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Shyam Sunder Tummanapalli

Shyam Sunder Tummanapalli
UNSW Sydney | UNSW · School of Optometry and Vision Science

Doctor of Philosophy (Optometry)

About

32
Publications
3,771
Reads
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204
Citations
Additional affiliations
March 2016 - January 2020
UNSW Sydney
Position
  • PhD Student

Publications

Publications (32)
Article
Full-text available
Clinical relevance: Hand hygiene is important to reduce the spread of microbes in clinical settings. Hand sanitisers that last longer may be beneficial. Background: Longevity of hand sanitisation products on fingers and hands may be important to help reduce microbial transmission. The current study evaluated the persistence of disinfection of th...
Article
Full-text available
Coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). SARS-CoV-2 belongs to the group IV Coronavirinae in the subfamily Orthocoronavirinae, order Nidovirales, with four genera: alphacoronavirus, betacoronavirus, gammacoronavirus, and deltacoronavirus (not to be confused with the variants...
Article
Clinical relevance Optometrists have been advised to wear face masks during the COVID-19 pandemic. This study examined whether face masks were equally protective against transmission of microbes. Background The aim of the current study was to examine the ability of face masks to reduce transmission of microbes in aerosols and during speech. Metho...
Article
Clinical relevance: There is potential benefit in analysing corneal nerve tortuosity as a marker for assessment and progression of systemic diabetic neuropathy. Background: The aim of this work was to determine whether tortuosity significantly differs in participants with type 1 (T1DM) and type 2 (T2DM) diabetes compared to controls and whether...
Article
Nitric oxide (NO) has a wide array of biological functions including the regulation of vascular tone, neurotransmission, immunomodulation, stimulation of proinflammatory cytokine expression and antimicrobial action. These functions may depend on the type of isoform that is responsible for the synthesis of NO. NO is found in various ocular tissues p...
Article
Background There is a strong association between the metabolic syndrome in diabetes and the development of peripheral neuropathy, however the pathophysiological mechanisms remain unknown. Methods Participants with type 2 diabetes and metabolic syndrome (T2DM/MetS, n = 89) and type 2 diabetes alone (T2DM, n = 59) underwent median nerve ultrasound a...
Article
Isolation of antimicrobial‐resistant microbes from ocular infections may be becoming more frequent. Infections caused by these microbes can be difficult to treat and lead to poor outcomes. However, new therapies are being developed which may help improve clinical outcomes. This review examines recent reports on the isolation of antibiotic‐resistant...
Article
Full-text available
Aim To examine the associations between of continuous overlapping net glycaemic action (CONGA), percentage time in hyperglycaemia (%HG) or normoglycaemia (%NG) and peripheral nerve structure and function in type 1 diabetes. Methods Twenty‐seven participants with type 1 diabetes underwent continuous glucose monitoring followed by corneal confocal m...
Article
Aims: To determine the utility of corneal confocal microscopy and tear neuromediator analysis in the diagnosis of diabetic peripheral neuropathy (DPN) as a result of type 1 and type 2 diabetes. Methods: Seventy individuals with either type 1 diabetes or type 2 diabetes (T1D/T2D) underwent corneal confocal microscopy to assess the corneal nerve mo...
Article
Objective Corneal confocal microscopy (CCM) has been identified as a non-invasive technique to assess corneal nerve fiber morphology. It is not known how corneal nerve changes relate to measures of peripheral nerve function in diabetic peripheral neuropathy (DPN). The present study investigates the relationship between nerve structure and function...
Article
Purpose: To evaluate the effect of age, gender and body mass index (BMI) on the levels of tear film neuromediators and corneal nerve parameters in healthy individuals. Methods: Twenty-six healthy subjects were screened for any neurological deficits. The concentration of substance P and calcitonin gene-related peptide (CGRP) in tears was measured b...
Article
Objective: To explore the changes that occur in the concentrations of substance P (SP) and calcitonin gene-related peptide (CGRP) in tears as a result of corneal denervation and its association with diabetic peripheral neuropathy (DPN). Methods: Sixty-three individuals with type 1 diabetes/type 2 diabetes (T1D/T2D) and 34 age-matched healthy con...
Poster
