Shinichiro Morishita

Shinichiro Morishita
Hyogo College of Medicine · Department of Rehabilitation

Ph.D.

About

96
Publications
14,416
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735
Citations
Additional affiliations
October 2003 - present
Hyogo College of Medicine
Position
  • Researcher

Publications

Publications (96)
Article
Full-text available
A recent study has reported that prefrontal cortex (PFC) activity during incremental exercise may be related to exercise termination on exhaustion. However, few studies have focused on motor-related areas during incremental exercise. This study investigated changes in the oxygenation of the PFC and motor-related areas using near-infrared spectrosco...
Article
Falls are a social problem that increase healthcare costs. Hemodialysis (HD) patients need to avoid falling because fractures increase their risk of death. Nutritional problems such as frailty, sarcopenia, undernutrition, protein-energy wasting (PEW), and cachexia may increase the risk of falls and fractures in patients with HD. This review aimed t...
Preprint
Purpose: To determine the percentage of and factors associated with unplanned transfer to the primary acute care service of glioblastoma multiforme acute rehabilitation inpatients.Methods: Retrospective review of glioblastoma multiforme acute rehabilitation inpatients admitted 4/1/2016-3/31/2020 at a National Cancer Institute Comprehensive Cancer C...
Article
Background: Glioblastoma multiforme (GBM) brain tumor patients often have functional deficits related to neurologic impairments and are commonly found in acute inpatient rehabilitation facilities. No previous studies specifically looking at the return to the primary acute care service of GBM patients has been published. Objective: To determine the...
Article
Full-text available
Background Hemodialysis (HD) patients are at a high risk of falls and fractures. The amount of physical activity (PA) they perform may be limited by psychosomatic factors associated with fear of falling, leading to frailty progression. This study aimed to clarify the relationship between fear of falling and PA in patients undergoing HD. Methods Th...
Article
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A previous study reported that cancer survivors exhibit decreased postural stability compared to age-matched controls. Another study showed that cancer survivors have a lower quality of life (QOL) compared to healthy subjects, and there was a significant relationship between muscle strength and QOL in cancer survivors. We aimed to investigate diffe...
Article
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Purpose This systematic review and meta-analysis aimed to determine whether physical function can predict mortality in patients with cancer. Methods Literature searches were conducted in Web of Science, CINAHL, the Cochrane Library, ProQuest, PEDro, and PubMed for articles published before September 2020. Four review authors retrieved studies usin...
Article
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PurposeThis study aimed to investigate the relationship between exercise intolerance, muscle oxidative metabolism, and cardiopulmonary function following allogeneic hematopoietic stem cell transplantation (allo-HSCT) in a sterile isolation room setting.Methods This was a prospective observational cohort study conducted in a single center. Fourteen...
Article
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Purpose Health utility, which is a measure of patient-reported outcome (PRO), has recently been used in health-related quality of life for patients with various cancers. However, the relationship between health utility and the physical function and of patients undergoing pleurectomy/decortication (P/D) as surgical treatment for malignant pleural me...
Article
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Introduction: Differences in cognitive performance with exercise between men and women have previously been reported. In this study, we evaluated between-sex differences in oxygenation of the prefrontal cortex (PFC) with moderate-intensity aerobic exercise (AE), which could contribute to noted differences in cognitive function. Method: The subje...
Chapter
Introduction: After hematopoietic stem-cell transplantation (HSCT), patients exhibit decreased muscle strength and muscle oxygen consumption. Furthermore, total corticosteroid dose affects the reduction in muscle strength after HSCT. However, to date, no studies have investigated the relationship between corticosteroid dose and muscle oxygen consu...
Chapter
A previous study considered that a decrease in cerebral oxyhemoglobin (O2Hb) immediately before maximal exercise during incremental exercise is related to cerebral blood flow (CBF) and partial pressure end-tidal carbon dioxide (PETCO2). This study aimed to investigate the relationship between O2Hb, PETCO2, and the estimated value of cerebral blood...
Chapter
Continuous moderate-intensity aerobic exercise improves cognitive function including working memory (WM). We aimed to determine the differences in the effects of exercise on WM based on pre-exercise WM function and oxyhemoglobin (O2Hb) changes. We enrolled 12 healthy adult males who, after a 4-min rest and warm-up, performed a 20-min exercise regim...
