Sid Ahmed Merzouk

Sid Ahmed Merzouk
Abou Bakr Belkaid University of Tlemcen · Département de Physique

Professor

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50
Publications
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1,107
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Publications

Publications (50)
Article
Full-text available
Background and aims: Interaction between oxidative stress and inflammation has not been comprehensively investigated in the association obesity – diabetes - hypertension. Our aim was to investigate interrelations between inflammatory and oxidative stress biomarkers in obese women with two complications (hypertension, type 2 diabetes). Material and...
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It has long been established that maternal nutritional condition and fatty acid intake during pregnancy and/or lactation may influence the modifications in the individual risk for developing metabolic diseases throughout life, but little is known about the possible role of maternal nutrition before conception. The aim of this study was to investiga...
Article
Background Physical activity has a positive influence on healthy state during menopause. Mediterranean diet is an indicator of healthy ageing. The aim of the work was to examine the effectiveness of one year aerobic training in the improvement of biochemical indices of lipid, glucose and oxidative stress status in postmenopausal women who totally a...
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Maternal nutrition is an easily modifiable environmental factor that can affect fetal growth and developmentwith potential long-term consequences. The search for new treatments based on medicinal plants has turned to find the beneficial effects of olive oil on the pathogenesis of maternal obesity. Here, we studied whether maternal supplementation w...
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To investigate the possible developmental programming, we analyzed the effects of maternal and postnatal low dose alpha-cypermethrin exposure on metabolic and redox parameters in the offspring. Postnatal changes in plasma biochemical parameters and plasma and tissue oxidative stress markers were determined in offspring of dams fed standard chow or...
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Liver diseases are linked in the majority of cases to oxidative stress that antioxidants could neutralize with reducing liver injury. Chlorogenic acid, a coffee polyphenol, possesses antioxidant prosperities. The aim of this study was to evaluate in vitro preventive and corrective effects of cholorogenic acid in hepatocyte toxicity induced by free...
Article
Introduction et but de l’etude En raison de l’exigence accrue en oxygene et du placenta riche en mitochondries, la grossesse est une condition qui expose a une sensibilite aggravee au stress oxydatif. Cela a ete prouve par des etudes demontrant des niveaux eleves de marqueurs de stress oxydatif lors d’une grossesse normale. La periode perinatale et...
Article
Aging is an inevitable biological event that is associated with immune alterations. These alterations are related to increased cellular oxidative stress and micronutrient deficiency. Antioxidant supplementation could improve these age-related abnormalities. The aim of this study was to determine in vitro effects of vitamin A, vitamin C, vitamin E,...
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Background: Dietary fatty acids have important homeostatic functions in regulating the immune response and may exert beneficial effects on immune alterations during obesity. Objective: To assess the in vitro effects of oil fatty acids, different oils (olive, linseed, Nigel, sunflower) were tested on T-lymphocyte proliferation, Th1- and Th2-type cyt...
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Introduction et but de l’étude L’obésité est considérée comme un facteur de risque durant la grossesse. À côté des désordres alimentaires, les mères obèses présentent une incidence élevée de troubles métaboliques et oxydatifs ainsi que des complications obstétricales, maternelles et fœtales. La grossesse tout comme l’obésité sont deux situations ca...
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The aim of this investigation was to determine the in vitro effects of vitamin C and E, n-3 and n-6 PUFA and n-9 MUFA on placental cell proliferation and function in type 1 diabetes. Placenta tissues were collected from 30 control healthy and 30 type 1 diabetic women at delivery. Placental cells were isolated and were cultured in RPMI medium supple...
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Pyrethroid insecticides are extensively used in agriculture and in household activities. During pregnancy, they might affect maternal metabolic status and there after fetal development. In this work, we studied metabolic and redox effects of low dose alpha-cypermethrin exposure in pregnant rats and their offspring. The diet containing alpha cyperme...
