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Sibnarayan Datta

Sibnarayan Datta

PhD

About

91
Publications
114,824
Reads
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2,314
Citations
Additional affiliations
January 2009 - December 2009
Tulane University
Position
  • PostDoc Position
January 2002 - October 2008
Indian Council of Medical Research Virus Unit, Kolata
Position
  • Research Associate
Education
August 1999 - July 2001
University of Calcutta
Field of study
  • Zoology
September 1996 - July 1999
Berhampore Krishnath college, University of Calcutta
Field of study
  • Zoology

Publications

Publications (91)
Article
Full-text available
Prevalence of hepatitis B genotype C in injection drug users in the northeastern Indian state of Manipur, neighboring the "Golden Triangle," correlates well with overland drug-trafficking routes, the injection drug use epidemic, and the spread of HIV. Further spread to other regions of India through mobile populations is possible.
Article
Full-text available
The compartmentalization of viral variants in distinct host tissues is a frequent event in many viral infections. Although hepatitis B virus (HBV) classically is considered hepatotropic, it has strong lymphotropic properties as well. However, unlike other viruses, molecular evolutionary studies to characterize HBV variants in compartments other tha...
Article
Full-text available
Cotton leaf curl disease (CLCuD) outbreaks caused by CLCuD associated begomoviruses (CABs) significantly constrain cotton production in India and Pakistan. In comparison to the CABs circulating in Pakistan, molecular epidemiology, evolution and recombination patterns of CABs circulating in India are less studied. In this work, we characterized CAB...
Article
Recently, two independent studies discovered 15 ancient Hepatitis B virus (aHBV) sequences, of which 7 dated back to the Neolithic age (NA) and the Bronze Age (BA). In the present research, all the available aHBV sequences were collective re-analysed with reference to extant HBV diversity to understand the role of these aHBV genotypes in evolution...
Article
Full-text available
In recent years, the use of bacteriophages (or 'phages') against multidrug-resistant (MDR) bacteria including Pseudomonas aeruginosa has drawn considerable attention, globally. In this work, we report the isolation and detailed characterization of a highly lytic Pseudomonasphage DRL-P1 isolated from wastewater. Under TEM, DRL-P1 appeared as a membe...
Preprint
Full-text available
To treat antibiotic resistance bacteria, bacteriophage (also called 'phage') application has recently drawn considerable attention from researchers globally. Bacteria like Pseudomonas aeruginosa are known to be associated with nosocomial infections especially in patients with compromised immune systems. In the present work, phage against P. aerugin...
Article
Eastern Himalayan foothills are known to have optimal agro-climatic conditions for the production of quality citrus fruits including oranges. Among the citrus-growing regions of eastern Himalayas, Wakro in the far eastern state of Arunachal Pradesh is known for its superior quality oranges, popular as the Wakro orange or the Arunachal orange, which...
Article
Multidrug resistant bacterial infections have become a potent risk, globally and there is an urgent need to phage and phage-derived enzymes as a therapeutic agent. The risk is more prominent in underdeveloped nations, where high population density, poor drinking water, inadequate sanitary and health care facilities ease the spread of infection. Bac...
Chapter
Viruses constitute one of the biggest groups of pathogens that cause significant morbidity and mortality in animals, humans, and plants. Most of the viruses are uncultivable in vitro. so identification and monitoring of viruses are primarily based on molecular biology tools, which often involve sequencing the virus genome. However, the emergence of...
Preprint
Full-text available
Eastern Himalayan foothills are known to have optimal agro-climatic conditions for the production of quality citrus fruits including oranges. Among the citrus growing regions of eastern Himalayas, Wakro in the far eastern state of Arunachal Pradesh is known for its superior quality oranges, popular as the Wakro orange or the Arunachal orange, which...
Article
Microflora plays an important role in modulating environmental quality. Among microflora, bacteria are omnipresent in the environment. Pathogenic bacteria, present in air, are known to affect significantly the health and well-being of human, animal or plant populations. Air bacteria monitoring is thus essential for surveillance of pathogenic microo...
Article
Present work was performed to isolate, enrich and characterize bacteriophage using basic laboratory set-up, and to demonstrate their lytic potential in pathogen reduction. Following standard microbiological and molecular biological procedures, we examined cultivable bacteria and bacteriophages in wastewater sample. Subsequently, from cultures of wa...
Article
In the context of change in global scenario of terrorism and economic competition, the risk of deliberate attack on agriculture is increasing. In a country, like India, whose economy is largely dependent on agriculture produce and exports, any such malicious attack can grossly destabilise the socio-economic structure. Additionally, an attack on maj...
