Shivaram Ch

Manipal Hospital · TRANSFUSION MEDICINE

Alloimmune thrombocytopenia is the most common cause of severe thrombocytopenia and intracranial bleed in the perinatal period, resulting from placental transfer of maternal platelet antibodies directed against the paternal-derived fetal platelet antigens. It is estimated to occur in 1 in 2500 births but continues to be an underdiagnosed and underr...

Hemovigilance is a set of surveillance procedures starting from the donor vein and ending with the patient vein, aimed at reducing the risks associated with transfusion which could be donor related, recipient related, or process related. Donor-related risks include local and systemic complications which need a variety of interventions to ensure saf...

Altruism, warm glove, kinship and a sense of duty are the primary driving forces behind blood donation. The concept of donor cycle starts with donor recruitment and ends with donor retention and recall or with notification of sero-reactive donors. Donor Selection criteria vary from country to country and from region to region. Blood donor counselin...

We report a rare case of Oh (D)-negative female with in vitro fertilization (IVF) pregnancy. Blood grouping was reported as O Rh (D) negative elsewhere and was referred at 28 weeks gestation for anti-D titration to our center. Blood grouping repeated at our laboratory was Oh Rh (D) negative. Owing to the absence of H antigen-negative cells, we did...

Background: Injury is the leading cause of life years lost, and hemorrhage is responsible for 40% of all trauma deaths and is commonly associated with coagulopathy, necessitating the use of blood and blood components. With logistical issues and concerns regarding safety of fresh whole blood because of the abbreviated less-sensitive technologies inv...

Background and Objectives Red cell antibody screening as a part of pretransfusion testing is not a routine practice in many developing countries. This study, was done to determine the incidence of allo- and auto-antibodies, assess their clinical significance and deliver antigen negative blood where warranted.Materials and Methods Red cell antibody...

Legal issues play a vital role in providing a framework for the Indian blood transfusion service (BTS), while ethical issues pave the way for quality. Despite licensing of all blood banks, failure to revamp the Drugs and Cosmetic Act (D and C Act) is impeding quality. Newer techniques like chemiluminescence or nucleic acid testing (NAT) find no men...

It is well established that Nucleic acid testing (NAT) reduces window phase of transfusion transmissible infections (TTI) and helps improve blood safety. NAT testing can be done individually or in pools. The objectives of this study were to determine the utility, feasibility and cost effectiveness of an in-house minipool-NAT(MP-NAT). Blood donors w...