Siavash Vaziri

• Kermanshah University of Medical Sciences

Background COVID-19 now is a serious concern for the world healthcare system. This study aimed to investigate possible therapeutic effect of colchicine and phenolic monoterpenes accompanied by standard care of treatment (SCT) in patients diagnosed with COVID-19. Methods In this randomized controlled parallel clinical trial, a total number of 179 (...

Background: Healthcare workers are at risk for HBV infection through percutaneous or mucosal contact with infected blood, body secretions, or blood products or via sharps injury. Hepatitis B vaccination, despite immunogenicity, may not induce a proper immune response in 5-10% of the general adult population. Increased immune response in healthcare...

People living with HIV (PLWH) are susceptible to severe COVID-19 infection and hence this fragile population has prioritised vaccination. This systematic review and meta-analysis aimed to assess the humoral immune response after receiving two doses schedule of COVID-19 mRNA vaccinations in this high-risk population. A systematic electronic search o...

Purpose: Solid organ transplant recipients (SOTR) have a high risk for severe COVID-19 infection; hence it is necessary to find alternative treatment strategies to protect these patients from the complications caused by the severe progression of the disease. This study aimed to determine the effectiveness of sotrovimab among SOTR with COVID-19. Mat...

Lactobacilli are the most common probiotic bacteria found in the human gut microbiota, and the presence of acquired antibiotic resistance determinants carried on mobile genetic elements must be screened due to safety concerns. Unnecessary and inappropriate antibiotic therapy, as well as ingested antibiotic resistance bacteria (originating from food...

Background: The aim of this study was to explore the effect of occupational exposure to X-ray on hematological parameters. Research design and methods: A systematic search was conducted in the Scopus, PubMed, Web of Science, and Embase databases up to April 2020. The methodological quality was assessed by the 10-item Joanna Briggs Institute (JBI...

Objectives The gut is a complex environment inhabited by a wide range of bacterial species. Lactobacillus species constitute a significant proportion of this environment, and, due to their mobile genetic elements such as plasmids and transposons, are more likely to acquire and transfer antibiotic resistance genes through horizontal gene transfer (H...

Background: Although corticosteroids are commonly used for COVID-19 disease during the inflammatory phase, the effective doses and the best choice of corticosteroids are not yet known. Methods: In the present study, the effects of non-pulse (30-250 mg/day of prednisolone equivalent) versus pulse equivalent (>250 mg/day of prednisolone equivalent) d...

The gut is a complex environment inhabited by a wide range of bacterial species. Lactobacillus species constitute a significant proportion of this environment, and, due to their mobile genetic elements such as plasmids and transposons, are more likely to acquire and transfer antibiotic resistance genes through horizontal gene transfer (HGT). The cu...

Context: Infections are a major cause of disease and mortality in transplant recipients. Despite the studies conducted in Iran, no comprehensive and general research is available in this area. The present study aimed to determine the frequency of infectious agents in patients after bone marrow transplantation in Iran. Method: In this systematic rev...

Background: Staphylococcus aureus is an opportunistic pathogen, which often causes asymptomatic diseases. This bacterium could cause several disorders, ranging from skin infections to life-threatening diseases. S. aureus could also develop resistance to a wide range of antibiotics. Objectives: The present study aimed to investigate the prevalence a...

Introduction: Cardiac disorders are common in patients with chronic obstructive pulmonary disease (COPD). They worsen shortness of breath and physical capacity and reduce the quality of life. Ultrasound assessment of cardiac function could contribute to assessing the severity of the disease. This study aimed to assess the prognostic significance of...

The COVID-19 has a wide range of symptoms. This novel infectious disease may also trigger a vast range of neurological involvements. The current report describes a case of COVID-19 complicated with Bell’s palsy. A 64-year-old woman with diabetes was admitted due to abrupt left hemifacial weakness. On examination, her left hemifacial expression abil...

Background: Diabetes mellitus (DM) is one of the main public health troubles diabetic foot ulcer (DFU) is one of the most important and relatively common causes of hospitalization. This study investigates the prevalence of peripheral artery disease (PAD) in Imam Reza Hospital of Kermanshah during 2017-2018. Materials and methods: This study is d...

Objectives: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the COVID-19 pandemic. The majority of patients experience asymptomatic to mild self-limited disease, but some cases progress to respiratory and multi-organ failure. However, so far, no approved antiviral therapy has been available for treatment of COVID-19....

Background: Antibiotic resistance is spreading worldwide against the Gram-negative bacteria that cause nosocomial infections. Objectives: The present study aimed to determine the antibiotic resistance pattern of Enterobacter isolated from the blood, urine, wound, and sputum samples of the patients referring to Imam Reza Hospital in Kermanshah, Iran...

