Shivprasad Patil

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• PhD
• Postdoctoral researcher at University of North Carolina at Greensboro

Natural deep eutectic solvents have a high solvation and food-grade characteristics, which make them a preffered choice for extracting bioactives to develop nutraceutical and cosmetic formulations. This research aimed to investigate the systematic effects of several NADESs on the ultrasonic-assisted extraction of steroidal saponins from the rhizome...

In the course of evolution, living organisms have become well equipped with diverse natural products that serve important functions, including defence from biotic and abiotic stress, growth regulation, reproduction, metabolism, and epigenetic regulation. It seems to be the organism's ecological niche that influences the natural product's structural...

Sustainability in natural product research is crucial for developing eco-friendly methodologies to transform biomass into high-value products without hampering the environment. The checkpoints critical to the sustainable production of natural products involve implementing green technologies for collecting bioresources, refining extraction processes...

Alcohol consumption perturbs the gut immune barrier and ultimately results in alcoholic liver diseases, but little is known about how immune-related cells in the gut are perturbed in this process. In this study, we employed laser capture microdissection and a label-free proteomics approach to investigate the consequences of alcohol exposure to the...

Megaphages are bacteriophages (i.e., phages) with exceptionally large genomes that are ecosystem cosmopolitans, infect various bacterial hosts, and have been discovered across various metagenomic datasets globally. To date, almost all megaphages have evaded cultivation, with only phage G being in active culture for over 50 years. We examined with m...

Frontiers in Clinical Drug Research - Anti Infectives (Volume 9) is a book series that provides updated reviews on the latest advancements in development of pharmaceutical agents for treating infectious diseases. The series covers various topics, including chemistry, pharmacology, molecular biology, and biochemistry of natural and synthetic drugs....

Objectives This study investigated the efficacy of a mixed beet-based supplement (BEET) versus placebo (PL) in countering inflammation during recovery from 2.25 h of intensive cycling in 20 male and female cyclists. A multi-omics approach was used that included untargeted proteomics and a targeted oxylipin panel. Methods A randomized, placebo-cont...

Introduction Trillium govanianum Wall. ex D.Don is a folk medicinal herb rich in structurally diverse steroidal saponins. The annual demand for this herb in India is about 200–500 metric tons, highlighting the need for a thorough quality assessment. Objective The objective of this study is to develop an easy and reliable ultrahigh‐performance liqu...

The diverse chemical scaffolds of the Cissampelos pareira make it pharmacologically distinct because of its pleiotropic therapeutical applications. Phytochemically, C. pareira is primarily known for its isoquinoline alkaloids, but flavonoids and their glycosides have also been reported from the aerial part. Among the several traditional uses of C....

Natural deep eutectic solvents (NADESs) are recognized as sustainable green media for extracting bioactive compounds from biomass. Herein, NADES-based green media was employed to extract bioactives from the Himalayan medicinal herb conitum heterophyllum Wall. Bioactive compounds such as aconitic acid (insecticidal, anti-bacterial, anti-fungal), at...

Four previously undescribed steroidal saponins named govanosides C-F (1-4) and nine known compounds (5-13) were isolated from the rhizomes of Trillium govanianum Wall. ex D.Don. Govanosides C-E contained a rare sugar moiety i.e., 6-deoxy allose, while govanoside F has acetylated rhamnose moiety in its glycan part. Also, this is the first report on...

Emerging evidence suggests that sustained diabetes-associated factors such as inflammation, hyperinsulinemia, and hyperglycemia are major contributors to aberrant cell proliferation and subsequent neoplastic transformation. Epidemiological studies have also highlighted that diabetes promoting a sedentary lifestyle, with or without the direct involv...

Malaria is a major global health issue due to the emergence of resistance to most of the available antimalarial drugs. There is an urgent need to discover new antimalarials to tackle the resistance issue. The present study aims to explore the antimalarial potential of chemical constituents reported from Cissampelos pareira L., a medicinal plant tra...

