Sheng-Ping Yang

• PhD
• Professor (Full) at Wuhan University

Nine new conjugates of sesquiterpenoids and acylphloroglucinols, named eucarobustols A-I (1-9), as well as 11 known analogues were isolated from the leaves of Eucalyptus robusta. The sesquiterpenoid motifs furnishing the new conjugates included four structural types of aristolane (1 and 2), guaiane (3), eudesmane (4), and aromadendrane (5-9) moieti...

Seven new limonoids, dysomollides A-G (1-7), and two new cycloapotirucallane-type triterpenoids, dysomollins A and B (8 and 9), together with three known compounds, dysoxylumin A (10) and toonapubesins A (11) and B (12), were isolated from the twigs of Dysoxylum mollissimum var. glaberrimum. The structures of 1-9 were elucidated on the basis of spe...

Ivorenolide B (1), an unprecedented 17-membered macrolide featuring conjugated acetylenic bonds and four chiral centers, was isolated from Khaya ivorensis. The structure of 1 was fully determined by spectroscopic analysis and total syntheses of its four most possible stereoisomers. Compound 1 showed significant immunosuppressive activity.

Four diastereoisomers, aphadilactones A-D (1-4) possessing an unprecedented carbon skeleton, were isolated from a Meliaceae plant Aphanamixis grandifolia. Their challenging structures and absolute configurations were determined by a combination of spectroscopic data, chemical degradation, fragment synthesis, experimental CD and ECD calculation. Aph...

Five new sesquiterpenoid dimers, sarcandrolides F−J (1−5), three new sesquiterpenoid monomers (6−8), and 14 known sesquiterpenoids, were isolated from the whole plants of Sarcandra glabra. The absolute configurations of compounds 1−5 were established by the CD exciton chirality method. Compound 1 represents the first example of a lindenane-type ses...

Ivorenolide A (1), a novel eighteen-membered macrolide featuring conjugated acetylenic bonds and five chiral centers, was isolated from Khaya ivorensis. The structure of 1 was fully determined by spectroscopic analysis, single crystal X-ray diffraction, and bioinspired total synthesis. Both compound 1 and its synthetic enantiomer 2 showed potent an...

Five new apotirucallane-type triterpenoids (1-5), named agladorals A-E, and 28 known compounds (20 triterpenoids and 8 rocaglamides) were isolated from the twigs of Aglaia odorata var. microphyllina. Their structures were elucidated by spectroscopic analysis.

This review describes the major discoveries of structurally diverse and/or biologically significant compounds from plant resources in China, mainly from the traditional Chinese medicines (TCMs) since the establishment of our research group in 1999. In the past decade, a large array of biologically significant and novel structures has been identifie...

Eucalyptin A (1), together with two known compounds 2 and 3 exhibiting potent inhibition on HGF/c-Met axis, was discovered from the fruits of Eucalyptus globulus . 1 possessed an unprecedented carbon framework of phloroglucinol-coupled sesquiterpenoid, and its structure was elucidated by spectroscopic method and ECD calculation. A brief structure-a...

Serratustones A (1) and B (2), featuring a new carbon skeleton and representing a novel dimerization pattern of two different types of sesquiterpenoids, were isolated from Chloranthus serratus. Their structures with absolute configuration were determined on the basis of a detailed explanation of spectroscopic data, X-ray crystallography, and CD ana...

We have recently discovered that c-Jun executes a non-transcriptional function to stabilize hypoxia inducible factor 1α (HIF-1α) and that pseudolaric acid B (PAB) accelerates HIF-1α degradation and phosphorylates c-Jun at Ser63/73. In this study, PAB was used as a probe to investigate whether and how the Ser63/73 phosphorylation of c-Jun regulates...

Three new sesquiterpenes (1-3), (6R,7S,11R,10S)-15-hydroxy-sesquisabinene hydrate (1), (6R,7R,11S,10S)-15-hydroxy-sesquisabinene hydrate (2), and (6R,7R,10S)-15-hydroxy-zingiberenol (3), along with three known compounds, were isolated from the stems of Dysoxylum oliganthum; and three new isodaucane (salvionane) sesquiterpenes, namely isodauc-6-ene-...