Chapter
It has been reported that the cardiovascular response in the supine position is different from that in the sitting position. However, there are few reports on the effects of posture on cerebral oxygenation during exercise. Cycling exercises change oxygenated hemoglobin (O2Hb) and deoxygenated hemoglobin (HHb) levels in motor-related areas. Therefor...
Chapter
Introduction: The Borg scale rating of perceived exertion is a reliable indicator and widely used to monitor and guide exercise intensity. We aimed to evaluate the relationships between the Borg scale score and oxygenated hemoglobin (O2Hb) and deoxygenated hemoglobin (HHb) concentrations in the leg muscle as measured by near-infrared spectroscopy...
Chapter
This study aimed to compare cerebral oxyhemoglobin (O2Hb) levels during incremental exercise by cycling vs. arm cranking in 12 healthy adult men aged 20.8 ± 0.2 years old. O2Hb was measured by near-infrared spectroscopy. Regions of interest included the left and right prefrontal cortices (LtPFC and RtPFC, respectively), the left and right premotor...
Chapter
A recent study based on near-infrared spectrometry (NIRS) showed that a single session of moderate-intensity exercise increases the cortical oxyhemoglobin (O2Hb) level. However, changes in the laterality of O2Hb throughout such exercises remain unknown. In the present study, we evaluated changes in the laterality of O2Hb in the prefrontal cortex (P...
Article
Full-text available
Background: The Borg scale is used to determine exercise intensity in rehabilitation but can be difficult for older adults to understand. By contrast, face scale that are used to evaluate pain are much easier to understand thanks to the inclusion of illustrations. On the other hand, the prevalence of atrial fibrillation (AF) increases with age. Th...
Article
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Previous studies have indicated that changes in oxygenated hemoglobin concentration (O2Hb) in the prefrontal cortex (PFC) are associated with changes in cognitive function. Therefore, the present study aimed to explore the effect of differences in O2Hb levels in the left and right PFC (L-PFC and R-PFC, respectively) on cognitive function after exer...
Article
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Osteopenia/osteoporosis and sarcopenia are common geriatric diseases among older adults and harm activities of daily living (ADL) and quality of life (QOL). Osteosarcopenia is a unique syndrome that is a concomitant of both osteopenia/osteoporosis and sarcopenia. This review aimed to summarize the related factors and clinical outcomes of osteosarco...
Article
The incidence of leptomeningeal disease (LMD) is believed to be increasing in part because of more effective chemotherapy treatments allowing cancer progression behind the blood-brain barrier. However, little has been published about the rehabilitation of this growing patient population. In this study, impairments and rehabilitation utilization by...
Article
Objectives: To investigate the differences between the Face Pain and Borg scales for rating of perceived exertion (RPE) during cardiopulmonary exercise testing (CPET) in healthy adults, and their relationships with work rate (watts), heart rate (HR), oxygen uptake (VO2), and minute ventilation (VE). Methods: In this prospective observational stu...
Article
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Many studies have reported that physical exercise can improve the levels of function, quality of life (QoL), and fatigue in patients with hematologic malignancies. However, exercises should be prescribed with caution in patients with thrombocytopenia to prevent exercise-related bleeding. Some studies have suggested threshold platelet counts at whic...
Article
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Aims To determine the relationship between physical activity time and physical function according to the Japanese Clinical Practice Guideline for Diabetes, which recommended 150 min of activity for outpatients with type 2 diabetes who may have diabetic neuropathy. Methods We examined a cross-sectional study with 79 outpatients with Type 2 diabetes...
Article
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[Purpose] One-repetition maximum is an essential statistic for physical therapists and coaches in rehabilitation and athletic settings. In a previous study, we showed that one-repetition maximum of the knee extensor could be predicted more accurately with the combination of maximal voluntary isometric contraction strength, as measured by a handheld...
Preprint
Full-text available
Background: The Borg scale is used to determine exercise intensity in rehabilitation but can be difficult for older adults to understand. By contrast, face scale that are used to evaluate pain are much easier to understand thanks to the inclusion of illustrations. On the other hand, the prevalence of atrial fibrillation (AF) increases with age. We...
