Shigeto Yamawaki

Shigeto Yamawaki
Hiroshima University | HU · Center for Brain Mind and KANSEI Sciences Research

About

625
Publications
40,852
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14,870
Citations
Additional affiliations
May 1990 - present
Hiroshima University
Position
  • Professor (Full) and Chairman

Publications

Publications (625)
Article
Vagus nerve stimulation (VNS) is used for treatment of refractory epilepsy and depression, particularly in western countries. In our country, VNS is covered by insurance for treatment of refractory epilepsy. In this study, we discuss the findings of previous studies that have reported VNS for depression, based on a history of VNS. Additionally, we...
Article
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Background Different perspectives are needed to understand the pathophysiology of burning mouth syndrome (BMS), including physiological and psychological standpoints. The significance of interoception in chronic pain has been suggested. However, few studies have investigated this relationship in BMS. Therefore, we examined the role of interoception...
Article
Full-text available
In the brain, the insular cortex receives a vast amount of interoceptive information, ascending through deep brain structures, from multiple visceral organs. The unique hierarchical and modular architecture of the insula suggests specialization for processing interoceptive afferents. Yet, the biological significance of the insula's neuroanatomical...
Article
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While the exteroceptive and interoceptive prediction of a negative event increases a person’s anxiety in daily life situations, the relationship between the brain mechanism of anxiety and the anxiety-related autonomic response has not been fully understood. In this fMRI study, we examined the neural basis of anxiety and anxiety-related autonomic re...
Article
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The effect of the change in cerebrovascular reactivity (CVR) in each brain area on cognitive function after extracranial-intracranial bypass (EC-IC bypass) was examined. Eighteen patients who underwent EC-IC bypass for severe unilateral steno-occlusive disease were included. Single-photon emission CT (SPECT) for evaluating CVR and the visual cancel...
Preprint
It is known that the value of an object can be increased by forming an image of owning the object without actually possessing it. However, the detailed mechanism behind this phenomenon remains unknown. In this study, we conducted two experiments using newly created three-dimensional abstract objects to examine whether the formation of a mental imag...
Preprint
Full-text available
The body sends interoceptive visceral information through deep brain structures to the cerebral cortex. The insula cortex, organized in hierarchical modules, is the major cortical region receiving interoceptive afferents and contains visceral topographic maps. Yet, the biological significance of the insula's modular architecture in relation to deep...
Preprint
Interoception plays an important role in emotion processing, but the relationship between the physiological responses associated with emotional experience and interoception is unclear. In this study, we measured interoceptive sensitivity using the heartbeat discrimination task and investigated the effects of individual differences in interoceptive...
Preprint
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Recent studies highlight interoception as the key to processing healthy emotion and pathophysiology of affective disorders such as major depressive disorder (MDD). It has been reported that interoceptive responses are impaired in MDD and in healthy individuals with a high depressive risk (HDR). However, it is unclear how individual differences in H...
Preprint
While the exteroceptive and interoceptive prediction of a negative event increases a person's anxiety in daily life situations, the relationship between the brain mechanism of anxiety and anxiety-related autonomic response have not been fully understood. In this fMRI study, we examined the neural basis of anxiety and anxiety-related autonomic respo...
Article
Full-text available
Animals suffering from uncontrollable stress sometimes show low effort to escape stress [learned helplessness (LH)]. Changes in serotonin (5-HT) signaling are thought to underlie this behavior. Although the release of 5-HT is triggered by the action potential firing of dorsal raphe nuclei 5-HT neurons, the electrophysiological changes induced by un...
Article
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Our current understanding of melancholic depression is shaped by its position in the depression spectrum. The lack of consensus on how it should be treated—whether as a subtype of depression, or as a distinct disorder altogethe—interferes with the recovery of suffering patients. In this study, we analyzed brain state energy landscape models of mela...
Article
Attention function is thought to be important in chronic pain, with the pathology of chronic pain closely associated with cognitive–emotional components. However, there have been few neuroimaging studies of the relationship between attention function and chronic pain. We used the method of functional connectivity analysis for resting-state fMRI (rs...