Sixteen new limonoids, walsucochinoids C-R (1-16) incorporating a rearranged carbon skeleton, were isolated from the twigs and leaves of Walsura cochinchinensis. Their structures were established by detailed interpretation of spectroscopic data with those of 1 and 10 being secured by single-crystal X-ray diffraction experiments. Bioassays revealed...

Eleven new phragmalin-type limonoids, swietenitins N-X (1-11), together with a known one, epoxyfebrinin B (12), were isolated from the twigs of Swietenia macrophylla. The structures of the new compounds were established on the basis of spectroscopic methods, and that of compound 1 was confirmed by single-crystal X-ray diffraction. The stereochemist...

Ten limonoids, toonacilianins A-J, and two norlimonoids, toonacilianins K and L, together with seven known compounds were isolated from the stems of Toona ciliata var. henryi (Meliaceae). Their structures were elucidated by spectroscopic analysis. Two compounds showed strong cytotoxic activities.

Two novel lindenane-type sesquiterpenoid dimers, sarcanolides A (1) and B (2), were isolated from the whole plants of Sarcandra hainanensis. These compounds feature a new nonacyclic scaffold in which the bond formation of C-11–C-7′ imposed the five-membered lactone ring in a full β-direction. Their structures, including the absolute configuration,...

Two new limonoids, namely aphanamolides A (1) and B (2), were isolated from the seeds of Aphanamixis polystachya . Their structures were established by spectroscopic methods. Aphanamolide A (1) featured an unprecedented carbon skeleton via the formation of a C-3-C-6 bond. Compounds 1 and 2 showed cytotoxic activity against two tumor cell lines.

Six new highly oxygenated daphnane-type diterpenoids, trigochinins D–I (1–6), were isolated from the twigs and leaves of Trigonostemon chinensis. Their structures with the absolute configuration were established on the basis of spectroscopic method and CD analysis. Trigochinins D–F (1–3) possessed a rare 4,6-oxetane moiety in this compound class. T...

Eight ergostane-type sterols and three their derivatives (one mono-linoleate and two mono-glucosides) were isolated from the ethyl acetate soluble fraction of the fungus Catathelasma imperiale. Two of them are novel compounds, namely 22E, 24R-ergosta-7,22-diene-3β,5-diol-6β-inoleate (1) and 22E,24R-ergosta-7,22-diene-3β,5β,6-triol (5) with an uncom...

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

Six new oxygenated daphnane-type diterpenoids, trigoxyphins A-F (1-6), a phenanthrene-type diterpenoid, trigoxyphin G (7), and two known compounds were isolated from twigs of Trigonostemon xyphophylloides. Their structures were established using spectroscopic methods. Compounds 1 and 2 exhibited strong cytotoxic activity against HL60 (IC50: 0.27 an...

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

Four new sesquiterpenoids, chlomultins A-D (1-4), were isolated from the whole plant of Chloranthus multistachys. Their structures were established on the basis of spectroscopic analysis.

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

Seven new limonoids (1-7), named khayalenoids C-I, three new triterpenoids (8-10), named senegalenes A-C, and eight known limonoids have been isolated from stems of Khaya senegalensis. The structures of these compounds were elucidated on the basis of spectroscopic analyses.

Three highly oxygenated new diterpenes, trigochinins A-C (1-3) were isolated from Trigonostemon chinensis. Their structures with the absolute configuration were determined by a spectroscopic method, X-ray crystallography, and CD analysis. This study suggested the revision of the C-6 stereochemistry of trigonothyrins A-C reported quite recently. Com...

Two novel sesquiterpenoid dimers, multistalides A and B (1–2), were isolated from the whole plant of Chloranthus multistachys. Their structures were established on the basis of spectroscopic analysis, and the absolute configuration of 1–2 was determined by CD exciton chirality method.

