Shin-wha Lee

• Professor
• Professor at Korea University

Background Ovarian cancer (OC) is a highly treatment-resistant malignancy, often diagnosed late due to minimal symptoms and extensive metastasis. Despite platinum-based chemotherapy, recurrence and chemoresistance highlight the need for new therapies. This study focuses on cancer-associated fibroblasts (CAFs), key TME components, to explore their i...

Background Recently, immunotherapy with immune checkpoint inhibitors (ICIs) has shown promising efficacy in endometrial cancer (EC), particularly in patients with mismatch repair deficiency (dMMR). Preclinical models of EC are essential for evaluating the efficacy of immuno-oncology (IO) drugs and investigating strategies to enhance the antitumor r...

Objective To evaluate the real-world efficacy and toxicity of olaparib maintenance therapy in Korean patients with BRCA-mutated ovarian cancer (OC), with an exploratory analysis of BRCA mutations. Methods We conducted a retrospective analysis of Korean BRCA-mutated OC patients treated with olaparib maintenance therapy as first-line (1Lm) or second...

Objective: Serous tubal intraepithelial carcinoma (STIC), a potential precursor of high-grade serous carcinoma, is associated with subsequent carcinomas development. This study aimed to identify cases of STIC and serous tubal intraepithelial lesions (STIL) and examine clinical outcomes and patterns of care in BRCA1/2 mutations carriers undergoing...

We updated the Korean Society of Gynecologic Oncology (KSGO) practice guideline for the management of ovarian cancer as version 5.1. The ovarian cancer guideline team of the KSGO published announced the fifth version (version 5.0) of its clinical practice guidelines for the management of ovarian cancer in December 2023. In version 5.0, the selectio...

Objective: To investigate the real-world efficacy and toxicity of paclitaxel-cisplatin-bevacizumab and identify prognostic factors for paclitaxel-cisplatin-bevacizumab in platinum-naïve primary stage IVB cervical cancer. Materials and methods: We retrospectively reviewed patients with stage IVB cervical cancer who received paclitaxel-cisplatin-beva...

[This corrects the article DOI: 10.1371/journal.pone.0294647.].

e17561 Background: Olaparib is approved for first-line (1L) and second or subsequent-line (2L+) maintenance therapy in BRCA-mutated ovarian cancer (OC). However, the correlation between location of BRCA mutation and benefit of olaparib maintenance therapy has not been thoroughly investigated. We aimed to analyze real-world clinical outcomes and ide...

TPS5635 Background: Hyperthermic intraperitoneal chemotherapy (HIPEC) during cytoreductive surgery has emerged to achieve a higher concentration of chemotherapeutic agents and treat micro-metastases on peritoneal surfaces. At advanced staged ovarian cancer treated with neoadjuvant chemotherapy, HIPEC during interval cytoreductive surgery with cispl...

Although immunotherapy has not yet been as successful in ovarian cancer (OC), it remains a potential therapeutic strategy. Preclinical models of OC are necessary to evaluate the efficacy of immuno-oncology (IO) drugs targeting human immune components but have been underutilized. Developing mouse models with a humanized (Hu) immune system can help u...

Objective To evaluate whether the maximum standardized uptake value (SUVmax) from initial 18F-FDG PET/CT (fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography) scans could be a predictor of complete response and recurrence in patients with endometrial cancer who are undergoing fertility sparing management. Methods We con...

Objective To evaluate whether treatment with erythropoiesis‐stimulating agents (ESAs) for chemotherapy‐induced anemia affects progression‐free survival (PFS) in patients receiving front‐line chemotherapy following surgery for ovarian cancer (OC). Methods We retrospectively reviewed all consecutive patients who received front‐line chemotherapy afte...

Background: Although immunotherapy has not yet been as successful in ovarian cancer (OC), it remains a potential therapeutic strategy. Preclinical models of OC are necessary to evaluate the efficacy of immuno-oncology (IO) drugs targeting human cancer and immune components but have been underutilized. Developing mouse models with a humanized (Hu) i...

Objectives: PARP inhibitor is effective in treating DNA repair deficiency endometrial cancer. Endometrial cancer (EC) is one of the most common gynecological cancers in developed countries and its incidence is increasing, and the prognosis of patients with early stage and low-risk EC is very good, but the prognosis of progressive and recurrent EC i...

