Sigrid Bjerge Gribsholt

• Aarhus University

Objective This study investigates the overall pattern and timing of medical diagnoses up to 10 years before an anorexia nervosa (AN) diagnosis and explores differences before and after AN diagnosis aiming to improve early detection. Method In this nationwide population‐based cohort study, we included all patients diagnosed with incident AN from 19...

Objectives We examined the association between Roux-en-Y gastric bypass (RYGB) or sleeve gastrectomy (SG) and fracture risk, including major osteoporotic fractures (MOF), and the use of anti-osteoporosis medication (AOM). While RYGB is associated with impaired bone health and increased fracture risk, it remains uncertain whether SG has a similar im...

Objective This study investigates the overall and cause‐specific mortality in males and females with anorexia nervosa (AN) from 1977 to 2018, focusing on the impact of psychiatric comorbidity on mortality risk, a less explored aspect despite a high prevalence in patients with AN. Method We conducted a nationwide population‐based cohort study in De...

Purpose After Roux-en-Y gastric bypass (RYGB), few patients develop severe complications, which ultimately may require reversal of RYGB. We aimed to examine the effect of reversal of RYGB on symptoms and well-being. Materials and Methods Via contact to medical and surgical departments treating patients with RYGB, we identified 18 patients, who had...

Objective: To examine the association between hospital-diagnosed overweight/obesity and incident cardiovascular disease (CVD) according to the time period of the overweight/obesity diagnosis. Design: Cohort study. Methods: From Danish national health registries, we identified all residents with a first-time hospital-based overweight/obesity diagnos...

Body mass index (BMI) is used to screen for under‐ or overweight. However, it is unknown whether BMI‐screening in school children reduces the incidence of overweight and obesity. We aimed to summarise the knowledge on positive and negative consequences on BMI and weight‐related perceptions and behaviours of BMI‐screening followed by an intervention...

Purpose Humans are living longer and may develop multiple chronic diseases in later life. The Better Health in Late Life cohort study aims to improve our understanding of the risks and outcomes of multimorbidity in the Danish population. Methods A randomly-selected sample of Danish residents who were 50–65 years of age received a questionnaire and...

Prior research has reported increased fracture risk in patients with anorexia nervosa (AN), but more knowledge on the long‐term risk, and the effect of age, male sex and time related changes is still needed. We examined the long‐term (up to 40 years) fracture risk among patients with AN compared to a matched comparison cohort from the general popul...

Aim: Weight bias, stigma and discrimination are pervasive in the health care system and society and may result in biased treatment of people living with obesity (PwO). We aimed to identify perceptions, attitudes and potential barriers that exist between people with obesity and health care professionals (HCPs) in Denmark. Methods: The ACTION-DK s...

Purpose Obesity may alter the severity of infection with Coronavirus disease 2019 (COVID‐19). Age may impact the association between body weight and severity of COVID‐19 in patients with obesity. The aim of the study was to examine the association between obesity and severity of infection in a Danish cohort hospitalized with COVID‐19 in the initial...

Purpose Data on long-term mortality among patients with hospital-diagnosed overweight/obesity are limited. Thus, we aim to examine 40-year mortality among patients with hospital-diagnosed overweight/obesity, including cause-specific deaths, secular time trends, and potential effect modification by age, comorbidity, and socioeconomic factors. Patie...

The ongoing coronavirus disease 2019 (COVID‐19) pandemic calls for identification of risk factors, which may help to identify people at enhanced risk for severe disease outcomes to improve treatment and, if possible, establish prophylactic measures. This study aimed to determine whether individuals with obesity compared to individuals with normal w...

Background/objectives Bariatric surgery as treatment of obesity is increasing worldwide. No guidelines exist on which type of bariatric procedure to choose for the individual patient. This study aims to compare Roux-en-Y Gastric bypass (RYGB) and sleeve gastrectomy (SG) with respect to weight loss, complications, comorbidities, and quality of life...

Objective: To examine the association between body mass index (BMI) and mortality after hospitalization for infection because obesity is associated with increased energy reserves that may protect against death from severe infections. Patients and methods: Of 76,044 patients admitted with a primary infection diagnosis from January 1, 2011, to Sep...

Background Postprandial hypoglycemia is a relatively common complication after Roux-en-Y gastric bypass (RYGB). The etiology remains incompletely understood and the association between biochemical hypoglycemia and hypoglycemic symptoms is unclear. Objectives To evaluate the association between postprandial hormonal responses and biochemical and sy...

Background: Obesity is associated with metabolic abnormalities that predispose patients to increased cancer risk. Contemporary data on the long-term risk of specific cancers are sparse among patients with hospital-diagnosed overweight and obesity. Objectives: To examine the overall cancer incidence and specific site-related cancer incidences amo...

Purpose Health care databases may be a valuable source for epidemiological research in obesity, if diagnoses are valid. We examined the validity and completeness of International Classification of Diseases, 10th revision [ICD-10] diagnosis coding for overweight/obesity in Danish hospitals. Patients and methods We linked data from the Danish Nation...

Background Data are sparse on the range of BMI among patients acutely admitted to general hospitals. We investigated BMI values and associated patient characteristics, reasons for hospital admission, and mortality in Denmark. Methods We identified all persons with an acute inpatient admission 2011–2014 in Central Denmark Region and assessed BMI me...

