Sheng-Hsuan Lin

Sheng-Hsuan Lin
National Yang Ming Chiao Tung University · Institute of Statistics

M.D., ScD, ScM

About

96
Publications
10,663
Reads
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1,130
Citations
Citations since 2016
79 Research Items
1056 Citations
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2016201720182019202020212022050100150200250
2016201720182019202020212022050100150200250
2016201720182019202020212022050100150200250
Introduction
Epidemiologic method, biostatistics, causal inference, mediation analysis, time-varying system, Epidemiology, decision science, cost-effectiveness analysis, psychiatry, behavior addiction, portable medical device, heart rate variability.
Additional affiliations
August 2020 - present
National Chiao Tung University
Position
  • Professor (Associate)
August 2020 - present
National Chiao Tung University
Position
  • Professor (Associate)
August 2018 - May 2020
National Chiao Tung University
Position
  • Professor (Assistant)
Education
September 2014 - June 2016
Harvard University, School of Public Health (HSPH),Department of Biostatistics
Field of study
  • General epidemiology
September 2011 - June 2016
Harvard University, School of Public Health (HSPH),Department of Epidemiology
Field of study
  • General epidemiology
September 2003 - June 2010
National Taiwan University (NTU)
Field of study

Publications

Publications (96)
Article
Full-text available
Background Increasing evidence suggests that glucagon-like peptide 1 (GLP-1) receptor agonists (RA) can stabilize glycemic variability (GV) and interfere with eating behavior. This study compared the impact of insulin, GLP-1 RA, and dietary components on GV using professional continuous glucose monitoring (CGM). Methods Patients with type 2 diabet...
Article
Full-text available
Background Treatment protocols for two-stage revision arthroplasty with diabetes mellitus (DM) have not yet been established. The control of glycated hemoglobin (HbA1c) in two-stage revision arthroplasty is still debated. This study aimed to clarify the importance of preoperative HbA1c levels before each stage of revision arthroplasty and to analyz...
Article
In longitudinal studies with time-varying exposures and mediators, the mediational g-formula is an important method for the assessment of direct and indirect effects. However, current methodologies based on the mediational g-formula can deal with only one mediator. This limitation makes these methodologies inapplicable to many scenarios. Hence, we...
Article
Causal mediation analysis is advantageous for mechanism investigation. In settings with multiple causally ordered mediators, path-specific effects have been introduced to specify the effects of certain combinations of mediators. However, most path-specific effects are unidentifiable. An interventional analog of path-specific effects is adapted to a...
Article
Purpose Population attributable fraction (PAF), defined as the proportion of the occurrence of a disease which will be reduced by eliminating risk factors in a population, is one of the most common measurements for evaluating the benefit of a health-related policy in epidemiologic study. In this article, we propose an alternative PAF defined based...
Article
Full-text available
Triple-negative breast cancer (TNBC) is treated with neoadjuvant chemotherapy (NAC). The response to NAC, particularly the probability of a complete pathological response (pCR), guides the surgical approach and adjuvant therapy. We developed a prediction model using a nomogram integrating blood tests and pre-treatment ultrasound findings for predic...
Preprint
Full-text available
Background: Treatment protocols for two-stage revision arthroplasty with diabetes mellitus (DM) have not yet been established. The control of glycated hemoglobin (HbA1c) in two-stage revision arthroplasty is still debated. This study aimed to clarify the importance of preoperative HbA1c levels before each stage of revision arthroplasty and to analy...
Article
Full-text available
Study question: Could the direct contribution of genetic variants to the pathophysiology of uterine fibroids and the contribution mediated by age at menarche be different? Summary answer: Age at menarche plays a mediation role in the genetic influence on uterine fibroids, and four causal genetic mechanisms underlying the age at menarche-mediated...
Article
Causal multimediation analysis (i.e. the causal mediation analysis with multiple mediators) is critical for understanding the effectiveness of interventions, especially in medical research. Deriving the path-specific effects of exposure on the outcome through a set of mediators can provide detail about the causal mechanism of interest However, exis...