Article
This study aimed to investigate the effects of unexpected trunk muscle contraction training for anticipatory muscle activity during a single leg lifting task. A total of 11 healthy adults performed 20 trials of rapid single‐leg lifts by flexing the hip joint of their dominant leg so that the thigh was 90° to the torso. As a training task, participa...
Article
Full-text available
Purpose: Exercise could lower the risk of cancer recurrence and improve mortality, exercise capacity, physical and cardiovascular function, strength, and quality of life in patients with cancer. This systematic review and meta-analysis of randomized controlled trials (RCTs) aimed to determine the effects of exercise on mortality and recurrence in p...
Chapter
Our previous research confirmed that patients with malignant hematopoietic disease already had a low hemoglobin level before allogeneic hematopoietic stem cell transplantation (allo-HSCT). However, no study has determined whether a correlation exists between exercise load, hemoglobin level, and muscle oxygen saturation (SmO2), during exercise. Ther...
Chapter
Measurement of oxyhemoglobin (O2Hb) changes in the cerebral cortex using near-infrared spectroscopy (NIRS) shows that its levels increase during moderate-intensity exercise and persists after exercise. However, the effects of exercise duration on O2Hb persistence in the premotor cortex (PMC) are unknown. We aimed to determine the effects of exercis...
Chapter
Near-infrared spectroscopy (NIRS) during cardiopulmonary exercise test (CPX) has shown a correlation between prefrontal cortex (PFC) oxygenated hemoglobin (O2Hb) level and negative affective responses. We hypothesized that O2Hb changes differ between the PFC and motor-related areas. This study investigated changes in hemoglobin levels in the PFC an...
Chapter
Patients with hematological malignancy might already have decreased muscle oxygen saturation at rest and exercise capacity before undergoing hematopoietic stem cell transplantation (HSCT). However, to date, no studies have investigated the relationship between exercise capacity and muscle oxygen saturation at rest in these patients. Therefore, purp...
Chapter
Cognitive function is reported to improve by moderate aerobic exercise. However, the effects of intermittent exercise with rest between the moderate-intensity exercise are unclear. Therefore, this study aimed to compare the effects of continuous and intermittent exercise on cerebral oxygenation and cognitive function. This study included 18 healthy...
Article
[Purpose] The purpose of this study was to evaluate the changes in skin temperature and blood flow in the big toe of the contralateral inactive leg during single-leg cycling. [Participants and Methods] A single-leg pedaling exercise that used the right leg was performed by 13 healthy adult males (age 21.2 ± 0.2 years, height 172.5 ± 7.1 cm, weight...
Article
Full-text available
Background: Intensive care unit-acquired weakness (ICU-AW) can be diagnosed using the Medical Research Council (MRC) score. However, such scoring may not be possible in ICU patients who may be sedated or delirious or have encephalopathy. Currently, a quantitative assessment of the cross-sectional area of the muscle is available to assess changes i...
Article
We evaluated the effects of moderate-intensity exercise in improving the decline in cognitive performance induced by a 24-h period of acute sleep deprivation (SD). We hypothesized that the positive effect of exercise is mediated by increased oxygenation (measured using near-infrared spectroscopy) of the dorsolateral prefrontal cortex (DLPFC). Cogni...
Article
Full-text available
Purpose According to reports, patients with lung cancer have decreased pulmonary function and exercise capacity after surgery. However, to date, physical function and health-related quality of life (HRQOL) after surgery for malignant pleural mesothelioma (MPM) have not been evaluated in detail in the convalescent phase. This study aimed to assess p...
Preprint
Objectives We aimed to investigate the differences as well as the relationship between muscle strength, balance function, quality of life (QOL), and fatigue in cancer survivors and healthy subjects. Design A cross-sectional observational study. Setting The Relay For Life Niigata in Japan Participants Forty-one cancer survivors and 33 healthy subjec...
Article
Background: Cancer survivors experience late and long-term effects of treatment; also, the disease itself might be responsible for persisting functional impairments. The purpose of this study was to investigate muscle strength, balance function using the Mini-Balance Evaluation Systems Test and Timed Up and Go test with single and cognitive dual t...
