Shiliang Liu

Shiliang Liu
Public Health Agency of Canada | PHAC · Centre for Surveillance and Applied Research

PhD, MB

About

156
Publications
16,739
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
8,103
Citations
Citations since 2016
38 Research Items
4030 Citations
20162017201820192020202120220200400600800
20162017201820192020202120220200400600800
20162017201820192020202120220200400600800
20162017201820192020202120220200400600800

Publications

Publications (156)
Article
Defects in decidual response are associated with adverse pregnancy outcomes which includes recurrent pregnancy loss (RPL). It is reported that cellular senescence happens during decidualization and pro-senescent decidual response in the luteal phase endometrium is related to RPL. However, the underlying mechanisms of how excessive decidual senescen...
Preprint
Full-text available
Background Despite the recent creation of several birth weight-for-gestational age references and standards, none has proven superior. We identified birth weight-for-gestational age cut-offs, and corresponding United States population-based, Intergrowth 21 st and World Health Organization centiles associated with higher risks of adverse neonatal ou...
Article
Full-text available
Objectives: The impacts of the current COVID-19 pandemic on maternal and foetal health are enormous and of serious concern. However, the influence of SARS-CoV-2 infection at early-to-mid gestation on maternal and foetal health remains unclear. Materials and methods: Here, we report the follow-up study of a pregnant woman of her whole infective c...
Article
Full-text available
The effects of coronavirus disease 2019 (COVID‐19), a highly transmissible infectious respiratory disease that has initiated an ongoing pandemic since early 2020, do not always end in the acute phase. Depending on the study referred, about 10%–30% (or more) of COVID‐19 survivors may develop long‐COVID or post‐COVID‐19 syndrome (PCS), characterised...
Article
Full-text available
Background Previous studies showed increases in rates of gastroschisis in Canada in the first decade of the 21st century. Objective We sought to examine the epidemiologic characteristics of gastroschisis in Canada in recent years. Methods We conducted a retrospective population-based cohort study of all livebirths and stillbirths delivered in Can...
Article
Full-text available
Objectives Successful pregnancy involves the homeostasis between maternal decidua and fetoplacental units, whose disruption contributes to compromised pregnancy outcomes, including recurrent spontaneous abortion (RSA). The role of cell heterogeneity of maternal decidua in RSA is yet to be illustrated. Materials and methods A total of 66,078 single...
Article
Full-text available
Objective Several studies have documented changes in the rates preterm birth and stillbirth during the COVID-19 pandemic. We carried out a study to examine obstetric intervention, preterm birth, and stillbirth rates in Canada from March to August 2020. Methods The study included all singleton hospital deliveries in Canada (excluding Québec) from M...
Article
Full-text available
Background Several studies of prenatal determinants and neonatal morbidity and mortality among very preterm births have resulted in unexpected and paradoxical findings. We aimed to compare perinatal death rates among cohorts of very preterm births (24–31 weeks) with rates among all births in these groups (≥24 weeks), using births-based and fetuses-...
Article
La nature exacte des répercussions de la maladie à coronavirus 2019 (COVID-19) sur la santé maternelle et néonatale reste à préciser. Nous avons cherché à évaluer l’association entre l’infection par le coronavirus du syndrome respiratoire aigu sévère 2 (SRAS-CoV-2) pendant la grossesse et les issues défavorables de la grossesse. MÉTHODES: Nous avon...
Article
Background: The impact of coronavirus disease 2019 (COVID-19) on maternal and newborn health is unclear. We aimed to evaluate the association between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection during pregnancy and adverse pregnancy outcomes. Methods: We conducted a systematic review and meta-analysis of observational...
Article
Full-text available
Aims To assess possible effect of air quality improvements, we investigated the temporal change in hospital admissions for acute exacerbations of chronic obstructive pulmonary disease (AECOPD) associated with pollutant concentrations. Methods We collected daily concentrations of particulate matter (i.e., PM2.5, PM10 and PMcoarse), sulfur dioxide (...
