
Sijani PrahastutiMaranatha Christian University | Maranatha · Faculty of Medicine
Sijani Prahastuti
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32
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Publications
Publications (32)
Leukemia, characterized by abnormal leukocyte proliferation, ranks ninth in Indonesia as the most common cancer. While treatments such as chemotherapy and radiation effectively target cancer cells, they also risk damaging healthy blood cells. This has spurred interest in exploring low-toxicity herbal compounds as potential therapies, with mangostee...
Massive tubule fibrosis is a histopathology hallmark of chronic renal failure (CRF). The previous study of protein hydrolysate of green pea (Pisum sativum) bromelain (PHGPB) showed promising results as an antifibrosis in glucose-induced renal mesangial culture cells, by decreasing their TGF-β levels. In this experiment the anti-inflammatory, anti-f...
Background
Chronic kidney disease (CKD) happens due to decreasing kidney function. Inflammation and oxidative stress have been shown to result in the progression of CKD. Quercetin is widely known to have various bioactivities including antioxidant, anticancer, and anti-inflammatory activities.
Objective
To evaluate the activity of quercetin to inh...
Despite green peas protein hydrolysate benefits, very few studies have described the potential toxicity. The acute oral toxicity of green peas protein which hydrolyzed by bromelain at a single dose of 5000 mg/kg BW has been evaluated in Swiss Webster mice and did not produce treatment-related signs of toxicity or mortality in any of the animals tes...
Objectives
The protein of green peas (Pisum sativum) hydrolyzed by bromelain (PHGPB) shows an effective renal fibrosis therapy by improving renal function parameters in the CKD rats model. The study aimed to determine anti-fibrotic properties effects of PHGPB and LERGDT on TGF-β1 level/ SMAD 2,3,4 and 7 gene expressions in a fibrosis renal cell lin...
Background and aim
Cis-Diamminedichloroplatinum (II) (Cisplatin) is one of the most synthetic anticancer drug but have several adverse effects and one of them is acute ren failure. Cisplatin can induce nephrotoxicity occur via the toxic generation of reactive oxygen species (ROS). Black soybean (Glycine max L. merr.) has been reported contain high...
The accumulation of high concentrations of cisplatin in the kidneys may cause nephrotoxicity. Cisplatin-induced nephrotoxicity happens through the inflammation of the tubules, and apoptosis, necrosis, and vascular defects. Jati Belanda (Guazuma ulmifolia L.) leave contain various natural compounds and the ethanolic extract of Jati Belanda decreased...
Objectives:
Fibrosis is the major cause of chronic kidney injury and the primary etiology in diabetic glomerulosclerosis. The initial study of protein hydrolysate of green peas hydrolyzed by bromelain (PHGPB) considered it to improve kidney function parameters and showed no fibrosis in histopathology features in gentamicin-induced nephrotoxicity r...
Green peas protein hydrolysate is used in the treatment of kidney disease. Nephrotoxicity of gentamicin (GM) is known to be involved in kidney changes, dyslipidemia, and hematology. The aim of the present study is to evaluate the effects of three doses of green peas protein hydrolysate bromelain (GPPHB) as antinephrotoxicity and antihyperlipidemia...
Guazuma ulmifolia, or commonly known as the bastard cedar, has many pharmaceutical activities and is, therefore, claimed as a source of various plant-based medicines. This reserach was purposed to identify the antioxidant activities of the ethanolic extract of G. ulmifolia (EEGU) by phytochemical screening assay, total flavonoid and total phenolic...
Dyslipidemia is a risk factor for Non Alcoholic Fatty Liver Disease causing hepatocyte damage. Bee pollen has hypolipodemic, anti-inflammatory effects. The purpose of the study was to analyze the effects of Bee Pollen on the levels of SGOT, SGPT, and its effects on the liver’s histopathologic. The experimental laboratory research method, 30 rats di...
Chronic Kidney Disease (CKD) has increased incidence and prevalence in developing nations. In this in vitro study, we evaluated the cells proliferative effects, fibronectin (FN), transforming growth factor β (TGF-β1), and Reactive oxygen species (ROS) - level inhibition potential of ethanol extract of detam 1 soybean seed (EEDS) on glucose-induced...
Inflammation response is related with various diseases. One of the useful therapeutic method to suppress inflammatory mediator synthesis is by application of compounds isolated from herbal medicine as treatment for inflammatory diseases. The aim of this study was to analyse the anti-inflammatory activity of black soybean extract (BSE), daidzein, an...
Antioxidants in chemical terms are electron donors and antioxidants are biologically compounds that can overcome the negative effects of oxidants in the body such as damage to vital cells of the body. The balance between oxidants and antioxidants is very important. Antioxidant from natural sources are safer than synthetic antioxidants. Soybeans are...