Article
Objective: Evaluate Functional Independence Measure (FIM) changes and incidence of serious medical complications requiring return to the primary acute care service of acute rehabilitation cancer inpatients with leptomeningeal disease (LMD). Design: Retrospective chart review. Setting: Tertiary referral based comprehensive cancer center acute i...
Article
[Purpose] The purpose of this study was to inspect the effect of sustained exercise and intermittent exercise on oxygen change in the vastus lateralis muscle. [Participants and Methods] The participants were 17 healthy males and females. Sustained exercise was performed for 30 minutes at 50% of maximal oxygen uptake, and intermittent exercise was p...
Article
Allogeneic hematopoietic stem-cell transplantation (allo-HSCT) is increasingly used in the treatment of hematologic cancers such as leukemias, lymphomas, and myeloma, and for other hematologic disorders such as primary immunodeficiency, aplastic anemia, and myelodysplasia. Allo-HSCT entails a conditioning regimen of frequent high-dose chemotherapy...
Article
[Purpose] The purpose of this study was to clarify and compare the effects of sustained exercise versus intermittent exercise on autonomic nervous activity and circulatory dynamics during exercise using a bicycle ergometer. [Participants and Methods] Seventeen healthy adults carried out both sustained exercise (30-minute steady-state exercise) and...
Article
Purpose: In elderly patients with collagen disease, walking ability tends to decrease due to treatment with corticosteroids and long-term hospitalization. The purpose of this study was to investigate the factors related to independent walking in elderly patients with collagen disease. Methods: A total of 65 inpatients, aged ≥65 years with collagen...
Article
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Introduction: The American College of Sports Medicine and American Heart Association recommends resistance training involving 60–70% of 1-repetition maximum (1RM) for 8–12 repetitions on 2 or 3 nonconsecutive days per week for the elderly. The Borg 6–20 scale, Borg category ratio (CR-10) scale, and OMNI scale are used to determine the rating of per...
Article
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Objective This study aimed to investigate the correlation between the face scale and heart rate (HR), exercise load and oxygen uptake (V̇O 2 ) during cardiopulmonary exercise testing. Methods This was a prospective, observational study of face scale rating of perceived exertion (RPE) and HR, exercise load and V̇O 2 during cardiopulmonary exercise t...
Article
Full-text available
Gazing at objects at a near distance (small eye-object distance) can reduce body sway. However, whether body sway is regulated by movement in the mediolateral or anteroposterior direction remains unclear. Galvanic vestibular stimulation (GVS) can induce body tilting in the mediolateral or anteroposterior direction. This study examined the direction...
Article
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Objective: To identify the frequency and characteristics of bleeding complications during acute inpatient rehabilitation of hematologic malignancy patients with severe thrombocytopenia. Design: Retrospective descriptive analysis. Setting: Comprehensive cancer center acute inpatient rehabilitation unit. Participants: Consecutive hematologic m...
Article
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Purpose: We aimed to investigate the relationship between Borg scale and intensity of resistance training in patients who had undergone allogeneic hematopoietic stem cell transplantation (allo-HSCT). Furthermore, the relationship between Borg scale, heart rate (HR), and intensity of exercise tolerance test was also studied. Methods: The study in...
Chapter
The purpose of this study was to compare the differences in fatigue to those in muscle oxygen consumption and blood flow to the skeletal muscles before and after allogeneic hematopoietic stem cell transplantation (allo-HSCT). This study included 25 male patients who had received allo-HSCT between November 2009 and August 2012. Fatigue was assessed...
Chapter
Aerobic exercise produces changes in cerebral oxyhaemoglobin (O2Hb) concentration; however, the effects of exercise on O2Hb during the post-exercise period remain to be established. The aim of the present study was to evaluate O2Hb levels during and after a 20-min bout of moderate-intensity cycling exercise. After a 3-min rest period, 12 healthy vo...
Chapter
The purpose of this study was to compare the prefrontal cortex (PFC) oxyhaemoglobin (HbO2) levels observed during cycling in the upright and supine positions. Twelve healthy volunteers were randomly assigned to either the upright or supine position. After measuring maximal oxygen consumption (VO2max) with a cycle ergometer in the upright position,...