Article
Introduction Pancreatic ductal adenocarcinoma (PDAC) is highly aggressive and has poor prognosis. There are few biomarkers to inform treatment decisions, and collecting tumour samples for testing is challenging. Methods Circulating tumour cells (CTCs) from patients with PDAC liquid biopsies were expanded ex vivo to form CTC-derived organoid cultur...
Article
Full-text available
Background and Aims Parkinson’s disease (PD) is a worldwide neurodegenerative disease with an increasing global burden, while constipation is an important risk factor for PD. The gastrointestinal tract had been proposed as the origin of PD in Braak’s gut–brain axis hypothesis, and there is increasing evidence indicating that intestinal microbial al...
Article
Full-text available
Background and Aims Entacapone, one of the most common drugs distributed among patients with Parkinson’s disease, is a peripherally acting catechol-O-methyltransferase (COMT) inhibitor that is used in addition to levodopa to control symptoms. However, there have been negative effects reported against entacapone, namely, gastrointestinal (GI) proble...
Article
Path-specific effects are a critical measure for assessing mediation in the presence of multiple mediators. However, the conventional definition of path-specific effects has generated controversy because it often causes misinterpretation of the results of multiple mediator analysis. For in-depth analysis of this issue, we propose the concept of dec...
Article
Aims: This retrospective study investigated the risk factors of sodium-glucose cotransporter 2 inhibitors (SGLT2i) -related genitourinary tract infection (GUTI). Methods: We used longitudinal claims data from May 2016 to December 2017 from the Chang Gung Research Database. Diabetic patients who used SGLT2i were included. The baseline characteris...
Article
Full-text available
Background The survival rate of head and neck squamous cell carcinoma (HNSCC) patients with secondary primary malignancy (SPM) showed no significant improvement for decades, however, the impact of advances in diagnostic tools is rarely mentioned. This study investigated the clinical characteristic of HNSCC with SPM over a 27-year period especially...
Article
Counterfactual‐model‐based mediation analysis can yield substantial insight into the causal mechanism through the assessment of natural direct effects (NDEs) and natural indirect effects (NIEs). However, the assumptions regarding unmeasured mediator‐outcome confounding and intermediate mediator‐outcome confounding that are required for the determin...
Article
Effect decomposition is a critical technique for mechanism investigation in settings with multiple causally ordered mediators. Causal mediation analysis is a standard method for effect decomposition, but the assumptions required for the identification process are extremely strong. Moreover, mediation analysis focuses on addressing mediating mechani...
Article
Full-text available
Regression-based approaches are widely used in causal mediation analysis. The presence of multiple mediators, however, increases the complexity and difficulty of mediation analysis. In such cases, regression-based approaches cannot efficiently address estimation issues. Hence, a flexible approach to mediation analysis is needed. Therefore, we devel...
Article
Full-text available
Objectives In patients with recurrent laryngeal nerve (RLN) injury after thyroid surgery, unrecovered vocal fold motion (VFM) and subjective voice impairment cause extreme distress. For surgeons, treating these poor outcomes is extremely challenging. To enable early treatment of VFM impairment, this study evaluated prognostic indicators of non-tran...
Article
Full-text available
Intraoperative neuromonitoring can qualify and quantify RLN function during thyroid surgery. This study investigated how the severity and mechanism of RLN dysfunction during monitored thyroid surgery affected postoperative voice. This retrospective study analyzed 1021 patients that received standardized monitored thyroidectomy. Patients had post-di...
Article
Full-text available
Objectives High-pitched voice impairment (HPVI) is not uncommon in patients without recurrent laryngeal nerve (RLN) or external branch of superior laryngeal nerve (EBSLN) injury after thyroidectomy. This study evaluated the correlation between subjective and objective HPVI in patients after thyroid surgery.Methods This study analyzed 775 patients w...
Preprint
Full-text available
Background Pancreatic ductal adenocarcinoma (PDAC) is highly aggressive and has poor prognosis. There are few biomarkers to inform treatment decisions, and collecting tumor samples for genomic or drug sensitivity testing is challenging.Methods Circulating tumor cells (CTCs) were prepared from the liquid biopsies of PDAC patients. These cells were s...