Anatomical Therapeutic Chemical Classification System codes (ATC-codes) for prescription medications from the Danish National Prescription Health Service Database. (DOCX)

Prevalences of prehospital medication users in the cohort according to BMI category. (DOCX)

The 15 most common ICD-10 diagnoses at the three-digit level in the Danish National Patient Registry, according to body mass index category. (DOCX)

ICD-10 codes for conditions included in the Charlson Comorbidity Index. (DOCX)

Prevalence of comorbidities in the Charlson Comorbidity Score, by BMI category. (DOCX)

Diagnosis codes for selected diseases and according to ICD-10 chapters used for disease categories. (DOCX)

Ingenuity Pathway Analysis ‘Disease and Biology’ data used to generate the heat map shown in Figure 3G.DOI: http://dx.doi.org/10.7554/eLife.23813.017

Ingenuity Pathway Analysis results for P3.DOI: http://dx.doi.org/10.7554/eLife.23813.015

Differential expression analysis data.DOI: http://dx.doi.org/10.7554/eLife.23813.012

Ingenuity Pathway Analysis results for P1.DOI: http://dx.doi.org/10.7554/eLife.23813.013

Ingenuity Pathway Analysis results for P2.DOI: http://dx.doi.org/10.7554/eLife.23813.014

Data used to generate the heat maps shown in Figure 3C.DOI: http://dx.doi.org/10.7554/eLife.23813.016

MFN2 encodes mitofusin 2, a membrane-bound mediator of mitochondrial membrane fusion and inter-organelle communication. MFN2 mutations cause axonal neuropathy, with associated lipodystrophy only occasionally noted, however homozygosity for the p.Arg707Trp mutation was recently associated with upper body adipose overgrowth. We describe similar massi...

In observational studies, control of confounding can be done in the design and analysis phases. Using examples from large health care database studies, this article provides the clinicians with an overview of standard methods in the analysis phase, such as stratification, standardization, multivariable regression analysis and propensity score (PS)...

Objective: To examine rates of acute inpatient hospital admissions patients undergoing Roux-en-Y gastric bypass (RYGB) surgery and a matched population-based comparison cohort. Summary background data: Little is known about the admission rates before and after RYGB. Methods: Nationwide population-based cohort study, including all 9985 patients...

A wide range of complications may occur after Roux-en-Y gastric bypass (RYGB) surgery, including surgical, medical/nutritional, and psychiatric complications. Some of the nutritional complications such as anaemia, dumping and hypoglycaemia may present rather unspecific symptoms that may easily not be diagnosed as complications after RYGB. Focus on...

Background: Few population-based studies provide data on mortality after bariatric surgery. We hypothesized that hypoglycemia could be an underdiagnosed cause of death. Objectives: To examine perioperative, all-cause, and cause-specific long-term mortality in Roux-en-Y gastric bypass (RYGB) patients versus population comparisons. Setting: Dani...

Objectives: To evaluate changes over time in drug use among patients undergoing Roux-en-Y gastric bypass (RYGB) surgery and a matched population-based comparison cohort. Background: A little is known about the prescription drug use before and after RYGB surgery. Methods: Nationwide population-based cohort study included 9908 patients undergoing RYG...

Background: Roux-en-Y gastric bypass (RYGB) results in pronounced weight loss in morbidly obese patients but may also cause adverse effects like early dumping and hypoglycemia. Prevalence data on these complications and their potential predictors are sparse. Objective: To assess the prevalence and possible predictors of early dumping and hypogly...

Importance Population-based studies on the prevalence of symptoms after Roux-en-Y gastric bypass (RYGB) surgery are sparse. Knowledge about possible predictors of these symptoms is important for prevention.Objectives To examine patients’ overall well-being and the prevalence and predictors of medical, nutritional, and surgical symptoms after RYGB...

Previous research suggests that patients using glucocorticoids may be at increased risk of postoperative bleeding and infection after major surgery. The objective was to investigate the association between preoperative glucocorticoid use and risk of bleeding and infection after Roux-en-Y gastric bypass surgery (RYGB). Nationwide cohort study of 13,...

Heterotopic ossification (HO) is a relatively common complication to e.g. hip arthroplasty. This case report is the first description of a patient, who developed intracranial HO without previous trauma or other provoking events including hereditary disease.

Treatment of severe obesity by Roux-en-Y gastric bypass (RYGB) causes sustained weight losses and improves health complica-tions. RYGB is, however, also associated with adverse effects. Dumping is a well-known complication causing invalidating symptoms, and lately there have been mounting concerns about post-RYGB hypoglycaemia. This condition is ch...

Treatment of severe obesity with Roux-en-Y gastric bypass (RYGB) results in pronounced weight loss but also in various nutritional complications. Iron deficiency anaemia is one of the most common nutritional complications due to reduced uptake of iron after this operation. Premenopausal women are particularly at risk of developing iron deficiency a...

In addition to permanent weight loss various complications are associated with bariatric surgery. This case report describes two women who developed pronounced anaemia after Roux-en-Y gastric bypass (RYGB), which had to be treated with intravenous iron substitution. Anaemia due to reduced iron uptake is common after RYGB and menstruating women are...