Shengwen Calvin Li

Shengwen Calvin Li
University of California, Irvine | UCI · CHOC Children's Hospital Research Institute

PhD/EIC/FRSM/FRSB/PI/AdjProf.

About

269
Publications
36,994
Reads
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10,226
Citations
Introduction
PhD, Mount Sinai School of Medicine, New York City; NIH-NCI-NRSA postdoctoral fellow at MIT/Whitehead and Harvard Medical School. Adjunct Professor, teaching at University. Principal Investigator - CHOC Children's Hospital Research Institute, University of California, Irvine, USA. His work is among the most-frequently-cited (single-papers with ~1000 citations), and remarked in Nature, Cell, and Ann Rev. Cell & Dev. Biol. As editorial board member for American Journal of Pathology, PLOS One, World J. of Stem Cells (Editor-in-Chief), Curr. Stem Cell Res. & Therapy, Med. Sci.(MDPI Inc., Switzerland), and Journal of Cell Science and Therapy. As ad-hoc reviewer for grant agencies. With membership of ASCB, ACTS, ISSCR, SfN, ASN, ASIP, AAAS. Elected Fellow, The Royal Society of Medicine, UK.
Additional affiliations
October 2021 - present
Frontiers
Position
  • Editor (Associate Editor)
Description
  • Associate Editor (Frontiers in Oncology) (IF 6.78) Invited position Lausanne, VD, CH
September 2019 - March 2022
Bentham Science Publishing
Position
  • Editor
Description
  • BENTHAM Open provides researchers a platform to rapidly publish their research
January 2019 - present
Baishideng Publish Group
Position
  • Editor-in-Chief,
Description
  • Editor-in-Chief, World J. Stem Cells 7901 Stoneridge Drive, Suite 501, Pleasanton, CA 94588, USA
Education
March 1997 - July 1998
Harvard University Medical School, Department of Cell Biology
Field of study
  • Molecular Cell Biology
August 1994 - June 1997
Massachusetts Institute of Technology/Whitehead Institute
Field of study
  • Molecular cell biology, signal transduction
October 1990 - July 1994
Icahn School of Medicine at Mount Sinai
Field of study
  • Biomedical Science, Molecular cell pathology, neuroscience

Publications

Publications (269)
Article
Full-text available
Currently, most neuroblastoma patients are treated according to the Children’s Oncology Group (COG) risk group assignment; however, neuroblastoma’s heterogeneity renders only a few predictors for treatment response, resulting in excessive treatment. Here, we sought to couple COG risk classification with tumor intracellular microbiome, which is part...
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Top Reviewer, Excellent Reviewer, record 271 verified manuscripts, 21 verified Editor handling manuscripts, as recorded by Web of Science Publons Academy. Publons links directly to the Web of Science, so researchers can claim and manage their Web of Science publication history, and display their history next to their peer review and journal editing...
Article
Full-text available
Reply to Schramm, L. Comment on “Li et al. BDP1 Variants I1264M and V1347M Significantly Associated with Clinical Outcomes of Pediatric Neuroblastoma Patients Imply a New Prognostic Biomarker: A 121-Patient Cancer Genome Study. Diagnostics 2021, 11, 2364”
Article
Full-text available
Background: The mechanism of tumorigenicity potentially evolved in mesenchymal stem cells (MSCs) remains elusive, resulting in inconsistent clinical application efficacy. We hypothesized that subclones in MSCs contribute to their tumorgenicity, and we approached MSC-subclones at the single-cell level. Methods: MSCs were cultured in an osteogenic di...
Article
Full-text available
Titanium dioxide nanoparticles (TiO2 NPs) have attracted substantial attention in various applications, including environmental remediation and nanomedicine. A detailed understanding of the toxicity of TiO2 NPs and the underlying mechanisms is fundamental to further development of their environmental and biomedical applications. Herein, we determin...
Data
Mφs mediate the repair of vascular ruptures through direct physical adhesion and mechanical traction, which may involve Piezo1 and Piezo2 [16] [Ardem Patapoutian’s work was recognized by The Nobel Prize in Physiology or Medicine 2021] and also indirectly through the secretion of pro-angiogenic factors, including VEGF-A [17]. It is still unclear whe...
Article
Background: Irradiation disrupts the vascular niche where hematopoietic stem cells (HSCs) reside, causing delayed hematopoietic reconstruction. The subsequent recovery of sinusoidal vessels is key to vascular niche regeneration and a prerequisite for hematopoietic reconstruction. We hypothesize that resident bone marrow macrophages (BM-Mφs) are res...
