Shigeru Nemoto

Shigeru Nemoto
Tokyo Medical and Dental University | TMDU · Department of Endovascular Surgery

About

57
Publications
3,770
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1,333
Citations
Citations since 2017
11 Research Items
475 Citations
2017201820192020202120222023020406080
2017201820192020202120222023020406080
2017201820192020202120222023020406080
2017201820192020202120222023020406080

Publications

Publications (57)
Article
Introduction: Both the size and location of unruptured intracranial aneurysms have been frequently researched in the last decades. However, little is known about ruptured intracranial aneurysms (RIAs). In this study, we thus aimed to verify whether the size of RIAs affects prognosis and clinical features. Material and Methods: A total of 185 patien...
Article
Full-text available
This study aimed to analyze the hemodynamic features of the offending artery at sites of neurovascular compression (NVC) using computational fluid dynamics (CFD). A total of 23 patients who underwent microvascular decompression (MVD) for primary trigeminal neuralgia (TN) between January 2015 and December 2016 were enrolled in this study. The compre...
Article
Here we report a case of subarachnoid hemorrhage (SAH) that was treated with neck clipping and coil embolization. A 76-year-old woman presented with multiple cerebral aneurysms, which made it difficult to identify the bleeding source. Cerebral angiography showed one internal carotid-posterior communicating (IC-PC) aneurysm on the left, one IC-PC an...
Article
We report a case of symptomatic chronic total occlusion of the common carotid artery after bilateral fronto-temporal craniotomies treated by carotid artery stenting (CAS). In June 2016, a 61-year-old man developed a subarachnoid hemorrhage. Neck clipping was performed on the ruptured cerebral aneurysm in the right internal carotid artery. In Septem...
Article
Background: Inventing an optimal curve on a microcatheter is required for successful intracranial aneurysm coiling. Shaping microcatheters for vertebrobasilar artery aneurysm coiling is difficult because of the vessel's long, tortuous and mobile anatomy. To overcome this problem, we devised a new method of shaping the microcatheter by using the pa...
Article
Full-text available
Many neuroendovascular treatments are supported by real-time anatomical and visual hemodynamic assessments through digital subtraction angiography (DSA). Here we used DSA in a single-center prospective randomized crossover study to assess the intracranial hemodynamics of patients undergoing coiling for cerebral aneurysm (n = 15) during sevoflurane-...
Article
We describe the case of a 75-year-old man with pharyngeal hemorrhage caused by a pseudoaneurysm of the lingual artery after accidentally swallowing his dentures. He developed sudden oral and nasal hemorrhage and was transported to a hospital near his residence. The doctors at the hospital diagnosed the case as epistaxis and treated the symptom with...
Article
Background: The aim of this study was to identify the unique morphological arterial features in patients with moyamoya disease on 3-dimensional rotational digital subtraction angiography. Materials and methods: One hundred seven hemispheres of 58 consecutive patients with moyamoya disease that were analyzed with fused 3-dimensional images of int...
Article
Background: The effectiveness of thrombectomy for acute ischemic stroke has been established, and earlier treatment produces better outcomes. If possible to identify large-vessel occlusion (LVO) at the prehospital phase, eligible patients can be shipped directly to a hospital that can perform thrombectomy. The purpose of this study was to determin...
Article
Full-text available
Relatively small unruptured intracranial aneurysms (UIAs) are often managed conservatively. However, rupture of UIA during follow-up occurs occasionally in clinical situations. We retrospectively analyzed cases of ruptured UIAs followed in our institution between 2012 and 2016. Four patients presented with subarachnoid hemorrhage caused by ruptured...
Article
Full-text available
Hemophilia is an X-linked hemorrhagic disease due to coagulation factor VIII or IX deficiency with approximately 5–10% incidence of central nervous system bleeding. We present an intriguing case of a refractory subacute subdural hematoma (SDH) controlled with endovascular embolization in a hemophilic patient. A 5-year-old severe hemophilic A boy pr...
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Full-text available
Ischemic stroke is a leading cause of death and disability worldwide. Much of the long-term disability occurs in patients with Emergent Large Vessel Occlusion (ELVO). In fact, in these patients, occlusion of a major intracerebral artery results in a large area of brain injury often resulting in
Article
Optimal microcatheter is necessary for successful coiling of an intracranial aneurysm. The optimal shape may be pre-determined before the endovascular surgery using a 3-dimensional (3D) printing rapid prototyping technology. We report a preliminary series of intracranial aneurysms treated with a microcatheter shape determined by the patient's anato...
Article
The present study retrospectively analyzed the database of the Japanese Registry of Neuroendovascular Therapy 1 and 2 (JR-NET1&2) to determine annual trends, including adverse events and clinical outcomes at 30 days after undergoing neuroendovascular therapy. JR-NET1&2 are surveys that targeted all patients in Japan who underwent neuroendovascular...
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Full-text available