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Objective: Hypothyroidism has been found to increase oxidative stress parameters and to disturb lipid profiles. The aim of this study was to determine the effect of high thyroid stimulating hormone level (TSH) on lipid profile and oxidative stress biomarkers in women particularly nitric oxide (NO •) and superoxide anion (O2 •-). Patients and method...
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The aim of this work was to investigate inflammatory, oxidative, and thrombotic parameters as biomarkers in farmers exposed to pesticides. Fifty farmers using chemical pesticides and 60 unexposed control men participated in this study. The Mediterranean diet compliance, the duration of pesticide use, and personal protection for pesticides handling...
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Obesity is characterized by iron deficiency, carbohydrate and fat alterations as well as oxidative stress. Iron status monitoring is recommended because of the conventional oral iron preparations that frequently exacerbate the already present oxidative stress. Iron complexation by natural antioxidants can be exploited. We herein investigated the me...
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Full-text available
To investigate the oxidative profile and thrombotic markers in obese and hypertensive mothers. Thirty obese, 28 hypertensive and 34 healthy control mothers were recruited from Tlemcen Hospital, Algeria. Plasma vitamin C, nitric oxide, superoxide anion, erythrocyte glutathione, malondialdehyde, carbonyl proteins and erythrocyte antioxidant enzyme ac...
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Because linseed oil may influence maternal and fetal metabolisms, we investigated its role in the modulation of lipid metabolism in cafeteria diet-induced obese rats and their offspring. Female Wistar rats were fed control or cafeteria food, which were either supplemented or not supplemented with linseed oil (5%) for 1 month before and during gesta...
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The effects of calcium antagonists (amlodipine) and angiotensin II receptor antagonists (telmisartan) on lipid profile and oxidative markers are investigated in Algerian hypertensive patients. At the beginning and after one year of antihypertensive therapy, blood samples are collected for biochemical parameters (glucose, cholesterol, triglycerides,...
Article
Background The aim of this investigation was to determine the in-vitro effects of linseed, olive and Nigel oils on T cell proliferation and function in gestational diabetes.Methods Blood samples were collected from 40 control healthy and 32 gestational diabetic mothers and their newborns. Peripheral blood lymphocytes were isolated using a density g...
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The aim of this work was to determine the effect of dietary n - 3 PUFA on oxidant/antioxidant status, in vitro very low and low density lipoprotein (VLDL-LDL), and VLDL-LDL-fatty acid composition in macrosomic pups of diabetic mothers. We hypothesized that n - 3 PUFA would improve oxidative stress in macrosomia. Diabetes was induced in female Wista...
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In this work we evaluated the in vivo effects of chronic metribuzin exposure at doses that mimic human exposure through diet. Male and female rats were fed a potato diet containing metribuzin at low doses (D1, 1.3 mg/kg or D2, 13 mg/kg) for 3 months. Plasma biochemical parameters (glucose, lipid, urea, creatinine, alanine aminotransferase (ALT), as...
Article
In this study, plasma lipids, lipoproteins and markers of oxidant/antioxidant status were investigated in young (n = 45) and older (n = 40) obese men and compared to those in young (n = 65) and older (n = 55) normal weight controls. The purpose was to determine whether obesity exacerbates or not lipid, lipoprotein abnormalities and oxidative stress...
Article
Pesticides have been shown to possess marked immunotropic activity. The aim of this work was to study the in vitro effects of different concentrations (1–100μM) of Mancozeb (fungicide) and Metribuzin (herbicide), on the proliferative responses of human and rat spleen lymphocytes stimulated by concanavalin A (ConA, mitogen), the Th1- (IL-2, INFγ) an...
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Background: Obesity has reached epidemic proportions world-wide. Its risk factors are poorly studied, especially among children in developing countries such as Algeria. Objectives: The purpose of this study was therefore to determine the prevalence and risk factors of obesity in Algerian schoolchildren 6 to 8 years aged by conducting a school-si...
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To investigate further the mechanisms of developmental programming, we analysed the effects of maternal overnutrition and of postnatal high-fat feeding on adipose tissue metabolism in the offspring. Postnatal changes in serum adiponectin, leptin and TAG [triacylglycerol (triglyceride)] levels, adipose tissue TAGs, fatty acids and enzyme activities...
Article
