Sijie Tan

Sijie Tan
Nanyang Technological University | ntu · Division of Molecular Genetics and Cell Biology

Doctor of Philosophy

About

11
Publications
2,575
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100
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Publications

Publications (11)
Chapter
Macroautophagy has generated considerable interest because of its ability to recognize and target protein inclusions found prevalent in neurodegenerative diseases to lysosomes for elimination. Pharmacological upregulation of macroautophagy to remove disease-linked aggresomes has been reported to slow down disease progression and to improve survivab...
Article
Full-text available
Mitochondria are important bioenergetic and signalling hubs critical for myriad cellular functions and homeostasis. Dysfunction in mitochondria is a central theme in aging and diseases. Mitophagy, a process whereby damaged mitochondria are selectively removed by autophagy, plays a key homeostatic role in mitochondrial quality control. Upregulation...
Article
Full-text available
Mitochondrial dysfunction underscores aging and diseases. Mitophagy (mitochondria + autophagy) is a quality control pathway that preserves mitochondrial health by targeting damaged mitochondria for autophagic degradation. Hence, molecules or compounds that can augment mitophagy are therapeutic candidates to mitigate mitochondrial-related diseases....
Article
Autophagy is an evolutionary conserved, self-eating process that targets cellular constituents for lysosomal degradation. Transcription factor EB (TFEB) is a master regulator of autophagy by inducing the expression of genes involved in autophagic and lysosomal degradation. In breast cancer, ligand-activated progesterone receptor has been reported t...
Article
Full-text available
Toxoplasma gondii is an obligate intracellular parasite that mainly infects warm-blooded animals including humans. T. gondii can encyst and persist chronically in the brain, leading to a broad spectrum of neurological sequelae. Despite the associated health threats, no clinical drug is currently available to eliminate T. gondii cysts. In a continuo...
Chapter
Mitochondrial dysfunction is a major driver of aging. Mitochondrial failure potentiates multiple declines in the homeostatic network that maintains health and precipitates many hallmarks of aging. Mitochondria are not just for energy production; the organelle also serves as an important signaling hub that coordinates many essential cellular process...
Preprint
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Mammalian Target of Rapamycin (mTOR) is a master regulator of autophagy and lysosomes, and its downstream kinase-dependent pathways have been extensively characterized. Here, we report an unexpected kinase-independent regulation of autophagy and lysosomes by S-nitrosylation at Cys423 position of mTOR that resulted in suppression of VPS34 and PIKfyv...
Article
Full-text available
Neurotoxoplasmosis, also known as cerebral toxoplasmosis, is an opportunistic chronic infection caused by the persistence of parasite Toxoplasma gondii in the latent cystic form in the brain. In wild animals, chronic infection is associated with behavioral manipulation evident by an altered risk perception towards predators. In humans, reactivation...

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