Article
The relation of acute fluctuations of air pollution to hospital admission for bronchiectasis remained uncertain, and large-scale studies were needed. We collected daily concentrations of particulate matter (PM), sulfur dioxide (SO 2), nitrogen dioxide (NO 2), carbon monoxide (CO), ozone (O 3), and daily hospitalizations for bronchiectasis for 21 ci...
Article
Full-text available
Few studies were conducted to assess safety and efficacy of continuous antiviral therapy administrated from preconception. In the present study, 136 eligible women with chronic HBV infection were recruited, and assigned to active chronic hepatitis B (CHB) (Group A, B or C) or chronic HBV carrier (Group D). Antiviral therapy was administrated in pre...
Article
Background: The rate of obstetric anal sphincter injury has increased in recent years, particularly among operative vaginal deliveries. We sought to characterize temporal trends in episiotomy use and to quantify the association between episiotomy and obstetric anal sphincter injury. Methods: Using a population-based retrospective cohort study de...
Article
Full-text available
Background: There is no international consensus on the definition and components of severe maternal morbidity (SMM). Objectives: To propose a comprehensive definition of SMM, to create an empirically justified list of SMM types and subtypes, and to use this to examine SMM in Canada. Methods: Severe maternal morbidity was defined as a set of he...
Article
Full-text available
Objectives To assess international trends and patterns of prenatal diagnosis of critical congenital heart defects (CCHDs) and their relation to total and live birth CCHD prevalence and mortality. Setting Fifteen birth defect surveillance programmes that participate in the International Clearinghouse for Birth Defects Surveillance and Research from...
Article
Objective: This study sought to quantify temporal trends and provincial and territorial variations in severe maternal morbidity (SMM) in Canada. Methods: The study used data on all hospital deliveries in Canada (excluding Québec) from 2003 to 2016 to examine temporal trends and from 2012 to 2016 to study regional variations. SMM was identified u...
Article
Full-text available
Objective Head circumference is considered a reliable assessment of the volume of the underlying brain. We sought to identify risk factors (maternal factors or antenatal antecedents) for microcephaly and to assess the effects of microcephaly on neonatal outcomes. Design Retrospective cohort study. Setting Data for all births in 2009-2017 were obt...
Article
Full-text available
Background and Purpose— Few studies have examined the epidemiology of stroke in pregnancy, despite the high associated burden of death and disability. We aimed to quantify the incidence, temporal trends, risk factors, and case fatality associated with stroke and cerebrovascular disease in pregnancy. Methods— All antepartum, peripartum, and postpar...
Article
Objective: To assess whether hypertensive disorders during pregnancy (HDPs) are associated with the subsequent development of end-stage renal disease (ESRD). Methods: The present study included 1 598 043 women who delivered in Canadian hospitals between April 1993 and March 2003. The baseline information was from the Canadian Institute for Healt...
Article
Background: The mode of delivery for women with a previous cesarean delivery remains contentious. We conducted a study comparing maternal and infant outcomes after attempted vaginal birth after cesarean delivery versus elective repeat cesarean delivery. Methods: We used data from the Discharge Abstract Database that includes all hospital deliver...
Article
Background Criteria of obstruction that establish a diagnosis of COPD have been debated in recent years. We carried out a follow-up study to assess the impact of the new LLN reference equation for Chinese on detecting COPD compared with the traditional 0.7fixed criteria. Methods We examined the prevalence and characteristics of airflow limitation...
Article
Objective: Online-to-offline is a new model for emergent medical service with the ability to connect care providers with patients on instant basis. This study aims to evaluate maternal and neonatal outcomes in patients with placenta accreta spectrum managed by an online-to-offline care model. Methods: Starting from January 1, 2015, management of...
Article
Objective: To assess the impact of the one-child policy in China on maternal mortality. Methods: The present retrospective study included maternal death data from Guangdong, China, from January 1, 2006, to December 31, 2015; data from 2013 were excluded because they were not available. Maternal deaths were divided into legal and illegal pregnanc...