Grandifotane A (1), a limonoid with an unprecedented carbon skeleton, was isolated from the stem bark of Khaya grandifoliola. The structure of 1 with the absolute configuration was determined by spectroscopic data, X-ray crystallography, and ECD calculation. A biogenetic route for grandifotane A (1) involving an enzymatic Baeyer-Villiger oxidation...

Four limonoids, 1-O-deacetyl-6-deoxykhayanolide E (1), 1-O-deacetyl-2 alpha-hydroxykhayanolide E (2), 3-acetyl-khayalactone (3), 11 alpha-acetoxy-2 alpha-hydroxy-6-deoxy-destigloylswietenine acetate (4), along with 12 known limonoids, were isolated from the stems of Khaya ivorensis. Their structures were elucidated on the basis of spectroscopic ana...

Sixteen new D-ring-opened phragmalin limonoid orthoesters, swietenitins A-M (1-6, 8, 10, 12-16), 2-acetoxyswietenialide D (7), 2,11-diacetoxyswietenialide D (9), and 11-deoxyswietenialide D (11), and four known compounds were isolated from the twigs of Swietenia macrophylla. The structures of 1-16 were established on the basis of spectroscopic meth...

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

Three new norlimonoids (1-3), two new tirucallane-type triterpenoids (4 and 5), and a new pimaradiene-type diterpenoid (6), along with two known limonoids and eight known tirucallane-type triterpenoids, were isolated from the leaves and twigs of Toona ciliata. Their structures were elucidated on the basis of spectroscopic data. Toonaciliatin M (6)...

Two limonoids, namely khayalenoids A (1) and B (2) with an unprecedented 8-oxa-tricyclo[4.3.2.0(2,7)]undecane motif in the nortriterpenoid core, were isolated from the stems of Khaya senegalensis. Their structures with absolute configuration were determined by spectroscopic data, X-ray crystallography, and CD analysis.

Five novel prenylated polyketides, harrisotones A–E (1–5) representing a rare spirocyclic skeleton, along with a new hydroperoxypolyketide harrisonol A (6), were isolated from the stems and leaves of Harrisonia perforata. The structures of harrisotones A–E (1–5) were extensively elucidated on the basis of spectroscopic analysis, especially 2D NMR a...

Two new depsidones, livistones A (1) and B (2), and a new benzofurane, livistone C (3), together with the 11 known compounds including three stilbenes (4-6), four steroids, three flavan-3-ols, and an alkaloid were isolated from the fruits of Livistona chinensis. The structures of the new compounds were determined by spectroscopic methods. Compounds...

Cinnacassides A–E (1–5), five novel glycosides with a unique geranylphenylacetate carbon skeleton, were isolated from the stem bark of Cinnamomum cassia. Each of the cinnacassides A–D (1–4) possesses one of the four stereoisomers in the aglycone. Their structures were established by extensive spectroscopic analysis and chemical and chiroptical meth...

Three degraded limonoids, dysodensiols A-C (1-3), and three sesquiterpenoids, dysodensiols D-F (4-6), along with 17 known compounds, were isolated from the twigs and leaves of Dysoxylum densiflorum. The structures of compounds 1-6 were established on the basis of extensive spectroscopic analysis.

Seven new limonoids, tabularisins J–P (1–7, resp.), together with eight known compounds, were isolated from the twigs and leaves of Chukrasia tabularis. Their structures were determined primarily by spectroscopic methods. The potassium channel blocking activities of some of these isolates were evaluated, and a few of them exerted significant activi...

Seven new sesquiterpenoids, chlorantenes A-G (1-7), two new phenylpropanoids (8 and 9), and six known sesquiterpenoids were isolated from the whole plants of Chloranthus serratus. Their structures were elucidated on the basis of spectroscopic analyses. Chlorantene A (1) was a sesquiterpene with a unique C-4 and C-10 linkage, and chlorantene B (2) p...

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

Twelve new alkaloids, caldaphnidines G-R (1-12), along with 24 known ones, were isolated from the twigs of Daphniphyllum calycinum. Their structures were elucidated by spectroscopic methods, especially two-dimensional NMR techniques.