Article
Neurofeedback (NF) aptitude, which refers to an individual's ability to change brain activity through NF training, has been reported to vary significantly from person to person. The prediction of individual NF aptitudes is critical in clinical applications to screen patients suitable for NF treatment. In the present study, we extracted the resting-...
Conference Paper
Recent studies highlight that interoception, or the perception of bodily states, is a key to understand emotional processing. The cardiac responses inevitably accompany as a part of emotional reactions. It has been reported that compared to predictable situations, uncertain situations elicit greater heart rate (HR) deceleration. Also, depressive pa...
Preprint
Full-text available
The effect of the change in cerebrovascular reactivity (CVR) in each brain area on cognitive function after extracranial-intracranial bypass was examined as a preliminary study in 20 patients with severe steno-occlusive disease. CVR studies and the visual cancellation task (VC) were performed before and after surgery. The Speed and Accuracy scores...
Poster
Alterations in the brain interoceptive network linked to abnormal cardiac autonomic regulation in major depressive disorder
Article
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Considering quality of life (QOL) after stroke, car driving is one of the most important abilities for returning to the community. In this study, directed attention and sustained attention, which are thought to be crucial for driving, were examined. Identification of specific brain structure abnormalities associated with post-stroke cognitive dysfu...
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Muscle sympathetic nerve activity (MSNA) is known as an effective measure to evaluate peripheral sympathetic activity; however, it requires invasive measurement with the microneurography method. In contrast, peripheral arterial stiffness affected by MSNA is a measure that allows non-invasive evaluation of mechanical changes of arterial elasticity....
Article
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Prediction is essential for the efficiency of many cognitive processes; however, this process is not always perfect. Predictive coding theory suggests that the brain generates and updates a prediction to respond to an upcoming event. Although an electrophysiological index of prediction, the stimulus preceding negativity (SPN), has been reported, it...
Article
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Brain activity associated with pain perception has been revealed by numerous PET and fMRI studies over the past few decades. These findings helped to establish the concept of the pain matrix, which is the distributed brain networks that demonstrate pain-specific cortical activities. We previously found that peripheral arterial stiffness βart respon...
Preprint
Neurofeedback (NF) aptitude, which refers to an individual's ability to change its brain activity through NF training, has been reported to vary significantly from person to person. The prediction of individual NF aptitudes is critical in clinical NF applications. In the present study, we extracted the resting-state functional brain connectivity (F...
Poster
Background: Major depressive disorder (MDD) is commonly associated with disturbances in the structure and function of brain regions involved in emotional and cognitive control. Changes in interoceptive visceral systems, such as in cardiac and gastric functions, are commonly observed in MDD (Hamilton and Alloy, 2016) and also predict later developme...
Article
Background The relationship between depression and personality has long been suggested, however, biomarker investigations for depression have mostly overlooked this connection. Methods We collected personality traits from 100 drug-free patients with major depressive disorders (MDD) and 100 healthy controls based on the Five-Factor Model (FFM) such...
Article
Background: The term “addiction” encompasses both substance dependence and behavioral addiction and is associated with major societal problems. Measures to combat addiction are currently insufficient in Japan, and further research on addiction is necessary. Methods: Science Council of Japan (SCJ) has three subcommittees – the Addiction Subcommittee...
Article
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Objectives: In recent years, a growing number of diffusion tensor imaging (DTI) studies have compared white matter integrity between patients with major depressive disorder (MDD) and bipolar disorder (BD). However, few studies have examined the pathophysiological significance of different degrees of white matter abnormalities between the two disor...
Article
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Stroke survivors majorly suffered from post-stroke depression (PSD). The PSD diagnosis is commonly performed based on the clinical cut-off for psychometric inventories. However, we hypothesized that PSD involves spectrum symptoms (e.g., apathy, depression, anxiety, and stress domains) and severity levels. Therefore, instead of using the clinical cu...