Article
Recent methodological developments in causal mediation analysis have addressed several issues regarding multiple mediators. However, these developed methods differ in their definitions of causal parameters, assumptions for identification, and interpretations of causal effects, making it unclear which method ought to be selected when investigating a...
Article
In medical research, the development of mediation analysis with a survival outcome has facilitated investigation into causal mechanisms. However, studies have not discussed the death-truncation problem for mediators, the problem being that conventional mediation parameters cannot be well defined in the presence of a truncated mediator. In the prese...
Article
Full-text available
Background The few studies that examined the association between residential greenness and birth outcomes have produced inconsistent results, and the underlying mechanisms of these associations remain unclear. Objectives We examined the mediation and interaction effects of particulate matter (PM) air pollution on the relationship between greenness...
Article
Full-text available
A recent review by Montag et al. raised a taxonomical argument about internet addiction. We propose a two-dimensional taxonomy of internet addiction by both the device and the content as the solution. For the assessment of smartphone addiction, measurements should be based on functional impairment and validated by diagnostic criteria rather than so...
Article
Full-text available
Background A mobile app generates passive data, such as GPS data traces, without any direct involvement from the user. These passive data have transformed the manner of traditional assessments that require active participation from the user. Passive data collection is one of the most important core techniques for mobile health development because i...
Article
Full-text available
Phantom vibration syndrome (PVS) and phantom ringing syndrome (PRS) are prevalent hallucinations during medical internship. Depression and anxiety are probably understudied risk factors of PVS and PRS. The aim was to evaluate the role of anxiety and depression on the relationship between working stress during medical internship and PVS and PRS. A p...
Article
The sufficient component cause (SCC) model and counterfactual model are two common methods for causal inference, each with their own advantages: the SCC model allows the mechanistic interaction to be detailed, whereas the counterfactual model features a systemic framework for quantifying causal effects. Hence, integrating the SCC and counterfactual...
Preprint
BACKGROUND Phantom vibrations syndrome (PVS) and phantom ringing syndrome (PRS) are prevalent hallucinations during medical internship. Depression and anxiety are probably understudied risk factors of PVS and PRS. OBJECTIVE The aim of this study was to investigate the role of anxiety and depression on the relationship between working stress during...
Preprint
BACKGROUND The prevalence of COVID-19 has caused 200 thousands death-cases since early 2020. The corresponding mortality rate among different countries and time varies. OBJECTIVE This study aims to investigate the relationship between mortality rate and the prevalence of COVID-19 in a country. METHODS We collected data from John Hopkins Coronavir...
Article
Full-text available
Background: The prevalence of COVID-19 has caused 200 thousand death-cases since early 2020. The corresponding mortality rate among different countries and time varies. Objective: This study aims to investigate the relationship between mortality rate and the prevalence of COVID-19 within a country. Methods: We collected data from Johns Hopkins...
Article
Full-text available
To determine whether policies to limit transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) hinder spread of other infectious diseases, we analyzed the National Health Insurance database in Taiwan. Rates of other infections were significantly lower after SARS-CoV-2 prevention measures were announced. This finding can be appl...
Article
Full-text available
Objectives: The purpose of this study was to identify the impact of chronic, unhealthy sleep practices in adolescence on substance use in young adulthood. Unhealthy sleep practices in adolescent samples exhibit a bidirectional relationship with substance use. The relationship is further complicated if we consider that confounders such as depressio...
Technical Report
In medical research, the development of mediation analysis with a survival outcome has facilitated investigation into causal mechanisms. However, studies have not discussed the death-truncation problem for mediators, the problem being that conventional mediation parameters cannot be well-defined in the presence of a truncated mediator. In the prese...
Article
Full-text available
Background: Medical residency is a time of high stress and long working hours, which increase the risk of cardiovascular disease. This study aimed to investigate the autonomic modulation of resident physicians throughout the on-call duty cycle. Methods: Spectral analysis of heart rate variability (HRV) was used to compute cardiac parasympathetic mo...
Article
Full-text available
Objectives Overwork has been recognized as a risk factor for cerebrovascular and cardiovascular disease (CCVD). To our best knowledge, Japan is the first country in the world to implement an independent act (the 2014 Act) for the prevention of overwork‐related disease, which was promoted through application of preventive measures, such as reduction...