Objective: To investigate the association between the concentration of tear film substance P and diabetic peripheral neuropathy (DPN) in type1 and type 2 diabetes. Conclusions: The concentration of substance P in tears is reduced in type 1 with DPN only, although corneal nerve physiology is changed with type1 and type 2 DPN. This may indicate a dif...
Article
Aims To investigate changes in corneal nerve morphology in Type 2 diabetes and to establish relationships between in vivo corneal confocal microscopy and markers of peripheral nerve structure and function. Participants and methods We recruited 57 participants with Type 2 diabetes and 26 healthy controls of similar age and sex distribution. We also...
Article
AIMS: To investigate changes in corneal nerve morphology in Type 2 diabetes and to establish relationships between in vivo corneal confocal microscopy and markers of peripheral nerve structure and function. PARTICIPANTS AND METHODS: We recruited 57 participants with Type 2 diabetes and 26 healthy controls of similar age and sex distribution. We al...
Presentation
Background: Patients with chronic kidney disease (CKD) in type 2 diabetes (T2DM) typically manifest with severe neuropathy. Corneal confocal microscopy (CCM) and axonal excitability are novel techniques that serve as biomarkers for the structure and function of peripheral nerves. Aim: This study aimed to investigate the relationship between CCM, a...
Poster
Abstract Purpose : To investigate morphological changes in the bulbar conjunctiva after mini-scleral contact lens (MScCL) wear using in vivo confocal microscopy (IVCM), and to explore the relationship between conjunctival changes at the cellular level and MScCL settling. Methods : 12 healthy subjects (age range 22-24 years; 5M, 7F) were fitted wit...
Poster
Abstract Purpose : To examine the ability of corneal nerve fibre assessment and axonal ion-channel function to diagnose diabetic peripheral neuropathy (DPN). Methods : A total of 36 subjects with type 1 diabetes and 10 age-matched controls underwent confocal microscopy to assess corneal nerve fibre length, density area, width, branch density, and...
Poster
Full-text available
To investigate the relationship between corneal nerve structure and axonal ion-channel function in patients with and without DPN.
Article
Diabetes mellitus is a chronic disease that results from inadequate insulin production or ineffective insulin utilization. It is one of the most common systemic diseases worldwide with increasing prevalence. Diabetes mellitus is associated with premature mortality, macrovascular complications such as cardiovascular disease, and microvascular compli...
Article
Full-text available
Article
Purpose To investigate and compare the efficacy of axial and tangential corneal topography maps obtained using the Orbscan IIz scanning-slit device to distinguish differences in eyes with subclinical keratoconus from normal eyes. Setting LV Prasad Eye Institute, Hyderabad, India. Design Retrospective cross-sectional study. Methods Axial and tangent...
Conference Paper
Purpose To estimate the variation in topography parameters due to inter session variations, diurnal variation and variability following pupillary dilation, to accurately identify progression in keratoconus. Methods Corneal topography was performed using the Orbscan IIz system on 100 normal eyes of 100 subjects and on 100 eyes of 100 subjects with c...
Article
PURPOSE: To determine and compare corneal elevation and thickness indices, thereby formulating a reliable index to distinguish eyes with pellucid marginal degeneration (PMD) from keratoconus eyes and normal (control) eyes. SETTING: LV Prasad Eye Institute, Hyderabad, India. DESIGN: Initial model-building retrospective study. METHODS: Anterior and p...
Article
Purpose: To investigate the accuracy of Back Optic Zone Radius (BOZR, base curve) measurements with manual keratometer for spherical polymethylmethacrylate (PMMA) lenses. Methods: 100 spherical PMMA contact lenses were selected randomly from the trial sets. One investigator measured the BOZR with radiuscope. The second investigator measured the BOZ...

Questions

Questions (3)
Question
Can it possible to share a word document with references created using "Mendeley Cite" for collaborative writing?
I need to merge two documents with citations created using regular Mendeley word plug-in and "Mendeley cite". Could you please suggest on it ?
Question
how to find the inverse of natural log value of 0.061
Question
Hi,
how to perform age- matching for a case control study? I have enrolled 26 healthy controls and 50 cases. Age has an influence on the outcome. Is it a good idea to manually match them?.

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Projects

Project (1)
Project
To investigate tear neuromediators and corneal nerves of people with diabetes.