Introduction/Background Clear cell carcinoma is a histologically rare type(about 1–5.5%) of endometrial cancer. Compared with endometrioid type, patients with CCC have a worse prognosis. Due to the low incidence rate of CCC of the endometrium, data on prognosis-related factors of CCC is still controversialThis study evaluated the oncological outcom...

Introduction/Background We investigated the feasibility of molecular classification using next-generation sequencing and its relationship with clinical outcomes in patients with endometrial cancer. Methodology Clinical data and next-generation sequencing data using tumor tissues were retrospectively collected. Next-generation sequencing assays wer...

Introduction/Background We aimed to identify the main oncogenic pathway by histological type of ovarian cancer based on Next-generation sequencing (NGS) test and to determine the correlation with clinical prognosis. Methodology We conducted a retrospective review of 420 patients with ovarian cancer who underwent NGS test at Asan Medical Center fro...

Introduction/Background Hyperthermic intraperitoneal chemotherapy (HIPEC) during cytoreductive surgery has emerged to achieve a higher concentration of chemotherapeutic agents and treat micro-metastases on peritoneal surfaces. At advanced staged ovarian cancer treated with neoadjuvant chemotherapy, HIPEC during interval cytoreductive surgery with c...

Introduction/Background This study aimed to evaluate to prognostic factors and treatment outcomes of first-line paclitaxel and cisplatin plus bevacizumab (TPB), specifically for cervical cancer (CC) stage IVB, in real-world setting. Methodology We retrospectively reviewed the patients with CC IVB who received TPB as first-line treatment between De...

Introduction/Background We aim to analyze stage I ovarian cancer and ovarian cancer precursor lesions with BRCA mutation to identify a specific proteomic signature that contributes to the onset of early ovarian cancer. Methodology We analyzed a total of 20 Formalin-Fixed Paraffin-Embedded (FFPE) tissue samples from patients with Serous Tubal Intra...

Objective To investigate the anti-cancer efficacy of ENB101-LNP, an ionizable lipid nanoparticles (LNPs) encapsulating siRNA against E6/E7 of HPV 16, in combination therapy with cisplatin in cervical cancer in vitro and in vivo. Methods CaSki cells were treated with ENB101-LNP, cisplatin, or combination. Cell viability assessed the cytotoxicity of...

Since the latest practice guidelines for ovarian cancer were developed by the Korean Society of Gynecologic Oncology (KSGO) in 2021, many studies have examined the efficacy and safety of various treatments for epithelial ovarian cancer (EOC). Therefore, the need to develop recommendations for EOC treatments has been raised. This study searched the...

Objectives This meta-analysis was undertaken to systematically evaluate the effects of poly (ADP-ribose) polymerase inhibitor (PARPi) maintenance therapy on the survival of newly diagnosed advanced epithelial ovarian cancer (EOC) patients. Methods/Materials A systematic literature search revealed 3,227 studies. A subsequent selection process ident...

Introduction Recently, open radical hysterectomy in early-stage cervical cancer has been preferred after the LACC trial was published. Also, the role of sentinel lymph node (SLN) mapping is increasing in the surgical treatment of cervical cancer. We evaluated the feasibility of SLN mapping by intra-abdominal indocyanine green (ICG) injection during...

Introduction To evaluate the long-term safety of ovarian cystectomy in patients with stage I unilateral borderline ovarian tumors (BOTs) who desire preserved fertility. Methods This retrospective study included 309 patients with stage I unilateral BOTs who underwent fertility-sparing surgery between 1990 and 2015. Patients were divided into two gr...

Background Although immunotherapy has not yet been as successful in ovarian cancer (OC), it remains a potential therapeutic strategy. Preclinical models of OC are necessary to evaluate the efficacy of immuno-oncology (IO) drugs targeting human cancer and immune components but have been underutilized. Developing mouse models with a humanized (Hu) im...

Objective Our study aimed to evaluate the incidence of pathological findings in asymptomatic Korean patients with BRCA1/2 pathogenic variants who underwent risk-reducing salpingo-oophorectomy and to assess their long-term prognosis. Methods We retrospectively analyzed the medical records of patients with a germinal BRCA1/2 pathologic variant who h...

Objectives: Dendritic cell (DC) based immunotherapies have been shown to be a potential treatment option for various cancers; however, the exact strategies in ovarian cancer remain unknown. This study aimed to evaluate the effectiveness of mouse CD8α+ dendritic cells (DCs), corresponding to human CD141+ DCs, derived from bone marrow (BM) hematopoie...