Article
Objectives: Few studies have assessed the impact of induction of labor on breech presentation. This study aims to summarize the effect of induction of labor of breech presentation on perinatal morbidity. Methods: Literature review was done in Medline, Embase, Web of science and Cochrane Library up to 20 October 2017. Randomized control studies,...
Article
Background: Recent reports show increases in rates of ankyloglossia and frenotomy in British Columbia. We carried out a study to determine temporal trends and regional variations in ankyloglossia and frenotomy in Canada. Methods: The study included all hospital-based live births in Canada (excluding Quebec) between April 2002 and March 2015, wit...
Article
Objective: To analyse the impaired lung functions of people with biofuel smoke exposure. Methods: Nonsmokers with biofuel smoke exposure were selected as research objects in a mountainous area of northern Guangdong where the families used biofuels as main energies and the nonsmokers without biofuel smoke exposure in the same area as control. Questi...
Article
Full-text available
Objective To evaluate the performance of the INTERGROWTH-21st Project newborn standard vis-a-vis the current Canadian birth weight-for-gestational age reference. Methods All hospital-based singleton live births in Canada (excluding Quebec) between 2002 and 2012 with a gestational age between 33 and 42 weeks were included using information obtained...
Article
Background: Cardiac arrest in pregnancy is a rare and devastating condition with high mortality and morbidity. The objective of this study was to generate information about maternal cardiac arrest in Canada by examining the frequency, temporal incidence, associated conditions, potential etiologies, and survival rates. Methods: This retrospective...
Article
Full-text available
Objective The association between exposure to ambient particles with a median aerodynamic diameter less than 10/2.5 µm (particulate matter, PM10/2.5) and COPD remains unclear. Our study objective was to examine the association between ambient PM10/2.5 concentrations and lung functions in adults. Methods A cross-sectional study was conducted in sou...
Article
Full-text available
Objective Most literature on length of stay (LOS) for childbirth focuses on ‘early’ discharge as opposed to ‘optimal’ time of discharge and has conflicting results due to heterogeneous definitions of ‘early’ discharge and differing eligibility criteria for these programmes. We aimed to determine the LOS associated with the lowest neonatal readmissi...
Article
Full-text available
Background: Previous studies have yielded inconsistent results for the effects of periconceptional multivitamins containing folic acid and of folic acid food fortification on congenital heart defects (CHDs). Methods: We carried out a population-based cohort study (N=5 901 701) of all live births and stillbirths (including late-pregnancy terminatio...
Article
Full-text available
Numerous studies have examined the association of air pollution with preterm birth and birth weight outcomes. Traffic-related air pollution has also increasingly been identified as an important contributor to adverse health effects of air pollution. We employed a national nitrogen dioxide (NO2) exposure model to examine the association between NO2...
Article
Background WHO's INTERGROWTH-21st Project published an international standard for newborn size using a rigorous method. We aimed to examine the frequency of small and large birth weight, length, and head circumference for gestational age for live births in Guangzhou, China. Methods Data for all singleton live births in 2009–12 were obtained from t...
Article
Full-text available
The sequelae of preterm births may differ, depending on whether birth follows an acute event or a chronic condition. In a population-based cohort study of 2,711,645 Canadian hospital deliveries from 2003 to 2012, 3,059 women experienced unintentional injury during pregnancy. We assessed the impact of the acute event on pregnancy outcome and on neon...
Article
Full-text available
Objective: To examine the impact of pre-pregnancy diabetes mellitus (DM) on the population birth prevalence of congenital anomalies in Canada. Methods: We carried out a population-based study of all women who delivered in Canadian hospitals (except those in the province of Quebec) between April 2002 and March 2013 and their live-born infants with a...
Article
Full-text available
To examine the impact of pre-pregnancy diabetes mellitus (DM) on the population birth prevalence of congenital anomalies in Canada. We carried out a population-based study of all women who delivered in Canadian hospitals (except those in the province of Quebec) between April 2002 and March 2013 and their live-born infants with a birth weight of 500...