Article
The northeastern part of India (NE India) is an important biodiversity hotspots and is blessed with a huge diversity of flora and fauna along with other natural resources. Being quite distinct in natural features from rest of the country, NE India has its own unique challenges and opportunities. This part of India is geographically isolated from Ch...
Article
Cold adapted bacteria undertake array of adaptive strategies and remain active with an active temperature range of 0–40 °C and activity in the acidic to neutral pH range (pH 4.5–7.0) to withstand in extreme environmental conditions and to retain metabolic and enzymatic activities. In soil, water or food, they were reported to comprise higher popula...
Article
Full-text available
Non Hodgkin lymphoma, predominantly Diffuse Large B-cell Lymphoma (DLBCL) has been reported to have a significant association with Hepatitis B virus (HBV). We investigated the presence of different gene segments of HBV in plasma, B-cells and tumor tissues from DLBCL patients and explored the genetic variability of HBV within and across different co...
Article
Begomovirus associated tomato leaf curl disease (ToLCD) is one of the major limiting factors in production of tomato worldwide, including India. In contrast to extensive diversity of ToLCD associated begomovirus species in the mainland India, information on begomovirus species circulating in the Northeastern part of India (NE India) is extremely sc...
Article
Gut bacterial diversity of Sitophilus oryzae, a commonly known granary insect pest was examined for their potential β-1,4-endoglucanase activity. After collection (from a granary at Tezpur Assam, India) and aseptically dissection, the insect gut content was cultured in Brain-Heart infusion agar to obtain individual bacterial colony. After morpholog...
Article
Tremendous explosion of population has led to about 200% increment of total energy consumptions in last twenty-five years. Apart from conventional fossil fuel as limited energy source, alternative non-conventional sources are being explored worldwide to cater the energy requirement. Lignocellulosic biomass conversion for biofuel production is an im...
Chapter
Plants absorb a range of heavy metals from soil. Some of them such as Cu, Zn, Mn, Fe, Ni and Co are essential micronutrients while some are nonessential (Cd, Hg, and Pb) for plants. The nonessential heavy metal ions as well as essential ones can have toxic effect when present in supra-optimal values. Thus for normal plant growth, mechanisms must ex...
Chapter
Phytoremediation is a promising, cost effective, green substitute to traditional soil remediation technologies, which can treat different environmental pollutants including heavy metals. However, selection of an ideal plant for cleaning the environment being polluted with specific pollutant(s) is a major task leading to potential possibilities of i...
Article
Full-text available
Life on Earth harbours an unimaginable diversity of microbial communities. Among these, gut microbiome, the ecological communities of commensal, symbionts (bacteria and bacteriophages) are a unique assemblage of microbes. This microbial population of animal gut helps in performing organism’s physiological processes to stay healthy and fit. The role...
Chapter
Arsenic is a widespread element in the environment and it is highly toxic to human health. It is a Group A human carcinogen. Chronic arsenic exposure causes various dreaded ailments including cancer in skin, lung, and bladder, as well as in other organs. Arsenic induces epigenetic alterations and aberrant DNA methylation, causing inherent damage to...
Chapter
Over the last three decades, the increase in the amount of ultraviolet (UV) radiation reaching Earth's surface has drawn attention of the researchers. Among UV-A (400–315 nm) and UV-B (315–280 nm) radiation, UV-B plays a major deleterious role affecting biota. Substantial reduction of the stratospheric ozone (O3) layer due to anthropogenic activiti...
Article
Full-text available
Aedes aegypti and Ae. albopictus are among the most important vectors of arboviral diseases , worldwide. Recent studies indicate that diverse midgut microbiota of mosquitoes significantly affect development, digestion, metabolism, and immunity of their hosts. Midgut microbiota has also been suggested to modulate the competency of mosquitoes to tran...
Data
Bacterial isolates based on 16S rRNA gene sequences, %identity to NCBI/ EZtaxon and its taxonomical affiliation. (PDF)
Conference Paper
Full-text available
Insect gut harbors a wide range of bacterial population. Rice weevil (Sitophilus oryzae) is a well known economic pest of seeds, grains, and grain products of rice. The gut bacteria of rice weevil might be a good source of bacteria having hydrolytic activities. However, fewer reports are available on the aspect of studying the potential of the bact...
Article
Bacteriophages (or phages), the most abundant viral entity of the planet, are omni-present in all the ecosystems. On the basis of their unique characteristics and anti-bacterial property, phages are being freshly evaluated taxonomically. Phages replicate inside the host either by lytic or lysogenic mode after infecting and using the cellular machin...
