Sherif Eltonsy

Sherif Eltonsy
University of Manitoba | UMN · Faculty of Pharmacy

BPharm, PhD

About

45
Publications
5,789
Reads
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196
Citations
Additional affiliations
January 2019 - present
University of Manitoba
Position
  • Professor (Assistant)
February 2016 - March 2017
Université de Montréal
Position
  • PostDoc Position
September 2011 - present
Université de Montréal
Position
  • PhD

Publications

Publications (45)
Preprint
Background Conflicting evidence exists on the impact of the COVID-19 pandemic restrictions on preterm birth (PTB) and stillbirth rates. We aimed to evaluate changes in PTB and stillbirth rates before and during the pandemic period and assess the potential effect modification of socioeconomic status (SES). Methods Using the linked administrative he...
Article
Full-text available
Objectives: The increasing spread of severe acute respiratory syndrome coronavirus-2 has prompted Canada to take unprecedented measures. The objective of this study was to examine the impact of the implemented public health measures on the incidence of COVID-19 in Manitoba. Results: Using the COVID-19 dataset, we examined the temporal trends of...
Article
Full-text available
Background: Evidence from developed countries demonstrates that the use of antiseizure medications (ASMs) has been increasing in the last decade. Pregnant women have a very challenging risk benefit trade-off in terms of ASM utilization, and it is crucial to know if increased utilization is seen among pregnant women. Objective: To examine time-trend...
Article
Full-text available
Background: The coronavirus disease 2019 (COVID-19) pandemic and public health measures that took place have led to concerns regarding mental health and receipt of psychotropic medications. We aimed to study the changes in psychotropic medication dispensation rates before and during the COVID-19 pandemic in the general population. Methods: Administ...
Article
Full-text available
Introduction: We aimed to measure the impact of the COVID-19 pandemic on maternal mental health, stratifying on pregnancy status, trimester of gestation, and pandemic period/wave. Methods: Pregnant persons and persons who delivered in Canada during the pandemic, >18 years, were recruited, and data were collected using a web-based strategy. The c...
Preprint
Full-text available
Introduction: We aimed to measure the impact of the COVID-19 pandemic on maternal mental health, stratifying on pregnancy status, trimester of gestation, and pandemic period/wave. Methods: Pregnant persons and persons who delivered in Canada during the pandemic, >18 years, were recruited, and data were collected using a web-based strategy. The curr...
Article
Full-text available
Background Since the emergence of COVID-19, preventative public health measures, including lockdown strategies, were declared in most countries to control viral transmission. Recent studies and anecdotes have reported changes in the prevalence of perinatal outcomes during national COVID-19lockdowns.The objective of this rapid review was to evaluate...
Article
Full-text available
Background The prevalence of epilepsy in pregnant women is estimated at 0.3-1%. Anti-epileptic drug (AED) exposure in-utero has been associated with various adverse health outcomes in neonates, including adverse birth weight outcomes. Objective This review aims to summarize the published evidence on the association between AED exposure in pregnanc...
Article
Aims: There are conflicting signals in the literature about comparative safety and effectiveness of direct oral anticoagulants (DOACs) for nonvalvular atrial fibrillation (NVAF). Methods: We conducted multicentre matched cohort studies with secondary meta-analysis to assess safety and effectiveness of dabigatran, rivaroxaban and apixaban across...
Article
The use of maternal antiepileptic drug (AED) during pregnancy is associated with an increased risk of cognitive adverse effects among the offspring. As new-generation AEDs continue to enter the market, evidence on their safety during pregnancy is limited yet necessary. To date, there are no published reviews summarizing the evidence of new-generati...
Article
Full-text available
Background: Direct oral anticoagulants (DOACs) have widely replaced warfarin for stroke prevention in nonvalvular atrial fibrillation. Our objective was to compare the safety and effectiveness of DOACs (dabigatran, rivaroxaban, apixaban) versus warfarin for stroke prevention in nonvalvular atrial fibrillation in the Canadian setting. Methods: We...
Preprint
Full-text available
Background: The prevalence of epilepsy in pregnant women is estimated at 0.3- 1%. Antiepileptic drug (AED) exposure in-utero has been associated with various adverse health outcomes in neonates including adverse birth weight outcomes. Methods: To summarize the evidence on the association between AED exposure in pregnancy and adverse birthweight ou...
Article
Trajectory analyses differentiate subgroups of smokers based on early patterns of cigarette use, but no study has summarized this literature. We systematically reviewed the literature on adolescent cigarette smoking trajectories to document the number and shapes of trajectories identified, assess if certain study characteristics influence the numbe...
Research Proposal
Full-text available
The main purpose of this systematic review is to identify and sum-up the available evidence related to the effect of body piercing and tattooing in developing Hepatitis-C (Hep-C).
Research Proposal
Full-text available