Preprint
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Trail making test (TMT) is one of the most extensively used neuropsychological tests. In this study, we examined the equivalence between the iPad version of TMT part A (iTMT-A) and the paper version of TMT part A (pTMT-A), and predicted the cognitive function with various data extracted from repeated TMT-A. Forty-two patients who performed five rep...
Article
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Mood disorders (e.g. depression, apathy, and anxiety) are often observed in stroke patients, exhibiting a negative impact on functional recovery associated with various physical disorders and cognitive dysfunction. Consequently, post-stroke symptoms are complex and difficult to understand. In this study, we aimed to clarify the cross-sectional rela...
Article
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Aim: Several studies have reported altered age-associated changes in white matter integrity in bipolar disorder (BD). However, little is known as to whether these age-related changes are illness-specific. We assessed disease-specific effects by controlling for age and investigated age-associated changes and Group × Age interactions in white matter...
Article
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An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Article
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Since optimal treatment at an early stage leads to remission of symptoms and recovery of function, putative biomarkers leading to early diagnosis and prediction of therapeutic responses are desired. The current study aimed to use a metabolomic approach to extract metabolites involved in both the diagnosis of major depressive disorder (MDD) and the...
Article
The lateral habenula (LHb) attracts a growing interest as a regulator of monoaminergic activity which were frequently reported to be defective in depression. Here we found that chronic social defeat stress (CSDS) increased production of pro-inflammatory cytokines in LHb associated with mobilization of monocytes and remodeling of extracellular matri...
Conference Paper
Full-text available
Major depression disorder is linked with interoceptive disturbances in multiple visceral organs, such as increased heart rate and myoelectric gastric signals, pupil unrest and slow digestion. However, the neural mechanisms of such dysfunctions remain elusive. We propose an Insula Hierarchical Modular Adaptive Interoception Control (IMAC) model to s...
Article
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Background: Achieving clear visibility through a windshield is one of the crucial factors in manufacturing a safe and comfortable vehicle. The optic flow (OF) through the windshield has been reported to divert attention and could impair visibility. Although a growing number of behavioral and neuroimaging studies have assessed drivers' attention in...
Article
Full-text available
Objectives: Multiple facets of human emotion underlie diverse and sparse neural mechanisms. Among the many existing models of emotion, the two-dimensional circumplex model of emotion is an important theory. The use of the circumplex model allows us to model variable aspects of emotion; however, such momentary expressions of one's internal mental s...
Article
Full-text available
Human habenula studies are gradually advancing, primarily through the use of functional magnetic resonance imaging (fMRI) analysis of passive (Pavlovian) conditioning tasks as well as probabilistic reinforcement learning tasks. However, no studies have particularly targeted aversive prediction errors, despite the essential importance for the habenu...
Article
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Resting-state fMRI has the potential to help doctors detect abnormal behavior in brain activity and to diagnose patients with depression. However, resting-state fMRI has a bias depending on the scanner site, which makes it difficult to diagnose depression at a new site. In this paper, we propose methods to improve the performance of the diagnosis o...
Article
Full-text available
Background: Real-time functional magnetic resonance imaging neurofeedback (rtfMRI-nf) have recently attracted attention as a novel, individualized treatment method for major depressive disorder (MDD). In this study, the antidepressant effect of neurofeedback training for left dorsolateral prefrontal cortex (DLPFC) activity was examined. Methods: Si...
Article
Pain experience is strongly affected by emotions, and especially, negative emotions cause more painful perception. And as mechanisms of linking to chronic pain, negative emotions are also important factors. We have been gradually studying the association between negative emotions and painful perception, and we will review these relationship by usin...
Article
Overall early improvement in depression after commencement of antidepressant treatment could be associated with subsequent response or remission, but its predictive ability is not adequate. We aimed to investigate whether early improvement of individual depressive symptoms and important baseline characteristics of patients including the number of p...