Technical Report
Causal mediation analysis with multiple mediators (causal multi-mediation analysis) is critical in understanding why an intervention works, especially in medical research. Deriving the path-specific effects (PSEs) of exposure on the outcome through a certain set of mediators can detail the causal mechanism of interest. However, the existing models...
Article
Characterizing the mechanistic interactions between exposures and diseases is one of the most critical issues in epidemiologic studies. Previous studies have proposed a stochastic sufficient component cause framework, under which each sufficient cause is treated as a stochastic process instead of a time‐invariant random variable. However, different...
Preprint
BACKGROUND Phantom vibrations syndrome (PVS) and phantom ringing syndrome (PRS) are prevalent hallucinations during medical internship. Depression and anxiety are probably understudied risk factors of PVS and PRS. OBJECTIVE The aim of this study was to investigate the role of anxiety and depression on the relationship between working stress during...
Preprint
BACKGROUND A mobile application (app) generates passive data without any direct involvement from the subject, such as Global Positioning System (GPS) data traces. These passive data transformed the manner of traditional assessment, which requires active participation from the subject. Passive data collection is one of the most important core techni...
Article
Full-text available
Objectives Taiwan revised its criteria for overwork-related cerebrovascular and cardiovascular disease (CCVD) in 2010. A new definition of overwork increased the number of recognised cases. Meanwhile, actual average working hours decreased. We estimated the effects of the revised criteria on the number of overwork-related CCVD cases and the mediati...
Technical Report
Causal mediation analysis has demonstrated the advantage of mechanism investigation. In conditions with causally ordered mediators, path-specific effects (PSEs) are introduced for specifying the effect subject to a certain combination of mediators. However, most PSEs are unidentifiable. To address this, an alternative approach termed interventional...
Article
Background Peritonitis is a serious complication after invasive procedures in patients undergoing peritoneal dialysis (PD). Most studies that have investigated peritonitis following invasive gynecologic procedures enrolled small patient populations. This study focuses on the clinical presentation, outcomes, and effects of prophylactic antibiotic us...
Article
Background Assessing human behaviors via smartphone for monitoring the pattern of daily behaviors has become a crucial issue in this century. Thus, a more accurate and structured methodology is needed for smartphone use research. Objective The study aimed to investigate the duration of data collection needed to establish a reliable pattern of use,...
Article
Agonistic interaction is one of the most important types of mechanistic interaction, which is difficult to be distinguished from synergistic interaction by empirical data. In this study, we propose four approaches that suffice to identify and estimate the agonistic interaction: (1) to make a strong assumption that synergism does not exist; (2) to e...
Preprint
BACKGROUND Assessing human behaviors via smartphone for monitoring pattern of daily behaviors has become a crucial issue in this century. Thus, more accurate and precise methodology is needed for smartphone use research. OBJECTIVE We aimed to investigate the duration of data collection needed to establish a reliable pattern of use, how long could...
Article
We propose an approach to conduct mediation analysis for survival data with time-varying exposures, mediators, and confounders. We identify certain interventional direct and indirect effects through a survival mediational g-formula and describe the required assumptions. We also provide a feasible parametric approach along with an algorithm and soft...
Chapter
In recent years as the prevalence of smartphones has increased, so too has excessive smartphone use become a prominent social issue. “Smartphone addiction” is one form of a more general technological addiction. In this chapter, we review the evolution of substance and behavioural addiction through an examination of the process for the diagnosis of...
Article
The assessment of direct and indirect effects with time-varying mediators and confounders is a common but challenging problem, and standard mediation analysis approaches are generally not applicable in this context. The mediational g-formula was recently proposed to address this problem, paired with a semiparametric estimation approach to evaluate...
Article
Full-text available
Global smartphone penetration has led to unprecedented addictive behaviors. To develop a smartphone use/non-use pattern by mobile application (App) in order to identify problematic smartphone use, a total of 79 college students were monitored by the App for 1 month. The App-generated parameters included the daily use/non-use frequency, the total du...