Background: High-risk human papillomavirus (HPV) type 16 is the major etiological agent found in more than 60% of patients with cervical cancer and associated with cancer development and progression. Persistent expression HPV E6 and E7 oncoproteins are essential for the initiation and maintenance of cervical cancer. The therapeutic approaches targe...

Background Resistance to PARP inhibitor occurs frequently and diversely in spite of germline/somatic BRCA mutations. Receptor tyrosine kinase cMET, which is frequently overexpressed in EOC associates with PARP1 activity and cell survival pathway. We investigated whether the combination of PARP inhibitor and cMET inhibitor could overcome PARP inhibi...

Dendritic cell (DC)-based immunotherapies have been shown to be a potential treatment option for various cancers; however, the exact strategies in ovarian cancer remain unknown. Here, we report the effectiveness of mouse CD8α+ DCs derived from bone marrow hematopoietic stem cells (BM-HSCs), equivalent to human CD141+ DCs, which have proven to be a...

Many studies have reported the efficacy of poly (ADP-ribose) polymerase (PARP) inhibitors in patients with epithelial ovarian cancer (EOC) with or without both germline/somatic BRCA mutations. However, resistance to PARP inhibitor occurs frequently in patients with advanced stage and recurrent. The receptor tyrosine kinase cMET, which is frequently...

Immune checkpoint inhibitors (ICIs) have been applied in patients with various solid tumors since they were approved by U.S. FDA in 2011. However, only less than 20% of patients benefit from ICIs including anti-programmed cell death protein 1 (aPD-1). Recently, many studies to improve the response of ICIs are in progress, and especially, vascular e...

Since the human papillomavirus (HPV) vaccine guidelines were developed by the Korean Society of Gynecologic Oncology (KSGO) in 2011, 2016, and 2019, several recent studies on the efficacy and safety of HPV vaccines in middle-aged women and men have been reported. Furthermore, there has been an ongoing debate regarding the efficacy of the HPV vaccin...

PurposeThe primary objective of our study was to investigate the effectiveness and safety of olaparib maintenance therapy in patients with BRCA-mutated recurrent ovarian cancer in daily practice. The secondary objective of this study was to identify prognostic factors associated with prolonged progression-free survival (PFS) in such patients.Method...

Immunoprofiling has an established impact on the prognosis of several cancers; however, its role and definition in high-grade serous ovarian cancer (HGSOC) are mostly unknown. This study is to investigate immunoprofiling which could be a prognostic factor in HGSOC. We produced tumor microarrays of 187 patients diagnosed with HGSOC. We performed a m...

We aimed to compare the perioperative outcomes of single-incision robotic myomectomy (SIRM) and multiport robotic myomectomy (MPRM) and provide surgical tips. We retrospectively analyzed the medical records of 462 patients with symptomatic leiomyoma who underwent MPRM or SIRM between March 2019 and April 2021. Demographic characteristics and surgic...

Robot-assisted laparoscopic myomectomy (RALM) has broadened the indications even in complex myomas. However, the high cost of RALM remains the main disadvantage. Therefore, a surgical technique that can reduce the cost of RALM and still has the advantages of robotic surgery is required. We propose a “locking suture on myoma (LSOM)” technique and co...

Purpose: Here, we compared the operative and perioperative outcomes between robot-assisted laparoscopic myomectomy (RALM) and abdominal myomectomy (AM) in patients with large (>10 cm) or heavy myomas (>250 g). Materials and methods: We included 278 patients who underwent multi-port RALM (n=126) or AM (n=151) for large or heavy myomas in a tertia...

Objective We aimed to investigate the effectiveness of continuing medical therapy in patients who did not achieve complete response (CR) despite 9 months of progestin treatment. We also sought to determine the prognostic factors associated with achieving CR among these patients. Methods We retrospectively analyzed 51 patients with presumed stage I...

Background As next‐generation sequencing (NGS) technology matures, various amplicon‐based NGS tests for BRCA1/2 genotyping have been introduced. This study was designed to evaluate an NGS test using a newly released amplicon‐based panel, AmpliSeq for Illumina BRCA Panel (AmpliSeq panel), for detection of clinically significant BRCA variants, and to...

Study objective: To investigate the prognostic factors and impact of minimally invasive surgery (MIS) in surgically treated early-stage high-grade (HG) neuroendocrine cervical carcinoma (NECC). Design: A retrospective cohort study SETTING: Asan Medical Center, Seoul, Korea PATIENTS: Patients with International Federation of Obstetrics and Gyneco...