Ruptured intracranial aneurysms are rare in the pediatric population compared to adults. This has incited considerable discussion on how to treat children with this condition. Here, we report a child with a ruptured saccular basilar artery aneurysm that was successfully treated with coil embolization. A 12-year-old boy with acute lymphoblastic leuk...
Article
The anatomy of the double ophthalmic artery was visualized using fused imaging. The images demonstrate the first angiographic visualization of the course of the vessel.
Article
ABSTRACT A percutaneous medial saphenous artery catheterization technique for swine femoral access is described. The medial saphenous artery is accessed with a 22-gauge catheter-over-needle assembly, followed by 4-Fr 10-cm sheath insertion using the Seldinger technique. The 4-Fr sheath is subsequently exchanged over a 0.035-inch guidewire for a 5-F...
Article
We read with great interest the article written by Alomari et al,[1][1] and agree with the authors that Klippel-Trenaunay syndrome is not associated with spinal cord AVM. However, in their discussion, in relationship to spinal cord AVM with Parkes Weber syndrome, they comment briefly that “Spinal
Article
A 54-year-old man developed apathy and memory impairment in 3 months. MRI showed bilateral thalamic hyperintensities with dilated cortical veins in the right cerebellum. Angiography revealed dural arteriovenous fistula (dAVF) at right transverse-sigmoid sinuses with retrograde flow through the vein of Galen (figure 1). Transvenous coil embolization...
Article
The aim of this study was to develop a technically simple swine aneurysm-training model by inserting a silicone aneurysm circuit in the cervical vessels. A silicone aneurysm circuit was created by designing multiple aneurysms in size and configuration on a silicone vessel. Five swine underwent surgical implantation of this circuit in the cervical v...
Article
During endovascular revascularization of subacute and chronic occlusion of the cervical internal carotid artery (ICA) it may be difficult to penetrate the lesion. Selecting the appropriate “true lumen”, a remnant of what had been the arterial lumen, at the initial step may facilitate the procedure. Because plaque at the carotid bifurcation is known...
Article
A 32-year-old Filipino female presented with Takayasu's arteritis manifesting as an abrupt onset of syncope. Physical examination revealed diminished consciousness, right hemiparesis, and a large discrepancy in blood pressure between the upper and lower extremities. Magnetic resonance imaging revealed cerebral infarcts in the left basal ganglia and...
Article
Carotid artery stenosis is increasingly a cause of stroke in Japan. Diagnostic imaging techniques are available, including ultrasound, 3D computed tomography angiography (CTA), magnetic resonance imaging (MRI), and cerebral angiography (DSA). The stenosis ratio measuring vessel diameter is a major criteria for surgical indications. CTA and DSA are...
Article
The development of cerebral aneurysms is related to hemodynamic stress. To elucidate the role of shear stress in the blister formation of cerebral aneurysms. Among 82 aneurysms detected during catheter-based 3D rotational angiography (3DRA), 4 aneurysms enlarged with blister formation during a mean follow-up period of 10.1 month. Three of these 4 a...
Article
Annual retrospective surveys of 20 to 31 medical centers performing endovascular treatment of cerebral aneurysms in Japan from 1997 to 2008 were performed to analyze technical and clinical outcomes of endovascular treatment for ruptured cerebral aneurysm. Patients treated with dome embolization using bare platinum coils within 14 days after onset w...
Article
【目的】治療困難な破裂内頚動脈瘤に対して部分塞栓術を行い,流速低下部位に一致した瘤内血栓化を認めた症例を報告する.【症例】軽症のくも膜下出血で来院した91歳女性.広頚かつ大型(22mm)の右内頚動脈瘤を認め,保存的に治療したが1ヵ月後に再出血した(WFNS GradeII).再出血当日の部分塞栓術直後は瘤全体が造影されたが,2週間後の血管撮影でブレブを含む動脈瘤先端部の血栓化を認めた.同部位は治療前の画像を元にコンピューターシミュレーションで可視化された流速低下部位に一致していた.【結論】塞栓術がdome fillingで終了した場合であっても,脳動脈瘤内の流速低下部位に血栓化が起こりやすいことが示唆された.
Article
Full-text available
The natural course of symptomatic carotid artery occlusion with hemodynamic impairment is poor. Surgical revascularization may improve the outcome; however, its efficacy has not been established yet. The goal of this study was to characterize the technical and clinical outcomes following endovascular recanalization of the ICA under cerebral circula...
Article
Although carotid artery stenting (CAS) has been proposed as an alternative to carotid endarterectomy in cerebral revascularization, restenosis remains an unsolved issue. Cilostazol is a unique antiplatelet drug that has vasodilatory effects and inhibits smooth muscle cell proliferation. We investigated whether cilostazol reduces restenosis after CA...
Article
Carotid endarterectomy (CEA) is a well-established surgical treatment for carotid artery stenosis. Carotid artery stenting (CAS) is a preferred treatment strategy in high-risk patients requiring surgery. Lacunar stroke has been the most prevalent stroke type among the Japanese. Recently carotid artery atherosclerotic thrombosis cases have been more...
Article
The Middle Cerebral Artery Embolism Local Fibrinolytic Intervention Trial (MELT) Japan was organized to determine the safety and clinical efficacy of intraarterial infusion of urokinase (UK) in patients with stroke within 6 hours of onset. Patients with ischemic stroke presenting within 6 hours of onset and displaying occlusions of the M1 or M2 por...
Article
Full-text available