Objectives:
Kidney disease is a global health problem that needs a solution to its therapy. In the previous study, we found that protein hydrolysate of green peas origin of Indonesia hydrolysed by bromelain (PHGPB) showed improve kidney function in cisplatin-induced nephropathy rats. In this study, we investigated the effect of PHGPB to obtain eff...
Background: People with diabetes mellitus in Indonesia are predicted to increase until 2035. High glucose in body (hyperglycemia) leads to increased fibronectin synthesis. Fibronectin that gets accumulated in glomerulus (mesangial cells), at the end, will lead to diabetic glomerulosclerosis. Jati belanda (Guazuma ulmifolia L.) leaf is well known as...
The usage of Cisplatin (CP) can cause side effects such as toxicity and impaired kidneyfunction. Poor kidney function causes dyslipidemia and hyperuricemia. Researchers in Canadastate that pea protein hydrolysates can improve kidney function. The aim was to examine thehypolipidemic effect of 8 types of pea protein hydrolysate on lipid profiles and...
Context: Chronic kidney disease (CKD) can lead to terminal kidney failure. Previous study has shown that protein hydrolysate in yellow peas (Pisum sativum L.) can be used as a natural remedy for CKD. Aims: To obtain hydrolysate protein that is most effective in improving kidney function of cisplatin (CP)-induced Wistar rats, based on urea, creatini...
Introduction: Renal damage can be caused by various causes. One of them is drugs that are toxic to the renal, such as cisplatin (CP). In an attempt to find a remedy for antinephrotoxicity, several hydrolyzed proteins were investigated. This study was conducted to find out the effects of 8 peas protein hydrolysates (PPH) hydrolyzed using simple proc...
Subchronic toxicity test is performed to evaluate the eff ect and monitor the toxicity eff ects of
a compound. The use of combination of ethanol extract of Detam 1 soybean (EEDS) and Jati Belanda
(EEJB) as an antiobesity therapy will be consumed for a long time, therefore this test need to be done.
The purpose of this research is to know the subchr...
The combination of Detam 1 soybean and Jati Belanda leaves proved to have effect of weight loss. Since it will become longterm using, toxicity effectvresearch is needed. This study was conducted to determine the effect of subchronic combination of ethanol extract of soybean Detam 1 (EEDS) and Jati belanda (EEJB) on kidney function, with parameters:...
Objective: As an antiobesity therapy, combination extracts of Detam 1 soybean and Jati Belanda will be consumed for a long time; therefore, their toxicities to the liver need to be investigated. To determine the effect of subchronic toxicity test of combination of ethanol extract of Detam 1 soybean (EEDS) and ethanol extract of Jati Belanda (EEJB)...
p class="Abstract">In this study, we evaluated the effects of ethanol extracts of Detam 1 soybean, Jati belanda leaf, and the combination toward expression of peroxisome proliferator-activated receptor gamma (PPARγ), CCAAT/enhancer-binding protein alpha (C/EBPα), and stearoyl-CoA desaturase 1 (SCD1) genes in 3T3-L1 cells as anti-adipogenesis and an...
Soybean Detam 1 and Jati Belanda leaves are potential alternative medicines for treating dyslipidemia. The purpose of this study is to explore the potential of the combination of Ethanolic Extract Soybean Detam 1 (EEKD) and Jati Belanda (EEJB) in lowering LDL cholesterol and triglycerides compared to single extract and Simvastatin. Using a real lab...
Background: Anti-Nutritional-Factors (ANF) are natural or synthetic compounds that interfere with the absorption of nutrients. ANF may cause changes in the histopathology of the small intestinal mucosa, and may affect the digestive, secretory and absorptive functions of the small intestine. Soybean and Jati Belanda leaves which can promote weight l...
Salah satu pilihan pengelolaan obesitas adalah memperlambat absorbsi asam lemak dengan cara menginhibisi enzim lipase dalam saluran pencernaan. Inhibitor lipase pankreas dilaporkan telah berhasil dalam pengelolaan terapi obesitas. Senyawa aktif dalam Jati Belanda dan kedelai dapat berfungsi sebagai inhibitor lipase. Tujuan penelitian ini adalah men...
Intake of excess high fat feeding in long term, especially accompanied with sedentary lifestyle, can lead to obesity and may caused fatty liver. The research objective was to determine the most effective dose of Calcium in inhibition of weight gain and improvement of histopathologic fatty liver in male Wistar rats that fed high fat feeding (HFF). T...
Intake of excess high fat feeding in long term, especially accompanied with sedentary lifestyle, can lead to obesity and may caused fatty liver. The research objective was to determine the most effective dose of Calcium in inhibition of weight gain and improvement of histopathologic fatty liver in male Wistar rats that fed high fat feeding (HFF). T...