Article
Full-text available
Background: Neuroblastoma (N.B.) is the most common tumor in children. The gene BDP1 (B Double Prime 1) plays a role in cancers but is less known in N.B. Thus, we conducted this study to investigate the value of BDP1 mutations in N.B. Prognosis: Methods: A dataset of 121 NB patients from the Cancer Genome Atlas database was used to analyze BDP...
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I was invited to join as Associate Editor at https://www.frontiersin.org/search/journal/oncology?query=Shengwen+Calvin+Li,+associate+editor&tab=people&origin=https%3A%2F%2Fwww.frontiersin.org%2Fjournals%2Foncology - I'm delighted to serve on Open Access Scientific Publishing, as I heard the OA concept in 1994 by Nobel Laureate Harold Varmus at MIT,...
Article
Full-text available
Developing ecological approaches for disease control is critical for future sustainable aquaculture development. White spot syndrome (WSS), caused by white spot syndrome virus (WSSV), is the most severe disease in cultured shrimp production. Culturing specific pathogen-free (SPF) broodstock is an effective and widely used strategy for controlling W...
Article
Full-text available
Background: Ectosomes are recognized as shedding from the plasma membranes into the extracellular environment. Recent research has demonstrated that ectosomes are surrounded by phospholipid membranes containing lipid rafts and caveolae. Some ectosomes contain cytokines in the lumen and have high levels of phosphatidylserine exposed to the outer mem...
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Support Open Access Scientific Publishing by serving on peer-review reporting (PRR) - 1176194 Li PRR-verified manuscripts 234 and verified Editor 17, with Metrics of PRR integrity. Updated: 09.23.2021 (Sept. 23, 2021).
Article
Full-text available
Purpose Repairing the irradiation-induced osteogenic differentiation injury of bone marrow mesenchymal stem cells (BM-MSCs) is beneficial to recovering haematopoiesis injury in radiotherapy; however, its mechanism is elusive. Our study aimed to help meet the needs of understanding the effects of radiotherapy on BM-MSC osteogenic potential. Methods...
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Frontiers in Cell and Developmental Biology: Impact Factor 6.684 (2020)
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The 2021 Edition of Journal Citation Reports cites the 2020 impact factor (IF) for WJSC as 5.326; IF without journal self cites: 5.035; 5-year IF: 4.956; (https://oaspa.org/member/baishidengpublishing-group-inc/) Journal Metrics: WJSC came with Journal Citation Indicator: 0.55; Ranking: 14 among 29 journals in cell and tissue engineering; Quartile...
Research
An increasing number of reports indicate that mesenchymal stem cells (MSCs) play an essential role in promoting tumorigenesis and progression of head and neck squamous cell carcinoma (HNSCC). However, the molecular mechanisms underlying this process remain unclear. Using the MSC model system, this study analyzes the molecular pathway by which diffe...
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Editor-in-Chief for World Journal of Stem Cells: IF 4.753 in 2020 Rank My mentors have served the scientific community as Editor-in-Chief of Journals, which has inspired me to follow in their footsteps. Before 1999, little comparison of quantifications surfaced across different publishers and Journals. In 1999 and after that, SCImago Journal Ran...
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I've served as peer-review for Journal "Current Stem Cell Research & Therapy" and its 2020 JCR Impact Factor scored 3.828. Given that fact from no IF score to up to 3.828, with the average Journals = IF1.0 of the total of 20,942 Journals indexed in Journal Citation Reports® by Clarivate, I am pleased to witness the CSCRT growth as a peer-reviewer a...
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Publons_Metrics-statistics for Li SC record 070721.
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QIMS issue of Aug. 2021
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Title of thematic issue: Reflection on scientist’s journey toward and beyond Stem Cells Guest Editors: Shengwen Calvin Li, Ph.D.; Philip Hitchins Schwartz, Ph.D. Aims & Scope: This Special Issue will organize around the theme "Research-based resolutions on stem cell biology & regenerative medicine." We want to emphasize the difficulty in identifyin...
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Title of thematic issue: Reflection on scientist’s journey toward and beyond Stem Cells Guest Editors: Shengwen Calvin Li, Ph.D.; Philip Hitchins Schwartz, Ph.D. Aims & Scope: This Special Issue will organize around the theme "Research-based resolutions on stem cell biology & regenerative medicine." We want to emphasize the difficulty in identifyin...