Two novel limonoids, chuktabrin A (1), featuring the unique motifs of a 1,3-dioxolan-2-one and a 3,4-dihydro-2 H-pyran, and chuktabrin B (2), possessing an unprecedented polycyclic skeleton, were isolated from Chukrasia tabularis. The structures of 1 and 2 bearing a biosynthetically extended C3 and C2 unit at C-15, respectively, were elucidated on...

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

Two new sesquiterpenoids, vernobockolides A (1) and B (2), along with five known ones, piptocarphin C (3), piptocarphin F (4), piptocarphin A (5), hirsutolide (6), and beta-d-glucopyranosyl taraxinic ester (7), were isolated from the aerial part of Vernonia bockiana. Their structures were determined by spectroscopic analysis, especially 2D NMR. Amo...

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

Walsucochins A (1) and B (2) with an unprecedented skeleton were isolated from Walsura cochinchinensis. Their structures including absolute configuration were elucidated by spectral methods. A biosynthetic pathway of 1 and 2 was postulated. Both 1 and 2 exhibited significant cell protecting activities against H2O2-induced PC12 cell damage.

A new highly oxygenated sterol, 22E, 24R-ergosta-7,22-diene-3beta,5alpha,6beta,9alpha,14alpha-pentol (1), as well as four known sterols (2-5) and seven known triterpenoids, have been isolated from the spores of Ganoderma lucidum. The structure of compound 1 was elucidated on the basis of spectroscopic method.

Two new diterpenoids, ent-17-hydroxyl-16beta-methoxyl-kauran-3-one (1) and ent-17-acetoxyl-16beta-methoxyl-kauran-3-one (2), along with nine known compounds (3-12), ent-17-hydroxyl-kaur-15-en-3-one (3), ent-3beta-acetoxyl-kaur-15-en-16beta, 17-diol (4), ent-kauran-3beta, 16beta, 17-triol (5), ent-3beta-acetoxyl-kauran-16beta, 17-diol (6), ent-kaura...

Four unusually fused polycyclic sesquiterpenoid dimers, chlorahololides C - F (1 - 4), were isolated from the whole plant of Chloranthus holostegius. Their structures and absolute configurations were established by spectroscopic methods, including 2D NMR and CD spectra. Chlorahololides C - F (1 - 4) exerted potent and selective inhibition on the de...

Pseudolaric acid B (PAB), discovered as a promising angiogensis inhibitor, was served as the anticancer drug lead, and a series of its derivatives were synthesized. Among them, some derivatives, such as 13c- 13k, exhibited potent inhibition on the HMEC-1 cell proliferation and strong cytotoxic activities against the tested six tumor cell lines. The...

Seven new limonoids, amotsangins A-G (1-7), two known limonoids, and four known sesquiterpenoids were isolated from the twigs and leaves of Amoora tsangii. Their structures were elucidated primarily on the basis of spectroscopic data.

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

Two new sesquiterpenoids, namely 1 beta,4 beta-dihydroxy-5 alpha,8 beta(H)-eudesm-7(11)Z-en-8,12-olide (1) and 1 beta,4 alpha-dihydroxy-5 alpha,8 beta(H)-eudesm-7(11)Z-en-8,12-olide (2), along with six known ones, homalomenol A (3), oplodiol (4), 5 alpha,7 alpha(H)-6,8-cycloeudesma-1 beta,4 beta-diol (5), oplopanone (6), 4 beta,10 alpha-dihydroxyar...

Five new limonoids, tabularisins E-I ( 1- 5), and a new dinorcycloartane, (24 R)-28,29-dinor-cycloartane-3beta,24,25-triol ( 6), together with three known compounds, were isolated from the twigs and leaves of Chukrasia tabularis var. velutina. Their structures were elucidated primarily on the basis of spectroscopic methods.

