Mechanical induction of osteogenesis and signal transduction targeting Rho/ROCK pathway
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
Citations since 2016
8 Research Items
Shuntaro Yamada is a Ph.D candidate at the department of Clinical Dentistry, the University of Bergen. He does research on signal transduction of mesenchymal stem cells by focusing on cytoskeltal regulation under dynamic culture condition.A previous work was on epithelial invagination during tooth morphogenesis.
June 2017 - December 2018
- Master's Student
- Investigation of tooth morphogenesis from mechanobiological aspects by means of advanced microscopy, image analyses and explant culture. Thesis Title: Mechano-biological regulation for cervical loop formation during tooth morphogenesis
Tooth germs undergo a series of dynamic morphologic changes through bud, cap, and bell stages, in which odontogenic epithelium continuously extends into the underlying mesenchyme. During the transition from the bud stage to the cap stage, the base of the bud flattens and then bends into a cap shape whose edges are referred to as “cervical loops.” A...
Various types of synthetic polyesters have been developed as biomaterials for tissue engineering. These materials commonly possess biodegradability, biocompatibility, and formability, which are preferable properties for bone regeneration. The major challenge of using synthetic polyesters is the result of low cell affinity due to their hydrophobic n...
The fatal determination of bone marrow mesenchymal stem/stromal cells (BMSC) is closely associated with mechano-environmental factors in addition to biochemical clues. The aim of this study was to induce osteogenesis in the absence of chemical stimuli using a custom-designed laminar flow bioreactor. BMSC were seeded onto synthetic microporous scaff...
Key points •Periodontal regeneration requires the hierarchical reorganization of soft and hard tissues, namely, periodontal ligament, cementum, alveolar bone, and gingiva. •Three-dimensional microporous scaffolds offer structural support and spatiotemporal guidance for cell growth and differentiation. •Biomimetic periodontal extracellular matrix sc...
Various perfusion bioreactor systems have been designed to improve cell culture with three-dimensional porous scaffolds, and there is some evidence that fluid force improves the osteogenic commitment of the progenitors. However, because of the unique design concept and operational configuration of each study, the experimental setups of perfusion bi...
Degradable polyester-based scaffolds are ideal for tissue engineering applications where long-term structural integrity and mechanical support are a requisite. However, their hydrophobic and unfunctionalized surfaces restrain their tissue-mimetic quality. Instead, hyaluronan (HA) hydrogels are able to act as cell-instructive materials with the abil...
Three-dimensional printing (3D printing) is a promising technique for producing scaffolds for bone tissue engineering applications. Porous scaffolds can be printed directly, and the design, shape and porosity can be controlled. 3D synthetic biodegradable polymeric scaffolds intended for in situ bone regeneration must meet stringent criteria, primar...
This study investigated the level of magnetic energy around implants possessing a static magnetic field (SMF) and assessed the in vivo influence of SMF on bone regeneration. Implants possessing a sintered neodymium magnet internally were placed in a rabbit femur. An implant without SMF was placed as control. After 12 weeks of healing in vivo, the b...