available
To characterize the family index case for detected SARS-CoV-2 and describe testing and secondary attack rates in the family, we used individual-level administrative data of all families and all PCR tests for SARS-CoV-2 in Norway in 2020. All families with at least one parent and one child below the age of 20 who lived at the same address (N=662 582...
Preprint
Full-text available
Background: Reported transmission rates of SARS-CoV-2 within families vary widely, and there are few reports on transmission from children to other family members. More knowledge is needed to guide infection control measures. Objective: To characterize the family index case for detected SARS-CoV-2 and describe testing and secondary attack rates in...
Article
Full-text available
Introduction A year into the pandemic, the knowledge of SARS-CoV-2 infection risks among healthcare workers remains limited. In this cross-sectional study, we examined whether healthcare workers with high exposure to Covid-19 patients had a higher risk of SARS-CoV-2 infection than other healthcare workers in a Norwegian University Hospital. We also...
Article
Full-text available
Background During the SARS-CoV-2 pandemic, healthcare workers (HCWs) are exposed to infection both at work and in their communities. Determining where HCWs might have been infected is challenging based on epidemiological data alone. At Akershus University Hospital, Norway, several clusters of possible intra-hospital SARS-CoV-2 transmission were ide...
Preprint
Full-text available
Background The risk factors for SARS-CoV-2 transmission are not well characterised. We sought to identify potential risk factors for transmission and actionable information that can be used to prevent SARS-CoV-2. Methods Individuals tested for SARS-CoV-2 at four accredited laboratories were invited. In addition, participants were recruited through...
Preprint
Full-text available
Background The risk factors for SARS-CoV-2 transmission are not well characterised in Western populations. We sought to identify potential risk factors for transmission and actionable information to prevent for SARS-CoV-2. Methods Individuals tested for SARS-CoV-2 at four major laboratories were invited. In addition, participants were sampled by c...
Article
Blomfeldt A, Jørgensen SB, Helmersen K, Eskonsipo PKJ, Aamot HV. Is increased Staphylococcus aureus colonisation during military service caused by specific genotypes? Molecular examination of long‐term carriage in a prospective cohort study A 22% increase in Staphylococcus aureus colonisation was observed in Norwegian recruits during first year of...
Article
Full-text available
The dynamics related to the loss of stx genes from Shiga toxin-producing Escherichia coli remain unclear. Current diagnostic procedures have shortcomings in the detection and identification of STEC. This is partly owing to the fact that stx genes may be lost during an infection or in the laboratory. The aim of the present study was to provide new i...
Article
Full-text available
Background We aimed to estimate the prevalence of faecal carriage of extended-spectrum cephalosporin (ESC) resistant E. coli and K. pneumoniae (ESCr-EK) and vancomycin resistant enterococci (VRE) in patients upon hospital admission and identify factors associated with carriage to better target interventions and to guide empirical antibiotic treatme...
Poster
Full-text available
Poster at the 18th International Symposium on Staphylococci and Staphylococcal infections (ISSSI), København, August 23-26, 2018
Article
Full-text available
Bakgrunn: I norsk helsevesen gjennomføres omfattende tiltak for å hindre spredning av meticillinresistente Staphylococcus aureus (MRSA). Vi ønsket å undersøke hvor mange smitteoppsporinger som gjøres rundt nyoppdagede MRSA-tilfeller hos pasienter og ansatte i sykehus, og hvor ofte smitteoppsporingene fører til ytterligere funn hos helsepersonell....
Article
Full-text available
Background: Cephalosporin resistance in clinical E. coli isolates is increasing internationally. The increase has been caused by virulent and often multidrug-resistant clones, especially the extended spectrum β-lactamase (ESBL) producing E. coli clone O25b-ST131. Methods: In Norway, recommended empirical treatment of sepsis consists of gentamici...
Article
Full-text available
Extended spectrum β-lactamase producing Escherichia coli (ESBL-EC) are excreted via effluents and sewage into the environment where they can re-contaminate humans and animals. The aim of this observational study was to detect and quantify ESBL-EC in recreational water and wastewater, and perform a genetic and phenotypic comparative analysis of the...
Data
Search settings for ResFinder, PlasmidFinder and VirulenceFinder. (PDF)
Data
Minimum spanning tree of ESBL producing E. coli ST10 MLVA-types. (TIF)
Data
E. coli MLVA-types in recreational water. (XLSX)
Data
Minimum spanning tree of ESBL producing E. coli MLVA-types in different STs. (PDF)
Article
Full-text available
A multidrug-resistant, methicillin-resistant Staphylococcus aureus (MRSA) clone, PVL-positive ST772-MRSA-V, named the Bengal Bay clone, is emerging worldwide. In Norway, where MRSA prevalence is low, a sudden increase in ST772-MRSA-V initiated a nationwide molecular epidemiological study. Clinical data were obtained from the Norwegian Surveillance...
Article
Objectives: Staphylococcus aureus colonization leading to skin and soft tissue infections (SSTI) are known challenges in crowded settings such as the military. The aim of the study was to a) establish and compare the prevalence of S. aureus colonization in recruits at enrolment and discharge after the first year of military service and b) investig...