The main goal of this systematic review is to map and sum-up the real-world evidence (RWE) on the effectiveness and safety profiles of interferon-free, direct-acting antiviral drugs (DAAs) for the treatment of Hepatitis-C (Hep-C).
Article
Full-text available
Background: Statins and exercise are recommended for managing hypercholesterolemia. However, statin types may vary in their interaction with exercise. We compared rosuvastatin versus atorvastatin combination with exercise on lipid profile and functional capacity. Methods: A retrospective cohort study using data from a 12-week cardiovascular reha...
Article
Full-text available
Objective: Although major anastomotic bleeding after lower gastrointestinal surgery is considered rare, it can be life-threatening if not properly managed. The objective of this study was to assess the incidence of postoperative lower gastrointestinal intraluminal bleeding and to identify its potential risk factors. This retrospective cohort study...
Article
Full-text available
Background: The preferred ambulatory IV therapy for cellulitis is often once-daily cefazolin combined with once-daily oral probenecid (C+P). However, due to a national probenecid drug shortage in 2011, our centre developed a replacement protocol for the administration of cefazolin continuous infusion (CCI) using elastomeric infusers. Our goal was t...
Article
Full-text available
Objective To evaluate the impact of the combination of metformin and exercise on changes in glycated hemoglobin (HbA1c), functional capacity, the lipid profile, quality of life, and weight. Methods Data from a 12-week cardiovascular rehabilitation program (2014–2016) were retrospectively evaluated. Metformin exposure was determined through recorde...
Article
Life stresses (LS) could affect levels of physical activity (PA) during adolescence, however research is limited. As different types of PA may have different determinants, the effects of LS on participation in moderate-to-vigorous PA (MVPA) and on organized and unorganized PA (OPA, UPA) were examined in a sample of 937 students (10-11 years-old) fo...
Article
Full-text available
Abstract Objective: To examine weight loss (WL) and excess weight loss (EWL) among newborns of caesarean delivery, comparing colloids plus crystalloids versus crystalloids only. Also, to examine different doses of intrapartum intravenous fluids on WL and EWL. Design: Comparative safety retrospective cohort study. Setting: University Teaching Hos...
Article
Full-text available
Objectives To compare the prevalence of major malformations using different case ascertainment definitions and to evaluate their impact on maternal asthma-major malformations association. Methods A cohort of pregnancies with and without asthma between 1990 and 2010 was formed. We used two classification methods: the Two step Congenital Malformation...
Article
Background: Although there is strong evidence that some medications are teratogenic, the current lists of teratogens to be used in research are outdated. The objective of this study was to develop an updatable and systematic procedure to the classification of medications proven and potentially teratogenic in the first trimester of pregnancy, for u...
Conference Paper
Background: In 2009, the concern has been raised that insulin analogues, especially insulin glargine, might increase risk of (breast) cancer. Many in vitro and epidemiological and some animal studies have been performed, but there is still no clarity on this issue. Objectives: The aim of this study was to investigate the association between insulin...
Research
Full-text available
A literature review on propensity score analysis, (Please cite as: Sherif Eltonsy; Propensity Score Analysis: A Literature Review, DOI: 10.13140/RG.2.1.3626.6400)
Research
A literature review on propensity score analysis, updated January 2012
Article
Full-text available
Background: Current recommendations for managing persistent asthma during pregnancy when low-dose inhaled corticosteroids (ICSs) are insufficient include adding a long-acting β₂-agonist (LABA) or increasing the ICS dose. However, there are no data to help clinicians evaluate the safest regimen during pregnancy. Objective: We sought to compare th...
Article
Short and long-acting beta2-agonists (SABA and LABA) have a crucial role in asthma management during pregnancy, as stated in the current guidelines. To systematically review the evidence on beta2-agonists use during pregnancy and adverse perinatal outcomes. Six databases were searched before January 1, 2013 for beta2-agonists use during pregnancy a...
Article
Treatment of asthma symptoms during pregnancy is crucial for maternal and fetal health. Short-acting beta2-agonists (SABA) are frequently used as rescue medications and long-acting beta2-agonists (LABA) are used as add-on controller therapy for asthma during pregnancy. The objective of this study was to investigate the association between exposure...
Conference Paper
Renin - angiotensin (RA) drugs (Angiotensin Converting Enzyme Inhibitors - ACEIs - and Angiotensin Receptor Blockers - ARBs) are accepted treatments for hypertension and Congestive Heart Failure. Coughing can occur with ACEIs leading to development of ARBs. Trials showed though discontinuation due to coughing in a minority of patients on ACEIs (2-...
Thesis
According to asthma management guidelines during pregnancy, short-acting β2-agonists (SABA) are the drug of choice in all types of asthma [intermittent or persistent, mild, moderate and severe] as a quick reliever medication and in the management of acute exacerbations or emergency hospitalizations. On the other hand, long-acting β2-agonists (LABA)...

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