Poster
Title of thematic issue: Reflection on scientist’s journey toward and beyond Stem Cells Guest Editors: Shengwen Calvin Li, Ph.D.; Philip Hitchins Schwartz, Ph.D. Aims & Scope: This Special Issue will organize around the theme "Research-based resolutions on stem cell biology & regenerative medicine." We want to emphasize the difficulty in identifyin...
Cover Page
Title of thematic issue: Reflection on scientist’s journey toward and beyond Stem Cells Guest Editors: Shengwen Calvin Li, Ph.D.; Philip Hitchins Schwartz, Ph.D. Aims & Scope: This Special Issue will organize around the theme "Research-based resolutions on stem cell biology & regenerative medicine." We want to emphasize the difficulty in identifyin...
Chapter
Title of thematic issue: Reflection on scientist’s journey toward and beyond Stem Cells Guest Editors: Shengwen Calvin Li, Ph.D.; Philip Hitchins Schwartz, Ph.D. Aims & Scope: This Special Issue will organize around the theme "Research-based resolutions on stem cell biology & regenerative medicine." We want to emphasize the difficulty in identifyin...
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Publons Academy Peer-review Verified Record as of April 23, 2021: Peer-review Verified Record: 202 manuscripts for Journals. Peer-review Verified Record for editor tasks: 14 Journal manuscripts.
Article
Full-text available
Macrophages are widely distributed in tissues and function in homeostasis. During cancer development, tumor-associated macrophages (TAMs) dominatingly support disease progression and resistance to therapy by promoting tumor proliferation, angiogenesis, metastasis, and immu-nosuppression, thereby making TAMs a target for tumor immunotherapy. Here, w...
Thesis
Background The tumor microenvironment consists of both physical and chemical factors. Tissue elasticity is one physical factor contributing to the microenvironment of tumor cells. To test the importance of tissue elasticity in cell culture, primitive neuroectodermal tumor (PNET) stem cells were cultured on soft polyacrylamide (PAA) hydrogel plates...
Article
Coronavirus disease 2019 (COVID-19) has become a global pandemic with a high rate of transmission. Currently, there is a lack of vaccines and specific drugs for this newly-emerged virus. Timely diagnosis and treatment, as well as isolation of patients and virus carriers, contribute to the effective prevention and control of this epidemic. This revi...
Article
Full-text available
Coronavirus disease 2019 (COVID-19) has become a global pandemic with a high rate of transmission. Currently, there is a lack of vaccines and specific drugs for this newly-emerged virus. Timely diagnosis and treatment, as well as isolation of patients and virus carriers, contribute to the effective prevention and control of this epidemic. This revi...
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Peer-review matrices of Publons database, as of Jan. 27, 2021
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Total 185 peer-review reports and 13 editor's reports were verified by Publons Academy record systems as of January 18, 2021.
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List of reviewers board members (500+)
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verified peer-review record and editor record.
Article
Full-text available
Erratum for Microfluidic enrichment of plasma cells improves treatment of multiple myeloma. Zeng Y, Gao L, Luo X, Chen Y, Kabeer MH, Chen X, Stucky A, Loudon WG, Li SC, Zhang X, Zhong JF. Mol Oncol. 2018 Jun;12(7):1004-1011. doi: 10.1002/1878-0261.12201. Epub 2018 May 12. PMID: 29638042 Free PMC article.
Presentation
Full-text available
Common clinical options, currently, for necessary splenectomy are vaccinations and antibiotic prophylaxis. However, despite these two adjuncts, there still occur numerous cases of overwhelming post-splenectomy infection. To examine whether reperfusion of critical splenic lymphocytes could boost immune response, we harvested splenic lymphocytes, rep...
Preprint
Due to the limited understanding of the characteristics of predator-pathogen-prey interactions, few attempts to use selective predation for controlling diseases in prey populations have been successful. The global pandemic of white spot syndrome (WSS), caused by white spot syndrome virus (WSSV), causes devastating economic losses in farmed shrimp p...
Article
Full-text available
The development of single-cell subclones, which can rapidly switch from dormant to dominant subclones, occur in the natural pathophysiology of multiple myeloma (MM) but is often "pressed" by the standard treatment of MM. These emerging subclones present a challenge, providing reservoirs for chemoresistant mutations. Technological advancement is req...
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Listed with my mentor - great honor! https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7017178/ DOI: 10.3390/cancers12010243
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list of the reviewers for Cells in 2019. DOI: 10.3390/cells9010251 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016538/
Article
Full-text available
Common clinical options, currently, for necessary splenectomy are vaccinations and antibiotic prophylaxis. However, despite these two adjuncts, there still occur numerous cases of overwhelming post-splenectomy infection. To examine whether reperfusion of critical splenic lymphocytes could boost immune response, we harvested splenic lymphocytes, rep...