Article
We hereby report a detection of the plasmid borne mcr-1 gene conferring colistin resistance in an extended-spectrum β-lactamase (ESBL) producing Escherichia coli ST10 strain retrieved from seawater at a public beach in Norway. The sample was collected in September 2010 and was investigated by whole-genome sequencing in 2016. This report illustrates...
Poster
Full-text available
Fluoroquinolone resistance (FQ) in Norwegian Escherichia coli has gradually increased (1). Studies from China and the USA have shown that FQ is observed in heterogeneous strains, with a dominance of the pandemic clone ST131. Simultaneously, ST1193 has been reported, as a new, virulent and resistant E. coli that frequently causes extraintestinal inf...
Article
Full-text available
We have performed a prospective cohort study to investigate the duration of and risk factors for prolonged fecal carriage of ESBL-producing Escherichia coli or Klebsiella pneumoniae in patients with community acquired urinary tract infection caused by these bacteria. From 2009 to 2011, 101 Norwegian patients were recruited. Stool swabs and question...
Data
Epidemiology and sample results. (SAV)
Data
Project protocol English translation. (PDF)
Data
Time-relations between antibiotic treatment and fecal samples. (XLS)
Data
S?raas-2014-High rate of per oral mecillinam treatment failure. (PDF)
Data
S?raas-2013-Risk factors for community acquired urinary tract infection. (PDF)
Article
Full-text available
Objectives: In 2012 and 2014 the Norwegian monitoring programme for antimicrobial resistance in the veterinary and food production sectors (NORM-VET) showed that 124 of a total of 406 samples (31%) of Norwegian retail chicken meat was contaminated with extended-spectrum cephalosporin-resistant Escherichia coli. The aim of this study was to compare...
Article
Full-text available
Background: The Bengal Bay clone, ST772-MRSA-V, associated with multi-drug resistance, Panton-Valentine leukocidin (PVL) and skin and soft tissue infections, is emerging worldwide. In Norway, a country with low prevalence of meticillin-resistant Staphylococcus aureus (MRSA), increased occurrence of ST772-MRSA-V has also caused hospital outbreaks....
Article
Full-text available
Background: We describe an outbreak with an extended-spectrum β-lactamase-producing Klebsiella pneumoniae strain in an intensive care unit in a secondary care hospital in Norway. The outbreak source was a fibreoptic intubation endoscope in which the outbreak strain survived despite chemothermal disinfection in a decontaminator designated for such...
Article
We investigated 197 anaerobic isolates recovered from blood cultures in the period 2009-2013. The isolates included were Bacteroides spp., Clostridium spp., Prevotella spp., Fusobacterium spp. and Gram-positive anaerobic cocci (GPAC). Identification results by MALDI-TOF MS were compared to those obtained by 16S rRNA sequencing, and the MICs of benz...
Conference Paper
Full-text available
Objectives: The aim of this study was to investigate if humans may have acquired cephalosporin resistant Escherichia coli isolates and/or their resistance plasmids from a poultry reservoir. Methods: Cephalosporin resistant E. coli isolates (n=257) with an AmpC phenotype from humans with infections (mostly urinary tract infection or blood stream in...
Article
Full-text available
At the age of 7-8 years a booster of diphtheria, tetanus, acellular pertussis and polio vaccine is recommended for children in Norway. In this cross-sectional study we have analysed the antibody levels against pertussis vaccine antigens in sera from 498 children aged 6-12 years. The purposes of this study were to investigate the duration of the boo...
Article
Full-text available
We conducted a cross-sectional study to examine the prevalence of faecal carriage of extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae in patients with gastroenteritis. During April 2011, all faecal samples submitted to our hospital laboratory were examined for ESBL-producing Enterobacteriaceae. Isolates expressing an ESBL phenot...
Article
Full-text available
A population-based study was performed to investigate the efficacy of mecillinam treatment of community-acquired urinary tract infections (CA-UTI) caused by extended-spectrum β-lactamase (ESBL) producing Escherichia coli. The study was conducted in South-Eastern Norway. Data from patients with CA-UTI caused by ESBL-producing and non-producing (rand...
Article
Full-text available
Background: The number of infections caused by MRSA has increased substantially in Norway in the past decade. It is an objective to prevent MRSA from becoming established in nursing homes and hospitals. The purpose of the article is to describe the features of the development of MRSA cases found in nursing homes in Oslo. Materials and method: We...
Article
Full-text available
Despite rapidly diminishing treatment options for Neisseria gonorrhoeae and high levels of ciprofloxacin resistance worldwide, Norwegian guidelines still recommend ciprofloxacin as empirical treatment for gonorrhea. The present study aimed to characterize phenotypical and genotypical properties of N. gonorrhoeae isolates in Norway in 2009. All viab...

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Projects

Projects (3)
Project
Multi-national prospective cohort-study. Primary objective: To determine the differential impact of inappropriate antibacterial prescription compared to adequate or no antibacterial prescription on intestinal microbiota domination by EPE or VRE or infection with C. difficile.