Although next-generation sequencing (NGS) is widely used for BRCA1/2 sequencing analysis, it involves a fragmented workflow along with complex bioinformatic analysis and interpretation. In this study, the performance characteristics and workflow of the GeneReader NGS System (QIAGEN), including BRCA1/2 sequencing, were evaluated. For BRCA1/2 genetic...

Objective Somatic TP53 mutation (TP53mut) is a characteristic finding in high-grade serous ovarian cancer (HGSOC). The aim of this study was to assess the clinical efficacy and utility of TP53mut circulating tumor DNA (ctDNA) monitoring as a biomarker for managing HGSOC. Methods TP53muts were evaluated in patients who received primary treatment fo...

In 2016, 9-valent human papillomavirus (HPV) vaccine has been newly introduced in Korea, thus the need to develop recommendations for the vaccine has raised. Until we decide to develop a guideline, no further studies on the bi-valent or quadri-valent HPV vaccine have been announced. We searched and reviewed the literatures focused on the efficacy o...

The Asian Society of Gynecologic Oncology International Workshop 2018 on gynecologic oncology was held in the Ajou University Hospital, Suwon, Korea on the 24th to 25th August 2018. The workshop was an opportunity for Asian doctors to discuss the latest findings of gynecologic cancer, including cervical, ovarian, and endometrial cancers, as well as...

Session A-2 Epithelial Ovarian Cancer, first row from left to right, Peng-Hui Wang, Taipei Veterans General Hospital, Taiwan; Suwanit Therasakvichya, Mahidol University, Thailand; Yusuke Kobayashi, Keio University School of Medicine, Japan; Maria Lee, Seoul National University College of Medicine, Republic of Korea; Tingyan Shi, Fudan University, C...

Session A-1 Cervical Cancer. Speakers, first row from left to right, Takayuki Enomoto, Niigata University Graduate School of Medical and Dental Sciences, Japan; Jin Li, Fudan University Shanghai Cancer Center, China; Kenneth H. Kim, University of Alabama at Birmingham, United States; Tae-Wook Kong, Ajou University School of Medicine, Republic of Ko...

Special Session, from left to right, Shin-Wha Lee, University of Ulsan College of Medicine, Asan Medical Center, Republic of Korea; Sang Wun Kim, Yonsei University College of Medicine, Republic of Korea; Dae Hoon Jeong, Busan Paik Hospital, Republic of Korea.

Development process of 9-valent human papillomavirus (HPV) vaccine guideline

Evidence table and risk of bias

Contrasting human security with national security, this chapter examines South Korea’s policies toward global refugees and North Korean defectors, an effective indicator of regime instability. It is argued that the security and welfare of individual persons, which are the very reason for the existence of a sovereign state, must be prioritized in hu...

Background: We aimed to review the burden and the potential impact of human papillomavirus (HPV) vaccines on HPV-related diseases in the Republic of Korea and to discuss cervical cancer prevention practices in this country. Methods: Cancer burden statistics were retrieved from GLOBOCAN-2018 and Statistics Korea. HPV disease burden was assessed v...

Abstract Background Palliative chemotherapy should be used with caution when attempting to alleviate symptoms in patients with end-stage cancer. However, palliative chemotherapy continues to be utilized in cancer patients during their last stages of life. In this study, we analyzed the pattern of chemotherapy administered during the last 6 months o...

[This corrects the article on p. 433 in vol. 60, PMID: 28989919.].

Objective This study aimed to evaluate the efficacy and safety of pegylated liposomal doxorubicin (PLD) with or without carboplatin in Korean patients with recurrent ovarian cancer (ROC), fallopian tube, or primary peritoneal cancer. Methods This retrospective study included 52 patients with ROC, fallopian tube, or primary peritoneal cancer who re...

To identify prognostic factors for overall survival after recurrence (OSr) in endometrioid endometrial cancer (EC) patients and categorize patient subgroups that predict outcomes using these variables. Consecutive patients with recurrent endometrioid EC seen in our institution from 1989 to 2013 were retrospectively reviewed. Cox regression models w...

e13046 Background: Most BRCA1/2 carriers do not undergo risk-reducing salpingo-oophorectomy (RRSO) by the recommended age of 40. Methods: We retrospectively reviewed breast cancer patients identified as BRCA mutation carriers who underwent RRSO at Asan Medical Center, Seoul, Korea, from 2013 to 2015. Both fallopian tubes of all cases were examined...