Article
Full-text available
Background: Radiation induces rapid bone loss and enhances bone resorption and adipogenesis, leading to an increased risk of bone fracture. There is still a lack of effective preventive or therapeutic method for irradiation-induced bone injury. Receptor activator of nuclear factor κB ligand (RANKL) provides the crucial signal to induce osteoclast...
Article
Full-text available
Allogenic stem-cell therapies benefit patients in the treatment of multiple diseases; however, the side effects of stem-cell therapies (SCT) derived from the concomitant use of immune suppression agents often include triggering infection diseases. Thus, analysis is required to improve the detection of pathogen infections in SCT. We develop a polyme...
Article
Full-text available
Coronavirus disease 2019 (COVID-19) has become a global pandemic with a high rate of transmission. Currently, there is a lack of vaccines and specific drugs for this newly-emerged virus. Timely diagnosis and treatment, as well as isolation of patients and virus carriers, contribute to the effective prevention and control of this epidemic. This revi...
Article
Full-text available
Rising concerns about the short- and long-term detrimental consequences of administration of conventional pharmacopeia are fueling the search for alternative, complementary, personalized, and comprehensive approaches to human healthcare. Qigong, a form of Traditional Chinese Medicine, represents a viable alternative approach. Here, we started with...
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Rising concerns about the short- and long-term detrimental consequences of administration of conventional pharmacopeia are fueling the search for alternative, complementary, personalized, and comprehensive approaches to human healthcare. Qigong, a form of Traditional Chinese Medicine, represents a viable alternative approach. Here, we started with...
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PNAS issue cover story: Leading article on iPSC - induced pluripotent stem cells derived from skin cells, which can be induced to differentiate into neural cells. Which has been read over 10,000 times, as of November 18, 2019. https://www.researchgate.net/profile/Shengwen_Li/achievement/5dd4c82f96d67a8d357cd1fc via @researchgate
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PNAS issue highlights by editor: Turning off p53 enables human skin cells to reprogram into nerve cells
Article
Full-text available
Resistance to ionizing radiation (IR), which is a conventional treatment for osteosarcoma that cannot be resected, undermines the efficacy of this therapy. However, the mechanism by which IR induces radioresistance in osteosarcoma is not defined. Here, we report that CR6-interacting factor-1 (CRIF1) is highly expressed in osteosarcoma and undergoes...
Data
in English, Spanish NP185, a neuronal-specific protein of 185 kDa, was first discovered when we prepared monoclonal anti-bodies (mAbs) against bovine brain clathrin coated vesicles. Two mAbs, 8G8 and 6G7, permitted us to characterize this protein both biochemically and in development (NP185 is expressed in a NGF-dependent manner in PC12 cells). The...
Article
Full-text available
Splenectomy in an animal model requires a standardized technique utilizing best practice to avoid variability which can result in adverse impact to the animal resulting in flawed physiologic responses simply due to technique rather than to the studied variables. In the case of the spleen, often investigators are analyzing the animal immune or infla...
Preprint
Full-text available
Radiation induces rapid bone loss and enhances bone resorption and RANKL expression. RANKL provides the crucial signal to induce osteoclast differentiation and plays an important role in bone resorption. However, the mechanisms of radiation-induced osteoporosis are not fully understood. Here, we show that Crif1 expression increases in bone marrow c...
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Biomolecules (ISSN 2218-273X),Impact Factor - 4.694! (Biomolecules - MDPI Inc., Basel, Switzerland)
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The impact factor for the 2018 citation year: 3.074. The impact factor, as published in the annual Journal Citation Reports (JCR), is a calculation based on the number of citations accumulated in 2018 for the manuscripts published in 2016 and 2017. The Quantitative Imaging in Medicine and Surgery is an international, open access, peer-reviewed j...
Article
Full-text available
Cancer epidemic led to worldwide to search for a new "game changer" concept to govern cancer research and cancer treatment. Western medicine-based cancer research has been extending the impasse without resolution in sigh for improving survival of patients with solid malignant tumors in the last four decades due to heterogeneity in cancer tissues. S...
Cover Page
Full-text available
Editor-in-Chief
Article
Full-text available
Tracking and monitoring implanted stem cells are essential to maximize benefits and to minimize the side effects of stem cell therapy for personalized or “precision” medicine. Previously, we proposed a comprehensive biological Global Positioning System (bGPS) to track and monitor stem cells in vivo. Magnetic resonance imaging (MRI), positron emissi...