Background: Acinetobacter is a gram-negative coccobacillus, which is widespread in nature and causes several nosocomial infections, such as pneumonia, meningitis, endocarditis, skin and soft tissue infections, conjunctivitis, and bacteremia. Acinetobacter has also demonstrated resistance against multiple antimicrobial agents. Objectives: The presen...

Background: The main pathogen causing various nosocomial infections, especially in burn patients, is Staphylococcus aureus. An important virulence factor of this bacterium is leukocidin, which binds to white blood cells and leads to apoptosis and necrosis. Objectives: In the present research, we aimed at investigating the prevalence of the panton-v...

Background: Nosocomial infections are important medical concerns in developed and developing countries. Pseudomonas aeruginosa is considered the third leading cause of nosocomial infections following Staphylococcus aureus and Escherichia coli. Objectives: The present study aimed to determine the antibiotic resistance of isolated P. aeruginosa strai...

Background: Coronaviruses are a large family of RNA viruses, which range from the common cold virus to the causative agent of more severe diseases. Coronavirus was declared a pandemic in December 2019 in Wuhan, China. Iran has been an endemic zone for the spread of the coronavirus since the outset of this global epidemic and has remained among the...

Abstract Background: Assessment of bacteria such as Klebsiella pneumonia has shown that Plasmid-mediated quinolone resistance (PMQR) affects antibiotics resistance (e.g., quinolones). Objectives:We studied the prevalence of qnr and aac(6’)Ib-cr genes in extended-spectrum beta-lactamase (ESBL)-producing K. pneumonia strains isolated from burn wounds...

Objectives: The first case of 2019 novel coronavirus disease (COVID-19) was reported in Iran in February 2020. Here, we report the epidemiological and clinical characteristics of patients with COVID-19 and factors associated with mortality in these patients. Methods: A retrospective cohort study was conducted from February 22, 2020, to March 24, 2...

Background: Spondylitis is an important osteoarticular manifestation of brucellosis that leads to serious complications. Objectives: We aimed to investigate various aspects of spondylitis in brucellosis patients in Kermanshah, a highly endemic area in the West of Iran. Methods: This retrospective, single-center, cross-sectional study investigated 2...

Introduction: Enterobacter cloacae are responsible for a variety of hospital acquired infections including sepsis and Urinary Tract Infection (UTI). High emergence rate of Extended Spectrum β-Lactam (ESBL) resistant bacteria has led to increased rates of mortality, therapeutic failure and healthcare expenses. Identification of Cefotaximase-Munich (...

Background: Medical errors are considered as a major threat to patient safety. To clarify medical errors' status in Iran, a review was conducted to estimate the accurate prevalence of medical errors. Methods:A comprehensive search was conducted in international databases (MEDLINE, Scopus and the Web ofScience), national databases (SID, Magiran, and...

Aim: This study aimed to determine the seroprevalence and viremic infection of hepatitis delta virus (HDV) in Kermanshah. Background: Hepatitis delta is one of the most complex viral infections of liver that along with hepatitis B virus could lead to fulminant hepatitis, progressive chronic hepatitis, cirrhosis, and hepatocellular carcinoma. Me...

Considering the unclear etiology of recurrent aphthous ulcers (RAUs), the clinical management of RAU is based on no optimal therapeutic approach. The current study aimed to review the clinical trials on the effectiveness of medicinal plants and their active phytochemicals in the treatment of RAU. Five databases including PubMed, Science Direct, Web...

Background: Acinetobacter is an opportunistic bacterial pathogen with intrinsic and acquired resistance to many antibiotics. Objectives: This study aimed to determine the prevalence of extended-spectrum β-lactamases (ESBLs) and antibiotic resistance patterns in A. baumannii isolated from clinical samples atImamReza hospital in Kermanshah, Iran, usi...

Background: One of the most common infections in patients with high mortality rate is ventilator-dependent pneumonia. This study aimed to determine the frequency of extended spectrum beta-lactamase (ESBL) in Klebsiella pneumonia isolated from patients with ventilator-associated pneumonia in Kermanshah City, Iran. Methods: This study performed on tr...

Background Occult hepatitis B infection (OBI) is considered a risk factor for progression of liver disease in patients with hepatitis B virus (HBV) infection. This disease progression is reported to be more significant in those with concomitant HIV infection. We aimed to determine the prevalence rate of OBI in a sample of HIV-positive patients. Mat...

Background: Repeated blood transfusions in Thalassemic patients predispose them to blood-borne infections including Hepatitis B, Hepatitis C, and human immunodeficiency virus. These infections cause cirrhosis, portal hypertension, and acquired immunodeficiency syndrome. Objectives: The current study aimed at determining the prevalence of these infe...

Background: Pseudomonas aeruginosa is one of the major pathogens causing burnt wound infection in hospitals. This study aimed to evaluate the prevalence of exoenzyme U (exoU) and exoenzyme S (exoS) genes and the antibiotic resistance pattern of Pseudomonas aeruginosa isolated from burn patients' samples in Kermanshah City, Iran. Methods: In this c...