Objective: The study aims to identify preoperative predictors of complete cytoreduction and early recurrence and death in epithelial ovarian, tubal, and peritoneal cancer after neoadjuvant chemotherapy (NACT). Methods: We performed a retrospective analysis of 85 patients who underwent 3 cycles of NACT. Patients were divided into 2 groups accordi...

Objective: To identify risk factors for distant recurrence in node-positive cervical cancer patients who underwent radical hysterectomy and pelvic lymph node dissection (PLND) with para-aortic lymph node sampling (PALNS) or para-aortic lymph node dissection (PALND). Methods: A total of 299 patients in whom lymph node metastasis was confirmed aft...

Operation record form for cervical cancer

Pathologic report form for cervical cancer (excision)

Pathologic report form for cervical cancer (trachelectomy, hysterectomy, pelvic exenteration)

Objective: Concurrent chemoradiotherapy is usually administered to patients with locally advanced cervical cancer (LACC). Extended-field chemoradiotherapy is required if para-aortic lymph node (PALN) metastasis is detected. This study aimed to construct a prediction model for PALN metastasis in patients with LACC before definitive treatment. Meth...

Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA Background: Endometrial cancer is the most common malignancy of the female reproductive tract and the third most common cause of death from women's cancer. Risk factors of endometrial cancer include high levels of estrogen, obesity, diabetes mellitus, breast cancer, lo...

Objectives: Epithelial ovarian cancer is the most lethal gynecologic cancer and it has a very high recurrence rate. Early detection of recurrence is very important as well as good treatment; however, the accuracy of CA-125 is approximately 50%. Circulating cell-free DNA (cfDNA) carrying tumor-specific somatic alterations, as called circulating tumo...

This paper examines the development of a new global order in Northeast Asia and its characteristics with a focus on U.S.-China relations and the limits to cooperation among Korea, China and Japan. The authors emphasize the need to build a multilateral security cooperation system in the region to complement the existing bilateral security architectu...

Objective: The objective of this study is to refine a simple, rapid and reproducible method for the isolation and characterization of epithelial ovarian cancer (EOC) cells from ovarian tumor tissues and to evaluate the intracellular expression of CK-7, CA-125, HE4 and FOLR-1 in primary ovarian cancer cells. Methods: Fourteen patients diagnosed with...

Effect of hyaluronic acid and hydroethyl starch mixture in ovarian cancer cell Objective: Post-operative tissue adhesion is a very serious problem in patients with ovarian cancer. This study is to investigate the role of hyaluronic acid and hydroethyl starch mixture against the tissue adhesion through in vitro experimentations with ovarian cancer c...

Objective: To evaluate the clinical role of adjuvant chemotherapy (AC) in FIGO stage IB-IIA cervical cancer patients. Study design: A cohort of 262 patients with cervical cancer who received radical hysterectomy (RH) and adjuvant therapy at Asan Medical Center between 1992 and 2012 was enrolled. In this cohort, 85 patients received adjuvant chem...

This study was to identify small inhibitory RNAs (siRNAs) that are effective in inhibiting growth of cervical cancer cell lines harboring human papilloma virus (HPV) and to examine how siRNAs interact with interferon beta (IFN-β) and thimerosal. The HPV18-positive HeLa and C-4I cell lines were used. Four types of siRNAs were designed according to t...

Malignant Brenner tumors (MBTs) of the ovary are very rare, and their definition, biology, and treatment modality have not been established. This study investigated the clinical characteristics of MBTs and the importance of chemotherapy for recurrent disease. We conducted a retrospective analysis of 10 patients with MBT of the ovary treated at a si...

To compare the operative outcomes of patients undergoing either single-port or multi-port laparoscopic hysterectomy (LH). Two hundred fifty-six women who were scheduled for LH for symptomatic myoma and/or adenomyosis from eight tertiary teaching hospitals were randomized to single-port or multi-port groups. Primary outcome was conversion and/or com...

Aims: We investigated the prognosis of patients with small-cell neuroendocrine carcinoma of the uterine cervix (SCNEC) in relation to treatment modalities. Methods: We retrospectively reviewed the medical records and pathological reports of 102 patients who were histologically diagnosed with SCNEC at 5 different institutes. Time to progression (...

The purpose of this study was to identify preoperative clinicopathological predictive factors for lymph node (LN) metastasis in women diagnosed with uterine papillary serous carcinoma (UPSC). Women diagnosed with UPSC in our institution from 1997 to 2012 were identified. All patients underwent hysterectomy and bilateral salpingo-oophorectomy plus p...