Research Proposal
Full-text available
I've been appointed to Editor-in-Chief of World Journal of Stem Cells (01/01/2019-12/31/2021). You're welcome to submit your manuscripts and serve on peer-review. Thanks so much for your support ! attached link: https://www.wjgnet.com/1948-0210/editorialboard.htm Blessings to all of you and for peace upon Earth!
Article
Full-text available
Studying on subclonal evolution of cancer stem cells can help illustrate how the immune system recognizes tumor cells, leading to subclonal treatment by immune-based therapies. Here, we discuss that cancer subclones derived from the patient's head and neck squamous cell carcinoma tumor stem cells can be used for the screening of personalized antitu...
Data
Studying on subclonal evolution of cancer stem cells can help illustrate how the immune system recognizes tumor cells, leading to subclonal treatment by immune-based therapies. Here, we discuss that cancer subclones derived from the patient's head and neck squamous cell carcinoma tumor stem cells can be used for the screening of personalized antitu...
Cover Page
Full-text available
Peer-review, like a Godfather to a child (manuscript or proposal), born to her parents (the authors), providing a steady guiding hand to the child growth. Thus, I much appreciate Journals update me on the manuscript I did peer-review by sending me an e-mail to alert its status, such as accepted, online publication, comment added, etc.- as I take pl...
Article
Full-text available
Peer-review, like a Godfather to a child (manuscript or proposal), born to her parents (the authors), providing a steady guiding hand to the child growth. Thus, I much appreciate Journals update me on the manuscript I did peer-review by sending me an e-mail to alert its status, such as accepted, online publication, comment added, etc.- as I take pl...
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updated faculty page
Book
Full-text available
https://www.mdpi.com/journal/medsci/special_issues/caveolins_in_disease Special Issue "Beyond Lipid Rafts and Caveolae: Caveolins in Disease" • Special Issue Editors • Special Issue Information •Published Papers Special Issue Editors Guest Editor Dr. Shengwen Calvin Li University of California, Irvine 1201 West La Veta Avenue CHOC Children...
Book
Full-text available
Special Issue "Beyond Lipid Rafts and Caveolae: From Caveolae Compartmentalization of Signal Transduction to Medicine" • Special Issue Editors • Special Issue Information •Published Papers A special issue of Biomolecules (ISSN 2218-273X). Deadline for manuscript submissions: 15 June 2019 Share This Special Issue Special Issue Editors Guest Edit...
Presentation
Full-text available
peer review verified record 2018-Sept.12
Article
Full-text available
The clinical benefits of the MammaPrint® signature for breast cancer is well documented; however, how these genes are related to cell cycle perturbation have not been well determined. Our single-cell transcriptome mapping (algorithm) provides details into the fine perturbation of all individual genes during a cell cycle, providing a view of the cel...
Presentation
Full-text available
global Top 1% in Field for peer review verified record 2018-Sept.12
Presentation
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"Publons helps you get the recognition you deserve for keeping watch over science and research. Easily import, verify, and store a record of every peer review you perform and every manuscript you handle as an editor, for any journal in the world, in full compliance with all editorial policies. "https://publons.com/home/
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Table of contents, covering English writing (training course) materials, broad spectrum of reading/writing blog posts - led to 5 million reads (accesses) between 2013 and 2017.
Article
Full-text available
Glioblastoma multiforme (GBM) remains an incurable brain tumor. The highly malignant behavior of GBM may, in part, be attributed to its intraclonal genetic and phenotypic diversity (subclonal evolution). Identifying the molecular pathways driving GBM relapse may provide novel, actionable targets for personalized diagnosis, characterization of progn...
Article
Full-text available
The enthusiasm of the clinical cancer research community has been renewed by clinically relevant demonstrations of molecular profiling arising from “whole genome sequencing” (WGS), leading to novel approaches of “personalised” cancer treatments. However, critics question the merits of such large-scale, expensive, time-consuming, dataharvesting, and...
Article
Full-text available
Cytogenetic alterations form the basis for risk stratification for multiple myeloma (MM) and guide the selection of therapy; however, current pathology assays performed on bone marrow samples can produce false negatives due to the unpredictable distribution and rarity of MM cells. Here, we report on a microfluidic device used to facilitate CD45 dep...
Article
Full-text available
Bone marrow mesenchymal stem cells (BMSCs), the important component and regulator of bone marrow microenvironment, give rise to hematopoietic supporting stromal cells and form hematopoietic niches for haematopoietic stem cells (HSCs). However, how BMSCs differentiation affects hematopoiesis is poorly understood. In this review, we focus on the role...