Three new apotirucallane-type triterpenoids, agladupols A-C (1- 3), and two new tirucallane-type triterpenoids, agladupols D and E (4 and 5), along with four known compounds, were isolated from the leaves and stems of Aglaia duperreana (Meliaceae). The structures of compounds 1- 5 were elucidated by spectroscopic data. A (13)C NMR-based general rul...

Chuktabularins A-D (1-4), four novel 16-norphragmalin-type limonoids that feature unprecedented skeletons with a biosynthetically extended C2 or C3 unit at C-15 forming a unique 2,7-dioxabicyclo[2.2.1]heptane moiety, were isolated from the stem bark of Chukrasia tabularis. Their structures were elucidated by spectroscopic analysis and computer mode...

Three new norlimonoids, toonaciliatins A (1), F (6), and G (7), four new limonoids, toonaciliatins B-E (2-5), and five known compounds, 5alpha,6beta,8alpha-trihydroxy-28-norisotoonafolin (8), toonaciliatins H (9) and I (10), febrifugin (11), and khayasin T (12), were isolated from the leaves and stems of Toona ciliata. Compounds 1-3 have an unusual...

[structure: see text] Chlorahololides A(1) and B(2), two highly complex sesquiterpenoid dimers, were isolated from Chloranthus holostegius. Their structures and absolute configurations were established by NMR spectroscopy, X-ray crystallography, and CD. Chlorahololides A (1) and B (2) exhibited potent and selective inhibition on the delayed rectifi...

A new alkaloid, daphnilongeridine (1), together with six known alkaloids, daphmacropodine (2), daphmacrine (3), codaphniphylline (4), daphniyunnine A (5), daphniyunnine C (6), and daphniyunnine E (7), were isolated from the leaves and stems of Daphniphyllum longeracemosum. The so far elusive configuration at C(25) of daphmacropodine (2) was assigne...

Three new alkaloids, gelsebanine (1), 14alpha-hydroxyelegansamine (2), and 14alpha-hydroxygelsamydine (3), and a new extraction artifact , gelsebamine (4), together with 12 known alkaloids, were isolated from the stems and leaves of Gelsemium elegans. The structures of 1-4 were determined by spectroscopic methods, especially 2D NMR techniques. Comp...

Three new 24-noroleanane triterpenoids, i.e., 2α,19α-dihydroxy-3-oxo-24-norolean-12-en-28-oic acid (1) and 19α-hydroxy-3-oxo-24-norolean-12-en-28-oic acid (2), and 2α,3β,19α-trihydroxy-24-norolean-12-en-28-oic acid (3) were isolated from Quercus aliena var. acuteserrata, together with three known compounds, bartogenic acid (4), ilexgenin A (5), and...

Four new polyoxygenated cyclohexene derivatives, uvarirufone A (1) and uvarirufols A–C (2–4), along with ten related known compounds, were isolated from the EtOH extract of the aerial parts of Uvaria rufaBl. Their structures and absolute configurations were determined by in-depth spectroscopic and spectrometric methods in combination with molecular...

[structure: see text] Two unprecedented C,C-linked dimeric indolizidine alkaloids, flueggenines A (1) and B (2), as well as their biosynthetic precursor (-)-norsecurinine, were isolated from the roots of Flueggea virosa. Their structures and absolute configurations were elucidated by spectroscopic methods, especially 2D NMR and CD spectral analyses...

A highly complex sesquiterpenoid dimmer, chloramultilide A (1), was isolated from Chloranthus multistachys. Its structure and relative stereochemistry were mainly established by using 1D NMR and 2D NMR spectra.

The first chemical study on the stems and leaves of Daphniphyllum yunnanense led to the isolation of five new alkaloids, daphniyunnines A-E (1-5). Daphniyunnines B-E (2-5) are four unusual C-22 nor-Daphniphyllum alkaloids. The structures of these alkaloids were characterized by spectroscopic methods, especially 2D NMR techniques. A single-crystal X...