Chapter
Impaired oxygen utilization in skeletal muscle potentially contributes to muscle weakness in patients with malignant hematopoietic disease and may explain altered hemodynamic responses to exercise in these patients. We investigated whether changes in hemoglobin parameters in the tibialis anterior muscle in patients with malignant hematopoietic dise...
Article
Older adults who have survived cancer experience significantly more falls compared with healthy adults. Adult cancer survivors may also have a lower balance function than healthy adults. We examined muscle strength and balance function among 19 cancer survivors and 14 healthy subjects. The mean age of the cancer survivors was 51.5 ± 11.2 years; 6 m...
Article
Full-text available
Introduction: Impaired skeletal muscle oxygenation potentially contributes to reduced exercise capacity in allogeneic hematopoietic stem cell transplantation (allo-HSCT) patients during early recovery and may explain altered hemoglobin responses to exercise following allo-HSCT. We investigated whether skeletal muscle oxygenation parameters and hem...
Article
Full-text available
Introduction/Background Older adults who have survived cancer experience significantly more falls compared with healthy adult subjects. Adult cancer survivors who are not elderly may also have lower balance function than healthy adults. Material and method We examined muscle strength and balance function among 19 cancer survivors and 14 healthy su...
Article
Introduction/Background Exercise therapy is a core component of rehabilitation for patients with cardiopulmonary disease and diabetes. A recent study showed that cognitive function improved after a single episode of moderate-intensity exercise. However, the laterality of cortical oxyhemoglobin (O2Hb) increases during exercise is unknown. We aimed t...
Article
Introduction/Background It has been reported that the noisy galvanic vestibular stimulation (n-GVS) could improve upright body sway in healthy subjects. It is unclear which sort of noise is appropriate for n-GVS. Our study aimed to investigate the effects of n-GVS with white and pink noise for upright standing sway in healthy adults. Material and...
Article
Introduction/Background Currently, there are no reports showing changes in heart rate (HR) and Borg scale scores after the exercise-tolerance test in patients who had undergone allogeneic hematopoietic stem cell transplantation (allo-HSCT). We investigated the change in HR and Borg scale after the exercise-tolerance test in allo-HSCT patients. Mat...
Article
Full-text available
Neurologic tumors account for over 50% of American acute inpatient rehabilitation facility cancer admissions. WHO grade IV astrocytoma (also known as glioblastoma multiforme, high-grade glioma or GBM) is the most common primary brain tumor in adults and is invariably fatal. The majority of primary brain tumor patients experience neurologic deficits...
Article
Objective: The aim of the current study was to examine the relationship between the straight leg raising (SLR) repetition count and both the knee extension strength (KES) and walking independence. Methods: We enrolled 106 inpatients aged ≥20 years with collagen disease in a cross-sectional study. We measured the SLR repetition count, KES, and wa...
Article
Full-text available
Studies have reported that the load intensity of Resistance training is related to the rating of perceived exertion scale in healthy subjects. The aim of our column was to evaluate current evidence regarding the relationship between the rating of perceived exertion scale and the load intensity of resistance training.
Article
We investigated the difference in relationship between muscle strength and quality of life (QOL)/fatigue in long‐term cancer survivors and healthy subjects. Thirty‐six cancer survivors and 29 healthy subjects were assessed for body composition and bone status at the calcaneus using the Osteo Sono Assessment Index. Muscle strength was evaluated via...
Article
Full-text available
IntroductionMalignant pleural mesothelioma (MPM) is a rare cancer that affects the thin cell wall lining of internal organs and structures. Studies have shown that patients with lung cancer have decreased pulmonary function and exercise capacity after pneumonectomy. However, to date, physical function and health-related quality of life (HRQOL) in s...
Chapter
The present study investigated whether changes in oxyhemoglobin (O2Hb) concentration over time differed across brain regions according to differences in gross movement intensity. Thirteen healthy adults (21.2 ± 1.0 years, 8 women) participated in this study. After 180 s of rest, the participants performed 600 s of exercise on a cycle ergometer. Exe...
Chapter
Near-infrared spectroscopy (NIRS) can measure cortical activity during gross motor tasks based on the cerebral hemodynamic response. Although some reports suggest that cycling exercise improves cortical oxygenation, its after-effects are unknown. We examined the after-effects of low- and moderate-intensity cycling exercise on cortical oxygenation....