Article
Full-text available
Objectif Examiner l’influence du diabète antérieur à la grossesse sur la prévalence à la naissance des anomalies congénitales au Canada. Méthodologie Nous avons réalisé une étude en population chez l’ensemble des femmes ayant accouché à l’hôpital au Canada (hors Québec) entre avril 2002 et mars 2013, ainsi que chez leurs enfants nés vivants ayant...
Article
Full-text available
Numerous studies have examined associations between air pollution and pregnancy outcomes but most have been restricted to urban populations living near monitors. To examine the association between pregnancy outcomes and fine particulate matter in a large national study including urban and rural areas. Analyses were based on approximately 3 million...
Article
Full-text available
Although rare, placental abruption is implicated in disproportionately high rates of perinatal morbidity and mortality. Understanding geographic and temporal variations may provide insights into possible amenable factors of abruption. We examined abruption frequencies by maternal age, delivery year, and maternal birth cohorts over three decades acr...
Article
This article provides a knowledge-based assessment of planned cesarean delivery compared with planned vaginal delivery for breech presentation at term gestation. The most critical evidence on this issue is the intention-to-treat analysis from the Term Breech Trial, which showed that planned cesarean delivery reduced composite perinatal death and se...
Article
To examine neonatal mortality and morbidity rates by mode of delivery among women with breech presentation at term gestation. We carried out a population-based cohort study examining neonatal outcomes among term, nonanomalous singletons in breech presentation among all hospital deliveries in Canada (excluding Quebec) between 2003 and 2011. Mode of...
Article
To quantify the contribution of placenta accreta to the rate of postpartum hemorrhage and severe postpartum hemorrhage. All hospital deliveries in Canada (excluding Quebec) for the years 2009 and 2010 (N=570,637) were included in a retrospective cohort study using data from the Canadian Institute for Health Information. Placenta accreta included pl...
Article
Full-text available
Objective To examine whether changes in postpartum haemorrhage, hypertensive disorders of pregnancy, or other risk factors explain the increase in obstetric acute renal failure in Canada. Design Retrospective cohort study. Setting Canada (excluding the province of Quebec). Participants All hospital deliveries from 2003 to 2010 (n=2 193 425). Main o...
Article
Full-text available
Biomass smoke is associated with the risk of chronic obstructive pulmonary disease (COPD), but few studies have elaborated approaches to reduce the risk of COPD from biomass burning. The purpose of this study was to determine whether improved cooking fuels and ventilation have effects on pulmonary function and the incidence of COPD. A 9-y prospecti...
Article
Objective: Increases in postpartum hemorrhage have been reported from several countries. We assessed temporal trends in postpartum hemorrhage and severe postpartum hemorrhage in Canada between 2003 and 2010. Methods: We carried out a population-based cohort study of all hospital deliveries in Canada (excluding Quebec) from 2003 to 2010 (n = 2 19...
Article
This study quantifies the association between maternal medical conditions/illnesses and congenital heart defects (CHD) among infants. We carried out a population-based study of all mother-infant pairs (N=2,278,838) in Canada (excluding Quebec) from 2002-2010 using data from the Canadian Institute for Health Information. CHDs among infants were clas...
Data
Full-text available
Background/aimsThis study examines temporal trends in incidence of lung cancer in 1972–2007, temporal trends in histological types of lung cancer in 1988–2007, and age–period–cohort effects on the incidence rates of lung cancer in Canada.Methods Using incidence data for 1972–2007, we calculated the three-year period rates and annual percentage chan...
Article
Objective: The purpose of this study was to examine the association between labor induction and gestational age-specific severe maternal morbidity. Study design: Our study was restricted to women who delivered singletons at 37-42 weeks' gestation who had no pregnancy complications from 2003-2010 (n = 1,601,253) in Canada (excluding Quebec). Usin...
