Shubham Upadhyay- Master of Science
- PhD Student at Yenepoya University
Shubham Upadhyay
- Master of Science
- PhD Student at Yenepoya University
About
13
Publications
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Introduction
Current institution
Publications
Publications (13)
Introduction: Bhallataka (Semecarpus anacardium Linn.) is used in traditional medicine to treat various ailments. The nut extract of Bhallataka, known as Bhallataka taila, has anticancer properties. Although several studies have explored to verify and evaluate its anticancer properties and efficacy against various cancers, the specific target prote...
Tinospora cordifolia has been used for thousands of years to treat various health conditions, including neurodegenerative diseases. The study aimed to elucidate the mechanism of action and protein targets of T. cordifolia in the context of Alzheimer’s disease through untargeted metabolomics and network pharmacology. LC–MS/MS analysis resulted in 11...
Triple negative breast cancer is a heterogeneous group of breast cancers that are not responsive to hormone-targeted treatment with a poor prognosis. Although molecular biomarkers for further stratification of TNBC have not been used in the clinical setting so far, several potential biomarkers have been reported through research that can predict re...
The identification of individuals with the greatest risk of progression to active tuberculosis (TB) disease from the huge reservoir of Mycobacterium tuberculosis (Mtb) infected individuals continues to remain an arduous ascent in the global effort to control TB. In a two-year prospective study, we analysed metabolic profiles in the unstimulated and...
Nutrition is the critical nongenetic factor that has a major influence on the health status of an organism. The nutritional status of the mother during gestation and lactation plays a vital role in defining the offspring’s health. Undernutrition during these critical periods may induce chronic metabolic disorders like obesity and cardiovascular dis...
Bacopa monnieri (L.) Wettst and Centella asiatica (L.) Urb., two nootropics, are recognized in Indian Ayurvedic texts. Studies have attempted to understand their action as memory enhancers and neuroprotectants, but many molecular aspects remain unknown. We propose that Bacopa monnieri (L.) Wettst and Centella asiatica (L.) Urb. share common neuropr...
Hemigraphis alternata (H. alternata), commonly known as Red Flame Ivy, is widely recognized for its wound healing capabilities. However, the pharmacologically active plant components and their mechanisms of action in wound healing are yet to be determined. This study presents the mass spectrometry-based global metabolite profiling of aqueous and et...
Bacopa monnieri (L.) Wettst and Centella asiatica (L.) Urb ., two nootropics are recognized in Indian Ayurvedic texts. Studies have attempted to understand their action as memory enhancers and neuroprotectants, but many molecular aspects remain unknown. We propose that Bacopa monnieri (L.) Wettst and Centella asiatica (L.) Urb . share common neurop...
Trophoblast cell surface antigen 2 (TROP2) is a calcium-transducing transmembrane protein mainly involved in embryo development. The aberrant expression of TROP2 is observed in numerous cancers, including triple-negative breast cancer, gastric, colorectal, pancreatic, squamous cell carcinoma of the oral cavity, and prostate cancers. The main signal...
Parkinson's disease (PD) is an age‐associated progressive neurodegenerative movement disorder, and its management strategies are known to cause complications with prolonged usage. We aimed to explore the neuroprotective mechanism of the Indian traditional medicine Yashtimadhu, prepared from the dried roots of Glycyrrhiza glabra L. (licorice) in the...
Questions
Questions (2)
I have been reading about Apoptosis which made me came across terms such as "membrane Blebs" and "Apoptotpodia". Both of these things seemed pretty similiar to me which happen after apoptosis is initiated after caspases cleaves certain substrates. But there are certain research papers which report that Apoptotpodia formation takes place after the formation of membrane Blebs. Can anyone tell me the difference between the two?
I have raw data for global/untargeted mass spectrometry metabolomic data. I have processed that data and now have with me the peak intensities of all the m/z values. I had also spiked the samples with an internal standard. Can anyone tell me how can I normalize my data using the internal standard?
