Shoko Konishi

Shoko Konishi
The University of Tokyo | Todai · School of Medicine

PhD

About

46
Publications
7,124
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
438
Citations
Additional affiliations
June 2018 - present
The University of Tokyo
Position
  • Professor (Associate)
September 2009 - September 2010
University of Washington Seattle
Position
  • Researcher
April 2007 - May 2018
The University of Tokyo
Position
  • Professor (Assistant)

Publications

Publications (46)
Article
Objective To examine the association between antimüllerian hormone (AMH) levels and menstrual-cycle and lifestyle characteristics among young Japanese women. Design Cross-sectional study. Setting A university. Patient(s) Female students aged 20–22 years (n = 65) who had never used oral contraceptives. Intervention(s) Participants completed a qu...
Article
Life history theory predicts a trade-off between immunostimulation and growth. Using a cross-sectional study design, this study aims to test the hypothesis that C-reactive protein (CRP) is negatively associated with height-for-age z-scores (HAZ scores) and BMI-for-age z-scores (BAZ scores) among 6- to 19-year olds (N = 426) residing in five Nepales...
Article
Between-individual variation of salivary progesterone (P4) and cortisol levels does not always closely reflect blood hormone concentrations. This may be partly a function of individual differences in salivary hormone excretion. We tested whether time of day at sampling and ethnicity contributed to individual variation in salivary hormones after adj...
Article
The microbiome is believed to be established during the birthing process through exposure to the maternal microbiome and immediate external environment. The absence of a microbiome prior to birth is based on the sterile womb hypothesis, which was formulated at the beginning of the 20th century and is supported primarily by the culture-based approac...
Article
Telomere length is thought to be a biomarker of biological aging. This study examined whether telomere length was associated with urinary concentrations of 8-hydroxy-2’-deoxyguanosine (8-OHdG), a biomarker of oxidative stress, and antioxidative trace elements in 73 female Japanese university students (age: 19.2 ± 0.7 years). We quantified 8-OHdG an...
Article
Full-text available
Background: Previous studies have suggested that exposures to heavy metals (arsenic, cadmium, lead, and selenium) may be associated with differences in blood pressure. However, the findings of these studies have been inconsistent. This study was performed to examine the associations between urinary heavy metal concentrations and blood pressure amo...
Article
Full-text available
Fecundability, the probability of conception in a month or in a menstrual cycle, varies across and within age groups for both women and men. Fertility treatment has become common in a number of countries including Japan, but its impact on the age pattern of fecundability is unknown. By utilizing the previously collected data on time to pregnancy (T...
Article
Objective Telomere length can be a biomarker of cumulative oxidative stress and inflammation indicating biological aging. Previous studies examined association of nutrient intake with telomere length targeting middle-aged and elderly individuals. This study examined whether dietary macro- and micronutrient intake was associated with telomere length...
Article
Full-text available
Background: Low fertility persists but remains unexplained in Japan. We examined whether the probability of pregnancy was influenced by coital frequency, age, reproductive age (assessed by antimüllerian hormone, AMH), and BMI. Methods: We established a two-year prospective study with a sample of hormonally monitored Japanese women aged 23–34 years...
Article
Full-text available
Cadmium is a toxic metal found ubiquitously throughout the world. Our study evaluated whether cadmium exposure was associated with telomere length in 73 female university students. Determination of telomere length was performed by quantitative polymerase chain reaction using DNA in blood. Urinary cadmium concentration was measured by inductively co...
Article
Full-text available
Higher concentrations of oxidative stress biomarkers are found in women with polycystic ovary syndrome (PCOS) and endometriosis, conditions linked to irregular menstrual cycles and menstrual pain. The aim of the present study was to test whether women with higher oxidative stress are more likely to show irregular menstrual cycles and severe menstru...
Article
Full-text available
Previous studies have reported the highest fecundability (monthly probability of conception) in women aged 20 to their early 30s, and declining fecundability with age. To better understand the age pattern of fecundability in Japanese couples we use time to pregnancy (TTP) to estimate conception probabilities by age. A total of 6,752 women aged 20-4...
Article