Article
Full-text available
The limited efficacy of available antidepressant therapies may be due to how they affect the underlying brain network. The purpose of this study was to develop a melancholic MDD biomarker to identify critically important functional connections (FCs), and explore their association to treatments. Resting state fMRI data of 130 individuals (65 melanch...
Article
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Touching is a fundamental human behavior used to evaluate objects in the external world. Many previous studies have used tactile stimulation to conduct psychological and psychophysiological experiments. However, most of these studies used solid material, not water stream, as an experimental stimulus. To investigate water perception, or to easily co...
Article
Background Personalized medicine in depression has been much discussed but has seen little success so far. We applied Qualitative interaction trees (QUINT), a recently developed method that focuses on qualitative, rather than quantitative, treatment-subgroup interactions, to identify subgroups of patients for whom efficacy of antidepressants may va...
Article
Full-text available
To date, a neuroscientific investigation of drivers’ steering behavior has never been performed because the reaction forces generated by the mechanical characteristics of a steering wheel have been difficult to assess in a magnetic resonance imaging (MRI) environment. In this study, using our previously developed MRI-compatible unit for steering re...
Conference Paper
Predictive coding theory describes how the brain updates internal representations to predict the probable events. The prediction based on prior information is compared with bottom-up sensory inputs to calculate the prediction errors. Our previous study showed the modulation of prediction accuracy on the frontal event-related potentials during the p...
Preprint
Full-text available
Objectives Multiple facets of human emotions underlie diverse and sparse neural mechanisms. Amongst many models of emotions, the circumplex model of emotion is one of a significant theory. The use of the circumplex model allows us to model variable aspects of emotion; however, such momentary expression of one’s internal mental state still lacks to...
Article
In preclinical models, it has been reported that social defeat stress activates microglial cells in the CNS. Translocator protein 18 kDa (TSPO) is a mitochondrial protein expressed on microglia in the CNS that has been proposed to be a useful biomarker for brain injury and inflammation. We hypothesized that a TSPO antagonist, ONO-2952, would inhibi...
Article
Peripheral lipopolysaccharide (LPS) injection induces systemic inflammation through the activation of the inhibitor of nuclear factor kappa B (NF-κB) kinase (IKK)/NF-κB signaling pathway, which promotes brain dysfunction resulting in conditions including anorexia. LPS-mediated reduction of food intake is associated with activation of NF-κB signalin...
Preprint
Full-text available
Resting-state fMRI has the potential to find abnormal behavior in brain activity and to diagnose patients with depression. However, resting-state fMRI has a bias depending on the scanner site, which makes it difficult to diagnose depression at a new site. In this paper, we propose methods to improve the performance of the diagnosis of major depress...
Article
Background: Tactile stimulation used to induce emotional responses is often not well-controlled. Replicating the same tactile stimulations across studies is difficult, compared to replicating visual and auditory modalities, which have standardized stimulus sets. Standardizing a stimulation method by replicating stimuli across studies is necessary...
Article
Full-text available
Reward anticipation is essential for directing behavior toward positively valenced stimuli, creating motivational salience. Task-related activation of the ventral striatum (VS) has long been used as a target for understanding reward function. However, some subjects may not be able to perform the respective tasks because of their complexity or subje...
Article
Full-text available
Background: Depression has major negative consequences for individuals and society, and psychological assessment tools for early disease detection are needed. Objectives: Here, we investigated the reliability and validity of an updated Japanese version of the Children's Depression Inventory (CDI-J) and set a cut-off score for the detection of de...
Article
Excessive alcohol consumption has a negative impact on graft survival after liver transplantation (LT). However, it is difficult to predict alcohol relapse before LT. This study surveyed the alcohol consumption of LT recipients to identify the risk factors for harmful drinking. We surveyed the alcohol consumption of LT recipients by using the Alcoh...
Article
Aims Cognitive behavioral therapy (CBT) is known to be effective for patients with persistent somatoform pain disorder (PSPD). Improvement of negative emotions in interpersonal stressful situations has been reported to reduce PSPD‐related clinical pain. However, these associations in CBT remain unclear. Therefore, we examined the relationship betwe...