Background: Pseudomonas aeruginosa is one of the major nosocomial pathogens with a vast antibiotic resistance and great ability in adaptation with environment. The purpose of this study was to evaluate the antibiotic resistance and bacterial detection using Exotoxin A (ETA) and algD genes in patients with burns wound infection. Methods: In this stu...

Cancer is a major public health problem in Iran. The aim of this study was to evaluate trends in incidence of ten common cancers in Iran, based on the national cancer registry reports from 2004 to 2009. This epidemiological study was carried out based on existing age-standardized estimate cancer data from the national report on cancer registry/Mini...

Objective: To determine the effects of decoction derived from the leaves of Nicotiana tabacum (L.) as a mouthwash on minor recurrent aphthous. Methods: A randomized double-blinded placebo-controlled clinical trial was conducted on 60 patients with minor recurrent aphthous. Treatment comprised of application of tobacco or placebo mouthwash (10 mL...

Background Neurological complications are a problematic factor in acute bacterial meningitis; hence, its prevention is the key to ensure the success of meningitis treatment. Glycerol and dexamethasone are both applied in this regard. Oral glycerol is an appropriate alternative instead of intravenous dexamethasone because it does not have problems r...

Tuberculous ventriculitis is an inflammatory infection of the ventricular system of the brain, and is caused by Mycobacterium tuberculosis. We herein present the case of an immunocompromised patient with brain tuberculomas who developed ventriculitis during treatment. The patient was successfully treated with a high dose of steroid, long-term antit...

Introduction: Influenza can cause more severe diseases and higher rate of morbidity and mortality in the elderly population. Therefore, they should receive influenza vaccine annually. However, the host response to vaccine is less in older individuals. On the other hand, selenium can act as a stimulator of the immune system and cause increased immun...

Aims: Urinary tract infection (UTI) is one the most common bacterial infection and Escherichia coli (E. coli) has been isolated from the majority of UTI cases. On the other hand, the rate of UTIs caused by quinolones resistant E. coli is increasing worldwide. We aimed to perform a systematic review of quinolones resistance of E. coli isolated from...

A 70 years old man was referred to our center with bilateral knee arthritis following intra-articular petrol injection. Because of previous antibiotics use gram stain and culture were negative. Septic arthritis was diagnosed and antibiotics and drainage were started. After 2 years he improved eventually and was able to walk. But, some movement limi...

Cytomegalovirus (CMV), a problematic virus in solid organ transplant recipients (SOTR) such as liver, can worsen overall mortality and transplant outcome, so its prevention and treatment is a key of success in such patients. This study is aimed to compare the efficacy of ganciclovir (GCV) and valganciclovir (VGC) for prevention and treatment of inf...

A 70 years old man was referred to our center with bilateral knee arthritis following intra-articular petrol injection. As a result of the previous use of antibiotics, gram stain and culture were negative. Patient was diagnosed with septic arthritis and was treated by antibiotics and drainage. After two years, his mobility improved and he was able...

Long-term course of hemospermia has not been addressed in the sexual medicine literature. We report our 15 years' experience. From 1997 to 2012, 165 patients presented with hemospermia. Mean age was 38 years. Mean follow-up was 83 months. Laboratory evaluation and testis and transabdominal ultrasonography was done in all. Since 2008, all sonographi...

Background: Poor response to various vaccines especially hepatitis B is common. The purpose of this study was to evaluate the effect of selenium on immune response against hepatitis B vaccine with accelerated method in insulin-dependent diabetes mellitus patients. Methods: In this randomized clinical trial study, 62 insulin dependent diabetic pa...

Influenza can causes morbidity and mortality that are greatly enhanced in patients with underlying chronic diseases such as Cirrhotic patients. This study was performed to assess the immunogenicity of Influenza vaccination in patients with cirrhosis and inactive carriers of Hepatitis B virus infection. In this clinical study 93 enrolled subjects di...

For healthcare workers, sometimes the conventional hepatitis-B virus (HBV) vaccination schedule might not provide seroconversion rapidly enough. The aim of this study was to compare the efficacy of conventional HBV vaccination with an accelerated schedule (days 0-1-21). In this randomized clinical trial, 161 healthcare workers were divided into two...

Background: HSV2 has an important role in acquiring and transmitting HIV through genital ulcers. This study was conducted to determine the prevalence of this virus in HIV infected subject in Kermanshah, Iran. Methods: This descriptive study was performed among 170 HIV positive patients (case group) and 165 non-HIV cases (control group)) referred...

Human immunodeficiency virus (HIV) infected patients are also frequently exposed to the hepatitis B virus (HBV), due to the common routes of transmission, therefore, prevention of hepatitis B results in decreased complications of the disease. Since the immune response of HIV patients to hepatitis B vaccination is less robust than that found in heal...