Aims Death ideation (thinking about/wishing for one's own death, thinking that one would be better off dead) is linked to an increased mortality risk. However, comparatively little is known about more general thoughts of death (GTOD) where no wish to die or life value is expressed. This study examined whether GTOD predicted mortality in a community...
Article
Full-text available
Aim: To examine whether a longer time to pregnancy is associated with preterm births distinguished as either spontaneous or indicated delivery. Methods: A cross-sectional survey was conducted targeting parous women aged 20-44 years old residing across Japan whose first-born children were singletons. Information on reproductive history including tim...
Article
Background: It has been suggested that exposure to fine particulate matter (PM2.5) adversely affects cardiovascular health. However, the effect modifications by individual characteristics and season have been less studied in developing countries where PM2.5 levels are high. Objectives: To estimate the risks of cardiovascular emergency room visit...
Article
Full-text available
Background Prospective cohort studies of contemporary populations in both Western and Asian settings have reported a U-shaped association between fertility and mortality. We examined whether an association exists between fertility and all-cause and cause-specific mortality in a sample of Japanese women. Methods A prospective cohort study was condu...
Chapter
Proximate determinants link both social and biological factors to fertility. In this section, we will summarize available data related to proximate determinants of fertility in Japan while referring to some of the related literature targeting populations overseas. In addition to data from published studies, we present our original data collected in...
Chapter
In the earlier chapters of this book, we have shown, with limited evidence, that both the duration of lactational infecundability and time to pregnancy (TTP) may be longer among Japanese couples than among Western couples. Longer TTP can be linked to the relatively low coital frequency and prolonged duration of lactation found in couples and mother...
Article
We evaluated the representativeness of concentrations of parabens in a spot urine sample for the assessment of long-term exposure levels. Urine sample was taken monthly from 10 male Japanese subjects (35.9 ± 6.8 years) and 12 female Japanese university students (21.1 ± 0.4 years) for 5 months and measured for methyl (MP), ethyl (EP), propyl (PP) an...
Article
Aim: Secular trends of preterm birth in Japan between 1979 and 2014 were examined to determine whether changes could be explained by a shift in the distribution of maternal age at delivery and parity and/or by changes in age-specific preterm birth rates. Methods: Live birth data for 1979 to 2014 were obtained from the Japanese Ministry of Health...
Article
Background: Previous studies have revealed the interactive effects of airborne pollen and particulate matter on the daily consultations for pollinosis, but it is uncertain which compositions are responsible. This study aimed to investigate the interactive effects of specific PM2.5 compositions and airborne pollen on the daily number of clinic visit...
Article
Prior research has indicated that pollen might be linked to suicide mortality although the few studies that have been undertaken to date have produced conflicting findings and been limited to Western settings. This study examined the association between the level of airborne pollen and suicide mortality in Tokyo, Japan in the period from 2001 to 20...
Article
Full-text available
Background The objective is to examine the association between AD and the daily number of medical consultations for pollinosis in Fukuoka City. Methods We analyzed 65,488 daily medical consultations for pollinosis from 4 clinics in Fukuoka City from February to April, 1989–2012. Time-series analyses were performed to estimate the clinic-specific re...
Article
Putative protective effects of selenium (Se) against methylmercury (MeHg) toxicity have been examined but no conclusion has been reached. We recently reported the lack of serious neurological symptoms in a Japanese fish-eating population with high intakes of MeHg and suggested a potential protective role for Se. Here, relationships between levels o...
Article
Full-text available
Objectives: To elucidate the patterns of contraceptive use in both married and unmarried women in Japan; and to examine which factors are associated with using no or unreliable contraceptives while adjusting for pregnancy intention.Methods: Using cross-sectional data from the Biodemography Project conducted in Japan in 2014, we analyzed current con...
Article
Background: Some evidence suggests an association may exist between the level of air pollution and suicide mortality. However, this relation has been little studied to date. The current study examined the association in Tokyo, Japan. Methods: Suicide mortality data for Tokyo for the 11-year period 2001-2011 were obtained together with data on fo...