In the past 25 years, interventional neuroradiology (IVNR) has widened its application not only to cerebrovascular diseases but also to vertebroplasty and tumor embolization. Gradually the positive evidence of its usefulness has accumulated in many diseases, and along with the progress of IVNR, the membership of the JSIN rapidly increased. Members...
Article
Revascularization treatment for occlusion of the intracranial artery is effective, but the outcome is still poor or sometimes death in patients with occlusion of the cervical internal carotid artery. We investigated the indications and limitations of percutaneous revascularization for cervical internal carotid artery occlusion.Five patients with at...
Article
Aneurysms arising around the carotid siphon, named juxta-dural ring aneurysms, are different from other cerebral aneurysms. These aneurysms are partially or totally covered with the dura mater and surrounded by the bone or the optic nerve. These anatomical specificity makes surgical access and clipping difficult, compared with other aneurysms. In o...
Article
Coil embolization was performed in 86 cerebral aneurysm patients using two types of detachable platinum coils, IDC (Interlocking detachable coil) and GDC (Guglielmi electrical detachable coil). Results of IDC and GDC were compared. The occlusion rate of the aneurysm sac was similar. Coil compaction occurred frequent and early in cases with GDC. As...
Article
Because arteriovenous malformations (AVMs) in the basal ganglia and thalamus are difficult to treat, the authors conducted a retrospective study to determine the best management strategy for these lesions. The authors reviewed the management and outcome in 101 patients with AVMs treated between 1971 and 1995. In 15 conservatively treated patients,...
Article
Ninety-six cases of arteriovenous malformation (AVM) in the basal ganglia and thalamus were retrospectively analyzed. The prognosis of patients presenting with hemorrhage was poor, if conservatively treated. The mortality and morbidity were 62.5% and 12.5%, respectively. In the surgically resected group, 10 (66.6%) out of 15 patients are working an...
Article
In transvenous endovascular treatment of dural arteriovenous fistula (AVF), access to the affected sinus is determined by venous drainage. In cavernous dural AVF, the route to the cavernous sinus is through the inferior petrosal sinus (IPS) or the superior ophthalmic vein. Other venous routes are not practical. Occlusive change of the IPS is a comm...
Article
抄録 To evaluate the clinical outcome of microsurgery, gamma-knife radiosurgery, and conservative treatment, we retrospectively reviewed 96 consecutive patients with cerebral arteriovenous malformation (AVM) in the thalamus and basal ganglia, treated at our institute between 1971 and 1995. Among 16 patients treated conservatively, 10 patients (62.5%)...
Article
A 51-year-old man presenting with radiculopathy a rare cervical dural arteriovenous fistula (AVF) is reported. Angiography revealed that the cervical dural AVF was fed mainly by the left C-3 and C-4 radicular arteries and drained into the internal vertebral venous plexus with no communication with intradural structures. The dural AVF was treated su...
Article
We have applied a new method of preoperative embolization to an intravagal and to carotid body paraganglioma, using estrogen dissolved in absolute alcohol and polyvinyl alcohol particles, which diffusely embolizes vessels from capillaries to main feeders. Total resection of the tumors after embolization was successively performed without postoperat...
Article
To evaluate the potential of superselective cavernous sinus (CS) sampling in patients with functioning pituitary adenomas, we performed direct CS sampling in 18 patients with Cushing syndrome and other functioning adenomas using a mini-catheter. Samples from the inferior petrosal sinuses (IPS) were also obtained. All of the samples from 20 CS of 10...
Article
Using superselective catheterization technique, venous sampling directly from the cavernous sinus was performed in seven patients with Cushing's disease and one patient with ectopic ACTH secreting tumor. In Cushing's disease the central/peripheral (c/p) gradients of ACTH in the cavernous sinus (11.9-111.1; mean, 49.6) were much greater than those i...
Article
Using superselective catheterization technique, venous sampling directly from the cavernous sinus was performed in seven patients with Cushing's disease and one patient with ectopic ACTH secreting tumor. In Cushing's disease the central/peripheral (c/p) gradients of ACTH in the cavernous sinus (11.9-111.1; mean, 49.6) were much greater than those i...
Article
Thirty-two patients were treated with embolization of brain arteriovenous malformations (AVM's). Of these patients, 16 underwent surgical removal of AVM and 16 radiosurgery following embolization. Embolization caused neurological deficit in six patients (morbidity 18%) and fatal brain swelling in one (mortality 3%). Complication occurred in 6 out o...
Article
An 18-month-old boy was admitted to our hospital with sudden onset of paraplegia, analgesia of the lower limbs, dysuria and constipation. His gestational and birth histories were unremarkable. Past history revealed he had lymphangioma in his left inguinal region, and had been treated in another hospital. Neurological examination revealed flaccid pa...
Article
FT207 is retained for long periods in tumor tissues and is gradually released as 5FU in an activated form. This 5FU has antitumor effects as an antimetabolite, and also blocks the repair mechanism of DNA by radiation therapy (potentiation). On the other hand, vitamin A has been said to cause lysosome release and cell coat changes of tumor cells, an...

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