Article
Full-text available
AIM To investigate the role of subgenotype specific RNA secondary structure in the compartment specific selection of hepatitis B virus (HBV) immune escape mutations. METHODS This study was based on the analysis of the specific observation of HBV subgenotype A1 in the serum/plasma, while subgenotype A2 with G145R mutation in the peripheral blood le...
Article
Full-text available
Background Hepatitis B virus (HBV) X protein (HBx) reported to be associated with pathogenesis of hepatocellular carcinoma (HCC) and miR-122 expression is down regulated in HCC. Previous studies reported miR-122 targets cyclin G1 (CCNG1) expression and this in turn abolishes p53-mediated inhibition of HBV replication. Here we investigated the invol...
Article
Background Polymerase chain reaction (PCR) is widely used in biological research and diagnostics because of its high sensitivity and specificity. However, the sensitivity of PCR is strongly influenced by topological characteristics of the template. Supercoiled templates are known to inhibit PCR, whereas linearized forms of the same supercoiled temp...
Conference Paper
Full-text available
Poor sanitation is a burden to society. Developing eco-friendly, appropriate and affordable sanitation solution is essential in flush toilet system. Water is the integral part of this globally Please note: Abstracts are published as received from the authors and are not subject to editing 81 ANNUAL CONFERENCE 2016 SESSION 17 – ENVIRONMENTAL AND AP...
Conference Paper
Full-text available
Bacteriophages are viruses that parasitize specific bacteria and multiply in metabolising host bacteria. Bacteriophages hunt for a single or a subset of bacterial species, making them potential antibacterial agents. Utilizing the ability of phages to control bacterial populations has several applications from medical to the fields of agriculture, a...
Article
Full-text available
A study was conducted to screen and isolate cellulase producing bacteria of termite gut from North east region of India. A total of 27 culturable bacterial isolates were screened for cellulase production. Out of the 27 bacterial isolates 11 showed zone of clearance on CMC agar media on staining with 1% Congo red, suggesting potential cellulose degr...
Article
Full-text available
Cellulose, a macromolecule of β -D- anhydroglucopyranose units linked by β (1,4)-glycosidic bonds, is the world’s most abundant organic polymer and is the main component of plant biomass that provides stability. Due to its sta-ble fibrous property, it has become one of the most important commercial raw materials for many industries. However, accumu...
Article
Cellulose, a macromolecule of β -D- anhydroglucopyranose units linked by β (1,4)-glycosidic bonds, is the world’s most abundant organic polymer and is the main component of plant biomass that provides stability. Due to its sta-ble fibrous property, it has become one of the most important commercial raw materials for many industries. However, accumu...
Article
Full-text available
A study was conducted to screen and isolate cellulase producing bacteria of termite gut from North east region of India. A total of 27 culturable bacterial isolates were screened for cellulase production. Out of the 27 bacterial isolates 11 showed zone of clearance on CMC agar media on staining with 1% Congo red, suggesting potential cellulose degr...
Article
Full-text available
Background: Microbiota inhabiting midguts of mosquitoes play a key role in the host - parasite interaction and enhance vectorial capacity of viral diseases like dengue and chikungunya fevers. Mosquito midgut is considered to be an important site for host-pathogen interaction and pathogen survival is thought to be an outcome of this interaction. In...
Article
Full-text available
Hepatitis B virus (HBV) is classically considered to be hepatotropic, but accumulating evidences strongly support its extra-hepatotropic nature too. HBV nucleic acids and proteins have long been reported in a variety of extra-hepatic tissues. Of these, HBV has been studied in details in the peripheral blood mononuclear cells (PBMCs), due to its acc...
Article
Full-text available
We report the phylogenetic characterization of a unique flavivirus sequence detected in a wild Culex tritaeniorhynchus mosquito pool, collected from the northeast Indian state of Assam. DNA and RNA were extracted from field-collected mosquito pools. Extracts were subjected to PCR and reverse transcriptase PCR amplification using universal and type-...
Article
Full-text available
Rapid development and commercial availability of next-generation sequencers (NGS) systems have dramatically changed almost every field of biological research, especially microbiology and metagenomics. Different NGS systems have been adapted and used for numerous applications in virology too. These systems are capable of rapidly sequencing and analy...
Article
Full-text available
Taken together, our finding of ToLCBV in G. niveum plants with typical symptoms, signifying persistent natural infection, is a new record. Although the possibility of a new viral genome created by DNA recombination remains to be explored, the detected monopartite virus differed significantly from previously reported bipartite begomovirus causing le...
Article
Full-text available
Hepatitis B Virus (HBV) X protein (HBx) is known to be involved in the initiation and progression of hepatocellular carcinoma (HCC) through modulation of host gene response. Alterations in miRNA expressions are frequently noted in HCC. This study is aimed to examine the role of HBx protein in the modulation of oncogenic miRNA-21, miRNA-222 and tumo...