Article
Parabens have been known to have estrogenic activity in many in vivo and in vitro studies and biomonitoring data indicated ubiquitous exposure in general populations. However, there are few human studies on reproductive effects of parabens. In this study, menstrual cycle length and its intra-individual variation were investigated by bleeding record...
Article
Objectives: Elevated and suppressed concentrations of cortisol have been linked with less favorable metabolic biomarkers, such as elevated lipids and glycosylated hemoglobin (HbA1c). Based on recent work reporting that some individuals secrete more cortisol into saliva (high saliva-to-blood cortisol ratio; high secretors) than others after correct...
Article
Background: Having an allergic disease may have health implications beyond those more commonly associated with allergy given that previous epidemiological studies have suggested that both atopy and allergy are linked to mortality. More viable immune functioning among the elderly, as indicated by the presence of an allergic disease, might therefore...
Article
Full-text available
To acquire fundamental knowledge on menstrual cycle and its intraindividual variation in healthy Japanese female students and their association with biological attributes, lifestyle and food habit. We asked female students of a nursing school to keep a diary of their menstruation over 5 consecutive months and to fill a questionnaire on their biolog...
Article
Full-text available
Objective: Injury is the leading cause of death among children and adolescents in Japan. Despite this, until now there has been comparatively little research on this phenomenon. The purpose of this study was to examine if there was seasonal variation in child and adolescent injury mortality in Japan in 2000-2010. Methods: Vital statistics injury...
Article
Full-text available
Examples of demographic transition include transitions from high-fertility-high-mortality to high-fertility-low-mortality and to low-fertility-low-mortality. In general, a high population growth rate is observed in the high-fertility-low-mortality phase, and the rate of population growth decreases in the low-fertility-low-mortality phase. Using ava...
Article
Full-text available
The purpose of this study is to evaluate the prevalence and intensity and examine the risk factors of soil transmitted helminth (STH; i.e., roundworm [Ascaris lumbricoides], hookworms [Ancylostoma duodenale and Necator americanus], and whipworm [Trichuris trichiura]) infections in Nepal. Five hundred and ninety-four adults (256 men and 338 women) w...
Article
Full-text available
Background: Ambient temperature affects mortality in susceptible populations, but regional differences in this association remain unclear in Japan. We conducted a time-series study to examine the variation in the effects of ambient temperature on daily mortality across Japan. Methods: A total of 731 558 all-age non-accidental deaths in 6 cities...
Article
Tongan adults show one of the highest prevalences of obesity in the world. The present study aims to estimate Tongans' energy and nutrient intakes and food sources using a 24-hour recall survey for 14 days targeting 15 men and 19 women. The mean (SD) daily energy intake was 12.2 (2.3) MJ for men and 10.6 (2.2) MJ for women. Imported foods accounted...
Article
Full-text available
The high prevalence of anemia and underweight among reproductive age women is a serious health concern in Nepal. The objective of the present study was to describe anemia prevalence and nutritional status of married women in Nepal. Total of 278 women were included in the present analysis. The five communities included an urban commercial area (W) i...
Conference Paper
Background/Question/Methods Most of the rural regions in Asian-Pacific countries undergo a rapid transition from traditional subsistence to cash economy-oriented agriculture and other subsistence mode. Such transition entails not only alteration of local “natural” environment but also introduction and release/accumulation of chemical substances, s...
Article
Full-text available
In the Kingdom of Tonga, migration to overseas developed countries has prevailed. To elucidate the effects of migration on population dynamics, an interview survey was conducted in the migrant-sending community of Kolovai, in the outer region of Tongatapu Island. All births, deaths, marriages and in- and out-migrations that took place between 1983...
Article
Full-text available
Despite much concern about adult obesity among Pacific Islanders, childhood obesity has seldom been investigated. Based on the anthropometry of Tongan children aged 5-19 years, this study aims to elucidate age and sex differences in obesity prevalence calculated from BMI and its relation to body fat estimated by skinfold thicknesses. 895 students,...

Projects

Project (1)