The combined effects of developmental programming and high-fat feeding at weaning on fatty acid metabolism of the offspring are not well known. In the present study, we aim at characterizing the influence of maternal and offspring's own diets on liver and very low-density lipoprotein (VLDL) lipids; fatty acid profiles of VLDL and liver phospholipid...
Article
To show that lipid and lipoprotein levels and cell sodium and potassium content and transport could change depending on the degree of hypertension. Forty-three hypertensive patients and 20 healthy subjects were recruited at the Cardiology and Biochemistry Departments of Tlemcen University Hospital Centre (Northwest of Algeria). Levels of CHOL, TG,...
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Obesity during pregnancy affects maternal and foetal lipid and lipoprotein levels, but our knowledge on oxidative stress biomarkers is limited. The aim of this study is to determine the oxidant and antioxidant status in obese mothers and their newborns. 43 obese and 50 normal weight mothers and their appropriate for gestational age newborns were co...
Article
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Objectifs : Les aziridines, molécules alkylantes à l’ADN, possèdent une grande activité anticancéreuse et antibiotique et modulent le système immunitaire. Une nouvelle aziridine, la 2-hydroxy-méthyl-1 (N-phtaloyltryptophyl) aziridine, a été synthétisée dans notre laboratoire. Cependant, sa toxicité n’est pas connue. L’objectif de ce travail est de...
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This study was carried out to determine the relationships between leptin concentrations, lipid alterations, oxidant/ antioxidant status, in vitro LDL oxidizability and LDL-fatty acid composition in overweight breast cancer patients. Glucose, insulin, leptin, lipids, LDL-cholesteryl ester fatty acids, markers of oxidant status (MDA, Hydroperoxides,...
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Full-text available
The aim of the present study was to determine the time course of changes in oxidant/antioxidant status, as well as serum glucose, insulin, leptin and lipid levels, liver adipose tissue and muscle lipid and protein contents, in cafeteria-diet-fed dams during gestation and lactation, and in their offspring throughout adulthood. Food intake was also e...
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The aim of this study is to determine the oxidant and antioxidant status in Algerian mothers and their newborns according to birth weight. Subjects for the study were consecutively recruited from Tlemcen hospital. 139 pregnant women and their newborns were included. The plasma total antioxidant activity (ORAC), vitamins A, C, E, hydroperoxides, car...
Article
In this work, we assessed the in-vitro effects of eicosapentaenoic acid (EPA; C20:5n-3) and docosahexaenoic acid (DHA; C22:6n-3) (final concentration, 15 microM) on T cell blastogenesis, interleukin-2 and -4 (IL-2, IL-4) secretion, fatty acid composition and intracellular oxidative status in type I diabetic patients with or without complications. C...
Article
The aim of this study was to determine serum lecithin:cholesterol acyltransferase (LCAT) activity in parallel with HDL2 and HDL3 amounts and composition in pregnancy induced hypertension (PIH) and chronic hypertensive (CH) mothers and in their small for gestational age (SGA) newborns. LCAT activity was assayed by conversion of [3H] cholesterol to l...
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The effects of dietary n-3 polyunsaturated fatty acids on lipoprotein concentrations and on lipoprotein lipase (LPL), hepatic triglyceride lipase (HTGL) and lecithin cholesterol acyltransferase (LCAT) activities were studied in streptozotocin-induced diabetic rats during pregnancy and in their macrosomic offspring from birth to adulthood. Pregnant...
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Full-text available
We investigated the role of dietary n-3 polyunsaturated fatty acids (n-3 PUFA) in the modulation of total antioxidant status in streptozotocin (STZ)-induced diabetic rats and their macrosomic offspring. Female wistar rats, fed on control diet or n-3 PUFA diet, were rendered diabetic by administration of five mild doses of STZ on day 5 and were kill...
Article
This study was carried out to determine the relationships between oxidant/antioxidant status, in vitro LDL oxidizability and LDL-fatty acid composition in diabetes mellitus. Plasma total antioxidant capacity (oxygen radical absorbance capacity, ORAC) and LDL-cholesteryl ester fatty acids were investigated in type 1 and type 2 diabetic subjects with...
Article
Plasma vitamin A, C and E levels and erythrocyte antioxidant enzyme activities were investigated in type I and type II diabetic subjects with and without complications, i.e., hypertension, coronary artery disease and renal failure. Reverse phase HPLC was used to quantify vitamin A and E levels. We observed that the vitamin C levels were not signifi...

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Projects (2)