Sikta ChattopadhyayaUniversity of Manitoba | UMN · Department of Physiology and Pathophysiology
Doctoral Student in Dr. Michael Czubryt's Lab
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Fibroblasts are stromal cells found in virtually every tissue and organ of the body. For many years, these cells were often considered to be secondary in functional importance to parenchymal cells. Over the past 2 decades, focused research into the roles of fibroblasts has revealed important roles for these cells in the homeostasis of healthy tissu...
Fibrosis is an energy-intensive process requiring the activation of fibroblasts to myofibroblasts, resulting in the increased synthesis of extracellular matrix proteins. Little is known about the transcriptional control of energy metabolism in cardiac fibroblast activation, but glutaminolysis has been implicated in liver and lung fibrosis. Here we...
Cardiac fibrosis is an aberrant wound healing process involving excessive production of extracellular matrix proteins resulting in impaired systolic and diastolic function of the heart, contributing to heart failure and death. Glutaminolysis, which involves conversion of glutamine to glutamate by glutaminase (GLS), and conversion of glutamate to α-...
Cardiovascular diseases are responsible for high mortality rates throughout the world, and diseases specifically affecting the myocardium including fibrosis, myocardial infarction, arrhythmias, and cardiomyopathies leading to cardiac dysfunction and heart failure remain significant contributors to this problem. For decades, therapeutic intervention...
The major distinguishing feature of fibrosis is significant deposition of collagen and other extracellular matrix (ECM) proteins, which can result in scarring if sufficiently excessive. Fibrosis affects many tissue types, and thus contributes to a broad group of diseases which, with few exceptions, continues to lack specific therapy. It has been es...