Article
This study examines temporal trends in incidence of lung cancer in 1972-2007, temporal trends in histological types of lung cancer in 1988-2007, and age-period-cohort effects on the incidence rates of lung cancer in Canada. Using incidence data for 1972-2007, we calculated the three-year period rates and annual percentage change (APC): from 1988 to...
Article
To extend our previous work on AFE in Canada by including stricter criteria for case identification and by examining risks for stillbirth, neonatal mortality and serious maternal and neonatal morbidity. Population-based cohort study. Canada. In all, 4,508,462 hospital deliveries from fiscal year 1991/92 to 2008/09. To reduce false-positive diagnose...
Article
Full-text available
Gilbert NL, Fell DB, Joseph KS, Liu S, León JA, Sauve R, for the Fetal and Infant Health Study Group of the Canadian Perinatal Surveillance System. Temporal trends in sudden infant death syndrome in Canada from 1991 to 2005: contribution of changes in cause of death assignment practices and in maternal and infant characteristics. Paediatric and Per...
Article
Full-text available
To examine variations in the registration of extremely low birthweight and early gestation births and to assess their effect on perinatal and infant mortality rankings of industrialised countries. Retrospective population based study. SETTING : Australia, Canada, European countries, and the United States for 2004; Australia, Canada, and New Zealand...
Article
Full-text available
Our study aimed to assess 1) the temporal trends in incidence and mortality of liver cancer and 2) age-period-cohort effects on the incidence in Canada. We analyzed data obtained from the Canadian Cancer Registry Database and Canadian Vital Statistics Death Database. We first examined temporal trends by sex, age group, and birth cohort between 1972...
Article
To estimate trends in incidence and identify risk factors and maternal and neonatal consequences of eclampsia in Canada. We conducted a population-based cohort study of all women and their newborns (N=1,910,729) delivered in the hospital in Canada (excluding Quebec) from 2003 to 2009. The data were obtained from the Canadian Institute for Health In...
Article
Vital Statistics and World Health Organization reports show a recent increase in maternal mortality in Canada. We carried out a study of temporal trends, regional variations, and causes of death in Canadian maternal mortality using Vital Statistics data. We used Vital Statistics death registrations to ascertain maternal deaths between 1981 and 2007...
Article
World Health Organization reports based on Canadian Vital Statistics data suggest a recent increase in maternal mortality rates in Canada. Since Vital Statistics data typically provide inaccurate estimates of maternal mortality, we examined temporal trends in Canada using hospitalization data. We identified in-hospital deaths among women aged 15 to...
Article
To determine the optimal timing of delivery in pregnancies with pre-existing (chronic) hypertension by quantifying the gestational age-specific risks of stillbirth associated with ongoing pregnancy and the gestational age-specific risks of neonatal mortality or serious neonatal morbidity following the induction of labour. Population-based cohort st...
Article
To examine the feasibility of using routine labour and delivery hospitalization data and international classification of diseases (ICD-10CA) codes for carrying out surveillance of severe maternal morbidity in Canada. We identified ICD-10CA diagnosis codes and Canadian Classification of Interventions (CCI) procedure codes associated with severe mate...
Article
To identify temporal trends and regional variations in severe maternal morbidity in Canada using routine hospitalization data. We used a previously identified set of International Statistical Classification of Diseases and Related Health Problems, 10th Revision (ICD-10CA) and Canadian Classification of Interventions (CCI) codes to estimate rates of...
Article
The nuclear radiation levels, magnetic fields and general access restrictions in the ITER Tokamak are such that it is undesirable to place remote control helium supply valves close to the coils. The Coil Terminal Boxes (CTB), which are further away from the coils, are therefore designed for easy access and contain as much as possible the components...
Article
To estimate the frequency of, and to identify risk factors for, pregnancy-associated venous thromboembolism (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE) requiring hospitalization. We conducted a population-based cohort study (N = 3 852 569) using the Discharge Abstract Database of the Canadian Institute for Health Informa...