Shivani Singh

• Research Assistant at Era's Lucknow Medical College and Hospital

This study’s objective is to evaluate the expression of Octamer-binding transcription factor 4 (OCT-4) as a prognostic biomarker for urinary bladder cancer (UBC) along with its histological grade and tissue invasiveness. It is also called the POU domain, class 5, transcription factor I(POU5FI). OCT-4 protein is a transcription factor and a well-kno...

Molecular docking is the prominent method for structural analysis and designing of drugs which is assisted by computer programs. The aim of docking is to predict the binding between two molecule ligand and receptor when they bind to form stable complex. The ligand could be any macromolecule but mainly this method is performed with protein of known...

As in our body, brain is the most powerful part and our mind could be excellent healing tool when any chance is provided. The idea that our brain can be one of the convincing parts in our body for the fake treatment is the real point this is called as placebo effect [1]. This effect refers to the impact of placebo on any one. However, treatments wh...

Technological era or Technological slave??“ The great myth of our time is that technology is communication” India stands second, internationally with about millions of Internet users and frequent enhancements in technology had increased the access of internet among all the age groups exceedingly in past years leap up the threat to various people bu...

Fungal infections have become more frequent, due to its extension population are at higher risk of utilization and treatment mode that permits long lasting survival of the patients. The histopathological detection of tissues shows fungal invasion of tissues and vessels along with host reaction with fungi and it could be a crucial tool for defining...

Currently ongoing outbreak of COVID-19 disease is a defining and unrivalled worldwide crisis of this time in both magnitude and scale level. Though the respiratory tract is the primary target of this disease evidences revealed that the virus could also enter in central and peripheral nervous system leading to numerous neurological issues inclusion...

COVID-19 associated infection is caused by the virus SARS-CoV-2, the virus is single stranded positive sense binds with greater affinity to Angiotensin Converting Enzyme-2 present in human cells it is 30 kb pair long RNA genome which take over the host cell machinery, immune system of host cell with the help of accessory proteins leads widespread i...

Zygomycosis was identified as easy and comprehensive factor for 2 clinicopathological distinct infection, mucormycosis resulted due to Mucorales and entomophthoramycosis occur due to order Entomophthorales of class Zygomycota. The name Zygomycosis has been used as similar word only for mucormycosis. As mucormycosis is systemic fungal infection occu...

Adverse event following immunization (AEFI) is basically an event of unexpected medical emergency occurring after vaccination on immunization without any causal association with vaccination. It can be any unintended, abnormal laboratory finding or anything. At the time of vaccination, there are many reasons like improper way of vaccination by healt...

The glycans are carbohydrate present with other macromolecules where it could act as ligand for glycan-binding protein called lectin. This glycan-lectin interaction plays important role in cell and organ functioning and immune regulation in both animals and humans. Glycan-lectin interaction is also utilized in viral pathogen interaction which is en...

New areas of problems keep surfacing as a result of the complex interactions among the various factors which eventually lead to diseases. Extensive studies of these different factors abnormality under taken so far have been able to provide an insight into the patho-physiological alterations in various diseases. Physiologically, iso-enzymes are stru...

: As from the first outbreak of COVID-19 the clinical feature of COVID-19 had been changing progressively. Various data had been reported viral intra and inter-host evolution favoring the mild COVID-19 strains are being accumulating, for better understanding the evolution of COVID-19. So it is essential to investigate the genetic and phenotypic fea...

Functional annotation provides the information of gene about its biological identity and various types of molecular function and biological role like sub-cellular location and its expression. It functions by attaching biological information of gene and protein. The primary level of annotation is performed by using Basic logical Alignment Tool (BLAS...

Coronaviruses are the fascinating group of viruses with the unusual molecular mechanism of recombination and transcription and also consist newly emerged pathogens. The emergence of SARS and coronavirus as its etiological agent was found totally surprising in community of coronaviruses. As it was the first strain found to be causing severe illness...

Human Papilloma Virus (HPV) is a DNA tumor virus with double stranded and non-enveloped DNA of 8 kilobase. Its genome is covered by capsid protein with icosahedral symmetry and a diameter of 55nm. It induces proliferative lesions in mucosal and cutaneous epithelia. It is ubiquitous in nature and have been detected in both animals and humans and wel...

INTRODUCTION Testicular cancer reports 1% for human malignancies in males and its incidence is increasing worldwide in last fifty years. This cancer develops in male reproductive part which results lump in testicles, swelling or pain in scrotum. Testicular cancer occurs mainly in germ cell accounts for more than 95% of testicular malignancies calle...

Cervical cancer is sexually transmitted disease resulting from the high risk oncogene infection by Human papillomavirus of type 16 and 18. In cervical cancer cells the two viral oncogene E6 and E7 are found to be variably expressed. These genes modulate the molecule involved in innate and adaptive immunity development and also inhibit the major tum...