Two new sesquiterpenoid lactones, namely eupalinilides K and L, were isolated from Eupatorium lindleyanum DC. Their structures were determined by spectral methods, including 1D‐ and 2D‐NMR spectra. Cytotoxic evaluation showed that eupalinilide L exhibited potent cytotoxicity against P‐388 and A‐549 tumor cell lines with IC 50 values of 0.17 and 2.6...

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.

Three new indole alkaloids, N(4)-demethyl-12-methoxyalstogustine (1), 17-carboxyl-N(4)-methylechitamidine chloride (2), and 17-carboxyl-12-methoxy-N(4)-methylechitamidine chloride (3), along with 15 known alkaloids, were isolated from the ethanolic extract of the stem bark of Winchia calophylla. The structures of 1-3 were elucidated on the basis of...

Four new Daphniphyllum alkaloids, daphnilongeranins A-D (1-4), along with four known ones, daphniphylline, longistylumphylline A, deoxyisocalyciphylline B, and daphnicyclidin D, were isolated from the leaves and stems of Daphniphyllum longeracemosum. Daphnilongeranin A (1) is the first seco-10,17-longistylumphylline A type Daphniphyllum alkaloid, a...

Seven new sesquiterpenoids, namely eupatochinilides I–VII (1–7), together with eight known compounds, euponin (8), mollisorin A (9), niveusin B (10), 8β-(4′,-acetoxy-tiglyloxy)-3β -hydroxy-6Hβ,7Hα-germacra-1(10)E,4E,11(13)-trien-6,12-olide (11), eupalinilide B (12), 8β-(4′-hydroxytigloyloxy)-5-desoxy-8-desacyleuparotin (13), 3-deacetyeupalinin A (1...

[structures: see text] Lathyranoic acid A (1), the first secolathyrane diterpenoid with an unprecedented skeleton, and a new diterpenoid Euphorbia factor L11 (2) were isolated from the seeds of Euphorbia lathyris. Their structures were elucidated by spectroscopic analysis and chemical methods. A biogenetic route involving an enzymatic Baeyer-Villig...

Four lignans, sacidumlignans A-D (1-4), and two degraded lignan derivatives, sacidumols A (5) and B (6), along with four known compounds, (+)-pinoresinol, 9alpha-hydroxypinoresinol, perforatic acid, and peucenine-7-O-methyl ether, were isolated from the ethanolic extract of the whole plant of Sarcostemma acidum. The structures and relative configur...

Two novel labdane-type diterpenoids, butanedioic acid mono[(13S)-13-hydroxylabda-8(17),14-dien-19-yl] ester (1) and butanedioic acid bis[(13S)-13-hydroxylabda-8(17),14-dien-19-yl] ester (2), along with the eleven known diterpenoids 3-13 and three other known compounds, were isolated from the bark of Larix chinensis. Their structures were elucidated...

A novel degraded triterpenoid isopseudolaritone A (1) and one new oligosaccharide, 1-O-isopropyl-6-O-[2-O-methyl-alpha-L-rhamnopyranosyl(1 --> 6)]-beta-D-glucopyranose (2), two new artefacts, 9-O-formacyl cedrusin (5) and 9,9'-O-diformacyl cedrusin (6), as well as 12 known phenolic Compounds (3-4, 7 16), were isolated from the root bark of Pseudola...

Ten new guaiane type sesquiterpene lactones, namely, eupalinilides A-J (1-10), as well as nine known compounds, eupachinilide C (11), eupachifolin D (12), eupachinilide E (13), 2alpha-hydroxyeupatolide (14), 3-deacetyleupalinin A (15), heliangine (16), 8beta-tigloyloxy-2,3-seco-6betaH,7alphaH-helianga-4Z,11(13)-diene-3,10beta;6, 12-diolid-2-oic aci...

Five new quassinoids, named picraqualides A–E (1–5), together with eleven known ones, nigakilactone E (6), nigakilactone F (7), kusulactone (8), javanicin U (9), 12-norquassin (10), quassin (11), 2,3-didehydropicrasin B (12), nigakilactone B (13), nigakilactone C (14), picrasin B (15), and simalikalacton C (16), were isolated from the EtOH extract...