Background: Beside various factors for producing diabetes, it seems that chronic hepatitis C, HIV/HCV co-infection, and anti-retroviral treatment especially including protease inhibitors may predispose to diabetes. This study conducted to determine prevalence of diabetes in HIV and HCV patients. Methods: The registries of 150 HCV patients, 50 HIV p...

Background: Given to the abundant incidence of malnutrition in HIV(+) patients and its effect on progress of AIDS disease, several studies have recommended supplementation therapy (such as Selenium, Levamisole, Zinc). Methods: This clinical trial was prefunded on patient's with HIV + in Behavior Diseases Consulting Center, Kermanshah, Iran 2006-...

Hepatitis B is the major cause of chronic hepatitis and cirrhosis in Iran. Sanitation and immunization is one of the most effective measures for prevention of the disease which is now widely used in developing countries. However, the immune response to the vaccine varies by age. To determine the effect of zinc sulfate on immune response to hepatiti...

Background: Influenza is a world-wide public health concern. It is one of the most important viral causes of acute respiratory illness, affecting all age groups, recurring several times during a lifetime. We assessed the antibody titers after vaccination against influenza among HIV-infected patients and health care workers (HCWs). Patients and meth...

تب مالت بيماري مشترک بين انسان و دام مي باشد و سندرم هاي باليني متنوعي از جمله اسپونديليت ايجاد مي نمايد. اسپونديليت و ساکرواليت از جمله شايع ترين عوارض ناشي از درگيري سيستم اسکلتي در تب مالت مي باشند و عفونت هاي عضلاني و تشکيل آبسه نيز از جمله عوارض نادر و اغلب ثانويه به اسپونديليت هستند. در اين مقاله دو مورد اسپونديليت بروسلائي و پيدايش آبسه در ي...

Background and Aims: There are limited data on the prevalence of viral hepatitis in human immunodeficiency virus (HIV) infected individuals. Comorbid illnesses in patients infected with HIV are of great interest due to their association with poor outcomes and failure of antiretroviral therapy. This study evaluated the prevalence of coinfection by H...

Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne disease that may also be transmitted through person-to-person transmission by exposure to infected body fluids. Despite its wide geographic distribution in animals, CCHF virus is rarely associated with recognized human diseases. We report the first case of CCHF in Kermanshah province, Iran. Cli...

Background and Aims: Chronic and serious outcomes of hepatitis C virus (HCV) infection impose a remarkable economic burden to the health system. The aim of this study was to evaluate the prevalence of HCV infection in the general population of Kermanshah in the year 2006.Methods: In this cross-sectional study, 1721 residents from Kermanshah were ch...

Background: Tuberculosis (TB) is a common infectious disease worldwide especially in developing countries. Diagnosis of TB is difficult and often needs paraclinical studies. Measuring immunoglobulin's against A-60 antigen of TB microorganism has been reported as a useful technique. The aim of the present study was to evaluate the diagnostic value o...

Background: Chicken pox is caused by Varicella zoster. Infected persons usually acquire permanent immunity and a reinfection is unusual. Case Presentation: We report on a leukemic girl aged 12 years and 4 months, who had two chicken pox infections during 2 months. Leukemia was diagnosed 20 months ago. In her past history she had a first chicken pox...

Background & Objectives: Antitubercular drugs can induce hepatic toxicity and it has still remained as a problem in treatment of tuberculosis (TB). In this study, we defined the prevalence of antitubercular drug induced hepatitis in the patients hospitalized for TB in Kermanshah Sina hospital during the period 1994 to 2004, and also a number of pro...

Background and Aims: Coinfection eventuality of HIV and HBV infection and having common transmission ways has turned Hepatitis B into a major health concern among HIV positive cases. The increasing number of HIV infected patients and their relevant problems, especially opportunistic infections, demands for Hepatitis B vaccination. This study, there...

Objectives: Immunodeficiency duo to HIV infection can produce unusual diseases in infected individuals & CD4 count is the main predictor of disease progression. In this study clinical syndromes resulting in admition, are considered according to CD4 count for the beter diagnosis and treatment of clinical problemes in HIV infected patients. Materrial...

Background: Hepatitis B is a major infectious risk factor for health-care workers (HCWs) and public- safety workers. Although seroconversion rate following hepatitis B vaccination is estimated to be more than 90%, serologic response to Heberbiovac HB vaccine currently given in our center in Kermanshah province has been varied in different experienc...

Parasites are important enteric pathogens among patients with human immunodeficiency virus (HIV) infection. There have been very few reports on the prevalence of intestinal parasites among such patients in Iran. To determine the prevalence of intestinal parasites among HIV-positive individuals, we collected single stool samples and analyzed them fo...