The anti-inflammatory drugs are vital agents used to manage the acute and chronic inflammation-related ailments including arthritis, bowel diseases, cancer, colitis, diabetes, and heart disease. The anti-inflammatory properties of chemical agents, i.e., non-steroidal anti-inflammatory drugs, exhibited their antagonistic effect on cyclooxygenase (CO...

There is a deep-rooted belief in mankind that for every illness, somewhere in the world, there exists a botanical-based healing agent in nature in the form of a natural product. Natural products are better equipped to become successful drugs because of their million years of coevolution in a biological milieu. Generally, most herbal formulations an...

Steroidal sapogenins (SS) are structural analogues of steroidal drugs, which are frequently used for the treatment of several diseases including reproductive, malignancies, neurological, and inflammation-related diseases. The glucocorticoid receptor (GR) is a nuclear receptor that regulates development, metabolism, and inflammation, in response to...

The gradual growth of the herbal drug industries has necessitated the need for the quality control measures for the quality assessment of herbal preparations. This has resulted in the employment of a comprehensive set of analytical methods that helps to give a complete picture of the quality of herbal material in terms of its phytochemical composit...

Background: Diabetic Kidney Disease (DKD) is a common complication of diabetes and a leading cause of end-stage renal disease progression. Therefore, therapeutic strategies are desirable to mitigate the progression of disease into more severe consequences. Hypothesis/Purpose: Tinospora cordifolia is a traditionally known antidiabetic plant; however...

Objective The rhizomes of Trillium govanianum have traditionally been used in the Ayurvedic system of medicine to treat inflammation, pain, burn, and reproductive malfunctions. However, the ethanopharmacology and chemical constituents of T. govanianum have not been effusively explored to date. The present study attempted to uncover the phytochemica...

Ethnopharmacological relevance Cissampelos pareira, a well-known medicinal climber-plant of the Menispermaceae family, has been extensively used in the traditional medicinal system since the ancient time for the treatment of numerous diseases such as ulcer, wound, rheumatism, fever, asthma, cholera, diarrhea, inflammation, snakebite, malaria, rabie...

Objective To provide the scientific basis for the utility of rhizome of Trillium govanianum as nutraceutical supplements in managing physiological glycemic levels. Methods The in vitro enzyme inhibitory activity of the extract, fractions, and the isolated steroidal saponins from the rhizome part of T. govanianum was carried out against α-amylase,...

The genus Trillium belongs to the family Melanthiaceae (alt. Trilliaceae) and comprises around ̴ 50 accepted species. Steroidal saponins are the principal phytomolecules in Trillium. A total of around ̴ 83 different steroidal saponins with three structurally different sapogenin skeletons have been reported from the Trillium genus. Steroidal saponin...

BACKGROUND Plutella xylostella L. is the major pest of crucifers globally, causing significant yield loss. Aphis craccivora Koch is the main sucking pest of legumes that transmit viral diseases, leading to economic yield reduction. To minimize loss due to pests, farmers/growers use synthetic insecticides frequently for their control, which led to i...

In current study, we have focused on the outline of different coronaviruses including COVID-19, along with potential therapeutic targets of SARC-CoV-2. Moreover, experimentally evident anti-coronavirus natural molecules were subjected for in silico screening against M^pro and RdRp of COVID-19, in order to predict effective cure agent for...

Introduction Trillium govanianum (Nag Chhatri and Teen Patra) is traditionally used for curing joint pains, wounds, and sexual disorders. Steroidal saponins are the main active components of this species. However, only a small amount of information is available about steroidal saponins of this plant. Objective To develop an ultra‐high‐performance...

Trillium govanianum, commonly known as Nag Chhatri and Teen Patra, is a popular herbal supplement traditionally used for curing different inflammatory and sexual disorders, infection and wound healing. Steroidal saponins are considered as active components of this species. The present study demonstrated the isolation of nine steroidal saponins, inc...