Ten new sesquiterpenoids, namely, eupachinilides A-J (1-10), together with seven known sesquiterpenoids, eupachifolin D (11), budlein B (12), 8 beta-(4'-hydroxytiglyloxy)-2 beta-hydroxy-1 alpha H,5 alpha H,6 beta H,7 alpha H-guai-3,10(14),11(13)-trien-6,12-olide (13), 1,10-hydrobahia (14), 2 alpha-hydroxyeupatolide (15), eupaserrin (16), and mollis...

[structure: see text] The first diamino Daphniphyllum alkaloid, daphnipaxinin (1), with an unprecedented hexacyclic fused skeleton, along with a known alkaloid, daphnicyclidin A (2), was isolated from the stem of Daphniphyllum paxianum Rosenth. The structure and absolute stereochemistry of 1 were established by spectral methods, especially two-dime...

A new alkaloid, namely laccarin A (1), along with four known alkaloids, laccarin (2), adenosine (3), indole-3-carboxaldehyde (4) and nicotinamide (5), was isolated from the fungus Lactarius subplinthogalus. The structure of laccarin A (1) was established mainly by spectroscopic methods.

Two novel alkaloids, paxdaphnidine A (1) with a unique pentacyclic skeleton and paxdaphnidine B (2) with an uncommon tetracyclic skeleton, were isolated from the stems and leaves of Daphniphyllum paxianum. Their structures were established by spectral methods, especially two-dimensional NMR techniques ((1)H-(1)H COSY, HSQC, HMBC, and NOESY).

Four novel sesquiterpenes, namely 7alpha,8beta,13-trihydroxy-5,13-marasmanolide (2), isoplorantinone (5), 4,8,14-trihydroxyilludala-2,6,8-triene (6), and 8-hydroxy-8,9-secolactara-1,6-dien-5,13-olide (10), together with six known ones, 7alpha,8beta-dihydroxy-5,13-marasmanolide (1), 7alpha,8alpha-dihydroxy-5,13-marasmanolide (3), isolactarorufin (4)...

The in vitro antifungal activities of 19 structurally diversified analogues of pseudolaric acids tested against the major pathogenic fungus Candida albicans has led to the establishment of a very clear structure-activity relationship of pseudolaric acids derivatives. Pseudolaric acid A was first found to be a potent antifungal component comparable...

Two novel major alkaloids, deoxycalyciphylline B (1) and deoxyisocalyciphylline B (2) with a unique fused hexacyclic skeleton, together with a quite recently reported alkaloid calyciphylline B (3), were isolated from the stem of Daphniphyllum subverticillatum. Their structures were established by spectral methods and chemical evidence, especially 2...

Four novel sesquiterpenes, namely 7α,8β,13-trihydroxy-5,13-marasmanolide (2), isoplorantinone (5), 4,8,14-trihydroxyilludala-2,6,8-triene (6), and 8-hydroxy-8,9-secolactara-1,6-dien-5,13-olide (10), together with six known ones, 7α,8β-dihydroxy-5,13-marasmanolide (1), 7α,8α-dihydroxy-5,13-marasmanolide (3), isolactarorufin (4), blennin A (7), blenn...

Five new diterpenoids, pseudolaric acids F (1), G (2), and H (3), 2',3'-dihydroxy-1'-propoxypseudolarate B (4), and 6'-O-acetylpseudolaric acid B O-beta-D-glucopyranoside (5), along with nine known diterpenoids, pseudolaric acids A, B, and C(1), deacetylpseudolaric acid C(2), deacetylpseudolaric acid A, methyl pseudolarate A, methyl pseudolarate B,...

Two novel antimicrobial and cytotoxic triterpenoids, isopseudolarifuroic acids A (1) and B (2), were isolated from the bark of Pseudolarix kaempferi. The structural elucidation of two novel compounds was carried out mainly by spectroscopic methods, and also by computer modeling. Compounds 1 and 2 exhibited significant cytotoxic activities against s...