Article
Full-text available
Hepatitis B virus (HBV) is one of the important global health problems today. Infection with HBV can lead to a variety of clinical manifestations including severe hepatic complications like liver cirrhosis and hepatocellular carcinoma. Presently, routine HBV screening and diagnosis is primarily based on the immuno-detection of HBV surface antigen (...
Article
Full-text available
The author declares that there is no conflict of interests regarding the publication of this paper.
Article
Full-text available
As a nonrenewable resource, phosphorus (P) is the second most important macronutrient for plant growth and nutrition. Demand of phosphorus application in the agricultural production is increasing fast throughout the globe. The bioavailability of phosphorus is distinctively low due to its slow diffusion and high fixation in soils which make phosphor...
Chapter
Full-text available
Heavy metal pollution due to anthropogenic activities like mining, smelting, untreated waste disposal and dumping, and pesticides and fertilizers application is becoming a major global concern. Once released into the environment, heavy metals find their way into aquatic systems contaminating water bodies and its associated life forms. Wetlands are...
Article
Full-text available
Although chronic hepatitis C virus (HCV) infection has been treated with the combination of interferon alpha (IFN-α) and ribavirin (RBV) for over a decade, the mechanism of antiviral synergy is not well understood. We aimed to determine the synergistic antiviral mechanisms of IFN-α and RBV combination treatment using HCV cell culture. The antiviral...
Article
Full-text available
Human papillomavirus (HPV) associated cervical cancer is the leading cause of deaths in India. However, cytological/HPV screening may result in early detection of cervical cancer, resulting in early treatment and reduced mortality. Although reports related to general population is available, data on HPV prevalence among women attending AFMS health...
Chapter
Full-text available
Phytoremediation is a developed technology which exploits naturally occurring uptake capabilities of plant root system, together with the translocation, bioaccumulation, or detoxifying abilities to clean up the surrounding environments. Several strategies used by plants for dealing with xenobiotics include phytostabilization, phytoextraction, phyto...
Article
Numerous vector-borne viral infections of human or veterinary health importance have emerged or re-emerged in the recent decades. These incidences are increasing because the vectors are highly adaptable and can easily embed themselves in the local ecology. The most important emerging/re-emerging vector borne viruses belong to predominantly three vi...
Article
Full-text available
A previous study from West Bengal documented very high rate of occult HBV infection (OBI) among the HBsAg negative blood donors. This study was aimed to characterize the OBI strains circulating among the blood donors and to estimate the risk associated with the prevailing viral variants/mutants. Blood samples from 2195 voluntary blood donors were i...
Article
Hepatitis B virus (HBV) infection is one of the major global health problems, especially in economically under-developed or developing countries. HBV infection can lead to a number of clinical outcomes including chronic infection, cirrhosis and liver cancer. It ranks among the top 10 causes of death, being responsible for around 1 million deaths ev...
Article
Non-Hodgkin's lymphoma (NHL) is among the haematological malignancies with high prevalence worldwide, causing estimated 355 900 new cases and 191 400 deaths in 2008. High prevalence of NHL is documented in economically more developed areas while low prevalence is observed in less developed areas of the globe. A wide array of environmental factors h...
Article
We have investigated the molecular diversity of Hepatitis B virus (HBV) among the HIV co-infected patients from eastern-India. HBsAg/HBV-DNA positive subjects (n=73) from 874 HIV-infected patients were analyzed by sequencing followed by genetic diversity quantification. HBV/genotype-D and HBV/sugenotype-D2 were predominant. HBV/D2 isolates from pat...
Article
Full-text available
Background: The prevalence of occult HBV, defined by the presence of HBV DNA in individuals with antibodies to HBV core antigen and with absence of HBV surface antigen, but its clinical significance and virological features in HIV-infected patients is still unclear. Aim: To investigate the prevalence, clinical significance and molecular characte...
Article
Non-Hodgkin’s lymphoma (NHL) is among the haematological malignancies with high prevalence worldwide, causing estimated 355?900 new cases and 191?400 deaths in 2008. High prevalence of NHL is documented in economically more developed areas while low prevalence is observed in less developed areas of the globe. A wide array of environmental factors h...
Article
Full-text available
Homalomena aromatica rhizomes are rich source of essential oils, which have been attributed for various medicinal uses. In the present investigation, essential oil from H. aromatica rhizomes was isolated and subjected to gas chromatography-mass spectrum (GC-MS) analysis. Fifty-five chemical constituents were reported from H. aromatica rhizomes of w...